2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Adenoma in 21 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Adenoma: A benign epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, we assessed a dose-response relationship." | 2.61 | Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis. ( Castaño, PR; Linseisen, J; Martínez Góngora, V; Matthes, KL; Rohrmann, S, 2019) |
| " The results show that PhIP is extremely toxic to XPA(-/-) mice, even at doses 10-fold lower than tolerated by wild-type C57BL/6 mice." | 1.31 | Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice. ( Beems, RB; Hamzink, M; Klein, JC; van Kreijl, CF; van Steeg , H; Zomer, G; Zwart, PE, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 13 (61.90) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martínez Góngora, V | 1 |
| Matthes, KL | 1 |
| Castaño, PR | 1 |
| Linseisen, J | 2 |
| Rohrmann, S | 2 |
| Budhathoki, S | 1 |
| Iwasaki, M | 1 |
| Yamaji, T | 1 |
| Sasazuki, S | 1 |
| Takachi, R | 1 |
| Sakamoto, H | 1 |
| Yoshida, T | 1 |
| Tsugane, S | 1 |
| Hermann, S | 1 |
| Dietrich, CG | 1 |
| Vehr, AK | 1 |
| Martin, IV | 1 |
| Gassler, N | 1 |
| Rath, T | 1 |
| Roeb, E | 1 |
| Schmitt, J | 1 |
| Trautwein, C | 1 |
| Geier, A | 1 |
| Yamagishi, M | 1 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Nakamura, H | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 2 |
| Nishikawa, A | 2 |
| Hirose, M | 3 |
| Ochiai, M | 3 |
| Ushigome, M | 1 |
| Fujiwara, K | 1 |
| Ubagai, T | 1 |
| Kawamori, T | 1 |
| Sugimura, T | 5 |
| Nagao, M | 4 |
| Nakagama, H | 2 |
| Shan, L | 1 |
| Yu, M | 1 |
| Qiu, C | 1 |
| Snyderwine, EG | 1 |
| Kuroiwa, Y | 1 |
| Kitamura, Y | 1 |
| Kanki, K | 1 |
| Ishii, Y | 1 |
| Umemura, T | 1 |
| Sinha, R | 1 |
| Peters, U | 1 |
| Cross, AJ | 1 |
| Kulldorff, M | 1 |
| Weissfeld, JL | 1 |
| Pinsky, PF | 1 |
| Rothman, N | 1 |
| Hayes, RB | 1 |
| Makino, H | 1 |
| Ushijima, T | 1 |
| Kakiuchi, H | 1 |
| Onda, M | 1 |
| Ito, N | 5 |
| Kimura, J | 1 |
| Hasegawa, R | 1 |
| Yaono, M | 1 |
| Kato, T | 1 |
| Wakabayashi, K | 3 |
| Shirai, T | 4 |
| Hagiwara, A | 3 |
| Boonyaphiphat, P | 1 |
| Tanaka, H | 2 |
| Kawabe, M | 2 |
| Tamano, S | 3 |
| Kaneko, H | 1 |
| Matsui, M | 1 |
| Dass, SB | 1 |
| Bucci, TJ | 1 |
| Heflich, RH | 1 |
| Casciano, DA | 1 |
| Steffensen, IL | 2 |
| Fretland, AJ | 1 |
| Paulsen, JE | 2 |
| Feng, Y | 1 |
| Eide, TJ | 1 |
| Devanaboyina, US | 1 |
| Hein, DW | 1 |
| Alexander, J | 2 |
| Tsukamoto, T | 1 |
| Fukami, H | 1 |
| Inoue, M | 1 |
| Takahashi, M | 1 |
| Tatematsu, M | 1 |
| Klein, JC | 1 |
| Beems, RB | 1 |
| Zwart, PE | 1 |
| Hamzink, M | 1 |
| Zomer, G | 1 |
| van Steeg , H | 1 |
| van Kreijl, CF | 1 |
| Vikse, R | 1 |
| Miyashita, K | 1 |
| Nakanishi, T | 1 |
| Sano, M | 1 |
| Kadota, T | 1 |
| Koda, T | 2 |
| Nakamura, M | 2 |
| Imaida, K | 2 |
| Yoshino, H | 1 |
| Ichihara, T | 1 |
| Aoki, H | 1 |
| Imai, H | 1 |
| Ogawa, K | 1 |
| Nagase, S | 1 |
| Esumi, H | 1 |
1 review available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Adenoma
| Article | Year |
|---|---|
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis.
Topics: Adenoma; Adult; Aged; Amines; Benzo(a)pyrene; Colorectal Neoplasms; Diet; Female; Heterocyclic Compo | 2019 |
20 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Adenoma
| Article | Year |
|---|---|
Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo.
Topics: Adenoma; Animals; Arylamine N-Acetyltransferase; Case-Control Studies; Colorectal Neoplasms; Diet; F | 2015 |
Heterocyclic aromatic amine intake increases colorectal adenoma risk: findings from a prospective European cohort study.
Topics: Adenoma; Adult; Aged; Animals; Case-Control Studies; Cohort Studies; Colorectal Neoplasms; Cooking; | 2009 |
Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen.
Topics: Adenoma; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Tran | 2011 |
Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents, Phyt | 2002 |
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Adenocarcinoma; Adenoma; Animals; beta Catenin; Carcinogens; Cell Division; Colon; Colonic Neoplasms | 2003 |
Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas.
Topics: Adenoma; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Carcinoma; Cell Differentiation; | 2003 |
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dextran Sul | 2005 |
Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
Topics: Adenoma; Aged; Benzo(a)pyrene; Carcinogens; Colorectal Neoplasms; Cooking; Diet; Female; Food Preser | 2005 |
Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo]4,5-b]pyridine.
Topics: Adenocarcinoma; Adenoma; Animals; Base Sequence; Carcinogens; Colonic Neoplasms; Genes, ras; Imidazo | 1994 |
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Female; Fibroadenoma; Imidazoles; Incidence; Lactatio | 1996 |
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Caffeine; Carcinogens; Chemoprevention; Colonic Neop | 1999 |
Evaluation of the transgenic p53+/- mouse for detecting genotoxic liver carcinogens in a short-term bioassay.
Topics: Adenoma; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Chrysenes; Dimethylnitrosami | 1999 |
DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Topics: Acetylation; Adenoma; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Cricetinae; DNA Add | 2000 |
More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.
Topics: Adenocarcinoma; Adenoma; Amino Acid Sequence; Animals; Base Sequence; beta Catenin; Cytoskeletal Pro | 2000 |
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Carcinogens; DNA Mutational Analysis; DNA Repair; Dos | 2001 |
Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele.
Topics: Adenoma; Alleles; Animals; Carcinogens; Female; Genes, APC; Imidazoles; Incidence; Intestinal Neopla | 2001 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
Induction of intestinal tumors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: Adenoma; Animals; Carcinogens; Female; Imidazoles; Immunohistochemistry; Intestinal Neoplasms; Lymph | 2002 |
Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.
Topics: Adenocarcinoma; Adenoma; Albumins; Animals; Carcinogenicity Tests; Cattle; Cooking; Food Contaminati | 1991 |