2-acetylaminofluorene has been researched along with Liver Neoplasms in 334 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 7.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "03% 2-acetylaminofluorene (AAF) resulted, 12 to 15 months later, in a massive production of hepatic cysts." | 7.66 | Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene. ( Pitot, HC; Potter, VR; Richards, WL, 1982) |
| "The incidence of bladder and liver neoplasms developed in mice continuously fed 2-acetylaminofluorene (2-AAF) in a multidisciplined study conducted at the National Center for Toxicological Research (NCTR) is represented using a probit model." | 7.66 | Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously. ( Farmer, JH; Greenman, DL; Kodell, RL; Shaw, GW, 1980) |
| "A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not." | 7.65 | Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. ( Becker, FF; Shurgin, A, 1975) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 5.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas." | 3.75 | Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival. ( Gasbarrini, A; Pani, G; Petersen, BE; Piscaglia, AC; Shupe, TD; Tesori, V, 2009) |
| "A rat cell line-nominated CC-62 derived from a combined hepatocellular and cholangiocellular carcinoma obtained by administration of 2-acetylaminofluorene to male Wistar rats, has been established." | 3.71 | Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma. ( Callaghan, R; Carda, C; Gil-Benso, R; Gregori-Romero, MA; Llombart-Bosch, A; Martinez-Lorente, A; Navarro-Fos, S; Pellin-Perez, A; Peydro-Olaya, A, 2001) |
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 3.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| " In contrast, the liver neoplasm promoter phenobarbital increased the multiplicity, although not the incidence, of liver neoplasms when given after FAA." | 3.67 | Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide. ( Furuya, K; Levine, WG; Mori, H; Numoto, S; Williams, GM, 1985) |
| "03% 2-acetylaminofluorene (AAF) resulted, 12 to 15 months later, in a massive production of hepatic cysts." | 3.66 | Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene. ( Pitot, HC; Potter, VR; Richards, WL, 1982) |
| " As an example of the application of the HF method, data for liver neoplasms caused by long-term exposure of mice to 2-acetylaminofluorene and data for radiation pneumonitis and pulmonary fibrosis caused by long-term exposure of dogs to ionizing radiation are analyzed." | 3.66 | Method of analysis of monotone dose-response probabilities after long-term exposure to a toxicant. ( Scott, BR, 1982) |
| "The incidence of bladder and liver neoplasms developed in mice continuously fed 2-acetylaminofluorene (2-AAF) in a multidisciplined study conducted at the National Center for Toxicological Research (NCTR) is represented using a probit model." | 3.66 | Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously. ( Farmer, JH; Greenman, DL; Kodell, RL; Shaw, GW, 1980) |
| "A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not." | 3.65 | Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. ( Becker, FF; Shurgin, A, 1975) |
| " The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation." | 2.38 | Cell proliferation in carcinogenesis. ( Cohen, SM; Ellwein, LB, 1990) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 1.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " Because the administration of 2-acetylaminofluorene (2AAF) followed by a partial hepatectomy, selectively induces the HPC proliferation, we investigated the effects of chronic 2AAF administration on the HCC development caused by the chronic administration of the carcinogen diethylnitrosamine (DEN) for 16 weeks in the rat." | 1.62 | Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo. ( Arellanes-Robledo, J; Castro-Gil, MP; Del-Pozo-Jauner, L; Gabiño-López, NB; López-Torres, CD; Pérez-Carreón, JI; Quintanar-Jurado, V; Sánchez-Rodríguez, R; Torres-Mena, JE; Villa-Treviño, S, 2021) |
| "HMGB3 in human liver cancer tissues were evaluated using bioinformatics databases from GEO, TCGA, and Oncomine." | 1.48 | Abnormal expression of ( Dong, ZZ; Fang, M; Wang, L; Yao, DF; Yao, M; Zheng, WJ, 2018) |
| "To develop DR-HepG2, hepatocellular carcinoma cell line (HepG2) was transfected with 2-Acetylaminofluorene (AAF) and Aflatoxin B1 (AFB)." | 1.39 | Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: an in vitro study. ( Chaudhary, H; Jena, PK; Seshadri, S, 2013) |
| " Our results showed a resistance to the toxic effects of EA since viability and cellular integrity values were significantly higher than control." | 1.34 | Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. ( Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT, 2007) |
| "Pioglitazone treatment was initiated the day after the first diethylnitrosamine injection." | 1.34 | The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver. ( Borbath, I; Horsmans, Y; Leclercq, I; Moulin, P; Sempoux, C, 2007) |
| "Within the scope of the Rat Liver Foci Bioassay the model carcinogens N-nitrosomorpholine (NNM), 2-acetylaminoflouren (2-AAF), phenobarbital (PB), and clofibrate (CF) were analyzed concerning their potency and dose-response relationship to induce foci of altered hepatocytes (FAHs), which are known to be precursor lesions of liver adenoma and carcinoma." | 1.34 | Comparison of mode of action of four hepatocarcinogens: a model-based approach. ( Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M, 2007) |
| "Acetaminophen was given in the diet either alone at 2400 or 4800 p." | 1.34 | Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Perrone, CE; Williams, GM, 2007) |
| " The slopes of the dose-response curves for bladder neoplasms from 17 months through 33 months were consistently very steep, while those for liver neoplasms increased from a shallow slope at 18 months to a steep slope at 33 months." | 1.32 | Thresholds of carcinogenicity in the ED01 study. ( Waddell, WJ, 2003) |
| "Fumonisin B1 (FB1) is a naturally occurring mycotoxin produced by Fusarium verticillioides." | 1.32 | Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. ( Gelderblom, WC; Hall, Pde L; Kirsch, RE; Lemmer, ER; Marasas, WF; Shephard, EG; Van Schalkwyk, DJ; Van Wijk, RA; Vessey, CJ, 2004) |
| " We conclude that long-term intake of TRF could reduce cancer risk by preventing hepatic lipid peroxidation and protein oxidation damage due to its antioxidant actions." | 1.32 | Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. ( Beg, ZH; Iqbal, J; Minhajuddin, M, 2004) |
| "In human hepatoma (Hep G2) cells and peripheral blood lymphocytes (HPBL) the cytokinesis-blocked micronuclei (MN) and fluorescent in situ hybridization (FISH) assays were applied to study aneugenic and clastogenic potentials of X-rays, directly and indirectly acting chemicals." | 1.29 | Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric pro ( Darroudi, F; Hadjidekova, V; Meijers, CM; Natarajan, AT, 1996) |
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| " It has previously been shown that a multiple dosing regimen with AFB1, started after 3 weeks of CMD diet, enhances tumor incidence." | 1.28 | Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1. ( Laver, GW; McMullen, E; Mehta, R; Stapley, R, 1992) |
| "While the first hepatocellular carcinoma in R16 fed either a CS or LC was seen at 9-10 months, one R16 rat fed a CD diet had liver cancer at 4 months." | 1.28 | Genetics and diet: synergism in hepatocarcinogenesis in rats. ( Gill, TJ; Kazanecki, ME; Kunz, HW; Melhem, MF; Rao, KN, 1990) |
| "The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study." | 1.28 | Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data. ( Felton, RP; Kodell, RL, 1991) |
| " By using a biologically based model of two-event carcinogenesis accounting explicitly for both genotoxic and nongenotoxic proliferative effects at the cellular level, we provide a unifying explanation for the apparently disparate dose-response results observed in the urinary bladder and liver." | 1.28 | Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study. ( Cohen, SM; Ellwein, LB, 1990) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " In the second experiment, the effect of chronic administration of PB and NAF given after I without S or after S without I was analyzed." | 1.27 | Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1986) |
| "Data for nine different types of tumors from the large ED01 study conducted at the National Center for Toxicological Research were used to compare tumor prevalence rates among litters with the tumor rates expected under the assumption of homogeneity of tumor rates among litters." | 1.27 | Occurrence of tumors among litters of BALB/c female mice. ( Chen, JJ; Gaylor, DW; Greenman, DL; Thompson, CH, 1985) |
| "One element of the ED01 Study contained a group of animals that were dosed with 2-acetylaminofluorene for 9, 12, 15, 18, or 24 mo and then sacrificed at 18 or 24 mo." | 1.27 | Influence of total dose and dose rate in carcinogenicity studies. ( Gaylor, DW; Littlefield, NA, 1985) |
| " A number of mathematical dose-response models have been proposed for extrapolation purposes; we have shown how similar they can appear to one another in the range of observable response rates, yet how different they become at lower, unobservable response rates, the region of primary interest." | 1.27 | Statistical aspects of the estimation of human risks. ( Brown, CC, 1985) |
| "2." | 1.26 | Purification and immunochemical characterization of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas. ( Feinstein, RN; Lindahl, R, 1976) |
| "Amount of cytochrome P-450 in hepatoma tissues also showed similar values as that in hyperplastic nodules." | 1.26 | Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. ( Fukumoto, Y; Noda, K; Okita, K; Takemoto, T, 1976) |
| "In vivo, hepatoma H-4-II-E is rapidly growing tumor with a mean doubling time of 49-2 hr." | 1.26 | Properties of the H-4-II-E tumor cell system. I. Growth and cell proliferation kinetics of an experimental hepatoma. ( Evans, MJ; Kovacs, CJ, 1977) |
| "The results indicate that the hepatoma-specific aldehyde dehydrogenases are not the result of the de-repression of genes normally repressed in adult rat liver or in some other adult tissue." | 1.26 | Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression. ( Lindahl, R, 1977) |
| "The incidence of hepatomas in the phorbol-treated offspring of AAF-injected mothers was 8/74 (11%), as compared with 2/80 (2." | 1.26 | Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice. ( Armuth, V; Berenblum, I, 1977) |
| "In contrast, the incidence of hepatocellular carcinomas in sham-operated rats was 38." | 1.26 | Inhibitory effect of hypothalamic lesions on liver tumor induction by N-2-fluorenylacetamide in male rats. ( Toh, YC, 1978) |
| "Hyperplastic nodules and hepatocellular carcinomas were induced in livers of rats by a low-protein diet containing 0." | 1.26 | Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development. ( Keenan, TW; Merritt, WD; Morré, DJ; Richardson, CL, 1978) |
| "(c) Spermine levels were significantly lowered, with 3 minima corresponding to the putrescine maxima." | 1.26 | Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide. ( Aussel, C; Lafaurie, M; Lalanne, CM; Milano, G; Soula, G; Stora, C, 1981) |
| "Well to moderately well differentiated hepatocellular carcinomas developed in 50% and 75% of rats fed the CD + AAF diet for 4 and 6 months, respectively." | 1.26 | Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet. ( Lombardi, B; Shinozuka, H, 1979) |
| "Phenacetin was most effective followed by N-ethylacetanilide." | 1.26 | Effect of phenacetin and N-alkylacetanilides on N-2-fluorenylacetamide hepatocarcinogenesis. ( Frankel, HH; Weisburger, EK; Yamamoto, RS, 1979) |
| " In the livers from 4 humans, 3 of whom had a history of long-term use of some drugs, multiple hyperplastic foci resembling eosinophilic or clear cell foci in rats were identified." | 1.26 | DNA content of liver cell nuclei of N-2-fluorenylacetamide-induced altered foci and neoplasms in rats and human hyperplastic foci. ( Mori, H; Sugie, S; Takahashi, M; Tanaka, T; Williams, GM, 1982) |
| "MeCh both reduced the incidence of hepatic neoplasms induced by 3'-MeDAB and delayed their development." | 1.26 | 3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3'-methyl-4-dimethylaminoazobenzene or 2-acetylamino-fluorene: a comparative study. ( Flaks, A; Flaks, B, 1982) |
| "Transplantable hepatomas varied in their fibronectin staining from fibronectin-negative hepatomas to ones with fibronectin staining within or around every tumor cell." | 1.26 | Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. ( Ruoslahti, E; Sell, S, 1982) |
| "In well differentiated, slowly growing hepatomas, the concentration of GSH approached the level in normal adult rat liver." | 1.26 | Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis. ( Fiala, AE; Fiala, S; Kettering, WG; Mohindru, A; Morris, HP, 1976) |
| " The study design consisted of sacrifice intervals, life span, and discontinued dosing groups." | 1.26 | Effects of dose and time in a long-term, low-dose carcinogenic study. ( Farmer, JH; Gaylor, DW; Littlefield, NA; Sheldon, WG, 1980) |
| "alpha-BHC inhibited the induction of hepatocellular carcinomas and oval cells infiltration in rats treated with 2-FAA for 5 months." | 1.26 | Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats. ( Hiasa, Y; Murata, Y; Ohmori, T; Ohshima, M, 1978) |
| "Since up to 60% of the hepatocellular carcinomas developing from this regimen will predictably produce AFP, it is tentatively concluded that hepatocellular carcinoma may arise not only from "premalignant" neoplastic nodules but also from oval cells or the atpyical differentiation of hepatocytes." | 1.26 | Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide. ( Sell, S, 1978) |
| " The linear dose-response relationship of tissue binding correlated well with the previously reported linear dose response curve for liver tumors but did not correlated with the reported non-linear dose response curve for bladder tumors." | 1.26 | Tissue binding of 2-acetylaminofluorene in BAlB/c and C57Bl/6 mice during chronic oral administration. ( Jackson, CD; Shellenberger, TE; Weis, C, 1980) |
| " Although a pronounced dose-response for time-to-tumor was expressed for both bladder and liver neoplasms, the time required for death from either neoplasm following its appearance was not dose-related." | 1.26 | Estimation of distributions of time to appearance of tumor and time to death from tumor after appearance in mice fed 2-acetylaminofluorene. ( Farmer, JH; Frith, CH; Greenman, DL; Kodell, RL, 1980) |
| "In primary hepatomas induced by 2-acetylaminofluorene, cytochrome P-450 content is 21% of that of controls, AHH activity is 11% of the activity of controls, and reductase is 50% of the control activity." | 1.26 | A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. ( Cameron, R; Farber, E; Jones, K; Lee, G; Sweeney, GD, 1976) |
| "Nineteen rearanged chromosomes were in hepatoma 8994, whereas only 8-10 markers could be found in the 80 +/- 3 chromosome complement of hepatoma 7316A." | 1.26 | Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines. ( Kovi, E; Kovi, J; Morris, HP; Rao, MS, 1978) |
| "These neoplasms included cholangiomas, hepatoadenomas, cholangiocarcinomas, and hepatocellular cancers." | 1.25 | Tumor induction by carcinogenic agents in aquarium fish. ( Khudoley, VV; Pliss, GB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 245 (73.35) | 18.7374 |
| 1990's | 43 (12.87) | 18.2507 |
| 2000's | 23 (6.89) | 29.6817 |
| 2010's | 20 (5.99) | 24.3611 |
| 2020's | 3 (0.90) | 2.80 |
| Authors | Studies |
|---|---|
| Sánchez-Meza, J | 1 |
| Campos-Valdez, M | 1 |
| Domínguez-Rosales, JA | 1 |
| Godínez-Rubí, JM | 1 |
| Rodríguez-Reyes, SC | 1 |
| Martínez-López, E | 1 |
| Zúñiga-González, GM | 1 |
| Sánchez-Orozco, LV | 1 |
| Nair, AB | 1 |
| Shah, J | 1 |
| Al-Dhubiab, BE | 1 |
| Patel, SS | 1 |
| Morsy, MA | 1 |
| Patel, V | 1 |
| Chavda, V | 1 |
| Jacob, S | 1 |
| Sreeharsha, N | 1 |
| Shinu, P | 1 |
| Attimarad, M | 1 |
| Venugopala, KN | 1 |
| Castro-Gil, MP | 1 |
| Sánchez-Rodríguez, R | 1 |
| Torres-Mena, JE | 1 |
| López-Torres, CD | 1 |
| Quintanar-Jurado, V | 1 |
| Gabiño-López, NB | 1 |
| Villa-Treviño, S | 1 |
| Del-Pozo-Jauner, L | 1 |
| Arellanes-Robledo, J | 1 |
| Pérez-Carreón, JI | 1 |
| Ali, G | 1 |
| Omar, H | 1 |
| Hersi, F | 1 |
| Abo-Youssef, A | 1 |
| Ahmed, O | 1 |
| Mohamed, W | 1 |
| P Katare, D | 1 |
| Malik, S | 1 |
| J Mani, R | 1 |
| Ranjpour, M | 1 |
| Jain, SK | 1 |
| Amidi, S | 1 |
| Hashemi, Z | 1 |
| Motallebi, A | 1 |
| Nazemi, M | 1 |
| Farrokhpayam, H | 1 |
| Seydi, E | 2 |
| Pourahmad, J | 2 |
| Hamza, AA | 1 |
| Heeba, GH | 1 |
| Elwy, HM | 1 |
| Murali, C | 1 |
| El-Awady, R | 1 |
| Amin, A | 1 |
| Satoh, K | 2 |
| Zheng, WJ | 1 |
| Yao, M | 5 |
| Fang, M | 1 |
| Wang, L | 2 |
| Dong, ZZ | 2 |
| Yao, DF | 6 |
| Thomas, NS | 1 |
| George, K | 1 |
| Selvam, AAA | 1 |
| Matboli, M | 1 |
| ElGwad, AA | 1 |
| Hasanin, AH | 1 |
| El-Tawdi, A | 1 |
| Habib, EK | 1 |
| Elmansy, RA | 1 |
| Ibrahim, D | 1 |
| Shehata, H | 1 |
| Tash, F | 1 |
| Sultana, S | 2 |
| Nafees, S | 1 |
| Khan, AQ | 1 |
| Chaudhary, H | 2 |
| Jena, PK | 2 |
| Seshadri, S | 2 |
| Papp, V | 2 |
| Rókusz, A | 1 |
| Dezső, K | 2 |
| Bugyik, E | 2 |
| Szabó, V | 1 |
| Pávai, Z | 1 |
| Paku, S | 2 |
| Nagy, P | 3 |
| Yan, XD | 1 |
| Zhang, HJ | 2 |
| Yan, MJ | 1 |
| Gu, X | 1 |
| Shi, Y | 1 |
| Chen, J | 1 |
| Kindrat, I | 1 |
| Tryndyak, V | 1 |
| de Conti, A | 1 |
| Shpyleva, S | 1 |
| Mudalige, TK | 1 |
| Kobets, T | 1 |
| Erstenyuk, AM | 1 |
| Beland, FA | 6 |
| Pogribny, IP | 2 |
| Rasekh, HR | 1 |
| Salimi, A | 1 |
| Mohsenifar, Z | 1 |
| Gjymishka, A | 1 |
| Pi, L | 1 |
| Oh, SH | 1 |
| Jorgensen, M | 1 |
| Liu, C | 1 |
| Protopapadakis, Y | 1 |
| Patel, A | 1 |
| Petersen, BE | 2 |
| Piscaglia, AC | 1 |
| Shupe, TD | 1 |
| Pani, G | 1 |
| Tesori, V | 1 |
| Gasbarrini, A | 1 |
| Jiang, H | 1 |
| Li, YM | 2 |
| Gu, WJ | 2 |
| Shen, YC | 1 |
| Qiu, LW | 4 |
| Wu, W | 4 |
| Wu, XH | 3 |
| Sai, WL | 3 |
| Shen, JJ | 1 |
| Yu, HB | 1 |
| Wang, YL | 1 |
| HOCH-LIGETI, C | 1 |
| HARRIS, PN | 1 |
| Taha, MM | 1 |
| Abdul, AB | 1 |
| Abdullah, R | 1 |
| Ibrahim, TA | 1 |
| Abdelwahab, SI | 1 |
| Mohan, S | 1 |
| Bian, YZ | 1 |
| Zhang, CG | 1 |
| Yang, JL | 1 |
| Shpyleva, SI | 1 |
| Muskhelishvili, L | 1 |
| Tryndyak, VP | 1 |
| Koturbash, I | 1 |
| Tokar, EJ | 1 |
| Waalkes, MP | 1 |
| Hegyesi, H | 1 |
| Sáfrány, G | 1 |
| Bödör, C | 1 |
| Waddell, WJ | 1 |
| Valentin-Severin, I | 1 |
| Le Hegarat, L | 1 |
| Lhuguenot, JC | 1 |
| Le Bon, AM | 2 |
| Chagnon, MC | 1 |
| Crump, KS | 1 |
| Clewell, HJ | 1 |
| Andersen, ME | 1 |
| Conolly, RB | 1 |
| Gaylor, DW | 6 |
| Sánchez, A | 1 |
| Thorgeirsson, SS | 2 |
| PIROZYNSKI, WJ | 1 |
| VON BERTALANFFY, L | 1 |
| MOSONYI, M | 1 |
| KORPASSY, B | 1 |
| RUTMAN, RJ | 3 |
| CANTAROW, A | 3 |
| PASCHKIS, KE | 3 |
| MORI, K | 2 |
| ICHII, S | 1 |
| NAGASE, K | 1 |
| HARUNO, K | 1 |
| SYMEONIDIS, A | 1 |
| MORRIS, HP | 4 |
| HACHISUGA, T | 1 |
| SINDO, H | 1 |
| IBATA, H | 1 |
| KATO, T | 1 |
| MIYAJI, T | 1 |
| SENOO, T | 1 |
| THERET, C | 2 |
| SIDRANSKY, H | 1 |
| CLARK, S | 1 |
| BABA, T | 1 |
| WEISBURGER, JH | 3 |
| WEISBURGER, EK | 3 |
| JABARA, AG | 1 |
| MILLER, EC | 4 |
| MILLER, JA | 3 |
| ENOMOTO, M | 1 |
| CHENG, YS | 1 |
| CHIANG, CM | 1 |
| YAO, T | 1 |
| ENGEL, RW | 1 |
| COPELAND, DH | 1 |
| BIELSCHOWSKY, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)[NCT00978250] | Phase 2 | 95 participants (Actual) | Interventional | 2009-08-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the count of participants with serious and non-serious adverse events assessed by the Common Terminology Criteria in Adverse Events (CTCAE v4.0). A non-serious adverse event is any untoward medical occurrence. A serious adverse event is an adverse event or suspected adverse reaction that results in death, a life threatening adverse drug experience, hospitalization, disruption of the ability to conduct normal life functions, congenital anomaly/birth defect or important medical events that jeopardize the patient or subject and may require medical or surgical intervention to prevent one of the previous outcomes mentioned. (NCT00978250)
Timeframe: Date treatment consent signed to date off study, approximately 109 months and 16 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| 5-Fluro-2'-Deoxycytidine (FdCyd) + Tetrahydrouridine (THU) | 91 |
Response was measured using the Response Evaluation Criteria in Solid Tumors (RECIST). Complete response is disappearance of all target lesions. Partial response is at least a 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum of the LD. (NCT00978250)
Timeframe: until subject progressed or went off study for other reasons (up to approximately 1 year)
| Intervention | percentage of participants (Number) |
|---|---|
| Non-Small Cell Cancer Stratum | 0.0 |
| Breast Cancer Stratum | 6.9 |
| Bladder Cancer Stratum | 5.6 |
| Head and Neck Cancer Stratum | 0.0 |
Progression-free survival (PFS) is defined as the time interval from start of treatment to documented evidence of disease progression. Disease progression was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) and is at least a 20% increase in the sum of the longest diameter (LD) of target lesions, taking as reference the smallest sum of the LD recorded since the treatment started or the appearance of one or more new lesions. (NCT00978250)
Timeframe: until subject progressed or went off study for other reasons (up to approximately 1 year)
| Intervention | months (Median) |
|---|---|
| Non-Small Cell Cancer Stratum | 2.3 |
| Breast Cancer Stratum | 3.7 |
| Bladder Cancer Stratum | 3.6 |
| Heand and Neck Cancer Stratum | 1.7 |
16 reviews available for 2-acetylaminofluorene and Liver Neoplasms
| Article | Year |
|---|---|
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; g | 1984 |
The first relevant cell stage in rat liver carcinogenesis. A quantitative approach.
Topics: 2-Acetylaminofluorene; Animals; Basophils; Carcinoma, Hepatocellular; Dimethylnitrosamine; Dose-Resp | 1980 |
The sequential analysis of liver cancer induction.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Female; | 1980 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; DNA Adducts; Female; Incidence | 1994 |
[In vivo fate of environmental carcinogens (author's transl)].
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Benzopyrenes; Carcinogens, Environmental; | 1978 |
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; | 1976 |
Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Biotransformation; Carcinogens; Carcinogens, Environment | 1978 |
Cocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Viral; Cocarcinogenesis; Diet; Gas | 1979 |
The role of hormones on digestive and urinary tract carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Diet; Female; Food; Gonadal Steroid Hormon | 1976 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyr | 1975 |
Cell proliferation in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Humans; Liver; Liver Neoplasms; Mice; Mi | 1990 |
Metabolic activation of aromatic amine carcinogens in vitro and in vivo.
Topics: 2-Acetylaminofluorene; Acetylation; Amines; Animals; Biotransformation; Carcinogens; Cytochrome P-45 | 1989 |
Cellular effects of chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Carcinogens; Cell Transformation, Neoplast | 1986 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; C | 1985 |
318 other studies available for 2-acetylaminofluorene and Liver Neoplasms
| Article | Year |
|---|---|
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; L | 2023 |
Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Antimetabolites, Antineoplastic; Asialoglycoprotein Receptor; Carcin | 2019 |
Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2021 |
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Din | 2022 |
Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Apolipoprotein A-I; Biomarkers, Tumor; Carcinom | 2018 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chr | 2017 |
Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer: In vivo and in vitro analyses.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Cycle Checkpoin | 2018 |
Strong carcinogenic stress response induction of preneoplastic cells positive for GST-P in the rat liver: Physiological mechanism for initiation.
Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; Bile Ducts; Enzyme Induction; Gene Expression Regula | 2018 |
Abnormal expression of
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Hepatocellular; | 2018 |
Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2-p53 interaction.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Disease Progressio | 2018 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Anticarcinogenic Agents; Aspartate Aminotransf | 2013 |
Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: an in vitro study.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cass | 2013 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different | 2014 |
Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, N | 2013 |
In vivo evaluation of Eclipta alba extract as anticancer and multidrug resistance reversal agent.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Aspartate A | 2014 |
MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, CD; Blotting, Western; Carcinogenesis; Carcinogens; Carcin | 2016 |
Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Apop | 2016 |
miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology.
Topics: 2-Acetylaminofluorene; Adenoviridae; Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Mov | 2016 |
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Move | 2009 |
Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neopl | 2009 |
Characteristics of hepatic nuclear-transcription factor-kappa B expression and quantitative analysis in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, N | 2009 |
Succinoxidase activity of hepatic tumours produced in rats by feeding 2-acetaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Liver; Liver Neoplasms; Neoplasms; Oxidoreductases; Rats | 1947 |
Production of tumors in rats by 2-aminofluorene and 2-acetylaminofluorene; failure of liver extract and of dietary protein level to influence liver tumor production.
Topics: 2-Acetylaminofluorene; Animals; Diet; Dietary Proteins; Fluorenes; Liver; Liver Extracts; Liver Neop | 1947 |
Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carc | 2010 |
Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Cel | 2011 |
Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Antimicrobial Cationic Peptides; Carcinogens; Cation Transport Prote | 2011 |
Structural analysis of oval-cell-mediated liver regeneration in rats.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Differentiation; Biopsy, Needle; Cell Differentiation; Cel | 2012 |
Thresholds of carcinogenicity in the ED01 study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Dose-Response Relationship, Drug | 2003 |
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet As | 2003 |
Evidence of a "clear and consistent threshold" for bladder and liver cancer in the large ED01 carcinogenicity study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Data Interpretation, Statistical | 2003 |
Thresholds of carcinogenicity in the ED01 study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Data Interpretation, Statistical | 2003 |
STAT-3 activity in chemically-induced hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Antineoplastic Agents, Hormonal; Blotting, Northe | 2003 |
Ribonucleic acid in cytoplasm of liver cells; its localization in hyperplasia and hepatoma produced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Carcinoma, Hepatocellular; Cytoplasm; Hepatocytes; Hyperplasia; Liver; Liver | 1952 |
Rapid production of malignant hepatomas by simultaneous administration of tannic acid and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Tannins | 1953 |
Studies in 2-acetylaminofluorene carcinogenesis. II. The in vitro uptake of alanine-1-C14 by preneoplastic liver and hepatoma mitochondrial protein.
Topics: 2-Acetylaminofluorene; Alanine; Carcinogenesis; Carcinoma, Hepatocellular; Fluorenes; In Vitro Techn | 1954 |
Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasm | 1954 |
Effect of liver feeding on the production of liver cancer of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinogens; Humans; Liver Ext | 1954 |
Catalase and uricase studies on rats during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Catalase; En | 1954 |
Asparaginase activity in tissues of the rats fed with carcinogens, p-dimethylaminoazobenzene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Animals; Asparaginase; Carcinogens; Carcinoma, Hepatocellula | 1954 |
Tumors induced by 2-acetylaminofluorene in virgin and breeding females of five strains of rats and in their offspring.
Topics: 2-Acetylaminofluorene; Animals; Breast Neoplasms; Breeding; Female; Fluorenes; Liver Neoplasms; Neop | 1954 |
Hepatocarcinogenesis by 2-acetylaminofluorene and related compounds including comments on dietary and other influences.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Fluorenes; Gonadal Steroid H | 1955 |
Utilization of uracil by acetylaminofluorene-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Liver Neoplas | 1955 |
[Hepatic tumor of rat induced by 2-acetylaminofluorene and its sex difference; tumors of the other organs].
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Liver Neoplasms; Liver Neoplasms, Experimental; Rats; Sex | 1957 |
[Experimental hepatic cancers. Selective modifications brought about by adrenaline and acetylcholine on the action of DAB and 2-AAF].
Topics: 2-Acetylaminofluorene; Acetylcholine; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcin | 1961 |
[Facilitation, by chlorpromazine, of hepatic cancer production by 2-acetylaminofluorene in female Wistar rats].
Topics: 2-Acetylaminofluorene; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chlorpromazine; Femal | 1962 |
Influence of p-hydroxy-propiophenone on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Carcinogens; Ethionine; Fluorenes; Hydroxypropiophen | 1963 |
ENDOGENOUS AND EXOGENOUS FACTORS IN CHEMICAL CARCINOGENESIS BY N-2-FLUORENYLACETAMIDE.
Topics: 2-Acetylaminofluorene; Carbon Isotopes; Carcinogenesis; Fluorenes; Liver Neoplasms; Metabolism; Neop | 1963 |
A COMPARISON OF THE PATHOLOGICAL EFFECTS OF 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOBIPHENYL, AND 2-ACETYLAMINOBIPHENYL IN THE DOG.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Biphenyl Compounds; Carcinogens; Carcinoma, | 1963 |
THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cricetinae; Croton Oil; Fluorenes; Guinea Pigs; Injecti | 1964 |
[THE EFFECTS OF DIET AND DOSAGE OF CARCINOGEN ON THE INDUCTION OF LIVER TUMORS IN RATS FED 2-ACETYLAMINOFLUORENE].
Topics: 2-Acetylaminofluorene; Carcinogens; Carcinoma, Hepatocellular; Diet; Fluorenes; Liver Neoplasms; Neo | 1965 |
Influence of diet on the relative incidence of eye, mammary, ear-duct, and liver tumors in rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Diet; Dietetics; Incidence; Liver Neoplasms; Neoplasms; Nutritional | 1951 |
Carcinogenesis in parabiotic rats; tumours of liver and seminal vesicle induced by acetylaminofluorene in normal males joined to castrated males or females.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Female; Humans; Liver Neoplasms; Male; Neoplasms; Ra | 1951 |
Production of cirrhosis and liver tumors in male rats using high dosages of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver N | 1951 |
Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Carcinogens; Carcinogens, Environmental; Carcin | 2004 |
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Crosses, Geneti | 2004 |
2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair.
Topics: 2-Acetylaminofluorene; Animals; DNA Mutational Analysis; DNA Repair; Genome; Lac Operon; Liver Neopl | 2005 |
Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticholesteremic Agents; Antioxidants; Carcinoge | 2004 |
Different inhibitory effects in the early and late phase of treatment with KAT-681, a liver-selective thyromimetic, on rat hepatocarcinogenesis induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell P | 2005 |
Preventive effect of tannic acid on 2-acetylaminofluorene induced antioxidant level, tumor promotion and hepatotoxicity: a chemopreventive study.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Cel | 2006 |
Dynamic alteration of telomerase expression and its diagnostic significance in liver or peripheral blood for hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adult; Aged; Animals; Carcinoma, Hepatocellular; Female; Gene Expression Regu | 2006 |
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; C | 2007 |
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinogens; | 2007 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms | 2007 |
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Hepato | 2007 |
Lack of evidence for isozymic shifts of adenylate deaminase during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; AMP Deaminase; Animals; Chromatography, Ion Exchange; Ethionine; Female; Isoe | 1980 |
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Li | 1981 |
In vitro measurement of resistance to phalloidin and gamma-glutamyltransferase of carcinogen-induced preneoplastic hepatocytes of rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Resistance; gamma-Glutamyltransferase; Histocytochemistry; In V | 1982 |
Isolation and enrichment of cells resistant to iron accumulation from carcinogen-induced rat liver altered foci.
Topics: 2-Acetylaminofluorene; Animals; Cell Separation; gamma-Glutamyltransferase; Iron; Liver; Liver Neopl | 1982 |
Comparison of hepatic carcinogen initiation-promotion systems.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; Epoxide Hydrolases; gamma-Glut | 1982 |
Promotion of chemically initiated hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Humans; Liver; Liver Neoplasms; Male; Mod | 1982 |
Immunohistochemical and biochemical detection of uridine-diphosphate-glucuronyltransferase (UDP-GT) activity in putative preneoplastic liver foci.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Female; gamma-Glutamyltransferase; Glucur | 1983 |
Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Cell Differentiation; DNA Replication; Liver; Live | 1983 |
Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; E | 1983 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Alterations of markers during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Ethylmorphine-N- | 1984 |
Binding of the dye intermediates Michler's ketone and methane base to rat liver nucleic acids and lack of mutagenicity in Salmonella typhimurium.
Topics: 2-Acetylaminofluorene; Aniline Compounds; Animals; Benzhydryl Compounds; Carcinogens; DNA; Dose-Resp | 1980 |
Thyroid activity during hepatocarcinogenesis by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Female; Liver Neoplasms; Neoplasms, Experimental | 1981 |
Metabolism and nucleic acid binding of 7-fluoro-2-acetamidofluorene in rats: oxidative defluorination and apparent dissociation from hepatocarcinogenesis of 8-(N-arylamide) guanine adducts on DNA.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Nucleus; DNA; Female; Fluorine; Guanine; Hydroxyla | 1982 |
Increased uridine diphosphate-glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Enzyme Activation; Epitopes; Glucuronosyltransferase; Liver; Liver N | 1982 |
Sex steroid hormones levels and testicular activity during hepatocarcinogenesis by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Estradiol; Gonadal Steroid Hormones; Liver Neopl | 1982 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Disease Models, Animal; Ep | 1984 |
Inhibition of N-2-fluorenylacetamide-induced mammary tumorigenesis in rats by dietary polybrominated biphenyls.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Biphenyl Compounds; Diet; Ear Neoplasms; Female; | 1980 |
Early events during liver carcinogenesis involving two carcinogen:protein complexes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cytosol; Ethionine; Female; | 1981 |
[Study on epoxide hydrolase in rat hyperplastic nodule and hepatoma during chemical hepatocarcinogenesis induced by 2-acetylaminofluorene (author's transl)].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Epoxide Hydrolases; Fluorescent Antibody | 1982 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibronectins; Glycopr | 1982 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Chemical and Drug Induced Liver Injury; Cysts; H | 1982 |
Simultaneous inhibition of liver carcinogenicity and enhancement of bladder carcinogenicity of N-2-fluorenylacetamide by butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Carcinoma; Carcinoma, Hepatocellular; Coca | 1983 |
Changes in protein kinase activities during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Cell Fractionation; Cell Nucleus; Cyclic AMP; Cytoplasm; Liver Neopl | 1983 |
Infectivity of avian myelocytomatosis virus MC29 in rats.
Topics: 2-Acetylaminofluorene; Animals; Avian Leukosis Virus; Chickens; Hepatectomy; Liver; Liver Neoplasms; | 1983 |
Role of dolichyl phosphate in regulation of protein glycosylation in 2-acetylaminofluorene-induced carcinogenesis in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Dolichol Phosphates; Dolichols; Liver Neopl | 1984 |
Flow cytometric analysis of proflavine uptake into normal rat hepatocytes and cells arising during AAF-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acridines; Animals; Azides; Cell Nucleus; Flow Cytometry; In Vitro Techniques | 1984 |
Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Ethylnitrosourea; Female; Hepatectomy; Liver; Li | 1984 |
Chemical liver carcinogenesis: monitoring of the process by flow cytometric DNA measurements.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Clone Cells; Dimethylnitrosamine; DNA, Neoplasm; Flow | 1983 |
Non-random interaction of N-2-acetylaminofluorene and its N-hydroxy metabolite with DNA of rat hepatic parenchymal and non-parenchymal cell nuclei following in vivo administration of carcinogen.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Chromatin; DNA, Neoplasm; Liver; Liver Neoplasms; Male | 1984 |
Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Transformation, Neoplastic; Choline Deficiency | 1984 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla | 1984 |
Modification of the development of N-nitrosomorpholine-induced hepatic lesions by 2-acetylaminofluorene, phenobarbital and 4,4'-diaminodiphenylmethane: a sequential histological and histochemical analysis.
Topics: 2-Acetylaminofluorene; Aniline Compounds; Animals; Carcinogens; Drug Interactions; Liver; Liver Neop | 1984 |
Sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Cytidine Monophosphate N-Acetylneur | 1984 |
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neopl | 1984 |
Gangliosides of liver tumors induced by N-2 fluorenylacetamide III. Galactosyl and sialyl transferases in single carcinomas and nodules.
Topics: 2-Acetylaminofluorene; Animals; Galactosyltransferases; Gangliosides; Kinetics; Liver Neoplasms; Liv | 1980 |
Effects of selenium on chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Butylated Hydroxytolue | 1980 |
Changes in activities of uridine diphosphate-glucuronyltransferases during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Diethylnitrosamine; Enzyme Induction; Gluc | 1982 |
3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3'-methyl-4-dimethylaminoazobenzene or 2-acetylamino-fluorene: a comparative study.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylcholanth | 1982 |
Sequential analysis of hepatic carcinogenesis. Regeneration of liver after carbon tetrachloride-induced liver necrosis when hepatocyte proliferation is inhibited by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Liver; Liver Neoplasms; Liver R | 1983 |
An experimental method for rapid growth of liver in spleen. The survival and proliferation of chemically induced preneoplastic hepatocytes in spleen.
Topics: 2-Acetylaminofluorene; Animals; Graft Survival; Hepatectomy; Liver Neoplasms; Male; Microscopy, Elec | 1983 |
Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimenta | 1983 |
Relative in vitro stability of ornithine decarboxylase from liver preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Carboxy-Lyases; Liver Neoplasms; Liver Neoplasms, | 1983 |
Cell specificity in DNA binding and repair of chemical carcinogens.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Binding Sites; Carcinogens; Dinitrobenzenes; DNA; | 1983 |
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Liver; Liver Neopl | 1983 |
Use of 2-acetamidophenanthrene and 2-acetamidofluorene in investigations of mechanisms of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diet; DNA; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Ph | 1983 |
Binding and repair of 2-acetylaminofluorene adducts in distinct liver cell populations.
Topics: 2-Acetylaminofluorene; Animals; Chromatography; DNA; DNA Repair; Liver; Liver Neoplasms; Male; Rats; | 1983 |
Properties of the increased glutathione S-transferase A form in rat preneoplastic hepatic lesions induced by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Immunochem | 1983 |
Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Fluorescein; Fluoresceins; Liver; Liver Circulat | 1983 |
Liver as a model system for analyzing mechanisms of tumor initiation and promotion.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Drug Evaluation, Preclinical; Liver Neoplasms; Mice; Ne | 1983 |
Initiation of focal hyperplastic hepatic lesions by transplacental administration of ethylnitrosourea in rats of F1 generation, and no transmission of the effect to F2 and F3 generations.
Topics: 2-Acetylaminofluorene; Animals; Ethylnitrosourea; Female; Hepatectomy; Hyperplasia; Liver; Liver Neo | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Absence of uniform progressive growth of long-term transplants of rat liver neoplastic nodules.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Animals; Liver Neoplasms; Male; Neoplasm Transplantation; Neo | 1980 |
A liver colony assay for a new hepatocyte phenotype as a step toward purifying new cellular phenotypes that arise during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Anti-Bacterial Agents; Cell Separation; Cells, Cultured; Clone Cells | 1980 |
Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; DNA; Female; Hydroxyacetylaminofluorene; Kidney; Liver; Liver Neopla | 1982 |
DNA content of liver cell nuclei of N-2-fluorenylacetamide-induced altered foci and neoplasms in rats and human hyperplastic foci.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; DNA; Humans; Hyperplasia; Liver; Liver Neoplasms; Male | 1982 |
Influence of cause-of-death assignment on time-to-tumor analyses in animal carcinogenesis studies.
Topics: 2-Acetylaminofluorene; Animals; Female; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mice; Mice | 1982 |
Development of a model to simulate the characteristics of rat liver tumor promotion by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Liver Neoplasms; Mathematics; Models, | 1982 |
Effects of prolonged oral treatment with N-fluoren-4-ylacetohydroxamic acid on rat liver fine structure.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Endoplasmic Reticulum; Hydroxyace | 1982 |
Method of analysis of monotone dose-response probabilities after long-term exposure to a toxicant.
Topics: 2-Acetylaminofluorene; Animals; Dogs; Dose-Response Relationship, Drug; Dose-Response Relationship, | 1982 |
Thyroid activity during hepatocarcinogenesis by N-2-fluorenylacetamide in the male rat.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms; Male; Neoplasms, Experimental; Pituitary Gland; Rat | 1982 |
Clonal growth of carcinogen-induced enzyme-deficient preneoplastic cell populations in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Clone Cells; Female; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; | 1982 |
Sequential 2-acetylaminofluorene--phenobarbital exposure induces a cytosolic aldehyde dehydrogenase during rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Cocarcinogenesis; Drug Administration Sche | 1982 |
Morphological classification of mouse liver tumors based on biological characteristics.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chlordan; Liver Neoplasms; Mice; Mice, Inbred Strains; | 1982 |
Hepatocellular ligandin during N-2-fluorenylacetamide carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Glutathione Transferase; Liver; Liver Neoplasms; Male; Neoplasms, Ex | 1982 |
A new type of glycolipid change associated with oncogenesis: a fucoganglioside accumulation in premalignant hepatic lesion and in hepatoma induced by n-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Chromatography, Thin Layer; Gangliosides; Liver; Liver Neoplasms; Li | 1982 |
Short term induction of preneoplastic nodules in the rat liver. I. The role of 2-AAF as selecting agent.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1980 |
The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine.
Topics: 2-Acetylaminofluorene; Animals; Behavior, Animal; Brain; Dextroamphetamine; Diethylnitrosamine; Live | 1980 |
Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Female; Liver Neoplasms; Neoplasms, Experimental; Organ | 1981 |
Short-term induction of neoplastic nodules in the rat liver. II. Study of their development and the effects of withdrawal of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Time Fa | 1981 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Resistance to the cytocidal effects of adriamycin is an early phenotypic change induced during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Survival; Cells, Cultured; Doxorubicin; Drug Resistance; Liver | 1981 |
Molecular structures of three hydroxyl derivatives of the hepatic carcinogen acetylaminofluorene. Evidence for preferred orientation of the acetylamino side-chain.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Hydroxylation; Liver Neoplasms; Models, Molecu | 1981 |
Effect of neonatal castration on liver tumor induction by N-2-fluorenylacetamide in suckling BALB/c mice.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Animals, Suckling; Castration; Liver Neoplasms; Li | 1981 |
Initiation and promotion of liver tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Kinetics; Liver Neoplasms; Neoplasms, Expe | 1981 |
The metabolic basis for inhibitory effects in chemical carcinogenesis by arylamines.
Topics: 2-Acetylaminofluorene; Acetanilides; Analgesics; Animals; Biotransformation; Blood Proteins; Butylat | 1981 |
The ED01 study: summary and conclusions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Dose-Response Relationship, Drug; Life Expectancy; Live | 1980 |
Effects of dose and time in a long-term, low-dose carcinogenic study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Dose-Response Relationship, Drug; Female; Liver Neoplas | 1980 |
Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Mice; Mic | 1980 |
Analysis of life-shortening effects in female BALB/C mice fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Diet; Female; Life Expectancy; Liver Neoplasms; Mice; Mice, Inbred B | 1980 |
Estimation of distributions of time to appearance of tumor and time to death from tumor after appearance in mice fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Female; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasms, Exper | 1980 |
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethy | 1980 |
Effects of acute or chronic treatment of rats with N-2-fluorenylacetamide on its N-hydroxylation and on hemoproteins of hepatic microsomes.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Female; Heme; Hemeprote | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; | 1980 |
Tissue binding of 2-acetylaminofluorene in BAlB/c and C57Bl/6 mice during chronic oral administration.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Female; Liver; Liver Neoplasms; Mice; Mice, In | 1980 |
Diminished hepatic binding protein for desialylated glycoproteins during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies; Carrier Proteins; Cell Membrane; Glycoproteins; Lectins; | 1980 |
p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Cell Differentiation; DNA Primers; DNA, Neoplasm; Gen | 1995 |
Alterations of ornithine decarboxylase gene during the progression of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; gamma-Glutamyltransferase; Gene Expression Regul | 1993 |
Enzymes of the mevalonate pathway in rat liver nodules induced by 2-acetylaminofluorene treatment.
Topics: 2-Acetylaminofluorene; Alkyl and Aryl Transferases; Animals; Dimethylallyltranstransferase; Dolichol | 1995 |
The effects of dietary iron on initiation and promotion in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diet; Diethylamines; Disease Models, Animal; Glutathione Transferase | 1995 |
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma | 1994 |
Light and electron microscopic analysis of liver sinusoids during hepatocarcinogenesis with 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Mal | 1994 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Changes in levels of ADP-ribose polymers in rat liver during 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine Diphosphate Ribose; Animals; Carcinogens; Cell Nucleus; DNA Damage; | 1993 |
Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Amino Acid Sequence; Animals; Antisense Elements (Genetics); Ba | 1993 |
Carcinogen-induced diploid hepatocytes: sensitive target cells for transformation by mutated c-Ha-ras oncogene.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Cell Separation; Cell Transformation, Neoplastic; Die | 1993 |
Persistent sex differences in growth control of early rat liver lesions are programmed during promotion in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Cell Division; Cytochrome P-450 Enzym | 1996 |
Quantitative analysis of changes in cell proliferation and apoptosis during preneoplastic and neoplastic stages of hepatocarcinogenesis in rat.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Cell Division; DNA Nucleo | 1996 |
Development of hepatomas in hyperplastic nodules induced in the rat liver: detection with superparamagnetic iron oxide-enhanced magnetic resonance imaging.
Topics: 2-Acetylaminofluorene; Animals; Contrast Media; Dextrans; Ferrosoferric Oxide; Hyperplasia; Iron; Li | 1996 |
Global tests for analysis of multiple tumour data from animal carcinogenicity experiments.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens; Carci | 1996 |
Biological model of ED01 hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Computer Simulation; Dose-Response Relationship, Drug; | 1996 |
Selective colocalization of lipid peroxidation and protein thiol loss in chemically induced hepatic preneoplastic lesions: the role of gamma-glutamyltranspeptidase activity.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; gamma-Glutamyltr | 1996 |
Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Cell Line; Cricetinae; Flavanones; Flavon | 1996 |
Changes in the binding capacity of hepatic membranes for epidermal growth factor during multistage hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Liver; Liver | 1996 |
Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric pro
Topics: 2-Acetylaminofluorene; Aneuploidy; Carcinoma, Hepatocellular; Cell Nucleus; Centromere; Colchicine; | 1996 |
Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Colchicine; Diethylnitrosamine; Dose-Response | 1997 |
Influence of the vitamin D status on the early hepatic response to carcinogen exposure in rats.
Topics: 2-Acetylaminofluorene; Animals; Calcium; Liver Neoplasms; Male; Precancerous Conditions; Rats; Rats, | 1997 |
The dual role of 2-acetylaminofluorene in hepatocarcinogenesis: specific targets for initiation and promotion.
Topics: 2-Acetylaminofluorene; Animals; Cell Survival; Liver Neoplasms; Mitochondria, Liver; Mutagens; NAD; | 1997 |
Aryl sulfotransferase IV deficiency in rat liver carcinogenesis initiated with diethylnitrosamine and promoted with N-2-fluorenylacetamide or its C-9-oxidized metabolites.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Carcinogens; Diethylnitrosamine; Down-Regulati | 1997 |
Potential effect of sodium nitrite on the expression of nuclear proto-oncogenes during 2-acetyl aminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Carcinoma, Hepatocellular; Drug I | 1997 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chromosome Mapping; Diethylnitrosamine; G | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver | 1999 |
In vitro detection of indirect-acting genotoxins in the comet assay using Hep G2 cells.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Biotransformation; Carcinog | 2000 |
Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aneuploidy; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma | 2001 |
Basal expression of the rat, but not of the human, multidrug resistance protein 2 (MRP2) gene is mediated by CBF/NF-Y and Sp1 promoter-binding sites.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette | 2001 |
Vitamin A and all-trans and 9-cis retinoic acids inhibit cell proliferation during the progression phase of hepatocarcinogenesis in Wistar rats.
Topics: 2-Acetylaminofluorene; Alitretinoin; Animals; Anticarcinogenic Agents; Bromodeoxyuridine; Carcinogen | 2001 |
New aldehyde dehydrogenase isozymes in chemically induced liver tumors in the rat.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Carcinoma, Hepatocellular; Ethionine; Isoe | 1976 |
Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chloramphenicol; gamma-Glutamyltransferas | 1976 |
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Fluorenes; gamm | 1977 |
Lack of carcinogenicity of oxprenolol, a beta-adrenergic blocking agent.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Ethanolamines; Liver Neoplasms; Mice; Oxprenolol; Rats | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Enzyme Induction; | 1978 |
Transfer of viable putative preneoplastic hepatocytes to the livers of syngeneic host rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; gamma-Glutamyltransferase; Liver Neoplasm | 1978 |
Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; Drug Eva | 1977 |
Cytologic changes induced in rat livers cells by short-term exposure to chemical substances.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Butanes; Carcinogens; Chromosome Aberrations; DDT; Dieth | 1975 |
Sequential analysis of transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Aneuploidy; Animals; Blood Proteins; Carcinoma, Hepatocel | 1975 |
Functional markers and growth behavior of preneoplastic hepatocytes.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Cell Aggregation; Cell Transformation, Neoplasti | 1976 |
Expression of an oncodevelopmental gene product (alpha-fetoprotein) during fetal development and adult oncogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; alpha-Fetoproteins; Animals; Animals, Newborn; Carcinoma, Hepato | 1976 |
[Evolution of hepatocyte population in the process of chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Cell Differentiation; Fluorescent Antibody Techn | 1977 |
alpha-fetoprotein-containing cells in the early stages of liver carcinogenesis induced by 3'-methyl-4-dimethyl-aminoazobenzene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Liver; Liver Neoplasms; Methyldimethylaminoazobe | 1977 |
Proliferation of hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Binding Sites; DNA; Glucagon; Glucocorticoids; In Vitro Techniques; | 1977 |
Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hexachlorocyclohexane; Isomeri | 1978 |
Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Albumins; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Fluorenes; | 1978 |
Changes in ovarian activity during hepatocarcinogenesis by N-2-fluorenylacetamide: role of alpha-fetoprotein.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Corpus Luteum; Estradiol; Female; Germ-Free Life | 1979 |
Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Drug Synergism; Fluorenes; L | 1977 |
Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Agglutination; Animals; Carcinoma, Hepatocellular; Concanavalin A; Liver Neop | 1975 |
Tumor induction by carcinogenic agents in aquarium fish.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Adenoma, Bile Duct | 1975 |
Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fructose-Bisphosphate Aldolase; Isoenzyme | 1975 |
Influence of age and sex on carcinoma and cirrhosis of the liver in AXC strain rats ingesting 0.025% N-2-fluorenyldiacetamide.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinoma, Hepatocellular; Diet; Female; Fluorenes; Liv | 1975 |
Pituitary growth hormone and somatotrophs in rats bearing chemically induced hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Growth Hormone; Liver | 1976 |
[Isoenzyme composition and properties of mitochondrial monoamine oxidase in normal and neoplastic cells].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Isoenzymes; Liver | 1976 |
Acceleration of hepatocarcinogenesis of 2,7-bis(acetamido)fluorene by carbon tetrachloride and time relation of treatment.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Fluorenes; | 1976 |
A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Carcinoma, H | 1976 |
Various degrees of susceptibility of different stocks of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hyperplasia; Liver; Liver Cirr | 1976 |
Purification and immunochemical characterization of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Carcinoma, Hepatocellular; Immunodiffusion | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplas | 1976 |
[Binding of 2-acetylaminofluorene-9-14C with rat liver nucleic acids during malignization and in primary hepatomas].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; DNA, Neoplasm; Fluorenes; Liver; Liver Ne | 1977 |
Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Endoplasmic Reticulum | 1977 |
Properties of the H-4-II-E tumor cell system. I. Growth and cell proliferation kinetics of an experimental hepatoma.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Survival; | 1977 |
Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Animals, Newborn; Carcinoma, Hepatocellula | 1977 |
Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Female; Fluorenes; Liver Neoplasms; Male; | 1977 |
Scanning electron microscopic surface morphology of isolated hepatocytes from normal and premalignant rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; Liver; Liver Neoplasms; Male; Microbial Collagenase; | 1977 |
Hepatic cell loss and proliferation induced by N-2-fluorenylacetamide, diethylnitrosamine, and aflatoxin B1 in relation to hepatoma induction.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosa | 1977 |
Inhibitory effect of hypothalamic lesions on liver tumor induction by N-2-fluorenylacetamide in male rats.
Topics: 2-Acetylaminofluorene; Adrenal Glands; Animals; Carcinoma, Hepatocellular; Fluorenes; Hypothalamus; | 1978 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Fluorenes; G(M1) Gangli | 1978 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. II. Alterations in biosynthetic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cerebrosides; Fluorenes; Galactosyltransf | 1978 |
Alteration of the ability of liver microsomes to activate N-2-fluorenylacetamide to a mutagen of Salmonella typhimurium during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hydroxyacetylaminofluorene; Li | 1978 |
Activation of endogenous type-C viral p30 antigen in chemically-induced rat hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Viral; Liver Neoplasms; Male; Neoplasm Transplantation; Ne | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cel | 1978 |
Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Aniline Compounds; Animals; Carcinoma, Hepat | 1978 |
Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Epoxide Hydrolases; H | 1978 |
[Disorders in the regulation of the activity of microsomal enzymes by lipids during chemical carcinogenesis in the liver].
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Fluorenes; Gluco | 1978 |
Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet.
Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; | 1979 |
The sensitivity and heterogeneity of histochemical markers for altered foci involved in liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Acyltransferases; Adenosine Triphosphatases; Animals; Glucose-6-Phosphatase; | 1979 |
[Effect of different classes of modifying factors on experimental hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Alkanesulfonates; Animals; Antimetabolites, Antineoplastic; Cytochrome P-450 | 1979 |
Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleolus; Cell Nucleus; Fluorenes; Hyperplasia; Iron; Kinetics | 1978 |
Purification and quantitation of preneoplastic antigen from hyperplastic nodules and normal liver.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Deoxycholic Acid; Hyperplasia; Immunosorbent Tec | 1978 |
Kupffer cell sarcoma in rats after exposure to small doses of dimethylnitrosamine and N-2-acetylaminofluorene during hepatic regeneration.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; Fluorenes; Liver Neoplasms; Liver Regeneration; | 1979 |
Induction of monooxygenases in rhesus monkeys by 3-methylcholanthrene: metabolism and mutagenic activation of N-2-acetylaminofluorene and benzo(a)pyrene.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cytochrome P-450 Enzyme | 1978 |
Enhancing effect of chemicals on production of hyperplastic liver nodules induced by n-2-fluorenylacetamide in hepatectomized rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Flavonoids; Fluorenes; Hepatectomy; Liver; Liver Neo | 1978 |
Metabolism of 2-aminofluorene and 2-acetylaminofluorene to mutagens by rat hepatocyte nuclei.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cell Nucleus; Drug Evaluation, Preclinical; Fluor | 1979 |
5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytosine; Diethylnitrosamine; Hepatectomy; Liver; Live | 1979 |
[Primary mechanism of a reduction in the intensity of extremely weak mitochondrial luminescence in the process of chemical hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Catalase; Diethylnitrosamine; Enzyme Activation; Liver Neoplasms; Lu | 1979 |
Ganglioside patterns of metastatic and non-metastatic transplantable hepatocellular carcinomas of the rat.
Topics: 2-Acetylaminofluorene; Animals; Gangliosides; Liver Neoplasms; Liver Regeneration; Male; Membrane Li | 1979 |
Effect of phenacetin and N-alkylacetanilides on N-2-fluorenylacetamide hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Liver Neoplasms; Male; Neoplasms, Experimental; Phenac | 1979 |
[Respiration of the cells and isolated mitochondria of the rat liver in the early stages of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; Mitochondria, | 1977 |
In vitro measurement of carcinogen-resistant liver cells during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogens; Cell Line; Cells, Cultured; Dexamethasone; | 1978 |
[Effect of DDT on the hepatotoxic action of 2-acetylaminofluorene in Wistar rats].
Topics: 2-Acetylaminofluorene; Animals; DDT; Fluorenes; Liver; Liver Neoplasms; Male; Neoplasms, Experimenta | 1978 |
Isozyme pattern of pyruvate kinase during hepatocarcino-genesis induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Isoenzymes; Liver Neoplasms; Male; Neoplasms, Experimenta | 1978 |
Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Cresols; Diet; DNA; Drug Synergism; Fluore | 1977 |
Normal endonuclease activities for damaged DNA during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Deoxyribonucleases; DNA Repair; DNA, Viral; Endonucleases; Kinetics; | 1977 |
Effects of varying the onset and duration of exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Fluorenes; Liver Neoplasms; Male; Neoplasms, Experim | 1977 |
Influence of dose rate on carcinogenesis resulting from x-ray, 113In, and 198Au irradiation.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Gold Radioisotopes; Indium; Isotopes; Liver; Liver Neop | 1976 |
Nuclear inclusions and other ultrastructural aspects in the liver of animals treated with n-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleolus; Cell Nucleus; Fluorenes; Heterochromatin; Liver; Liv | 1976 |
Varying degrees of susceptibility of inbred strains of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Fluorenes; Hyperplasia; Liver; Liver Cirrhosis; Liver N | 1976 |
Gangliosides and other lipids of hyperplastic liver nodules induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Fatty Acids; Fluorenes; Gangliosides; Hyperplasia; Lipid Metabolism; | 1976 |
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Cell Transformation, Neoplastic; | 1976 |
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; Hyperplasia; Iron; Liver Neoplasms; Male; Mitos | 1976 |
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Amobarbital; Animals; DDT; DNA, Neoplasm; Drug Synergism; Liver; Liver Neopla | 1975 |
[Proceedings: Peroxisome in 2-fluorenylacetamide-induced hyperplastic liver nodule cells].
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Fluorenes; Hyperplasia; Liver Neoplasms; Microbodies; Or | 1975 |
Immunosuppression in primary liver and colon tumor induction with N-hydroxy-N-2-fluorenylacetamide and azoxymethane.
Topics: 2-Acetylaminofluorene; Animals; Antilymphocyte Serum; Azoxymethane; Colonic Neoplasms; Hemangiosarco | 1975 |
Carcinoma and cirrhosis of the liver in A X C male rats with one kidney ingesting 0.025% N-2-fluorenyldiacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma; Carcinosarcoma; Diet; Fluorenes; Kidney; Liver Cirrhosis, | 1975 |
Unscheduled DNA synthesis in cells from N-2-fluorenylacetamide-induced hyperplastic nodules of rat liver maintained in a primary culture system.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Division; Cell Survival; Cells, Cultured; DNA | 1975 |
Effect of age and testosterone on the induction of hyperplastic nodules, carcinomas, and cirrhosis of the liver in rats ingesting n-2-fluorenyldiacetamide.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Body Weight; Castration; Fluorenes; Hyperplasia; Liver | 1976 |
Decreased incidence of renal cell carcinoma in rats with one kidney ingesting N-4-(4'-fluorobiphenyl)acetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma; Kidney Neoplasms; Liver Neoplasms; Male; Nep | 1976 |
Sequential phenotypic changes in hyperplastic areas during hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Glucuronidase; Hyperplasia; L-Serin | 1976 |
Sequential phenotypic and biochemical alterations during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Aggregation; Chromatin; Dimethylnitrosamine; Lectins; Liver Neo | 1976 |
Effect of acyl derivatives of 4,4,4-trifluoro-1-phenyl-1,3-butanedione on 2-acetylaminofluorene-induced glutathione S-transferase positive foci in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Benzoates; Biological Assay; Enzyme Inducti | 1992 |
Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Arylsulfotransferase; Base Sequence; Cloning, M | 1992 |
Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alanine Transaminase; Analysis of Variance; Animals; Aspartate | 1992 |
Mitogenic activity of quinoline to the rat, mouse, and guinea pig liver: empirical correlations with hepatic carcinogenicity.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Liver; Liver Neoplasm | 1992 |
Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Southern; Carcinoma, Hepatocellular; Cell Transformation, | 1991 |
Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Female; Liver Neoplasms; Mice; Models | 1991 |
Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Cell Transformation, N | 1990 |
NADH oxidase of liver plasma membrane stimulated by diferric transferrin and neoplastic transformation induced by the carcinogen 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; Enzyme Activation; Liver; Liver Neoplasms; Male; Mult | 1991 |
Prevention of 2-acetylaminofluorene-induced loss of nuclear envelope cytochrome P450 by the simultaneous administration of 3-methylcholanthrene.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; | 1991 |
Comparison between DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Autoradiography; Carcinoma; Chromatography, High Pressure L | 1991 |
Genetics and diet: synergism in hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Choline; Diet; Genes; Live | 1990 |
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; | 1990 |
Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Data Interpretation, Statistical; DNA; Dose-Response Re | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatect | 1990 |
Ovarian function during aflatoxin B1-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; alpha-Fetoproteins; Animals; Body Weight; Dietary P | 1986 |
Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogens, Environmental; Carcinoma, Hepatocellular; C | 1989 |
gamma-Glutamyltranspeptidase-negative phenotypic property of preneoplastic and neoplastic liver lesions induced by ciprofibrate does not change following 2-acetylaminofluorene administration.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosa | 1989 |
Expression pattern of the genes for different members of the heat-shock protein 70 family, ornithine decarboxylase, and c-Ha-ras during the early stages of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, | 1989 |
Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biopsy; Biotransformation; Carcinoma, Hepatocellular; Female; Humans | 1987 |
Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Biliary Tract Diseases; gamma-Glutamyltransferase; | 1985 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
The initiation of gamma-glutamyltranspeptidase positive foci in the rat liver by N-hydroxy-2-acetylaminofluorene. The effect of the sulfation inhibitor pentachlorophenol.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chlorophenols; Enzyme Induction; gamma-Glutamyltransfer | 1985 |
Activities of drug-metabolizing enzymes in isolated gamma-glutamyltranspeptidase positive preneoplastic hepatocytes from carcinogen treated rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Carcinogens; Cell Separation; Cells, Cultur | 1985 |
Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Survival; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Ne | 1986 |
Enhancement of low-dose N-2-fluorenylacetamide-induced hyperplastic liver nodules by pre-existing cirrhosis.
Topics: 2-Acetylaminofluorene; Animals; Choline Deficiency; Diet; gamma-Glutamyltransferase; Hyperplasia; Li | 1987 |
Comparative study of abnormality in glycogen storing capacity and other histochemical phenotypic changes in carcinogen-induced hepatocellular preneoplastic lesions in rats.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Iron; Liver Glycoge | 1985 |
Decrease in glucokinase and glucose-6-phosphatase and increase in hexokinase in putative preneoplastic lesions of rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Female; Glucokinase; Glucose-6-Phosphatas | 1987 |
Interindividual differences in the activation of two hepatic carcinogens to mutagens by human liver.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Alkaline Phosphatase; Aryl Hydrocarbon Hydroxylases | 1986 |
In vitro binding of aflatoxin B1 and 2-acetylaminofluorene to rat, mouse and human hepatocyte DNA: the relationship of DNA binding to carcinogenicity.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Cells, Cultured; DNA; Female; Humans; Live | 1988 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; | 1988 |
Decreased fibronectin in rat liver altered foci and adenomas induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Fibronectins; Liver; Liver Neoplasms; Male; Precancerous Co | 1988 |
The essential role of microsomal deacetylase activity in the metabolic activation, DNA-(deoxyguanosin-8-yl)-2-aminofluorene adduct formation and initiation of liver tumors by N-hydroxy-2-acetylaminofluorene in the livers of infant male B6C3F1 mice.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Animals; Animals, Newborn; Biotransformation; Cytosol; DNA D | 1988 |
Analysis of DNA adducts in putative premalignant hepatic nodules and nontarget tissues of rats during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; DNA; Kidney; Liver; Liver Neoplasms; Male; Precancerous Conditions; | 1988 |
Significance of immune responses to mucosal carcinogens: a hypothesis and a workable model system.
Topics: 2-Acetylaminofluorene; Animal Nutritional Physiological Phenomena; Animals; Gastrointestinal Neoplas | 1986 |
Inhibitory effect of reserpine on N-2-fluorenylacetamide-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Drug Interactions; Female; Injections, Subcuta | 1987 |
Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice.
Topics: 2-Acetylaminofluorene; Aging; Animals; Body Weight; Environment; Female; Liver Neoplasms; Liver Neop | 1987 |
The pattern of metabolism of 2-acetylaminofluorene in carcinogen-induced hepatocyte nodules in comparison to normal liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Line; Liver; Liver Neoplasms; Male; Rats; Rats, Inbred F344 | 1986 |
Pituitary regulation of cytochrome P-450-mediated metabolism of steroids and xenobiotics in rat liver microsomes.
Topics: 2-Acetylaminofluorene; Age Factors; Androstenedione; Animals; Cytochrome P-450 Enzyme System; Female | 1986 |
Hepatoblastoma with squamous differentiation in a B6C3F1 mouse.
Topics: 2-Acetylaminofluorene; Animals; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; | 1986 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li | 1987 |
Promoting effect of oxazepam in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamin | 1987 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; | 1987 |
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liv | 1987 |
Occurrence of tumors among litters of BALB/c female mice.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Female; Litter Size; Liver Neoplasms; Mice; Mice, Inbre | 1985 |
Decreased NADH-oxidoreductase activities as an early response in rat liver to the carcinogen 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Kinetics; Liver; Liver Neoplasms; Male; NAD; NADH, NADPH Oxidoreduct | 1985 |
Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Carcinogens; Drug Synergism; Live | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Statistical aspects of the estimation of human risks.
Topics: 2-Acetylaminofluorene; Carcinogens; Environmental Pollution; Humans; Liver Neoplasms; Models, Biolog | 1985 |
Influence of total dose and dose rate in carcinogenicity studies.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Liver Neo | 1985 |