2-acetylaminofluorene has been researched along with Experimental Mammary Neoplasms in 24 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Other malignant neoplasms, including leiomyosarcomas, granulosa cells tumors, adrenocortical carcinomas, angiosarcomas, squamous cell carcinomas, and harderian gland tumors, metastasized at an incidence of less than 5%." | 1.26 | Incidence of pulmonary metastases for various neoplasms in BALB/cStCrlfC3H/Nctr female fed N-2-fluorenylacetamide. ( Frith, CH; Littlefield, NA; Umholtz, R, 1981) |
| "Lower body weight was observed in operated rats but it is not considered to be the major cause of a complete inhibition of mammary tumor induction." | 1.26 | An inhibitory effect of salivary gland extirpation on the induction of mammary tumors in rats by N,N'-2,7-fluorenylenebisacetamide. ( Hirano, T; Jackson, CM; Lewis, JW; Morris, HP, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SCARF, RF | 1 |
| ROSS, RC | 1 |
| SKORYNA, SC | 1 |
| MILLER, EC | 2 |
| MILLER, JA | 2 |
| ENOMOTO, M | 1 |
| POIRIER, MM | 1 |
| Shirai, T | 1 |
| Fysh, JM | 1 |
| Lee, MS | 1 |
| Vaught, JB | 1 |
| King, CM | 2 |
| Schwartz, EL | 1 |
| Kluwe, WM | 1 |
| Sleight, SD | 1 |
| Hook, JB | 1 |
| Goodman, JI | 1 |
| Frith, CH | 1 |
| Littlefield, NA | 1 |
| Umholtz, R | 1 |
| Tonelli, QJ | 3 |
| Long, CA | 1 |
| Vaidya, AB | 1 |
| Sorof, S | 3 |
| Schaefer, FV | 1 |
| Dickens, MS | 1 |
| Custer, RP | 2 |
| Vernie, LN | 1 |
| Purdy, RH | 1 |
| Marshall, MV | 1 |
| McCay, PB | 1 |
| King, M | 1 |
| Rikans, LE | 1 |
| Pitha, JV | 1 |
| Rogers, AE | 1 |
| Wetsel, WC | 1 |
| Malejka-Giganti, D | 3 |
| McIver, RC | 1 |
| Rydell, RE | 2 |
| Allaben, WT | 1 |
| Weeks, CE | 1 |
| Weis, CC | 1 |
| Burger, GT | 1 |
| Grantham, PH | 1 |
| Rubenchik, BL | 1 |
| Romanenko, AM | 1 |
| Pozharisskiĭ, KM | 1 |
| Gutmann, HR | 1 |
| Hirano, T | 1 |
| Morris, HP | 1 |
| Jackson, CM | 1 |
| Lewis, JW | 1 |
| Ip, C | 1 |
| Greenman, DL | 1 |
| Boothe, A | 1 |
| Kodell, R | 1 |
| Hoch-Ligeti, C | 1 |
| Wagner, BP | 1 |
| Deringer, MK | 1 |
| Stewart, HL | 1 |
2 reviews available for 2-acetylaminofluorene and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Selenium in carcinogenesis.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Cisplatin; Environme | 1984 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyr | 1975 |
22 other studies available for 2-acetylaminofluorene and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Effect of local lesions on experimental breast tumors produced by 2-acetyl-aminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Breast Neoplasms; Humans; Mammary Neoplasms, Experimental; Neoplasms | 1953 |
THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cricetinae; Croton Oil; Fluorenes; Guinea Pigs; Injecti | 1964 |
THE CARCINOGENIC ACTIVITIES OF N-HYDROXY-2-ACETYLAMINOFLUORENE AND ITS METAL CHELATES AS A FUNCTION OF RETENTION AT THE INJECTION SITE.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chelating Agents; Cobalt; Copper; Fluorenes; Iron; Mamm | 1965 |
Relationship of metabolic activation of N-hydroxy-N-acylarylamines to biological response in the liver and mammary gland of the female CD rat.
Topics: 2-Acetylaminofluorene; Acyltransferases; Aminobiphenyl Compounds; Animals; Biotransformation; Biphen | 1981 |
Inhibition of N-2-fluorenylacetamide-induced mammary tumorigenesis in rats by dietary polybrominated biphenyls.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Biphenyl Compounds; Diet; Ear Neoplasms; Female; | 1980 |
Incidence of pulmonary metastases for various neoplasms in BALB/cStCrlfC3H/Nctr female fed N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Animals; Carcinogens; Female; Fibrosarcoma; Kidney Neoplasms; | 1981 |
Lack of induction of murine mammary tumor virus expression in cultured mammary glands treated with chemical carcinogens.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, | 1981 |
Nononcogenic hormone-independent alveoli produced by carcinogens in cultured mouse mammary glands.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Dose-Response | 1983 |
Enhancement of the mutagenicity of carcinogenic arylamines by ethinyl estradiol.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Carcinogens; Cocarcin | 1984 |
Interactions between dietary fats and antioxidants on DMBA-induced mammary carcinomas and on AAF-induced hyperplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benz(a)Anthracenes; | 1980 |
Mammary carcinogenesis in rats fed different amounts and types of fat.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Cocarcinogenesis; Die | 1981 |
Activation of certain N-arylacetamides and N-arylacetohydroxamic acids in relation to mammary gland tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Adenofibroma; Adenoma; Animals; Biotransformation; Carcinogen | 1981 |
Inhibitory effect of disulfiram on rat mammary tumor induction by N-2-fluorenylacetamide and on its metabolic conversion to N-hydroxy-N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Adenofibroma; Adenoma; Animals; Biotransformation; Body Weigh | 1980 |
Rat mammary gland carcinogenesis after local injection of N-hydroxy-N-acyl-2-aminofluorenes: relationship to metabolic activation.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Acyltransferases; Adenocarcinoma; Adenofibroma; Animals; | 1982 |
The metabolic basis for inhibitory effects in chemical carcinogenesis by arylamines.
Topics: 2-Acetylaminofluorene; Acetanilides; Analgesics; Animals; Biotransformation; Blood Proteins; Butylat | 1981 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Transformation of cultured mouse mammary glands by aromatic amines and amides and their derivatives.
Topics: 1-Naphthylamine; 2-Acetylaminofluorene; 2-Naphthylamine; Acetoxyacetylaminofluorene; Animals; Cell T | 1979 |
Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acids and their acetates.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Acetylation; Administration, Topical; Animals; Cy | 1977 |
An inhibitory effect of salivary gland extirpation on the induction of mammary tumors in rats by N,N'-2,7-fluorenylenebisacetamide.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Animals; Atrophy; Body Weight; Diet; Female; Fluorenes; Mamma | 1976 |
Selenium and experimental cancer.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Ascorbic Ac | 1986 |
Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice.
Topics: 2-Acetylaminofluorene; Aging; Animals; Body Weight; Environment; Female; Liver Neoplasms; Liver Neop | 1987 |
Tumor induction in Praomys (Mastomys) natalensis by N,N'-2,7-fluorenylenebisacetamide.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Adenoma; Adrenal Gland Neoplasms; Animals; Carcinogens; Diges | 1985 |