2-acetylaminofluorene has been researched along with Sensitivity and Specificity in 13 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Swelling was determined as maximal rate of absorption decrease at 540 nm (delta A/delta t)." | 1.30 | Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene. ( Bitsch, A; Klöhn, PC; Neumann, HG, 1998) |
| "In human hepatoma (Hep G2) cells and peripheral blood lymphocytes (HPBL) the cytokinesis-blocked micronuclei (MN) and fluorescent in situ hybridization (FISH) assays were applied to study aneugenic and clastogenic potentials of X-rays, directly and indirectly acting chemicals." | 1.29 | Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric pro ( Darroudi, F; Hadjidekova, V; Meijers, CM; Natarajan, AT, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dezső, K | 1 |
| Papp, V | 1 |
| Bugyik, E | 1 |
| Hegyesi, H | 1 |
| Sáfrány, G | 1 |
| Bödör, C | 1 |
| Nagy, P | 1 |
| Paku, S | 1 |
| Vian, L | 2 |
| Yusuf, A | 1 |
| Guyomard, C | 1 |
| Cano, JP | 2 |
| Valentin-Severin, I | 1 |
| Le Hegarat, L | 1 |
| Lhuguenot, JC | 1 |
| Le Bon, AM | 1 |
| Chagnon, MC | 1 |
| Oberly, TJ | 1 |
| Huffman, DM | 1 |
| Scheuring, JC | 1 |
| Garriott, ML | 1 |
| Grollman, AP | 1 |
| Shibutani, S | 2 |
| Strömblad, S | 1 |
| Eriksson, LC | 1 |
| Andersson, G | 1 |
| Möller, L | 1 |
| Zeisig, M | 1 |
| Vodicka, P | 1 |
| Darroudi, F | 1 |
| Meijers, CM | 1 |
| Hadjidekova, V | 1 |
| Natarajan, AT | 1 |
| Klöhn, PC | 1 |
| Bitsch, A | 1 |
| Neumann, HG | 1 |
| Machado, J | 1 |
| Grimont, F | 1 |
| Grimont, PA | 1 |
| Jenkins, GJ | 1 |
| Parry, JM | 1 |
| Yusuf, AT | 1 |
| Sabatier, R | 1 |
2 reviews available for 2-acetylaminofluorene and Sensitivity and Specificity
| Article | Year |
|---|---|
Mutagenic specificity of chemical carcinogens as determined by studies of single DNA adducts.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Benzo(a)pyrene; Carcinogens; DNA; DNA Adducts; Humans | 1994 |
Mutagenic specificity of acetylaminofluorene-derived DNA adducts in vitro.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; DNA Adducts; Molecular Sequence Data; Mutagens; Sensi | 1994 |
11 other studies available for 2-acetylaminofluorene and Sensitivity and Specificity
| Article | Year |
|---|---|
Structural analysis of oval-cell-mediated liver regeneration in rats.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Differentiation; Biopsy, Needle; Cell Differentiation; Cel | 2012 |
The Liverbeads as a tool for the comet assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aged; Animals; Benzo(a)pyrene; Biotransform | 2002 |
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet As | 2003 |
An evaluation of 6 chromosomal mutagens in the AS52/XPRT mutation assay utilizing suspension culture and soft agar cloning.
Topics: 2-Acetylaminofluorene; Acrylates; Aminophenols; Animals; Benzo(a)pyrene; Benzoin; Cell Line; Cloning | 1993 |
Increased expression of and sensitivity to transforming growth factor-alpha: a promotive role during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; DNA Probes; DNA, Neoplasm; Epidermal Growth Factor; E | 1994 |
Optimization of an HPLC method for analyses of 32P-postlabeled DNA adducts.
Topics: 2-Acetylaminofluorene; Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DN | 1993 |
Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric pro
Topics: 2-Acetylaminofluorene; Aneuploidy; Carcinoma, Hepatocellular; Cell Nucleus; Centromere; Colchicine; | 1996 |
Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cyclosporine; Intracellular Membranes; Liver Neoplasms, | 1998 |
Computer identification of Escherichia coli rRNA gene restriction patterns.
Topics: 2-Acetylaminofluorene; Bacterial Proteins; Bacterial Typing Techniques; Deoxyribonuclease HindIII; D | 1998 |
Restriction site mutation (RSM) analysis of 2-acetylaminofluorene (2-AAF)-induced mouse liver mutations and comparison with the measurement of in vivo micronucleus induction in the bone marrows of (2-AAF)-treated mice.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Bone Marrow; Deoxyribonucleases, Type II Site-Spe | 2000 |
In vitro detection of indirect-acting genotoxins in the comet assay using Hep G2 cells.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Biotransformation; Carcinog | 2000 |