Compounds > 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Adenocarcinoma

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Adenocarcinoma in 33 studies

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
"We tested in human breast cancer adenocarcinoma cell line MCF-7 whether ethanol affects ABCG2/BCRP, which is also the major transporter in human placenta."1.37Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion. ( Auriola, S; Halonen, T; Karttunen, V; Myllynen, P; Myöhänen, K; Vähäkangas, K; Veid, J, 2011)
" The results show that PhIP is extremely toxic to XPA(-/-) mice, even at doses 10-fold lower than tolerated by wild-type C57BL/6 mice."1.31Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice. ( Beems, RB; Hamzink, M; Klein, JC; van Kreijl, CF; van Steeg , H; Zomer, G; Zwart, PE, 2001)
"The carcinogenic potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), identified as the most abundant mutagenic heterocyclic amine in cooked meat and fish, was investigated in dose-response studies."1.29Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies. ( Hasegawa, R; Ito, N; Masui, T; Sano, M; Shirai, T; Tamano, S, 1995)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (36.36)18.2507
2000's18 (54.55)29.6817
2010's3 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Immonen, E1
Serpi, R1
Vähäkangas, K2
Myllynen, P2
Tang, MX1
Ogawa, K4
Asamoto, M3
Chewonarin, T1
Suzuki, S3
Tanaka, T4
Shirai, T13
Veid, J1
Karttunen, V1
Myöhänen, K1
Auriola, S1
Halonen, T1
Nicken, P1
Schröder, B1
von Keutz, A1
Breves, G1
Steinberg, P1
Yamagishi, M1
Natsume, M1
Osakabe, N1
Nakamura, H1
Furukawa, F1
Imazawa, T2
Nishikawa, A2
Hirose, M7
Cho, YM2
Takahashi, S3
Inaguma, S2
Hokaiwado, N1
Ochiai, M5
Ushigome, M1
Fujiwara, K1
Ubagai, T1
Kawamori, T1
Sugimura, T10
Nagao, M7
Nakagama, H3
Ohnishi, H1
Suzuki, R2
Kohno, H2
Sugie, S2
Takahashi, M2
Wakabayashi, K7
Kuroiwa, Y1
Kitamura, Y1
Kanki, K1
Ishii, Y1
Umemura, T1
Ohnishi, M1
Ushida, J1
Yamamoto, T1
Hara, A1
Koide, A1
Mori, Y1
Mori, H1
Nakanishi, M1
Tazawa, H1
Tsuchiya, N1
Creton, SK1
Zhu, H1
Gooderham, NJ1
Doi, K1
Hagihara, A1
Wei, M1
Yunoki, T1
Fukushima, S2
Wanibuchi, H1
Akagi, K1
Hasegawa, R7
Yaono, M2
Satoh, T1
Hara, Y1
Ito, N11
Makino, H1
Ushijima, T4
Kakiuchi, H2
Onda, M1
Kushida, H1
Sano, M3
Tamano, S5
Imaida, K5
Imai, K1
Yachi, A1
Kimura, J1
Kato, T1
Masui, T2
Hagiwara, A4
Yada, H1
Iwasaki, S1
Esumi, H2
Boonyaphiphat, P1
Tanaka, H2
Kawabe, M1
Kaneko, H1
Matsui, M1
Sinha, R1
Kulldorff, M1
Swanson, CA1
Curtin, J1
Brownson, RC1
Alavanja, MC1
Tsukamoto, T1
Fukami, H1
Inoue, M1
Tatematsu, M1
Nelson, CP1
Kidd, LC1
Sauvageot, J1
Isaacs, WB1
De Marzo, AM1
Groopman, JD1
Nelson, WG1
Kensler, TW1
Klein, JC1
Beems, RB1
Zwart, PE1
Hamzink, M1
Zomer, G1
van Steeg , H1
van Kreijl, CF1
Miyashita, K1
Nakanishi, T1
Kadota, T1
Koda, T1
Nakamura, M1
Futakuchi, M1
Miki, T1
Watanabe, N1
Okochi, E1
Nagase, S1

Reviews

1 review available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Adenocarcinoma

ArticleYear
Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats.
    Environmental and molecular mutagenesis, 2002, Volume: 39, Issue:2-3

    Topics: Adenocarcinoma; Animals; Carcinogens; DNA Damage; Female; Forecasting; Genes, p53; Hypoxanthine Phos

2002

Other Studies

32 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Adenocarcinoma

ArticleYear
Responses of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in MCF-7 cells are culture condition dependent.
    Chemico-biological interactions, 2009, Nov-10, Volume: 182, Issue:1

    Topics: Adenocarcinoma; Adenosine Triphosphate; Breast Neoplasms; Carcinogens; Cell Culture Techniques; Cell

2009
Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.
    Nutrition and cancer, 2011, Volume: 63, Issue:2

    Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Carcinogens; Chemoprevention; Colonic Neoplasms; Flavo

2011
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion.
    Toxicology letters, 2011, Sep-10, Volume: 205, Issue:3

    Topics: Adenocarcinoma; Antipyrine; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cas

2011
The colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is actively secreted in the distal colon of the rat: an integrated view on the role of PhIP transport and metabolism in PhIP-induced colon carcinogenesis.
    Archives of toxicology, 2013, Volume: 87, Issue:5

    Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Casset

2013
Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.
    Cancer letters, 2002, Nov-28, Volume: 185, Issue:2

    Topics: Adenocarcinoma; Adenoma; Animals; Anthocyanins; Anticarcinogenic Agents; Antineoplastic Agents, Phyt

2002
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
    Cancer science, 2003, Volume: 94, Issue:2

    Topics: Adenocarcinoma; Age Factors; Aminobiphenyl Compounds; Androgen Antagonists; Androgen-Binding Protein

2003
Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    The American journal of pathology, 2003, Volume: 163, Issue:4

    Topics: Adenocarcinoma; Adenoma; Animals; beta Catenin; Carcinogens; Cell Division; Colon; Colonic Neoplasms

2003
High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis.
    Cancer science, 2003, Volume: 94, Issue:11

    Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Disease Progression; Disease S

2003
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Carcinogenesis, 2005, Volume: 26, Issue:1

    Topics: Adenocarcinoma; Animals; Anticoagulants; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms

2005
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 84, Issue:2

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dextran Sul

2005
Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.
    International journal of cancer, 2005, Jun-20, Volume: 115, Issue:3

    Topics: 1-Naphthylisothiocyanate; Adenocarcinoma; Animals; Carcinogens; Diet; Drug Therapy, Combination; Fem

2005
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis.
    Cancer science, 2007, Volume: 98, Issue:8

    Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Colitis; Colon; Colon

2007
The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.
    Cancer research, 2007, Dec-01, Volume: 67, Issue:23

    Topics: Adenocarcinoma; Breast; Carcinogens; Cell Movement; Cell Proliferation; Cells, Cultured; Chemotaxis;

2007
Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model.
    Oncology, 2007, Volume: 73, Issue:3-4

    Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, D

2007
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats.
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinogens; Female; Fi

1995
Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo]4,5-b]pyridine.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:5

    Topics: Adenocarcinoma; Adenoma; Animals; Base Sequence; Carcinogens; Colonic Neoplasms; Genes, ras; Imidazo

1994
Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods.
    Cancer, 1994, Aug-01, Volume: 74, Issue:3 Suppl

    Topics: Adenocarcinoma; Amines; Animals; Carcinogens; Cooking; Female; Food Analysis; Heterocyclic Compounds

1994
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
    Carcinogenesis, 1993, Volume: 14, Issue:12

    Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dose-Response Relati

1993
Rare frequency of activation of the Ki-ras gene in rat colon tumors induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis.
    Molecular carcinogenesis, 1993, Volume: 8, Issue:1

    Topics: Adenocarcinoma; Amines; Animals; Base Sequence; Carcinogens; Codon; Colonic Neoplasms; Exons; Gene E

1993
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats.
    Cancer letters, 1996, Mar-19, Volume: 101, Issue:1

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Female; Fibroadenoma; Imidazoles; Incidence; Lactatio

1996
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Diet; DNA Adducts; Dose-

1995
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:11

    Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Cell Division; Dose-Response Relationship, Drug;

1996
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
    Mutation research, 1997, May-12, Volume: 376, Issue:1-2

    Topics: Adenocarcinoma; Animals; Carcinogens; Chlorophyllides; Colonic Neoplasms; Dose-Response Relationship

1997
Modification by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) of 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis.
    Cancer letters, 1998, Feb-13, Volume: 124, Issue:1

    Topics: Adenocarcinoma; Aminobiphenyl Compounds; Animals; Body Weight; Carcinogens; Drug Synergism; Imidazol

1998
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:4

    Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Caffeine; Carcinogens; Chemoprevention; Colonic Neop

1999
Dietary heterocyclic amines and the risk of lung cancer among Missouri women.
    Cancer research, 2000, Jul-15, Volume: 60, Issue:14

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cas

2000
More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.
    Japanese journal of cancer research : Gann, 2000, Volume: 91, Issue:8

    Topics: Adenocarcinoma; Adenoma; Amino Acid Sequence; Animals; Base Sequence; beta Catenin; Cytoskeletal Pro

2000
Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.
    Cancer research, 2001, Jan-01, Volume: 61, Issue:1

    Topics: Adenocarcinoma; Aged; Biotransformation; Carcinogens; Cytosol; DNA; DNA Adducts; Glutathione S-Trans

2001
Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
    Carcinogenesis, 2001, Volume: 22, Issue:4

    Topics: Adenocarcinoma; Adenoma; Animals; Body Weight; Carcinogens; DNA Mutational Analysis; DNA Repair; Dos

2001
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
    Cancer letters, 2001, Sep-28, Volume: 171, Issue:1

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim

2001
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
    Carcinogenesis, 2002, Volume: 23, Issue:2

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animal Feed; Animals; Carcinogens; Colonic Neoplasms; DNA Add

2002
Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:4

    Topics: Adenocarcinoma; Adenoma; Albumins; Animals; Carcinogenicity Tests; Cattle; Cooking; Food Contaminati

1991