2-acetylaminofluorene has been researched along with Liver Dysfunction in 16 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After 20 weeks cysts were observed in the majority of rats." | 5.28 | Experimental liver cysts induced by 2-acetylaminofluorene. ( Itoshima, T; Mizutani, S; Tsuji, T, 1991) |
| " The ability of butylated hydroxyanisole (BHA) to attenuate the toxic effect of 2-AAF was also examined." | 1.31 | Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract. ( Agboola, AO; Emerole, GO; Farombi, EO; Nwankwo, JO; Tahnteng, JG, 2000) |
| "After 20 weeks cysts were observed in the majority of rats." | 1.28 | Experimental liver cysts induced by 2-acetylaminofluorene. ( Itoshima, T; Mizutani, S; Tsuji, T, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pintilie, DG | 1 |
| Shupe, TD | 1 |
| Oh, SH | 2 |
| Salganik, SV | 1 |
| Darwiche, H | 1 |
| Petersen, BE | 2 |
| Okumoto, K | 1 |
| Saito, T | 1 |
| Haga, H | 1 |
| Hattori, E | 1 |
| Ishii, R | 1 |
| Karasawa, T | 1 |
| Suzuki, A | 1 |
| Misawa, K | 1 |
| Sanjo, M | 1 |
| Ito, JI | 1 |
| Sugahara, K | 1 |
| Saito, K | 1 |
| Togashi, H | 1 |
| Kawata, S | 1 |
| Dudas, J | 1 |
| Elmaouhoub, A | 1 |
| Mansuroglu, T | 1 |
| Batusic, D | 1 |
| Tron, K | 1 |
| Saile, B | 1 |
| Papoutsi, M | 1 |
| Pieler, T | 1 |
| Wilting, J | 1 |
| Ramadori, G | 1 |
| Witek, RP | 1 |
| Bae, SH | 1 |
| Zheng, D | 1 |
| Jung, Y | 1 |
| Piscaglia, AC | 1 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 1 |
| Rahman, S | 1 |
| Sultana, S | 1 |
| Wada, S | 2 |
| Kato, T | 1 |
| Mutai, M | 1 |
| Ozaki, K | 1 |
| Yamaguchi, S | 2 |
| Kim, DJ | 1 |
| Baba-Toriyama, H | 1 |
| Asamoto, M | 1 |
| Ito, N | 3 |
| Tsuda, H | 1 |
| Imai, T | 1 |
| Masui, T | 1 |
| Ichinose, M | 1 |
| Nakanishi, H | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Muramatsu, M | 1 |
| Tatematsu, M | 2 |
| Farombi, EO | 1 |
| Tahnteng, JG | 1 |
| Agboola, AO | 1 |
| Nwankwo, JO | 1 |
| Emerole, GO | 1 |
| Murasaki, G | 1 |
| Nakanishi, K | 1 |
| Miyata, Y | 1 |
| Shinohara, Y | 1 |
| Ogawa, K | 1 |
| Hasegawa, R | 1 |
| Mizutani, S | 1 |
| Itoshima, T | 1 |
| Tsuji, T | 1 |
| Moslen, MT | 1 |
| Ahluwalia, MB | 1 |
| Farber, E | 1 |
| Carubelli, R | 1 |
| Palakodety, RB | 2 |
| Griffin, MJ | 2 |
| Vaz, AD | 1 |
| Stout, DL | 1 |
| Becker, FF | 1 |
16 other studies available for 2-acetylaminofluorene and Liver Dysfunction
| Article | Year |
|---|---|
Hepatic stellate cells' involvement in progenitor-mediated liver regeneration.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Connective Tissue Growth Factor; Cysteine; Hepat | 2010 |
Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver.
Topics: 2-Acetylaminofluorene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride | 2006 |
Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".
Topics: 2-Acetylaminofluorene; Acute-Phase Reaction; alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers; Ca | 2006 |
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Animals, Genetically Modified; Antimitotic Agent | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Protective effects of Picorrhiza kurroa extract against 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; DNA; Female; Lipid Peroxidat | 2007 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Biflavonoids; Carcinogens; Chemical and Dru | 2000 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Experimental liver cysts induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts; Chemical and Drug Induced Liver Injury; Cysts; Dilatatio | 1991 |
1,2-Dibromoethane initiation of hepatic nodules in Sprague-Dawley rats selected with Solt-Farber system.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induce | 1985 |
Loss of cytochrome P-450 from hepatic nuclear membranes of rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Biotransformation; Chemical and Drug Induced L | 1986 |
Microsomal cholesterol epoxide hydrolase activity in 2-acetylaminofluorene-induced rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; Hyperpla | 1987 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li | 1987 |