2-acetylaminofluorene has been researched along with Pregnancy in 40 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A supernatant prepared from the human hepatoma cell line Hep G2 was used to activate benzidine, 2-aminofluorene (2-AF) and 2-acetylaminofluorene (2-AAF) in the Salmonella typhimurium reversion assay." | 1.29 | Mutagenic activation of aromatic amines by a human hepatoma cell (Hep G2) supernatant tested by means of Salmonella typhimurium strains with different acetyltransferase activities. ( Crutzen, MC; Dierickx, PJ; Duverger-van Bogaert, M, 1995) |
| "Data for nine different types of tumors from the large ED01 study conducted at the National Center for Toxicological Research were used to compare tumor prevalence rates among litters with the tumor rates expected under the assumption of homogeneity of tumor rates among litters." | 1.27 | Occurrence of tumors among litters of BALB/c female mice. ( Chen, JJ; Gaylor, DW; Greenman, DL; Thompson, CH, 1985) |
| "The results indicate that the hepatoma-specific aldehyde dehydrogenases are not the result of the de-repression of genes normally repressed in adult rat liver or in some other adult tissue." | 1.26 | Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression. ( Lindahl, R, 1977) |
| "The incidence of hepatomas in the phorbol-treated offspring of AAF-injected mothers was 8/74 (11%), as compared with 2/80 (2." | 1.26 | Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice. ( Armuth, V; Berenblum, I, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (82.50) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lupp, A | 1 |
| Lucas, N | 1 |
| Tralls, M | 1 |
| Fuchs, U | 1 |
| Danz, M | 1 |
| Dudas, J | 1 |
| Elmaouhoub, A | 1 |
| Mansuroglu, T | 1 |
| Batusic, D | 1 |
| Tron, K | 1 |
| Saile, B | 1 |
| Papoutsi, M | 1 |
| Pieler, T | 1 |
| Wilting, J | 1 |
| Ramadori, G | 1 |
| Yovchev, MI | 1 |
| Grozdanov, PN | 1 |
| Joseph, B | 1 |
| Gupta, S | 1 |
| Dabeva, MD | 1 |
| Lin, H | 1 |
| Mao, Q | 1 |
| Wang, YM | 1 |
| Jiang, L | 1 |
| Ogawa, K | 2 |
| Yokokawa, K | 2 |
| Tomoyori, T | 2 |
| Onoé, T | 1 |
| Scribner, JD | 1 |
| Scribner, NK | 1 |
| Koponen, G | 1 |
| Seralini, GE | 1 |
| Lafaurie, M | 1 |
| Castelli, D | 1 |
| Krebs, B | 1 |
| Stora, C | 1 |
| Ritter, CL | 3 |
| Malejka-Giganti, D | 4 |
| Decker, RW | 2 |
| Faustman-Watts, EM | 5 |
| Greenaway, JC | 5 |
| Namkung, MJ | 6 |
| Fantel, AG | 3 |
| Juchau, MR | 12 |
| Hedner, K | 1 |
| Iselius, L | 1 |
| Mitelman, F | 1 |
| Nordén, A | 2 |
| Pero, RW | 2 |
| Bryngelsson, C | 1 |
| Bryngelsson, T | 1 |
| Kitahara, A | 1 |
| Satoh, K | 1 |
| Nishimura, K | 1 |
| Ishikawa, T | 1 |
| Ruike, K | 1 |
| Sato, K | 1 |
| Tsuda, H | 1 |
| Ito, N | 1 |
| Gocke, E | 1 |
| Wild, D | 1 |
| Eckhardt, K | 1 |
| King, MT | 1 |
| Faustman-Watts, E | 1 |
| Narasaki, M | 1 |
| Farber, E | 1 |
| Derewlany, LO | 1 |
| Koren, G | 1 |
| Duverger-van Bogaert, M | 1 |
| Dierickx, PJ | 1 |
| Crutzen, MC | 1 |
| Dragan, YP | 1 |
| Campbell, HA | 1 |
| Xu, XH | 1 |
| Pitot, HC | 1 |
| Lindahl, R | 1 |
| Armuth, V | 1 |
| Berenblum, I | 1 |
| Takahashi, G | 1 |
| Yasuhira, K | 1 |
| Zachariah, PK | 2 |
| Berry, DL | 1 |
| Hixson, DC | 1 |
| Allison, JP | 1 |
| Stark, KL | 2 |
| Harris, C | 2 |
| Yang, HY | 1 |
| Raineri, R | 1 |
| Poiley, JA | 1 |
| Hillesund, T | 1 |
| Ernst, MK | 1 |
| Tennant, RW | 1 |
| Giachelli, CM | 2 |
| Becker, RA | 1 |
| Planche-Martel, G | 1 |
| Gaylor, DW | 1 |
| Chen, JJ | 1 |
| Greenman, DL | 1 |
| Thompson, CH | 1 |
| Ryzewski, CN | 1 |
| Polovina, MR | 1 |
| Shepard, TH | 1 |
| Aune, T | 1 |
| Haugen, A | 1 |
| Dybing, E | 1 |
| Bark, DH | 1 |
| Shewey, LM | 1 |
1 review available for 2-acetylaminofluorene and Pregnancy
| Article | Year |
|---|---|
The sequential analysis of liver cancer induction.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Female; | 1980 |
39 other studies available for 2-acetylaminofluorene and Pregnancy
| Article | Year |
|---|---|
Effects of different mitogens on intrasplenic liver tissue transplants in comparison to orthotopic liver.
Topics: 2-Acetylaminofluorene; 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme System; Femal | 2003 |
Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".
Topics: 2-Acetylaminofluorene; Acute-Phase Reaction; alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers; Ca | 2006 |
Novel hepatic progenitor cell surface markers in the adult rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Adhesion Molecules; Cell Line, Tumor; Female; Gene Expression P | 2007 |
Proliferation of L02 human hepatocytes in tolerized genetically immunocompetent rats.
Topics: 2-Acetylaminofluorene; Animals; Carbocyanines; Cell Proliferation; Cell Survival; Female; Fluorescen | 2008 |
Induction of gamma-glutamyltranspeptidase-positive altered hepatocytic lesions by combination of transplacental-initiation and postanal-selection.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diethylnitrosamine; E | 1982 |
Metabolism and nucleic acid binding of 7-fluoro-2-acetamidofluorene in rats: oxidative defluorination and apparent dissociation from hepatocarcinogenesis of 8-(N-arylamide) guanine adducts on DNA.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Nucleus; DNA; Female; Fluorine; Guanine; Hydroxyla | 1982 |
[Alpha-fetoprotein and blockade of the sexual cycle].
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Estrus; Female; Organ Size; Ovary; Ovulation; Pr | 1984 |
Mixed function oxidase in the mammary gland and liver microsomes of lactating rats. Effects of 3-methylcholanthrene and beta-naphthoflavone.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Fe | 1982 |
Modifications of carcinogen metabolism in hepatic microsomes of suckling young by 3-methylcholanthrene or beta-naphthoflavone administered to lactating rats.
Topics: 2-Acetylaminofluorene; Animal Population Groups; Animals; Animals, Suckling; Benzo(a)pyrene; Benzofl | 1983 |
Teratogenicity in vitro of two deacetylated metabolites of N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; E | 1984 |
A twin study of sister chromatid exchanges in human lymphocytes following carcinogen exposure and DNA repair incubation.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Adult; Cells, Cultured; DNA Repair; Female; Human | 1984 |
A genetic component of the variance of N-acetoxy-2-acetylaminofluorene-induced DNA damage in mononuclear leukocytes determined by a twin study.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Adult; Blood Pressure; DNA; DNA Replication; Fema | 1983 |
Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Diethylnitrosamine; Female; Fetus; Glutathione Transferase; | 1984 |
Mutagenicity studies with the mouse spot test.
Topics: 2-Acetylaminofluorene; Animals; Colchicine; Embryo, Mammalian; Environmental Pollution; Ethyl Methan | 1983 |
Teratogenicity in vitro of 2-acetylaminofluorene: role of biotransformation in the rat.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; DNA; Embryo, Mammalian; Female; Microsomes, Liver | 1983 |
Initiation of focal hyperplastic hepatic lesions by transplacental administration of ethylnitrosourea in rats of F1 generation, and no transmission of the effect to F2 and F3 generations.
Topics: 2-Acetylaminofluorene; Animals; Ethylnitrosourea; Female; Hepatectomy; Hyperplasia; Liver; Liver Neo | 1983 |
Biotransformation of carcinogenic arylamines and arylamides by human placenta.
Topics: 2-Acetylaminofluorene; Acetylation; Biotransformation; Carcinogens; Female; Fluorenes; Humans; Isocy | 1994 |
Mutagenic activation of aromatic amines by a human hepatoma cell (Hep G2) supernatant tested by means of Salmonella typhimurium strains with different acetyltransferase activities.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Benzidines; Biotransformation; Carcinoma, Hepato | 1995 |
Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylni | 1997 |
Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Animals, Newborn; Carcinoma, Hepatocellula | 1977 |
Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Female; Fluorenes; Liver Neoplasms; Male; | 1977 |
Nacroautoradiographic assays in pregnant mice and their fetuses given N-acetyl-9-[14C]-2-aminofluorene and p-[14C]-dimethylaminoazobenzene.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Chromatography, Gel; Chromatography, Thin Layer; Fe | 1975 |
Inhibition of human placental mixed-function oxidations with carbon monoxide: reversal with monochromatic light.
Topics: 2-Acetylaminofluorene; Androstenedione; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme Inhib | 1977 |
Transplacental induction of carcinogen-hydroxylating systems with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cytochrome P-450 Enzyme | 1976 |
Monoclonal antibodies recognizing oval cells induced in the liver of rats by N-2-fluorenylacetamide or ethionine in a choline-deficient diet.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Antibody Specificity; An | 1985 |
Modulation of the embryotoxicity and cytotoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Acetaminophen; Acetylation; Animals; Cell Surviv | 1989 |
Immunodetection, immunoinhibition, immunoquantitation and biochemical analyses of cytochrome P-450IA1 in tissues of the ratoffceptus during the progression of organogenesis.
Topics: 2-Acetylaminofluorene; Amnion; Animals; Benzo(a)pyrene; Benzoflavones; Chorion; Cytochrome P-450 Enz | 1989 |
Increased carcinogen metabolism and survival of retrovirus-infected Fischer rat embryo cells following repetitive carcinogen treatment.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; | 1985 |
Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro.
Topics: 2-Acetylaminofluorene; Animals; Cytochalasin D; Cytochalasins; Female; Glutathione; Hydroxyacetylami | 1988 |
Carbon monoxide inhibits monooxygenation by the conceptus and embryotoxic effects of proteratogens in vitro.
Topics: 2-Acetylaminofluorene; Animals; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P- | 1986 |
Enhanced O6-methylguanine-DNA alkyltransferase activity in rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; DNA Repair; Female; Kinetics; Liver; Liver Neo | 1986 |
Modulation of the embryotoxicity in vitro of reactive metabolites of 2-acetylaminofluorene by reduced glutathione and ascorbate and via sulfation.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Ascorbic Acid; Drug Interactions; Embryo | 1986 |
Occurrence of tumors among litters of BALB/c female mice.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Female; Litter Size; Liver Neoplasms; Mice; Mice, Inbre | 1985 |
Microsomal metabolism of the carcinogen, N-2-fluorenyl-acetamide, by the mammary gland and liver of female rats. II. Glucuronidation of ring- and N-hydroxylated metabolites of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Carbon Radioisotopes; Female; Gl | 1985 |
Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P | 1985 |
Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Biotransformation; Cyclophosphamide; Em | 1985 |
Metabolism and mutagenicity of aromatic amines by human fetal liver.
Topics: 2-Acetylaminofluorene; Amines; Biotransformation; Female; Fetus; Gestational Age; Humans; Microsomes | 1985 |
Analysis of metabolites of 2-acetylaminofluorene generated in an embryo culture system. Relationship of biotransformation to teratogenicity in vitro.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Biotransformation; Chromatography, High | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Ch | 1985 |