2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Adenomatous Polyposis Coli in 2 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Loss of function of the adenomatous polyposis coli (APC) gene product is an early and frequent event in human colorectal carcinogenesis." | 1.35 | High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation. ( Bellocq, D; Canlet, C; Martin, PG; Molina, J; Paris, A; Pierre, F; Rathahao, E; Taché, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Husøy, T | 1 |
| Abramsson-Zetterberg, L | 1 |
| Ølstørn, HB | 1 |
| Paulsen, JE | 1 |
| Alexander, J | 1 |
| Bellocq, D | 1 |
| Molina, J | 1 |
| Rathahao, E | 1 |
| Canlet, C | 1 |
| Taché, S | 1 |
| Martin, PG | 1 |
| Pierre, F | 1 |
| Paris, A | 1 |
2 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Adenomatous Polyposis Coli
| Article | Year |
|---|---|
Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes.
Topics: Acrylamide; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Animals; Colchicine; Cyt | 2005 |
High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.
Topics: Adenomatous Polyposis Coli; Animals; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; B | 2008 |