2-acetylaminofluorene has been researched along with Polyploid in 6 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The proliferative activity of tumor cells differing in DNA content (ploidy) and nuclearity was investigated in primary hepatocellular carcinomas of the rat by flow cytometric analysis of collagenase-isolated cells immunostained after labelling with bromodeoxyuridine (BrdU) in vivo." | 3.68 | Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma. ( Erikstein, B; Gerlyng, P; Grotmol, T; Seglen, PO; Stokke, T, 1992) |
| "Nineteen rearanged chromosomes were in hepatoma 8994, whereas only 8-10 markers could be found in the 80 +/- 3 chromosome complement of hepatoma 7316A." | 1.26 | Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines. ( Kovi, E; Kovi, J; Morris, HP; Rao, MS, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kovi, J | 1 |
| Kovi, E | 1 |
| Morris, HP | 1 |
| Rao, MS | 1 |
| Gerlyng, P | 1 |
| Grotmol, T | 1 |
| Erikstein, B | 1 |
| Stokke, T | 1 |
| Seglen, PO | 2 |
| Watkins, JB | 1 |
| Thierau, D | 1 |
| Schwarz, LR | 1 |
| Clawson, GA | 1 |
| Blankenship, LJ | 1 |
| Rhame, JG | 1 |
| Wilkinson, DS | 1 |
| Saeter, G | 2 |
| Schwarze, PE | 1 |
| Nesland, JM | 1 |
| Juul, N | 1 |
| Pettersen, EO | 1 |
| Schwarze, E | 1 |
| Seglen, O | 1 |
6 other studies available for 2-acetylaminofluorene and Polyploid
| Article | Year |
|---|---|
Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Aniline Compounds; Animals; Carcinoma, Hepat | 1978 |
Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; Flow Cy | 1992 |
Biotransformation in carcinogen-induced diploid and polyploid hepatocytes separated by centrifugal elutriation.
Topics: 2-Acetylaminofluorene; Animals; Cell Separation; Diethylnitrosamine; Diploidy; Enzyme Induction; Hep | 1992 |
Nuclear enlargement induced by hepatocarcinogens alters ploidy.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Dimethylnitrosamine; Diploidy; L | 1992 |
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Diploidy; DNA; DNA, Neoplasm; Flo | 1988 |
Shift from polyploidizing to nonpolyploidizing growth in carcinogen-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Flow Cytometry; Liver; Liver Neoplasms, Experime | 1988 |