2-acetylaminofluorene has been researched along with Xeroderma Pigmentosum in 9 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Xeroderma Pigmentosum: A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of exposure to UV irradiation or to the N-acetoxy-ester derivatives of four carcinogenic aromatic amides, 4-acetylaminobiphenyl (AABP), 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene, and 4-acetylaminostilbene, on cell survival was compared in strains of cultured human fibroblasts possessing normal rates of excision repair of DNA and in three strains of xeroderma pigmentosum (XP) cells, each differing in its rate of excision repair." | 3.65 | Cytotoxicity of carcinogenic aromatic amides in normal and xeroderma pigmentosum fibroblasts with different DNA repair capabilities. ( Birch, N; MacCormick, JJ; Maher, VM; Otto, JR, 1975) |
| "Mouse models that mimic the human skin cancer-prone disease xeroderma pigmentosum (XP) provide an useful experimental system with which to study the relationship between the DNA repair process of nucleotide excision repair (NER) and ultraviolet- (UV) induced skin carcinogenesis." | 2.41 | Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions. ( Burns, DK; Cheo, DL; Friedberg, EC; Meira, LB; Nahari, D; Reis, AM, 2001) |
| " In order to compare DNA-incising capacities of the various cell strains after UV irradiation with those after treatment with (Ac)2ONFln, dose-response experiments including up to 8 dose levels were performed." | 1.27 | Comparison of DNA-incising capacities in fibroblast strains from the Mannheim XP collection after treatment with N-acetoxy-2-acetylaminofluorene and UV light. ( Popanda, O; Thielmann, HW, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoogervorst, EM | 1 |
| van Oostrom, CT | 1 |
| Beems, RB | 1 |
| van Benthem, J | 1 |
| Gielis, S | 1 |
| Vermeulen, JP | 1 |
| Wester, PW | 1 |
| Vos, JG | 1 |
| de Vries, A | 1 |
| van Steeg, H | 2 |
| Sivak, A | 1 |
| Rudenko, L | 1 |
| Teague, LG | 1 |
| Kaneko, M | 1 |
| Cerutti, PA | 1 |
| Cheo, DL | 2 |
| Burns, DK | 2 |
| Meira, LB | 2 |
| Houle, JF | 1 |
| Friedberg, EC | 2 |
| Mullenders, LH | 1 |
| Vijg, J | 1 |
| Reis, AM | 1 |
| Nahari, D | 1 |
| Roberts, JD | 1 |
| Lieberman, MW | 1 |
| Maher, VM | 1 |
| Birch, N | 1 |
| Otto, JR | 1 |
| MacCormick, JJ | 1 |
| Popanda, O | 1 |
| Thielmann, HW | 1 |
1 review available for 2-acetylaminofluorene and Xeroderma Pigmentosum
| Article | Year |
|---|---|
Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Disease Models, Animal; DNA Repair; Genes, p53; Genetic | 2001 |
8 other studies available for 2-acetylaminofluorene and Xeroderma Pigmentosum
| Article | Year |
|---|---|
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Crosses, Geneti | 2004 |
Variations among species and cell types in the effects of caffeine on mutagen-induced cytotoxicity and postreplication repair of DNA.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Line; Cell Survival; Cricet | 1982 |
Excision of N-acetoxy-2-acetylaminofluorene-induced DNA adducts from chromatin fractions of human fibroblasts.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Cells, Cultured; Chromatin; DNA; DNA Repair; Fibr | 1980 |
Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice.
Topics: 2-Acetylaminofluorene; Animals; DNA Repair; Female; Genes, p53; Humans; Liver Neoplasms, Experimenta | 1999 |
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Benzo(a)pyrene; Cocarcinogenesis; DNA Repair; DNA-Bin | 2000 |
Deoxyribonucleic acid repair synthesis in permeable human fibroblasts exposed to ultraviolet radiation and N-acetoxy-2-(acetylamino)fluorene.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Cell Line; DNA; DNA Repair; Fibroblasts; Humans; | 1979 |
Cytotoxicity of carcinogenic aromatic amides in normal and xeroderma pigmentosum fibroblasts with different DNA repair capabilities.
Topics: 2-Acetylaminofluorene; Amides; Biphenyl Compounds; Carcinogens; Cell Survival; Cells, Cultured; DNA | 1975 |
Comparison of DNA-incising capacities in fibroblast strains from the Mannheim XP collection after treatment with N-acetoxy-2-acetylaminofluorene and UV light.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Cells, Cultured; DNA; DNA Damage; Fibroblasts; Hu | 1988 |