2-acetylaminofluorene has been researched along with Precancerous Conditions in 197 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not." | 7.65 | Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. ( Becker, FF; Shurgin, A, 1975) |
| "The nuclear pore density and area were measured on freeze-fractured nuclei of ACI/N rat liver altered foci, adenomas and carcinomas induced by 2-acetylaminofluorene, and compared with those of normal hepatocytes." | 3.69 | Alterations of nuclear pores in preneoplastic and neoplastic rat liver lesions induced by 2-acetylaminofluorene. ( Mori, H; Sugie, S; Tanaka, T; Williams, GM; Yoshimi, N, 1994) |
| "A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not." | 3.65 | Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. ( Becker, FF; Shurgin, A, 1975) |
| "Ethacrynic acid (EA) is an inhibitor of rat and human GSTs." | 1.34 | Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. ( Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT, 2007) |
| " The rats were observed daily and body weights were taken before initial dosing and at weekly intervals thereafter." | 1.34 | Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Williams, GM, 2007) |
| "Acetaminophen was given in the diet either alone at 2400 or 4800 p." | 1.34 | Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Perrone, CE; Williams, GM, 2007) |
| "5 ppm dosage in drinking water in a defined model of a two-stage experimental rat hepatocarcinogenesis." | 1.33 | Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Saralaya, MG, 2006) |
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| " It has previously been shown that a multiple dosing regimen with AFB1, started after 3 weeks of CMD diet, enhances tumor incidence." | 1.28 | Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1. ( Laver, GW; McMullen, E; Mehta, R; Stapley, R, 1992) |
| "ZAMI 1305-treatment also induces liver DNA damage, as evaluated by alkaline sucrose gradient analysis." | 1.27 | Tumor-initiating activity of the beta-blocker ZAMI 1305 in the liver of the female Wistar rat. ( Braga, G; Dimito, E; Mazzocchi, C; Presta, M; Ragnotti, G; Zavanella, T; Ziliani, S, 1984) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " Drug resistance was not induced by chronic administration of the tumor promoters phenobarbital, choline-deficient diet, phorbol, nor with 2,3,7,8-tetrachlorodibenzo-p-dioxin, but was induced to a variable extent by three hepatotoxins (ethanol, methotrexate, carbon tetrachloride)." | 1.27 | Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats. ( Carr, BI, 1987) |
| "Since up to 60% of the hepatocellular carcinomas developing from this regimen will predictably produce AFP, it is tentatively concluded that hepatocellular carcinoma may arise not only from "premalignant" neoplastic nodules but also from oval cells or the atpyical differentiation of hepatocytes." | 1.26 | Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide. ( Sell, S, 1978) |
| "Hyperplastic nodules and hepatocellular carcinomas were induced in livers of rats by a low-protein diet containing 0." | 1.26 | Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development. ( Keenan, TW; Merritt, WD; Morré, DJ; Richardson, CL, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 128 (64.97) | 18.7374 |
| 1990's | 45 (22.84) | 18.2507 |
| 2000's | 17 (8.63) | 29.6817 |
| 2010's | 7 (3.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Satoh, K | 5 |
| Matboli, M | 1 |
| ElGwad, AA | 1 |
| Hasanin, AH | 1 |
| El-Tawdi, A | 1 |
| Habib, EK | 1 |
| Elmansy, RA | 1 |
| Ibrahim, D | 1 |
| Shehata, H | 1 |
| Tash, F | 1 |
| Pisani, GB | 1 |
| Valenti, JL | 1 |
| Quintana, AB | 1 |
| Solano, ML | 1 |
| Rocha, NS | 2 |
| Barbisan, LF | 3 |
| Franchi, CA | 1 |
| Spinardi-Barbisan, AL | 1 |
| de Oliveira, ML | 1 |
| Salvadori, DM | 2 |
| Ribeiro, LR | 2 |
| de Camargo, JL | 2 |
| Yamakawa, D | 2 |
| Sugio, H | 1 |
| Kida, K | 1 |
| Sato, T | 1 |
| Hosoi, K | 1 |
| Hayakari, M | 2 |
| Furtado, KS | 1 |
| Pires, PW | 1 |
| Justulin, LA | 1 |
| Rodrigues, MA | 2 |
| Felisbino, SL | 1 |
| Yao, DF | 1 |
| Jiang, H | 1 |
| Yao, M | 1 |
| Li, YM | 1 |
| Gu, WJ | 1 |
| Shen, YC | 1 |
| Qiu, LW | 1 |
| Wu, W | 1 |
| Wu, XH | 1 |
| Sai, WL | 1 |
| Shpyleva, SI | 1 |
| Muskhelishvili, L | 2 |
| Tryndyak, VP | 2 |
| Koturbash, I | 1 |
| Tokar, EJ | 1 |
| Waalkes, MP | 1 |
| Beland, FA | 2 |
| Pogribny, IP | 2 |
| Kasai, K | 1 |
| Uchida, K | 1 |
| Miura, T | 1 |
| Macías-Pérez, JR | 1 |
| Beltrán-Ramírez, O | 1 |
| Vásquez-Garzón, VR | 1 |
| Salcido-Neyoy, ME | 1 |
| Martínez-Soriano, PA | 1 |
| Ruiz-Sánchez, MB | 1 |
| Angeles, E | 1 |
| Villa-Treviño, S | 2 |
| Cui, R | 1 |
| He, J | 1 |
| Wang, B | 1 |
| Zhang, F | 1 |
| Chen, G | 1 |
| Yin, S | 1 |
| Shen, H | 1 |
| Choudhuri, SK | 1 |
| Majumder, S | 1 |
| González de Mejía, E | 1 |
| Ramírez-Mares, MV | 1 |
| Arce-Popoca, E | 1 |
| Wallig, M | 1 |
| Arora, A | 2 |
| Shukla, Y | 2 |
| Chakraborty, T | 2 |
| Samanta, S | 1 |
| Ghosh, B | 1 |
| Thirumoorthy, N | 1 |
| Chatterjee, M | 2 |
| Kalra, N | 1 |
| Katiyar, S | 1 |
| Siddiqui, IA | 1 |
| Chatterjee, A | 1 |
| Saralaya, MG | 1 |
| Dhachinamoorthi, D | 1 |
| Imai, K | 1 |
| Yamamoto, M | 1 |
| Tanaka, H | 1 |
| Hashimoto, N | 1 |
| Miyakoshi, M | 1 |
| Honmou, S | 1 |
| Yoshie, M | 1 |
| Tamakawa, S | 1 |
| Yaginuma, Y | 1 |
| Kasai, S | 1 |
| Ogawa, K | 3 |
| Parody, JP | 1 |
| Alvarez, Mde L | 1 |
| Quiroga, A | 1 |
| Ronco, MT | 1 |
| Francés, D | 1 |
| Carnovale, C | 1 |
| Carrillo, MC | 1 |
| Williams, GM | 15 |
| Iatropoulos, MJ | 2 |
| Jeffrey, AM | 2 |
| Duan, JD | 2 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 2 |
| Perrone, CE | 1 |
| Bagnyukova, TV | 1 |
| Montgomery, B | 1 |
| Churchwell, MI | 1 |
| Karpf, AR | 1 |
| James, SR | 1 |
| Miki, A | 1 |
| Yano, Y | 1 |
| Kato, H | 1 |
| Seo, Y | 1 |
| Kuriyama, M | 1 |
| Azuma, T | 1 |
| Hayashi, Y | 1 |
| Tsuda, H | 6 |
| Lee, G | 4 |
| Farber, E | 14 |
| Sawada, N | 3 |
| Furukawa, K | 2 |
| Tsukada, H | 2 |
| Fischer, G | 2 |
| Ullrich, D | 1 |
| Katz, N | 2 |
| Bock, KW | 3 |
| Schauer, A | 1 |
| Tamano, S | 1 |
| Fukushima, S | 2 |
| Masui, T | 3 |
| Hosoda, K | 1 |
| Ito, N | 13 |
| Rotstein, J | 1 |
| Macdonald, PD | 1 |
| Rabes, HM | 3 |
| Goldfarb, S | 2 |
| Pugh, TD | 2 |
| Koen, H | 1 |
| Elliott, WL | 2 |
| Sawick, DP | 1 |
| Creek, KE | 1 |
| Deutscher, SL | 1 |
| Quinn, JF | 1 |
| Yeo, E | 1 |
| Webb, WR | 1 |
| Morré, DM | 1 |
| Harrington, DD | 1 |
| Heinstein, PF | 2 |
| Benedetti, A | 1 |
| Malvaldi, G | 1 |
| Fulceri, R | 1 |
| Comporti, M | 2 |
| Zavanella, T | 1 |
| Presta, M | 1 |
| Braga, G | 1 |
| Dimito, E | 1 |
| Mazzocchi, C | 1 |
| Ziliani, S | 1 |
| Ragnotti, G | 1 |
| Lilienblum, W | 1 |
| Pfeil, H | 1 |
| Eriksson, LC | 11 |
| Hasegawa, R | 6 |
| Imaida, K | 3 |
| Evarts, RP | 1 |
| Marsden, E | 1 |
| Hanna, P | 1 |
| Wirth, PJ | 1 |
| Thorgeirsson, SS | 1 |
| Vinarchuk, MP | 1 |
| Bykorez, AI | 1 |
| Scherer, E | 1 |
| Feringa, AW | 1 |
| Emmelot, P | 1 |
| Katayama, S | 1 |
| Ohmori, T | 2 |
| Maeura, Y | 3 |
| Croci, T | 1 |
| Kondo, M | 1 |
| Tabei, R | 1 |
| Furuya, K | 2 |
| Kitahara, A | 2 |
| Nishimura, K | 1 |
| Ishikawa, T | 1 |
| Ruike, K | 1 |
| Sato, K | 2 |
| Rao, KN | 1 |
| Shinozuka, H | 1 |
| Kunz, HW | 1 |
| Gill, TJ | 1 |
| Aström, A | 2 |
| DePierre, JW | 2 |
| Finkelstein, SD | 1 |
| Medline, A | 1 |
| Tatematsu, M | 9 |
| Makowka, L | 1 |
| Gravela, E | 1 |
| Zuretti, MF | 1 |
| Papino, F | 1 |
| Sartorio, L | 1 |
| Conway, JG | 1 |
| Popp, JA | 1 |
| Ji, S | 1 |
| Thurman, RG | 1 |
| Eriksson, L | 1 |
| Shirai, T | 3 |
| Nakanishi, K | 4 |
| Enomoto, K | 2 |
| Ying, TS | 1 |
| Griffin, MJ | 5 |
| Okita, K | 2 |
| Ando, K | 1 |
| Fukumoto, Y | 1 |
| Miyazaki, M | 1 |
| Tsubota, W | 1 |
| Kodama, T | 1 |
| Takemoto, T | 2 |
| Kunz, W | 1 |
| Schaude, G | 1 |
| Schwarz, M | 1 |
| Tennekes, H | 1 |
| Holmes, EH | 2 |
| Hakomori, S | 2 |
| Bücher, T | 2 |
| Hartmann, A | 1 |
| Linke, I | 1 |
| Dünnwald, M | 1 |
| Gotoh, M | 1 |
| Mochizuki, Y | 1 |
| Bhargava, MM | 1 |
| Ohmi, N | 1 |
| Arias, IM | 1 |
| Becker, FF | 10 |
| Nakayama, T | 1 |
| Lindahl, R | 1 |
| van der Heijden, CA | 1 |
| Dormans, JA | 1 |
| van Nesselrooij, JH | 1 |
| Frith, CH | 1 |
| Ayres, PH | 1 |
| Shinohara, Y | 1 |
| Takano, T | 1 |
| Ogiso, T | 1 |
| Solt, DB | 1 |
| Cayama, E | 1 |
| Sarma, DS | 3 |
| Stout, DL | 2 |
| Pascale, RM | 2 |
| Simile, MM | 3 |
| Gaspa, L | 3 |
| Daino, L | 6 |
| Seddaiu, MA | 3 |
| Pinna, G | 1 |
| Carta, M | 1 |
| Zolo, P | 1 |
| Feo, F | 6 |
| Olsson, JM | 1 |
| Schedin, S | 1 |
| Teclebrhan, H | 1 |
| Dallner, G | 1 |
| La Porta, CA | 1 |
| Comolli, R | 1 |
| Pascale, R | 4 |
| De Miglio, MR | 2 |
| Nufris, A | 1 |
| Hammerl, R | 1 |
| Kirchner, T | 1 |
| Neumann, HG | 3 |
| Leibold, E | 1 |
| Schwarz, LR | 3 |
| Kurokawa, F | 2 |
| Kanduc, D | 1 |
| Ghoshal, A | 1 |
| Nagai, M | 1 |
| Sugie, S | 3 |
| Yoshimi, N | 1 |
| Tanaka, T | 8 |
| Mori, H | 4 |
| Kojima, T | 1 |
| Okumura, A | 1 |
| Hadjiolov, N | 1 |
| Bitsch, A | 1 |
| Skarpen, E | 2 |
| Lindeman, B | 2 |
| Thoresen, GH | 1 |
| Låg, M | 1 |
| Christoffersen, T | 3 |
| Huitfeldt, HS | 2 |
| Imai, T | 3 |
| Nakanishi, H | 2 |
| Inada, K | 1 |
| Kobayashi, K | 1 |
| Nakamura, T | 2 |
| Wada, S | 3 |
| Kato, T | 1 |
| Mutai, M | 2 |
| Ozaki, K | 1 |
| Yamaguchi, S | 3 |
| Kim, DJ | 1 |
| Baba-Toriyama, H | 1 |
| Asamoto, M | 1 |
| Kong, J | 1 |
| Ringer, DP | 3 |
| Pompella, A | 1 |
| Paolicchi, A | 1 |
| Dominici, S | 1 |
| Tongiani, R | 1 |
| Chaumontet, C | 1 |
| Suschetet, M | 1 |
| Honikman-Leban, E | 1 |
| Krutovskikh, VA | 1 |
| Berges, R | 1 |
| Le Bon, AM | 1 |
| Heberden, C | 1 |
| Shahin, MM | 1 |
| Yamasaki, H | 1 |
| Martel, P | 1 |
| Ichinose, M | 2 |
| Yanai, T | 2 |
| Masegi, T | 2 |
| Muramatsu, M | 2 |
| He, RK | 1 |
| Gascon-Barré, M | 1 |
| Tsukamoto, T | 1 |
| Kitoh, K | 1 |
| Roomi, MW | 1 |
| Parke, DV | 1 |
| Dagli, ML | 1 |
| Guerra, JL | 1 |
| Sinhorini, IL | 1 |
| Wu, TS | 1 |
| Rizzi, MB | 1 |
| Penteado, MV | 1 |
| Spinardi, AL | 1 |
| Kaneno, R | 1 |
| Muroni, MR | 1 |
| Pusceddu, S | 1 |
| Calvisi, D | 1 |
| Carru, A | 1 |
| Deiana, L | 1 |
| Wood, GA | 1 |
| Archer, MC | 1 |
| Yusuf, A | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sawaki, M | 1 |
| Hattori, A | 1 |
| Tsuzuki, N | 1 |
| Mori, M | 1 |
| Trautwein, C | 1 |
| Will, M | 1 |
| Kubicka, S | 1 |
| Rakemann, T | 1 |
| Flemming, P | 1 |
| Manns, MP | 1 |
| Liao, G | 1 |
| Chen, J | 1 |
| Ding, L | 1 |
| Cameron, R | 2 |
| Kellen, J | 1 |
| Kolin, A | 1 |
| Malkin, A | 1 |
| Laishes, BA | 2 |
| Roberts, E | 1 |
| Sell, S | 6 |
| Roberfroid, M | 1 |
| Lans, M | 2 |
| de Gerlache, J | 3 |
| Mercier, M | 1 |
| Murasaki, G | 2 |
| Miyata, Y | 1 |
| Hirose, M | 2 |
| Shurgin, A | 1 |
| Rubenchik, BL | 1 |
| Romanenko, AM | 1 |
| Lin, JC | 1 |
| Hiasa, Y | 1 |
| Boman, D | 1 |
| Berg, T | 1 |
| Merritt, WD | 2 |
| Richardson, CL | 1 |
| Keenan, TW | 2 |
| Morré, DJ | 3 |
| Levin, W | 1 |
| Lu, AY | 1 |
| Thomas, PE | 1 |
| Ryan, D | 1 |
| Kizer, DE | 2 |
| Watanabe, K | 2 |
| Hirota, N | 2 |
| Liau, MC | 1 |
| Chang, CF | 1 |
| Smith, LD | 1 |
| Emerson, RL | 1 |
| Nixon, LK | 1 |
| Yamada, S | 1 |
| Ito, M | 1 |
| Nagayo, T | 1 |
| Okumura, Y | 1 |
| Pozharisskiĭ, KM | 1 |
| Parker, S | 1 |
| Gruenstein, M | 1 |
| Klaiber, M | 1 |
| Parker, SE | 1 |
| Kitagawa, T | 3 |
| Michalopoulos, G | 1 |
| Pitot, HC | 4 |
| Reuber, MD | 1 |
| Ball, WJ | 1 |
| Salser, JS | 1 |
| Balis, ME | 1 |
| Yerokun, T | 1 |
| Etheredge, JL | 1 |
| Norton, TR | 2 |
| Carter, HA | 1 |
| Chung, KH | 1 |
| Birckbichler, PJ | 1 |
| Mehta, R | 1 |
| Laver, GW | 1 |
| Stapley, R | 1 |
| McMullen, E | 1 |
| Glauert, HP | 1 |
| Lay, LT | 1 |
| Kennan, WS | 1 |
| Chowdhury, NR | 1 |
| Saber, MA | 1 |
| Lahiri, P | 1 |
| Mackenzie, PI | 1 |
| Novikoff, PM | 1 |
| Chowdhury, JR | 1 |
| Takahashi, S | 1 |
| Maruyama, H | 3 |
| Weisburger, JH | 1 |
| Zang, E | 1 |
| Sessa, A | 2 |
| Desiderio, MA | 1 |
| Perin, A | 2 |
| Diwan, BA | 1 |
| Ward, JM | 1 |
| Rice, JM | 1 |
| Tiwawech, D | 1 |
| Kurata, Y | 2 |
| Shibata, MA | 1 |
| Thamavit, W | 1 |
| Blanck, A | 5 |
| Gustafsson, JA | 3 |
| Porsch Hällström, I | 1 |
| Aoki, T | 1 |
| Lindhe, B | 1 |
| Porsch-Hällström, I | 1 |
| Masuda, A | 1 |
| Palakodety, RB | 2 |
| Broyles, RH | 1 |
| Dunsford, HA | 3 |
| Karnasuta, C | 1 |
| Hunt, JM | 1 |
| Andersson, GN | 1 |
| Torndal, UB | 1 |
| Embleton, MJ | 2 |
| James, HS | 1 |
| Haynes, AJ | 1 |
| Butler, PC | 2 |
| Yeldandi, AV | 1 |
| Subbarao, V | 1 |
| Rajan, A | 1 |
| Reddy, JK | 1 |
| Rao, MS | 1 |
| Oesterle, D | 1 |
| Gerbracht, U | 1 |
| Deml, E | 1 |
| Schlatterer, B | 1 |
| Eigenbrodt, E | 2 |
| Gebhardt, R | 2 |
| Maset, R | 1 |
| Salman, J | 1 |
| Cameron, RG | 1 |
| Herren-Freund, SL | 1 |
| Pereira, MA | 1 |
| Lebsanft, J | 2 |
| Luippold, G | 2 |
| Campbell, HA | 1 |
| Xu, YD | 1 |
| Hanigan, MH | 2 |
| Gregg, RG | 1 |
| Davidson, M | 1 |
| Wilce, PA | 1 |
| Cesarone, CF | 1 |
| Scarabelli, L | 1 |
| Orunesu, M | 1 |
| Kroese, ED | 2 |
| Tijdens, RB | 1 |
| Mulder, GJ | 2 |
| Meerman, JH | 2 |
| Garcea, R | 3 |
| Pirisi, L | 1 |
| Donaera, A | 1 |
| Frassetto, S | 2 |
| Cozzolino, P | 2 |
| Ruggiu, ME | 2 |
| Vannini, MG | 1 |
| Carr, BI | 1 |
| Fairchild, CR | 1 |
| Ivy, SP | 1 |
| Rushmore, T | 1 |
| Koo, P | 1 |
| Goldsmith, ME | 1 |
| Myers, CE | 1 |
| Cowan, KH | 1 |
| Saeter, G | 3 |
| Schwarze, PE | 2 |
| Nesland, JM | 2 |
| Seglen, PO | 2 |
| Martelli, A | 1 |
| Ghia, M | 1 |
| Mereto, E | 1 |
| Marinari, UM | 1 |
| Brambilla, G | 1 |
| van de Poll, ML | 1 |
| Iwata, H | 1 |
| Niwa, K | 1 |
| Mori, Y | 1 |
| Yokoyama, T | 1 |
| Refsnes, M | 1 |
| Sager, G | 1 |
| Sandnes, D | 1 |
| Sand, TE | 1 |
| Jacobsen, S | 1 |
| Ruschenburg, I | 1 |
| Kuniyasu, T | 1 |
| Shima, H | 1 |
| Takahashi, M | 1 |
| Hirono, I | 1 |
| Cox, B | 1 |
| Howell, BA | 1 |
| Berghem, L | 1 |
| Schwarze, E | 1 |
| Seglen, O | 1 |
| Gupta, RC | 1 |
| Earley, K | 1 |
| Esaki, T | 1 |
| Fujikura, Y | 1 |
| Fukumoto, T | 1 |
| Hansson, T | 1 |
| Mannervik, B | 2 |
| Wicksell, L | 1 |
| Vaz, AD | 1 |
| Ritter, E | 1 |
| Becker, RA | 1 |
| Planche-Martel, G | 1 |
| Deleener, A | 2 |
| Castelain, P | 1 |
| Preat, V | 1 |
| Alexandre, H | 1 |
| Kirsch-Volders, M | 2 |
| Sun, I | 1 |
| MacKellar, WC | 1 |
| Crane, FL | 1 |
| Barr, R | 1 |
| Lem, N | 1 |
| Varnold, RL | 1 |
| Sugioka, Y | 1 |
| Fujii-Kuriyama, Y | 1 |
| Jensson, H | 1 |
| Kuchlbauer, J | 1 |
| Romen, W | 1 |
| Kerler, R | 1 |
| Schuster, C | 1 |
| Rode, G | 1 |
| Legner, M | 1 |
| Müller, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for 2-acetylaminofluorene and Precancerous Conditions
| Article | Year |
|---|---|
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; g | 1984 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyr | 1975 |
Modification of liver tumor development in rodents.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; Disease Models, Animal; Disease Susceptibili | 1991 |
Metabolism of xenobiotics in hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Drug Resistance; Inactivation, Metabolic; Liver; Liver Neoplasms, Ex | 1987 |
192 other studies available for 2-acetylaminofluorene and Precancerous Conditions
| Article | Year |
|---|---|
Strong carcinogenic stress response induction of preneoplastic cells positive for GST-P in the rat liver: Physiological mechanism for initiation.
Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; Bile Ducts; Enzyme Induction; Gene Expression Regula | 2018 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Hepatic preneoplasia induction in male Wistar rats: histological studies up to five months post treatment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms | 2016 |
Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Carcinogenicity Tes | 2016 |
Bile duct-bound growth of precursor cells of preneoplastic foci inducible in the initiation stage of rat chemical hepatocarcinogenesis by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts; Biomarkers, Tumor; gamma-Glutamyltransferase; Glutathion | 2008 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S- | 2009 |
Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neopl | 2009 |
Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Antimicrobial Cationic Peptides; Carcinogens; Cation Transport Prote | 2011 |
Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Glutathione Transferase; Hepatocyte | 2012 |
The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Anticarcinogenic Agents; Antioxidants; Caffeic Acids; | 2013 |
Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Astragalus Plant; Astragalus propinquus; Blotting, Northern; Blottin | 2003 |
Modulation of doxorubicin sensitivity by a novel organic compound, oxalyl bis (N-phenyl) hydroxamic acid on acetyl aminofluorene-induced preneoplastic hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfa | 2003 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Ca | 2004 |
Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Biomarkers, Tumor; | 2004 |
Vanadium induces apoptosis and modulates the expressions of metallothionein, Ki-67 nuclear antigen, and p53 during 2-acetylaminofluorene-induced rat liver preneoplasia.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Body Weight; DNA Damage; Gene Expression Regulation; Ki-6 | 2005 |
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Diethylnitrosamine; g | 2004 |
Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chromosome Aberra | 2006 |
Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Growth Processes; Genetic Predisposition to Diseas | 2007 |
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; C | 2007 |
Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Carcinogens; Cell Division; Cell Transformation, Neopl | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Hepato | 2007 |
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA (Cytosine-5-) | 2008 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.
Topics: 2-Acetylaminofluorene; Amines; Animals; Carcinogens; Cell Division; Drug Evaluation, Preclinical; Dr | 1980 |
In vitro measurement of resistance to phalloidin and gamma-glutamyltransferase of carcinogen-induced preneoplastic hepatocytes of rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Resistance; gamma-Glutamyltransferase; Histocytochemistry; In V | 1982 |
Immunohistochemical and biochemical detection of uridine-diphosphate-glucuronyltransferase (UDP-GT) activity in putative preneoplastic liver foci.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Female; gamma-Glutamyltransferase; Glucur | 1983 |
Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; E | 1983 |
Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Cycle; gamma-Glutamyltransferase; Kinetics; Liver; Liver Neopla | 1984 |
Hepatocellular injury, hyperplasia and putative premalignancy in rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; gamma-Glutamyltransferase; Glucose-6-Phos | 1984 |
Early biochemical alterations induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Acid Anhydride Hydrolases; Animals; Fasting; gamma-Glutamyltransferase; Liver | 1984 |
Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocytochem | 1984 |
Tumor-initiating activity of the beta-blocker ZAMI 1305 in the liver of the female Wistar rat.
Topics: 2-Acetylaminofluorene; Adrenergic beta-Antagonists; Animals; DNA; Female; Hepatectomy; Liver; Liver | 1984 |
Increased uridine diphosphate-glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Enzyme Activation; Epitopes; Glucuronosyltransferase; Liver; Liver N | 1982 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins | 1984 |
Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Ethylnitrosourea; Female; Hepatectomy; Liver; Li | 1984 |
Early stages of N-2-fluorenylacetamide-induced hepatocarcinogenesis in male and female rats and effect of gonadectomy on liver neoplastic conversion and neoplastic development.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Castration; Cell Transformation, Neop | 1984 |
High susceptibility of specific inbred colonies of rats to n-2-fluorenylacetamide-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Disease Susceptibility; Liver Neoplasms, Experimental; Male; Precanc | 1983 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla | 1984 |
Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Diethylnitrosamine; Female; Fetus; Glutathione Transferase; | 1984 |
Enhanced susceptibility to a chemical carcinogen in rats carrying MHC-linked genes influencing development (GRC).
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; DNA; Genetic Linkage; Lipid Metabolism; Lipoproteins; L | 1984 |
A preliminary characterization of drug-metabolizing systems in preneoplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Glutathione Tran | 1981 |
An experimental method for rapid growth of liver in spleen. The survival and proliferation of chemically induced preneoplastic hepatocytes in spleen.
Topics: 2-Acetylaminofluorene; Animals; Graft Survival; Hepatectomy; Liver Neoplasms; Male; Microscopy, Elec | 1983 |
Relative in vitro stability of ornithine decarboxylase from liver preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Carboxy-Lyases; Liver Neoplasms; Liver Neoplasms, | 1983 |
Properties of the increased glutathione S-transferase A form in rat preneoplastic hepatic lesions induced by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Immunochem | 1983 |
Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Fluorescein; Fluoresceins; Liver; Liver Circulat | 1983 |
Characterization of drug-metabolizing systems in hyperplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Immunohistochemical study of epoxide hydrolase during experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epoxide Hydrolases; Histocytochemistry; Immunoen | 1981 |
Increase of T cells in the liver during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Antilymphocyte Serum; Fluorescent Antibody Technique; Liver; Liver N | 1981 |
Isolation and characterization of a new fucoganglioside accumulated in precancerous rat liver and in rat hepatoma induced by N-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Gangliosides; Glycolipids; Liver; Liver Neoplasms, Experimental; Mal | 1982 |
Clonal growth of carcinogen-induced enzyme-deficient preneoplastic cell populations in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Clone Cells; Female; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; | 1982 |
Primary culture of preneoplastic hepatocytes from rats treated with 2-acetylaminofluorene and clofibrate: relationship between resistance to dimethylnitrosamine and responsiveness of peroxisomes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Clofibrate; Dimethylnitrosamine; Drug Resistance; L | 1982 |
Hepatocellular ligandin during N-2-fluorenylacetamide carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Glutathione Transferase; Liver; Liver Neoplasms; Male; Neoplasms, Ex | 1982 |
A new type of glycolipid change associated with oncogenesis: a fucoganglioside accumulation in premalignant hepatic lesion and in hepatoma induced by n-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Chromatography, Thin Layer; Gangliosides; Liver; Liver Neoplasms; Li | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1982 |
Short term induction of preneoplastic nodules in the rat liver. I. The role of 2-AAF as selecting agent.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1980 |
A scanning and transmission electron microscopic study of urinary bladders of mice treated with 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Microscopy, E | 1981 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Drug Resistance; Hepatectomy; Liv | 1980 |
Progressive DNA damage in hepatic nodules during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; DNA, Neoplasm; Liver Neoplasms, Experimental; M | 1980 |
Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; gamma-Glutamyltransferase; Gene Expression Regul | 1993 |
Enzymes of the mevalonate pathway in rat liver nodules induced by 2-acetylaminofluorene treatment.
Topics: 2-Acetylaminofluorene; Alkyl and Aryl Transferases; Animals; Dimethylallyltranstransferase; Dolichol | 1995 |
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Caseins; Diet; Diethylnitrosamine; gamma-G | 1995 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul | 1994 |
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma | 1994 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta | 1993 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Sequential alterations in tRNA population of 2-acetylaminofluorene-induced hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; | 1993 |
Alterations of nuclear pores in preneoplastic and neoplastic rat liver lesions induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Cell Nucleus; Disease Models, Animal; Freeze Fracturing; Li | 1994 |
Inhibitory effect of the non-steroidal anti-inflammatory drugs, indomethacin and piroxicam on 2-acetylaminofluorene-induced hepatocarcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Indomethacin; Liver; Liver Neoplasms, Experimental; Mal | 1993 |
Early initiating and promoting effects in 2-AAF-induced rat liver carcinogenesis: an immunohistochemical study.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; DNA Damage; Dose-Response Relationship, Drug | 1995 |
CCAAT/enhancer-binding protein (C/EBP) immunoreactivity during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Western; Carcinogens; CCAAT-Enhancer-Binding Proteins; Cel | 1995 |
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocyte | 1996 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Quantitative analysis of changes in cell proliferation and apoptosis during preneoplastic and neoplastic stages of hepatocarcinogenesis in rat.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Cell Division; DNA Nucleo | 1996 |
Selective colocalization of lipid peroxidation and protein thiol loss in chemically induced hepatic preneoplastic lesions: the role of gamma-glutamyltranspeptidase activity.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; gamma-Glutamyltr | 1996 |
Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Cell Line; Cricetinae; Flavanones; Flavon | 1996 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Influence of the vitamin D status on the early hepatic response to carcinogen exposure in rats.
Topics: 2-Acetylaminofluorene; Animals; Calcium; Liver Neoplasms; Male; Precancerous Conditions; Rats; Rats, | 1997 |
Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hepatocyte | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis.
Topics: 2-Acetylaminofluorene; Actins; Animals; beta Carotene; Bile Ducts, Intrahepatic; Collagen; Diethylni | 1998 |
Stress protein expression in rat liver during tumour promotion: induction of heat-shock protein 27 in hepatocytes exposed to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Heat-Shock Proteins; Liver; Liver Neoplasms, Experiment | 1998 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Transformation, Neoplastic; Chloroform; Diethylnitro | 1999 |
Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Glu | 1999 |
Development of resistance during the early stages of experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Resistan | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver | 1999 |
2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression.
Topics: 2-Acetylaminofluorene; Animals; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cyclin E; DNA-Bin | 1999 |
[Relationship between oval cells and preneoplastic lesions induced by 2-acetylaminofluorene in rat liver].
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Hepatectomy; Liver; Liver Neoplasms, Experimental; Ma | 1998 |
Abnormalities in liver iron accumulation during N-2-fluorenylacetamide hepatocarcinogenesis that are dependent or independent of continued carcinogen action.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Iron; Iron-Dextran Complex; Liver; Liver Neoplasms, Exp | 1984 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Enzyme Induction; | 1978 |
Transfer of viable putative preneoplastic hepatocytes to the livers of syngeneic host rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; gamma-Glutamyltransferase; Liver Neoplasm | 1978 |
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu | 1978 |
Functional markers and growth behavior of preneoplastic hepatocytes.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Cell Aggregation; Cell Transformation, Neoplasti | 1976 |
Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Albumins; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Fluorenes; | 1978 |
Biochemical characterization of liver hyperplastic nodules induced by 2-acetylaminofluorene [proceedings].
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Hyperplasia; Liver; Liver Neoplasms, Experimental; Mixed | 1978 |
Differences in serum alpha-fetoprotein concentrations during the carcinogenic sequences resulting from exposure to diethylnitrosamine or acetylaminofluorene.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Diethylnitrosamine; Fluorenes; Liver Neoplasms, | 1979 |
alpha-Fetoprotein levels and hepatic alterations during chemical carcinogenesis in C57BL/6N mice.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Chlordan; Liver; Liver Neoplasms, Experimental; | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Agglutination; Animals; Carcinoma, Hepatocellular; Concanavalin A; Liver Neop | 1975 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Endoplasmic Reticulum | 1977 |
Scanning electron microscopic surface morphology of isolated hepatocytes from normal and premalignant rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; Liver; Liver Neoplasms; Male; Microbial Collagenase; | 1977 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Fluorenes; G(M1) Gangli | 1978 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. II. Alterations in biosynthetic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cerebrosides; Fluorenes; Galactosyltransf | 1978 |
Alteration of the ability of liver microsomes to activate N-2-fluorenylacetamide to a mutagen of Salmonella typhimurium during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hydroxyacetylaminofluorene; Li | 1978 |
Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Epoxide Hydrolases; H | 1978 |
Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleolus; Cell Nucleus; Fluorenes; Hyperplasia; Iron; Kinetics | 1978 |
Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions.
Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Con | 1978 |
Persistence and growth of rat liver neoplastic nodules following cessation of carcinogen exposure.
Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Male; Precancerous Conditions; | 1979 |
Purification and quantitation of preneoplastic antigen from hyperplastic nodules and normal liver.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Deoxycholic Acid; Hyperplasia; Immunosorbent Tec | 1978 |
Enhancing effect of chemicals on production of hyperplastic liver nodules induced by n-2-fluorenylacetamide in hepatectomized rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Flavonoids; Fluorenes; Hepatectomy; Liver; Liver Neo | 1978 |
Alteration of S-adenosylmethionine synthetases during chemical hepatocarcinogenesis and in resulting carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Female; Isoenzymes; Kinetics; Liver; Liver Neoplasms, Experimental; | 1979 |
Effect of hepatocarcinogens on the adenine purine nucleotide cycle during the initiation phase of carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenylosuccinate Lyase; Adenylosuccinate Synthase; AMP Deaminase; Animals; Ca | 1979 |
Kinetics of preneoplastic epithelia of the the intestinal mucosa induced in Buffalo rats by oral administration of N,N'-2,7-fluorenylenebisacetamide.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Epithelium; Female; Fluorenes; Intestinal Muco | 1977 |
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Cell Transformation, Neoplastic; | 1976 |
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; Hyperplasia; Iron; Liver Neoplasms; Male; Mitos | 1976 |
Unscheduled DNA synthesis in cells from N-2-fluorenylacetamide-induced hyperplastic nodules of rat liver maintained in a primary culture system.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Division; Cell Survival; Cells, Cultured; DNA | 1975 |
Effect of age and testosterone on the induction of hyperplastic nodules, carcinomas, and cirrhosis of the liver in rats ingesting n-2-fluorenyldiacetamide.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Body Weight; Castration; Fluorenes; Hyperplasia; Liver | 1976 |
Sequential phenotypic changes in hyperplastic areas during hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Glucuronidase; Hyperplasia; L-Serin | 1976 |
Sequential phenotypic and biochemical alterations during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Aggregation; Chromatin; Dimethylnitrosamine; Lectins; Liver Neo | 1976 |
Biochemical changes in preneoplastic rodent intestines.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carboxy-Lyases; Cell Transformation, Neoplastic; Dimeth | 1976 |
Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Arylsulfotransferase; Base Sequence; Cloning, M | 1992 |
Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alanine Transaminase; Analysis of Variance; Animals; Aspartate | 1992 |
Effect of dietary fat on the initiation of hepatocarcinogenesis by diethylnitrosamine or 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Dietary Fats; Diethylnitrosamine; Female; | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Glucuronates; Glucuronosyltransferase; Immunoblotting; Immunohistoch | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Modulation by butylated hydroxytoluene of liver and bladder carcinogenesis induced by chronic low-level exposure to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Butylated Hydroxytoluene; Dose-Response Relationship, D | 1991 |
Diamine oxidase activity in a model of multistep hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amine Oxidase (Copper-Containing); Animals; Diethylnitrosamine; gamma-Glutamy | 1990 |
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Ne | 1991 |
Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Dose-Response Relationship, Drug; Glutathione Transfe | 1991 |
Sex-differentiated and growth-hormone-regulated mitoinhibition in rat liver during treatment with 2-acetylaminofluorene and partial hepatectomy in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Castration; Cell Division; Female; Growth Hormone; Hepatectomy; Live | 1991 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; | 1990 |
Effects of neonatal and adult castration and of testosterone substitution in male rats on growth of enzyme-altered hepatic foci in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Castration; Female; Liver; Liver Neoplasms, Experi | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatect | 1990 |
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver | 1986 |
Circulating epoxide hydrolase immunodeterminants in rats bearing hyperplastic nodules induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Enzyme-Linked Immunosorbent Assay; Epitopes; Epoxide Hydrolases; Liv | 1988 |
Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diethylnitrosamine; Enzy | 1989 |
Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Diethylnitrosamine; gamm | 1989 |
Decreased vacuolar acidification capacity in drug-resistant rat liver preneoplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; Drug Resistance; Hydrogen-Ion Concentration; Liver; L | 1989 |
Heterogeneity of hepatocyte antigen expression in rat liver carcinogenesis: concordance between neoplastic nodules and tumours.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens; Cell Transformation, Neoplastic; I | 1989 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1989 |
Comparison of three rat liver foci bioassays--incidence of preneoplastic foci initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Diethylnitrosamine; Fe | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosa | 1989 |
Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Barium; Bile Ducts; Cell Division; Choline Defic | 1985 |
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Activities of drug-metabolizing enzymes in isolated gamma-glutamyltranspeptidase positive preneoplastic hepatocytes from carcinogen treated rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Carcinogens; Cell Separation; Cells, Cultur | 1985 |
Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamy | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym | 1986 |
Uptake of taurocholate by isolated gamma-glutamyltranspeptidase positive, putatively preneoplastic hepatocytes from 2-acetylaminofluorene treated rats.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; In Vitro Techniques; Kinetics; Liver; Liv | 1986 |
Effect of glutathione and N-acetylcysteine on hepatocellular modifications induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; DNA; Drug Interactions; gamma-Glutamyltransferase; G | 1986 |
Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing gamma-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Chlorophenols; gamma-Glutamyltransferase; Hydroxyac | 1987 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma | 1987 |
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamylt | 1987 |
Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats.
Topics: 2-Acetylaminofluorene; Adaptation, Physiological; Animals; Carcinogens; Drug Resistance; gamma-Gluta | 1987 |
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 1987 |
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; L | 1988 |
Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal.
Topics: 2-Acetylaminofluorene; Aldehydes; Animals; Carbon Tetrachloride; gamma-Glutamyltransferase; Liver Ne | 1988 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamylt | 1988 |
Inhibitory effect of ellagic acid on N-2-fluorenylacetamide-induced liver carcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrans; Body Weight; Ellagic Acid; gamma-Glutamyltransferase; L | 1988 |
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Diploidy; DNA, Neoplasm; Liver Neoplasms, Experi | 1989 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
Comparative study of abnormality in glycogen storing capacity and other histochemical phenotypic changes in carcinogen-induced hepatocellular preneoplastic lesions in rats.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Iron; Liver Glycoge | 1985 |
Increased number of beta-adrenoceptors in hepatocytes from rats treated with 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenylyl Cyclases; Animals; Cyclic AMP; Dihydroalprenolol; Iodocyanopindolol; | 1986 |
Decrease in glucokinase and glucose-6-phosphatase and increase in hexokinase in putative preneoplastic lesions of rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Female; Glucokinase; Glucose-6-Phosphatas | 1987 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
Changes in rat liver N-hydroxy-2-acetylaminofluorene aryl sulfotransferase activity at early and late stages of hepatocarcinogenesis resulting from dietary administration of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Diet; Hyperplasia; Liver; Liver Neoplasms, Experimenta | 1988 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; | 1988 |
Decreased fibronectin in rat liver altered foci and adenomas induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Fibronectins; Liver; Liver Neoplasms; Male; Precancerous Co | 1988 |
Shift from polyploidizing to nonpolyploidizing growth in carcinogen-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Flow Cytometry; Liver; Liver Neoplasms, Experime | 1988 |
Analysis of DNA adducts in putative premalignant hepatic nodules and nontarget tissues of rats during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; DNA; Kidney; Liver; Liver Neoplasms; Male; Precancerous Conditions; | 1988 |
An antigen specific to hyperplastic liver nodules defined with monoclonal antibody: a new marker for preneoplastic cells in rat chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Hybridomas; Immunoglobul | 1988 |
Growth hormone modifies the growth rate of enzyme-altered hepatic foci in male rats treated according to the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Female; Growth Hormone; Hepatectomy; Liver Neoplasms, Experimental; | 1987 |
Sulfation of N-hydroxy-2-acetylaminofluorene in normal and nodular liver from male Wistar rats.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Hydroxyacetylaminofluorene; Liver Neoplasms, Experi | 1987 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
Microsomal cholesterol epoxide hydrolase activity in 2-acetylaminofluorene-induced rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; Hyperpla | 1987 |
Benzaldehyde: NADP aldehyde dehydrogenase activity in hepatocyte nodules, hepatocellular carcinomas and drug-induced rat liver.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Benzaldehyde Dehydrogenase (NADP+); Cytoso | 1987 |
Enhanced O6-methylguanine-DNA alkyltransferase activity in rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; DNA Repair; Female; Kinetics; Liver; Liver Neo | 1986 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; | 1987 |
Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Female; Liver; Liver Transplantation; Male; Phenobarbit | 1985 |
Decreased NADH-oxidoreductase activities as an early response in rat liver to the carcinogen 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Kinetics; Liver; Liver Neoplasms; Male; NAD; NADH, NADPH Oxidoreduct | 1985 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Selective expression of glutathione transferase isoenzymes in chemically induced preneoplastic rat hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Glutathione Transferase; Isoenzymes; Liver; Male; Precancer | 1985 |
Syncarcinogenic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; DNA; Female; Liver Neoplasms, Experim | 1985 |
Cell proliferation and DNA repair in the liver during early stages of chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Cycle; Cell Division; Clone Cells; DNA Repair; Gua | 1985 |