Page last updated: 2024-11-07

2-acetylaminofluorene and Liver Dysfunction

2-acetylaminofluorene has been researched along with Liver Dysfunction in 16 studies

2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

Research Excerpts

ExcerptRelevanceReference
"After 20 weeks cysts were observed in the majority of rats."5.28Experimental liver cysts induced by 2-acetylaminofluorene. ( Itoshima, T; Mizutani, S; Tsuji, T, 1991)
" The ability of butylated hydroxyanisole (BHA) to attenuate the toxic effect of 2-AAF was also examined."1.31Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract. ( Agboola, AO; Emerole, GO; Farombi, EO; Nwankwo, JO; Tahnteng, JG, 2000)
"After 20 weeks cysts were observed in the majority of rats."1.28Experimental liver cysts induced by 2-acetylaminofluorene. ( Itoshima, T; Mizutani, S; Tsuji, T, 1991)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19905 (31.25)18.7374
1990's4 (25.00)18.2507
2000's6 (37.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pintilie, DG1
Shupe, TD1
Oh, SH2
Salganik, SV1
Darwiche, H1
Petersen, BE2
Okumoto, K1
Saito, T1
Haga, H1
Hattori, E1
Ishii, R1
Karasawa, T1
Suzuki, A1
Misawa, K1
Sanjo, M1
Ito, JI1
Sugahara, K1
Saito, K1
Togashi, H1
Kawata, S1
Dudas, J1
Elmaouhoub, A1
Mansuroglu, T1
Batusic, D1
Tron, K1
Saile, B1
Papoutsi, M1
Pieler, T1
Wilting, J1
Ramadori, G1
Witek, RP1
Bae, SH1
Zheng, D1
Jung, Y1
Piscaglia, AC1
Mazzantini, RP1
de Conti, A1
Moreno, FS1
Rahman, S1
Sultana, S1
Wada, S2
Kato, T1
Mutai, M1
Ozaki, K1
Yamaguchi, S2
Kim, DJ1
Baba-Toriyama, H1
Asamoto, M1
Ito, N3
Tsuda, H1
Imai, T1
Masui, T1
Ichinose, M1
Nakanishi, H1
Yanai, T1
Masegi, T1
Muramatsu, M1
Tatematsu, M2
Farombi, EO1
Tahnteng, JG1
Agboola, AO1
Nwankwo, JO1
Emerole, GO1
Murasaki, G1
Nakanishi, K1
Miyata, Y1
Shinohara, Y1
Ogawa, K1
Hasegawa, R1
Mizutani, S1
Itoshima, T1
Tsuji, T1
Moslen, MT1
Ahluwalia, MB1
Farber, E1
Carubelli, R1
Palakodety, RB2
Griffin, MJ2
Vaz, AD1
Stout, DL1
Becker, FF1

Other Studies

16 other studies available for 2-acetylaminofluorene and Liver Dysfunction

ArticleYear
Hepatic stellate cells' involvement in progenitor-mediated liver regeneration.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:8

    Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Connective Tissue Growth Factor; Cysteine; Hepat

2010
Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver.
    Journal of gastroenterology, 2006, Volume: 41, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride

2006
Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".
    Histochemistry and cell biology, 2006, Volume: 126, Issue:5

    Topics: 2-Acetylaminofluorene; Acute-Phase Reaction; alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers; Ca

2006
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
    Gastroenterology, 2007, Volume: 132, Issue:3

    Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Animals, Genetically Modified; Antimitotic Agent

2007
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
    Journal of cellular biochemistry, 2008, Feb-01, Volume: 103, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis;

2008
Protective effects of Picorrhiza kurroa extract against 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2007, Volume: 26, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; DNA; Female; Lipid Peroxidat

2007
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo

1996
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
    Carcinogenesis, 1997, Volume: 18, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc

1997
Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, Volume: 38, Issue:6

    Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Biflavonoids; Carcinogens; Chemical and Dru

2000
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
    Gan, 1979, Volume: 70, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo

1979
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
    Teratogenesis, carcinogenesis, and mutagenesis, 1991, Volume: 11, Issue:5

    Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi

1991
Experimental liver cysts induced by 2-acetylaminofluorene.
    Gastroenterologia Japonica, 1991, Volume: 26, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Bile Ducts; Chemical and Drug Induced Liver Injury; Cysts; Dilatatio

1991
1,2-Dibromoethane initiation of hepatic nodules in Sprague-Dawley rats selected with Solt-Farber system.
    Archives of toxicology, 1985, Volume: 58, Issue:2

    Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induce

1985
Loss of cytochrome P-450 from hepatic nuclear membranes of rats fed 2-acetylaminofluorene.
    Chemico-biological interactions, 1986, Volume: 58, Issue:2

    Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Biotransformation; Chemical and Drug Induced L

1986
Microsomal cholesterol epoxide hydrolase activity in 2-acetylaminofluorene-induced rat liver hyperplastic nodules.
    Biochemical pharmacology, 1987, Jul-15, Volume: 36, Issue:14

    Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; Hyperpla

1987
Heme enzyme patterns in rat liver nodules and tumors.
    Cancer research, 1987, Feb-15, Volume: 47, Issue:4

    Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li

1987