2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Breast Neoplasms in 23 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response modelling of the data for these three tumour types gives BMDL10 values of 0." | 2.46 | Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). ( Carthew, P; DiNovi, M; Setzer, RW, 2010) |
| " Chronic administration of PhIP in the diet has been shown to cause mammary gland cancer in rats." | 2.39 | Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer. ( Snyderwine, EG, 1994) |
| "Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP)." | 1.51 | Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells. ( David, RM; Gooderham, NJ; Malik, DE, 2019) |
| "Initiation of carcinogenesis was measured by transient endpoints induced in a single exposure, while progression of carcinogenesis was measured by acquisition of constitutive endpoints in cumulative exposures." | 1.40 | Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties. ( Pluchino, LA; Wang, HC, 2014) |
| "More than 85% breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens through a multistep and multiyear disease process." | 1.40 | Dipyridamole intervention of breast cell carcinogenesis. ( Choudhary, S; Sood, S; Wang, HC, 2014) |
| "More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens, such as those in the diet, through a multistep disease process progressing from non-cancerous to premalignant and malignant stages." | 1.38 | Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. ( Choudhary, S; Donnell, RL; Sood, S; Wang, HC, 2012) |
| "Treatment of the mammary cancer cell lines MCF-7 and T47D with PhIP induces cells to digest and migrate through a reconstituted basement membrane." | 1.37 | The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells. ( Gooderham, NJ; Lauber, SN, 2011) |
| "We tested in human breast cancer adenocarcinoma cell line MCF-7 whether ethanol affects ABCG2/BCRP, which is also the major transporter in human placenta." | 1.37 | Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion. ( Auriola, S; Halonen, T; Karttunen, V; Myllynen, P; Myöhänen, K; Vähäkangas, K; Veid, J, 2011) |
| "Between 1996 and 2006, 2,317 breast cancer cases were diagnosed during 533,618 person-years." | 1.36 | Meat mutagens and breast cancer in postmenopausal women--a cohort analysis. ( Cho, E; Giovannucci, E; Holmes, MD; Sinha, R; Willett, W; Wu, K, 2010) |
| "Diallyl sulfide (DAS) has been shown to prevent cancer in several animal models, presumably by metabolic modulation." | 1.34 | Diallyl sulfide inhibits PhIP-induced DNA strand breaks in normal human breast epithelial cells. ( Aboyade-Cole, A; Darling-Reed, S; Newell, O; Oriaku, E; Thomas, R; Wilson, C, 2007) |
| " We detected significant dose-response relationship and correlation (r=0." | 1.32 | Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. ( Bondy, ML; Chang, P; Li, D; Sahin, AA; Shirai, T; Singletary, SE; Takahashi, S; Zhu, J, 2003) |
| "For 114 cases with breast cancer and 280 controls with benign breast disease, NAT2 genotype was determined using allele-specific PCR amplification to detect slow acetylator mutations." | 1.31 | Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype. ( Anton-Culver, H; Butler, J; Delfino, RJ; Gim, JS; Liao, SY; Lin, HJ; Ma, HL; Sinha, R; Smith, C; West, J; White, E, 2000) |
| " The aim of this study was to examine the bioavailability of these compounds to human breast tissue and their ability to bind to DNA to form DNA adducts." | 1.31 | Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene. ( Coxhead, JM; Cupid, BC; Garner, RC; Lightfoot, TJ; Nicholson, S, 2000) |
| "An increased risk of breast cancer has been observed in women who consume "very well-done" meats." | 1.31 | Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women. ( DeBruin, LS; Josephy, PD; Martos, PA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malik, DE | 2 |
| David, RM | 2 |
| Gooderham, NJ | 5 |
| Papaioannou, MD | 1 |
| Koufaris, C | 1 |
| Pluchino, LA | 1 |
| Wang, HC | 3 |
| Immonen, E | 1 |
| Serpi, R | 1 |
| Vähäkangas, K | 2 |
| Myllynen, P | 2 |
| Carthew, P | 1 |
| DiNovi, M | 1 |
| Setzer, RW | 1 |
| Wu, K | 1 |
| Sinha, R | 3 |
| Holmes, MD | 1 |
| Giovannucci, E | 1 |
| Willett, W | 1 |
| Cho, E | 1 |
| Lauber, SN | 2 |
| Veid, J | 1 |
| Karttunen, V | 1 |
| Myöhänen, K | 1 |
| Auriola, S | 1 |
| Halonen, T | 1 |
| Choudhary, S | 2 |
| Sood, S | 2 |
| Donnell, RL | 1 |
| Zhu, J | 1 |
| Chang, P | 1 |
| Bondy, ML | 1 |
| Sahin, AA | 1 |
| Singletary, SE | 1 |
| Takahashi, S | 2 |
| Shirai, T | 2 |
| Li, D | 1 |
| Wilson, C | 1 |
| Aboyade-Cole, A | 1 |
| Newell, O | 1 |
| Darling-Reed, S | 1 |
| Oriaku, E | 1 |
| Thomas, R | 1 |
| Naiki-Ito, A | 1 |
| Asamoto, M | 1 |
| Hokaiwado, N | 1 |
| Yamashita, H | 1 |
| Tsuda, H | 1 |
| Ogawa, K | 1 |
| Hewitt, R | 1 |
| Forero, A | 1 |
| Luncsford, PJ | 1 |
| Martin, FL | 1 |
| Snyderwine, EG | 1 |
| Synderwine, EG | 1 |
| Delfino, RJ | 1 |
| Smith, C | 1 |
| West, J | 1 |
| White, E | 1 |
| Lin, HJ | 1 |
| Liao, SY | 1 |
| Gim, JS | 1 |
| Ma, HL | 1 |
| Butler, J | 1 |
| Anton-Culver, H | 1 |
| Gustafson, DR | 1 |
| Kulldorff, M | 1 |
| Wen, WQ | 1 |
| Cerhan, JR | 1 |
| Zheng, W | 1 |
| Lightfoot, TJ | 1 |
| Coxhead, JM | 1 |
| Cupid, BC | 1 |
| Nicholson, S | 1 |
| Garner, RC | 1 |
| DeBruin, LS | 1 |
| Martos, PA | 1 |
| Josephy, PD | 1 |
| Felton, JS | 1 |
| Knize, MG | 1 |
| Salmon, CP | 1 |
| Malfatti, MA | 1 |
| Kulp, KS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Search for the Transfer of Bovine miRNA to Humans by Comparing the Omnivore Group With a Vegan Group After a Dietary Intervention[NCT03740087] | 29 participants (Actual) | Interventional | 2015-04-13 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Breast Neoplasms
| Article | Year |
|---|---|
Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
Topics: Animals; Breast Neoplasms; Carcinogens; Colonic Neoplasms; Cooking; Data Interpretation, Statistical | 2010 |
Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer.
Topics: Amines; Breast Neoplasms; Carcinogens; Cooking; Female; Food Analysis; Heterocyclic Compounds; Human | 1994 |
The food-derived heterocyclic amines and breast cancer: a 1995 perspective.
Topics: Amines; Animals; Breast Neoplasms; Carcinogens; Dietary Fats; Food; Heterocyclic Compounds; Humans; | 1996 |
Human exposure to heterocyclic amine food mutagens/carcinogens: relevance to breast cancer.
Topics: Amines; Animals; Breast Neoplasms; Carcinogens; Cooking; Female; Food Analysis; Glucuronides; Hetero | 2002 |
19 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Breast Neoplasms
| Article | Year |
|---|---|
Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.
Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cytochrome P-450 CYP1B1; DNA Damage | 2019 |
Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer.
Topics: Breast Neoplasms; Carcinogens; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2E1; DNA Damage; Estroge | 2018 |
The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.
Topics: Animals; Breast Neoplasms; Carcinogens; Cattle; Cell Line, Tumor; Cooking; Epigenesis, Genetic; Estr | 2014 |
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogenesis; Carcinogens; DNA Damage; Drug Synergism; Epithelia | 2014 |
Responses of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in MCF-7 cells are culture condition dependent.
Topics: Adenocarcinoma; Adenosine Triphosphate; Breast Neoplasms; Carcinogens; Cell Culture Techniques; Cell | 2009 |
Meat mutagens and breast cancer in postmenopausal women--a cohort analysis.
Topics: Adult; Breast Neoplasms; Cohort Studies; Female; Humans; Imidazoles; Meat; Middle Aged; Mutagens; Nu | 2010 |
The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells.
Topics: Basement Membrane; Breast Neoplasms; Carcinogens; Cathepsin D; Cell Line, Tumor; Cell Movement; Cook | 2011 |
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion.
Topics: Adenocarcinoma; Antipyrine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cas | 2011 |
Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Base Sequence; Breast Neoplasms; Carcinogens; Catechin; Cell Line, Tumor; Cell Transformation, Neopl | 2012 |
Dipyridamole intervention of breast cell carcinogenesis.
Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion; | 2014 |
Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer.
Topics: Adult; Breast; Breast Neoplasms; Carcinogens; Diet; DNA Adducts; Dose-Response Relationship, Drug; E | 2003 |
Diallyl sulfide inhibits PhIP-induced DNA strand breaks in normal human breast epithelial cells.
Topics: Allyl Compounds; Anticarcinogenic Agents; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Chemoprev | 2007 |
The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer.
Topics: Animals; Breast Neoplasms; Carcinogens; Cell Growth Processes; Estradiol; Flavonoids; Fulvestrant; I | 2007 |
Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Animals; Animals, Genetically Modified; Blotting, Wes | 2007 |
Enhanced micronucleus formation and modulation of BCL-2:BAX in MCF-7 cells after exposure to binary mixtures.
Topics: bcl-2-Associated X Protein; Benzo(a)pyrene; Breast Neoplasms; Cell Line, Tumor; Cyclin-Dependent Kin | 2007 |
Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype.
Topics: Adult; Aged; Arylamine N-Acetyltransferase; Breast Neoplasms; Carcinogens; Cooking; Diet; Female; Ge | 2000 |
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a carcinogen in high-temperature-cooked meat, and breast cancer risk.
Topics: Breast Neoplasms; Carcinogens; Cooking; Female; Hot Temperature; Humans; Imidazoles; Meat; Mutagens; | 2000 |
Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene.
Topics: Aged; Benzo(a)pyrene; Biological Availability; Biotransformation; Breast; Breast Neoplasms; Carbon R | 2000 |
Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the milk of healthy women.
Topics: Adult; Breast Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Chromatography, Liquid; Cooki | 2001 |