2-acetylaminofluorene has been researched along with Hyperplasia in 71 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| "Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB)." | 1.28 | Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats. ( Chen, ZY; Eaton, DL, 1991) |
| "In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment." | 1.27 | Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma. ( Sakata, T, 1984) |
| "Using the Solt and Farber model (Nature, 263 (1976) 701), dose-response relationships between initiating agents and the induction of hyperplastic nodules in rat liver were investigated." | 1.26 | Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. ( Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M, 1981) |
| " In the livers from 4 humans, 3 of whom had a history of long-term use of some drugs, multiple hyperplastic foci resembling eosinophilic or clear cell foci in rats were identified." | 1.26 | DNA content of liver cell nuclei of N-2-fluorenylacetamide-induced altered foci and neoplasms in rats and human hyperplastic foci. ( Mori, H; Sugie, S; Takahashi, M; Tanaka, T; Williams, GM, 1982) |
| "Mild hyperplasia was retained in a portion of each population and the prevalence of this hyperplasia was dependent on both the period of exposure and the dose of 2-AAF." | 1.26 | Effects of continuous and discontinued exposure to 2-AAF on urinary bladder hyperplasia and neoplasia. ( Farmer, JH; Greenman, DL; Littlefield, NA; Sheldon, WG, 1980) |
| "In primary hepatomas induced by 2-acetylaminofluorene, cytochrome P-450 content is 21% of that of controls, AHH activity is 11% of the activity of controls, and reductase is 50% of the control activity." | 1.26 | A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. ( Cameron, R; Farber, E; Jones, K; Lee, G; Sweeney, GD, 1976) |
| "Amount of cytochrome P-450 in hepatoma tissues also showed similar values as that in hyperplastic nodules." | 1.26 | Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. ( Fukumoto, Y; Noda, K; Okita, K; Takemoto, T, 1976) |
| "Hyperplastic nodules and hepatocellular carcinomas were induced in livers of rats by a low-protein diet containing 0." | 1.26 | Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development. ( Keenan, TW; Merritt, WD; Morré, DJ; Richardson, CL, 1978) |
| "Bladder cancer was also present in rats administered the sequence of FANFT, 2-FAA, and 3,3'-DCB." | 1.26 | Summation effect of N-butyl-n-(4-hydroxybutyl)nitrosamine, N-(4-(5-nitro-2-furyl)-2-thiazoly)formamide, N-2-fluoroenylacetamide, and 3,3'-dichlorobenzidine on urinary bladder carcinogenesis in rats. ( Hananouchi, M; Hirose, M; Miyata, Y; Mizutani, M; Tatematsu, M, 1977) |
| " Feeding the chemical at levels of 8 to 86 ppm results in a dose-response related urinary bladder hyperplasia and, after 9 to 12 months, in bladder neoplasia at the higher dose levels." | 1.26 | Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals. ( Farmer, J; Frith, C; Haley, TJ; Jaques, WE; Schieferstein, G; Sprowls, RW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (85.92) | 18.7374 |
| 1990's | 9 (12.68) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oyasu, R | 2 |
| Sumie, H | 1 |
| Burg, HE | 1 |
| Yao, M | 1 |
| Yao, DF | 1 |
| Bian, YZ | 1 |
| Zhang, CG | 1 |
| Qiu, LW | 1 |
| Wu, W | 1 |
| Sai, WL | 1 |
| Yang, JL | 1 |
| Zhang, HJ | 1 |
| PIROZYNSKI, WJ | 1 |
| VON BERTALANFFY, L | 1 |
| LAWS, JO | 1 |
| RUDALI, G | 1 |
| ROYER, R | 1 |
| MABILLE, P | 1 |
| Ogawa, K | 2 |
| Yokokawa, K | 2 |
| Tomoyori, T | 2 |
| Onoé, T | 1 |
| Spater, HW | 1 |
| Quintana, N | 1 |
| Becker, FF | 2 |
| Novikoff, AB | 2 |
| Goldfarb, S | 2 |
| Pugh, TD | 2 |
| Koen, H | 1 |
| Eriksson, LC | 1 |
| Torndal, UB | 1 |
| Andersson, GN | 1 |
| Vinarchuk, MP | 1 |
| Bykorez, AI | 1 |
| Noda, K | 2 |
| Ando, K | 1 |
| Numa, Y | 1 |
| Tsubota, W | 1 |
| Oda, M | 1 |
| Esaki, T | 1 |
| Okita, K | 2 |
| Takemoto, T | 2 |
| Hasegawa, R | 5 |
| Tatematsu, M | 10 |
| Tsuda, H | 4 |
| Shirai, T | 3 |
| Hagiwara, A | 2 |
| Ito, N | 11 |
| Schaefer, FV | 1 |
| Tonelli, QJ | 1 |
| Dickens, MS | 1 |
| Custer, RP | 3 |
| Sorof, S | 3 |
| Sakata, T | 1 |
| McCay, PB | 1 |
| King, M | 1 |
| Rikans, LE | 1 |
| Pitha, JV | 1 |
| Imaida, K | 4 |
| Takano, T | 3 |
| Yin, Z | 1 |
| Sato, K | 1 |
| Narasaki, M | 1 |
| Nakanishi, K | 5 |
| Fukushima, S | 1 |
| Tamano, S | 1 |
| Mori, H | 1 |
| Tanaka, T | 1 |
| Sugie, S | 1 |
| Takahashi, M | 2 |
| Williams, GM | 4 |
| Shinohara, Y | 3 |
| Frith, CH | 1 |
| Greenman, DL | 2 |
| Ogiso, T | 1 |
| Malvaldi, G | 1 |
| Littlefield, NA | 1 |
| Farmer, JH | 1 |
| Sheldon, WG | 1 |
| Murasaki, G | 3 |
| Ho, YS | 1 |
| Lin, JK | 1 |
| Kurokawa, F | 1 |
| Yamamoto, H | 1 |
| Yamashita, Y | 1 |
| Ikebe, T | 1 |
| Yamamoto, T | 1 |
| Kubo, S | 1 |
| Hirohashi, K | 1 |
| Kinoshita, H | 1 |
| Kaneda, K | 1 |
| Sakurai, M | 1 |
| Miyata, Y | 4 |
| Roberfroid, M | 1 |
| Lans, M | 1 |
| de Gerlache, J | 1 |
| Mercier, M | 1 |
| Hirose, M | 2 |
| Kozuka, S | 1 |
| Sassa, R | 1 |
| Cameron, R | 1 |
| Sweeney, GD | 1 |
| Jones, K | 1 |
| Lee, G | 1 |
| Farber, E | 5 |
| Reuber, MD | 3 |
| Rubenchik, BL | 1 |
| Romanenko, AM | 1 |
| Fukumoto, Y | 1 |
| Lin, JC | 1 |
| Hiasa, Y | 1 |
| Merritt, WD | 3 |
| Richardson, CL | 1 |
| Keenan, TW | 3 |
| Morré, DJ | 2 |
| Levin, W | 2 |
| Lu, AY | 1 |
| Thomas, PE | 2 |
| Ryan, D | 1 |
| Kizer, DE | 2 |
| Griffin, MJ | 3 |
| Watanabe, K | 1 |
| Novikoff, PM | 1 |
| Stockert, RJ | 1 |
| Yam, A | 1 |
| Poruchynsky, MS | 1 |
| Anichkov, NM | 1 |
| Laishes, BA | 1 |
| Roberts, E | 1 |
| Mizutani, M | 1 |
| Hananouchi, M | 1 |
| Haley, TJ | 1 |
| Farmer, J | 1 |
| Jaques, WE | 1 |
| Frith, C | 1 |
| Sprowls, RW | 1 |
| Schieferstein, G | 1 |
| Morré, JD | 1 |
| Parker, S | 1 |
| Gruenstein, M | 1 |
| Matsumoto, M | 1 |
| Hopp, ML | 1 |
| Klaiber, M | 1 |
| Parker, SE | 1 |
| Goto, M | 1 |
| Mochizuki, Y | 1 |
| Tsukada, H | 1 |
| Kitagawa, T | 1 |
| Ledda-Columbano, GM | 1 |
| Coni, P | 1 |
| Curto, M | 1 |
| Giacomini, L | 1 |
| Faa, G | 1 |
| Sarma, DS | 1 |
| Columbano, A | 1 |
| Yokota, H | 1 |
| Ohgiya, N | 1 |
| Yuasa, A | 1 |
| Degawa, M | 1 |
| Miura, S | 1 |
| Hashimoto, Y | 1 |
| Chen, ZY | 1 |
| Eaton, DL | 1 |
| Poirier, MC | 1 |
| Fullerton, NF | 1 |
| Kinouchi, T | 1 |
| Smith, BA | 1 |
| Beland, FA | 1 |
| Watanabe, A | 1 |
| Yamauchi, Y | 1 |
| Kobayashi, M | 1 |
| Nagashima, H | 1 |
| Ringer, DP | 1 |
| Norton, TR | 1 |
| Cox, B | 1 |
| Howell, BA | 1 |
| Shimizu, A | 1 |
| Palakodety, RB | 1 |
| Vaz, AD | 1 |
2 reviews available for 2-acetylaminofluorene and Hyperplasia
| Article | Year |
|---|---|
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; g | 1984 |
[Experimental replication of bladder tumors. Morphologic features of early stages of their development].
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; Animals; Butylhydroxybutylnitrosamine; Cell Membrane; Cell T | 1979 |
69 other studies available for 2-acetylaminofluorene and Hyperplasia
| Article | Year |
|---|---|
Neoplasms of urinary bladders of hamsters treated with 2-acetylaminofluorene and indole.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Carcinogens; Carcinoma, Transitional Cell; Criceti | 1970 |
Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Cel | 2011 |
Ribonucleic acid in cytoplasm of liver cells; its localization in hyperplasia and hepatoma produced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Carcinoma, Hepatocellular; Cytoplasm; Hepatocytes; Hyperplasia; Liver; Liver | 1952 |
The early changes produced in the auditory sebaceous gland (Zymbal's gland) of the rat by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Ear, External; Fluorenes; Hyperplasia; Hypertrophy; Neoplasms; Rats; | 1955 |
Induction of gamma-glutamyltranspeptidase-positive altered hepatocytic lesions by combination of transplacental-initiation and postanal-selection.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diethylnitrosamine; E | 1982 |
Immunocytochemical localization of gamma-glutamyltransferase in induced hyperplastic nodules of rat liver.
Topics: 2-Acetylaminofluorene; Acyltransferases; Adenosine Triphosphatases; Animals; Histocytochemistry; Hyp | 1983 |
Hepatocellular injury, hyperplasia and putative premalignancy in rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; gamma-Glutamyltransferase; Glucose-6-Phos | 1984 |
Isolation and characterization of endoplasmic reticulum and Golgi apparatus from hepatocyte nodules in male wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Cell Fractionation; Centrifugation; Diet; Endoplasmic Reticulum; Gol | 1983 |
[Study on epoxide hydrolase in rat hyperplastic nodule and hepatoma during chemical hepatocarcinogenesis induced by 2-acetylaminofluorene (author's transl)].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Epoxide Hydrolases; Fluorescent Antibody | 1982 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Nononcogenic hormone-independent alveoli produced by carcinogens in cultured mouse mammary glands.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Dose-Response | 1983 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1984 |
Target polypeptide of a carcinogen is associated with normal mitosis and carcinogen-induced hyperplasias in adult hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytoplasm; Female; Hyperplasia; Liver; Liver Neoplasms | 1984 |
Interactions between dietary fats and antioxidants on DMBA-induced mammary carcinomas and on AAF-induced hyperplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benz(a)Anthracenes; | 1980 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethyln | 1981 |
Changes in activities of uridine diphosphate-glucuronyltransferases during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Diethylnitrosamine; Enzyme Induction; Gluc | 1982 |
Initiation of focal hyperplastic hepatic lesions by transplacental administration of ethylnitrosourea in rats of F1 generation, and no transmission of the effect to F2 and F3 generations.
Topics: 2-Acetylaminofluorene; Animals; Ethylnitrosourea; Female; Hepatectomy; Hyperplasia; Liver; Liver Neo | 1983 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
DNA content of liver cell nuclei of N-2-fluorenylacetamide-induced altered foci and neoplasms in rats and human hyperplastic foci.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; DNA; Humans; Hyperplasia; Liver; Liver Neoplasms; Male | 1982 |
Correlation of urothelial morphologic characteristics with the development of bladder carcinomas in BALB/c female mice administered 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cystitis; Female; Hyperplasia; Lymphocytes; Metaplasia; Mice; Mice, | 1982 |
Route-dependent, organ-specific effects of carcinogens on induction of hyperplastic liver nodules in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hyperplasia; Liver; Male; Methyldim | 1982 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Appearance of iron free hyperplastic hepatocytes following ferric nitrilotriacetate and 2-acetaminofluorene sequential administration.
Topics: 2-Acetylaminofluorene; Acetates; Animals; Ferric Compounds; Hyperplasia; Iron; Liver; Male; Nitrilot | 1981 |
Effects of continuous and discontinued exposure to 2-AAF on urinary bladder hyperplasia and neoplasia.
Topics: 2-Acetylaminofluorene; Animals; Drug Administration Schedule; Female; Hyperplasia; Mice; Mice, Inbre | 1980 |
Effects of various promoters on the induction of hyperplastic nodules in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Hyperplasia; | 1980 |
Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Dose-Response Relationship, Drug; Dr | 1980 |
N-nitroso-2-acetylaminofluorene: a direct-acting carcinogen inducing hepatocellular carcinoma in Sprague-Dawley rats.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body | 1994 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Development of hepatomas in hyperplastic nodules induced in the rat liver: detection with superparamagnetic iron oxide-enhanced magnetic resonance imaging.
Topics: 2-Acetylaminofluorene; Animals; Contrast Media; Dextrans; Ferrosoferric Oxide; Hyperplasia; Iron; Li | 1996 |
Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats.
Topics: 2-Acetylaminofluorene; Animals; Antibiotics, Antineoplastic; Carcinogens; Cyclohexanes; Hyperplasia; | 1998 |
Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; Drug Eva | 1977 |
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu | 1978 |
Functional markers and growth behavior of preneoplastic hepatocytes.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Cell Aggregation; Cell Transformation, Neoplasti | 1976 |
Biochemical characterization of liver hyperplastic nodules induced by 2-acetylaminofluorene [proceedings].
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Hyperplasia; Liver; Liver Neoplasms, Experimental; Mixed | 1978 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Acceleration of hepatocarcinogenesis of 2,7-bis(acetamido)fluorene by carbon tetrachloride and time relation of treatment.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Fluorenes; | 1976 |
A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Carcinoma, H | 1976 |
Various degrees of susceptibility of different stocks of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hyperplasia; Liver; Liver Cirr | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplas | 1976 |
Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Endoplasmic Reticulum | 1977 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Fluorenes; G(M1) Gangli | 1978 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. II. Alterations in biosynthetic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cerebrosides; Fluorenes; Galactosyltransf | 1978 |
Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Epoxide Hydrolases; H | 1978 |
Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleolus; Cell Nucleus; Fluorenes; Hyperplasia; Iron; Kinetics | 1978 |
Immunocytochemical localization of epoxide hydrase in hyperplastic nodules induced in rat liver by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Epoxide Hydrolases; Hyperplasia; Liver; Microscopy, Electron | 1979 |
Purification and quantitation of preneoplastic antigen from hyperplastic nodules and normal liver.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Deoxycholic Acid; Hyperplasia; Immunosorbent Tec | 1978 |
In vitro measurement of carcinogen-resistant liver cells during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogens; Cell Line; Cells, Cultured; Dexamethasone; | 1978 |
Summation effect of N-butyl-n-(4-hydroxybutyl)nitrosamine, N-(4-(5-nitro-2-furyl)-2-thiazoly)formamide, N-2-fluoroenylacetamide, and 3,3'-dichlorobenzidine on urinary bladder carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; 3,3'-Dichlorobenzidine; Animals; Benzidines; Biliary Tract Diseases; Butylhyd | 1977 |
Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 1976 |
Varying degrees of susceptibility of inbred strains of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Fluorenes; Hyperplasia; Liver; Liver Cirrhosis; Liver N | 1976 |
Gangliosides and other lipids of hyperplastic liver nodules induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Fatty Acids; Fluorenes; Gangliosides; Hyperplasia; Lipid Metabolism; | 1976 |
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Cell Transformation, Neoplastic; | 1976 |
Effect of pair-feeding of carcinogen on the incidence of bladder tumors in hamsters. Role of indole, age, and sex.
Topics: 2-Acetylaminofluorene; Administration, Oral; Age Factors; Animals; Carcinoma; Cricetinae; Diet; Fema | 1976 |
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; Hyperplasia; Iron; Liver Neoplasms; Male; Mitos | 1976 |
[Proceedings: Peroxisome in 2-fluorenylacetamide-induced hyperplastic liver nodule cells].
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Fluorenes; Hyperplasia; Liver Neoplasms; Microbodies; Or | 1975 |
Effect of age and testosterone on the induction of hyperplastic nodules, carcinomas, and cirrhosis of the liver in rats ingesting n-2-fluorenyldiacetamide.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Body Weight; Castration; Fluorenes; Hyperplasia; Liver | 1976 |
Sequential phenotypic changes in hyperplastic areas during hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Glucuronidase; Hyperplasia; L-Serin | 1976 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Gluta | 1992 |
Decrease of cytochrome P-450 having arylhydrocarbon hydroxylase and increase of UDP-glucuronyltransferase glucuronizing phenolic xenobiotics in rat liver nodule.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Glucuronosy | 1991 |
Expression and induction of cytochrome P450 isozymes in hyperplastic nodules of rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Carcinogens; Cytochrome P-450 | 1991 |
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alkylation; Animals; Cytochrome P-450 Enzyme System; Diethylnit | 1991 |
Comparison between DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Autoradiography; Carcinoma; Chromatography, High Pressure L | 1991 |
Enhancement of low-dose N-2-fluorenylacetamide-induced hyperplastic liver nodules by pre-existing cirrhosis.
Topics: 2-Acetylaminofluorene; Animals; Choline Deficiency; Diet; gamma-Glutamyltransferase; Hyperplasia; Li | 1987 |
Changes in rat liver N-hydroxy-2-acetylaminofluorene aryl sulfotransferase activity at early and late stages of hepatocarcinogenesis resulting from dietary administration of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Diet; Hyperplasia; Liver; Liver Neoplasms, Experimenta | 1988 |
Experimental studies on hepatic cirrhosis and hepatocarcinogenesis. II. Influence of cirrhotic liver on 2-FAA hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Furaldehyde; Histocytochemistry; | 1986 |
Microsomal cholesterol epoxide hydrolase activity in 2-acetylaminofluorene-induced rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; Hyperpla | 1987 |
Elevated expression and cell cycle deregulation of a mitosis-associated target polypeptide of a carcinogen in hyperplastic and malignant rat hepatocytes.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Cell Cycle; Hyperplasia; Liver; Liver Neoplasms, Experiment | 1987 |