Page last updated: 2024-11-07

2-acetylaminofluorene and Leukemia

2-acetylaminofluorene has been researched along with Leukemia in 2 studies

2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
" The purpose of this present study is to evaluate the question of whether luteolin could affect arylamine N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adduct formation in human (HL-60) and mouse (L1210) leukemia cells."7.71Luteolin-inhibited arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human and mouse leukemia cells. ( Chung, JG; Hung, CF; Li, YC; Lin, JP; Yeh, FT, 2001)
" The purpose of this present study is to evaluate the question of whether luteolin could affect arylamine N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adduct formation in human (HL-60) and mouse (L1210) leukemia cells."3.71Luteolin-inhibited arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human and mouse leukemia cells. ( Chung, JG; Hung, CF; Li, YC; Lin, JP; Yeh, FT, 2001)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vernie, LN1
Li, YC1
Hung, CF1
Yeh, FT1
Lin, JP1
Chung, JG1

Reviews

1 review available for 2-acetylaminofluorene and Leukemia

ArticleYear
Selenium in carcinogenesis.
    Biochimica et biophysica acta, 1984, Volume: 738, Issue:4

    Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Cisplatin; Environme

1984

Other Studies

1 other study available for 2-acetylaminofluorene and Leukemia

ArticleYear
Luteolin-inhibited arylamine N-acetyltransferase activity and DNA-2-aminofluorene adduct in human and mouse leukemia cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001, Volume: 39, Issue:7

    Topics: 2-Acetylaminofluorene; Acetylation; Animals; Arylamine N-Acetyltransferase; Cytosol; DNA Adducts; Do

2001