2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with Aberrant Crypt Foci in 4 studies
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine: mutagen from fried ground beef; structure given in first source
PhIP : An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, the effect of three controversially discussed risk factors for colorectal cancer, a fat-rich diet (16% raw fat content), dietary folic acid supplementation (50 mg folic acid/kg lab chow) and a human-relevant concentration (0." | 3.78 | Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon. ( Brauer, N; Lampen, A; Nicken, P; Steinberg, P, 2012) |
| "Obesity is highly associated with colon cancer development." | 1.40 | AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats. ( Fukuda, H; Hippo, Y; Igarashi, M; Nakagama, H; Ochiai, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Igarashi, M | 1 |
| Hippo, Y | 1 |
| Ochiai, M | 1 |
| Fukuda, H | 1 |
| Nakagama, H | 1 |
| Tang, MX | 1 |
| Ogawa, K | 1 |
| Asamoto, M | 1 |
| Chewonarin, T | 1 |
| Suzuki, S | 1 |
| Tanaka, T | 1 |
| Shirai, T | 1 |
| Nicken, P | 1 |
| Brauer, N | 1 |
| Lampen, A | 1 |
| Steinberg, P | 1 |
| Klewicka, E | 1 |
| Nowak, A | 1 |
| Zduńczyk, Z | 1 |
| Juśkiewicz, J | 1 |
| Cukrowska, B | 1 |
4 other studies available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and Aberrant Crypt Foci
| Article | Year |
|---|---|
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Carcinogenesis; Carcinogens; Cell Line; Colon; Colonic Neop | 2014 |
Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Carcinogens; Chemoprevention; Colonic Neoplasms; Flavo | 2011 |
Influence of a fat-rich diet, folic acid supplementation and a human-relevant concentration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on the induction of preneoplastic lesions in the rat colon.
Topics: Aberrant Crypt Foci; Animals; Colon; Colorectal Neoplasms; Diet, High-Fat; Dietary Supplements; Foli | 2012 |
Protective effect of lactofermented red beetroot juice against aberrant crypt foci formation, genotoxicity of fecal water and oxidative stress induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in rats model.
Topics: Aberrant Crypt Foci; Animals; Antioxidants; Beta vulgaris; Caco-2 Cells; Carcinogens; Comet Assay; F | 2012 |