2-acetylaminofluorene has been researched along with Experimental Hepatoma in 413 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated." | 7.85 | Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH, 2017) |
| "03% 2-acetylaminofluorene (AAF) resulted, 12 to 15 months later, in a massive production of hepatic cysts." | 7.66 | Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene. ( Pitot, HC; Potter, VR; Richards, WL, 1982) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 5.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated." | 3.85 | Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH, 2017) |
| "The nuclear pore density and area were measured on freeze-fractured nuclei of ACI/N rat liver altered foci, adenomas and carcinomas induced by 2-acetylaminofluorene, and compared with those of normal hepatocytes." | 3.69 | Alterations of nuclear pores in preneoplastic and neoplastic rat liver lesions induced by 2-acetylaminofluorene. ( Mori, H; Sugie, S; Tanaka, T; Williams, GM; Yoshimi, N, 1994) |
| " However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci." | 3.68 | Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine. ( Armstrong, D; Blanck, A; Cameron, RG, 1990) |
| "The proliferative activity of tumor cells differing in DNA content (ploidy) and nuclearity was investigated in primary hepatocellular carcinomas of the rat by flow cytometric analysis of collagenase-isolated cells immunostained after labelling with bromodeoxyuridine (BrdU) in vivo." | 3.68 | Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma. ( Erikstein, B; Gerlyng, P; Grotmol, T; Seglen, PO; Stokke, T, 1992) |
| " Two diets used widely in toxicological and/or nutritional studies, and considered to be nutritionally adequate, were compared with respect to their influence on growth, body weight, lifespan, spontaneous neoplasia, and neoplastic responses to 2-acetylaminofluorene (2-AAF)." | 3.68 | Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet. ( Bucci, TJ; Fullerton, FR; Greenman, DL, 1992) |
| " Rats were initially given a single ip injection of diethylnitrosamine (200 mg/kg body weight) and fed basal diet containing 0." | 3.67 | Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. ( Inoue, K; Ito, N; Masui, T; Ogiso, T; Tsuda, H, 1986) |
| "03% 2-acetylaminofluorene (AAF) resulted, 12 to 15 months later, in a massive production of hepatic cysts." | 3.66 | Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene. ( Pitot, HC; Potter, VR; Richards, WL, 1982) |
| " There are no molecular dosimetry studies on the DNA adducts of 2-AAF, even though such a unique data base exists for the dose-response relationship of mouse liver tumors." | 2.37 | DNA damage and repair in mouse liver. ( Fennell, TR; Swenberg, JA, 1987) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 1.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| "HMGB3 in human liver cancer tissues were evaluated using bioinformatics databases from GEO, TCGA, and Oncomine." | 1.48 | Abnormal expression of ( Dong, ZZ; Fang, M; Wang, L; Yao, DF; Yao, M; Zheng, WJ, 2018) |
| " The rats were observed daily and body weights were taken before initial dosing and at weekly intervals thereafter." | 1.34 | Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Williams, GM, 2007) |
| "5 ppm dosage in drinking water in a defined model of a two-stage experimental rat hepatocarcinogenesis." | 1.33 | Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Saralaya, MG, 2006) |
| " Swelling was determined as maximal rate of absorption decrease at 540 nm (delta A/delta t)." | 1.30 | Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene. ( Bitsch, A; Klöhn, PC; Neumann, HG, 1998) |
| "Selenomethionine was also found to protect and improve the histopathological indices without any toxic side effects as revealed from the haematoxylin and eosin staining." | 1.29 | Biochemical basis of selenomethionine-mediated inhibition during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat. ( Chatterjee, M; Mukherjee, B; Sarkar, A, 1996) |
| "Treatment with selenomethionine either on initiation, or on selection/promotion, or during the entire experiment showed that selenom-ethionine was most effective when it was used as a supplement during the entire experiment, in terms of the antioxidant defense system and in reducing tumor incidence." | 1.29 | Chemopreventive efficacy of selenomethionine and its role in the antioxidant defense system in 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chatterjee, M; Ghosh, S; Mukherjee, B, 1996) |
| " The data indicate that at least in hepatocellular tumours of the C57Bl/10J strain and using chronic dosing regimes the ras genes do not represent markers for in vivo genotoxic activity." | 1.28 | Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours. ( Hardaker, KJ; Lord, PG; Loughlin, JM; Marsden, AM; Orton, TC, 1992) |
| " At nodular and post-nodular stages biliary excretion of radioactive metabolites was decreased, although hepatic content of radioactivity was similar to controls not dosed with AAF." | 1.28 | Protein binding, nuclear translocation and biliary secretion of metabolites of 3'-methyl-N,N-dimethyl-4-aminoazobenzene during hepatocarcinogenesis in rats. ( Bhargava, MM; Levine, WG; Srinivasan, K, 1991) |
| "Estimates of carcinogenic potency for bladder tumors were similar, within a factor of two, across the four hybrids." | 1.28 | Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment. ( Blackwell, BN; Gaylor, DW; Moore, GE; Wolff, GL, 1991) |
| " Each group consisted of 96 mice, except the groups of females dosed at 0 and 150 ppm, which consisted of 120 and 72 mice, respectively." | 1.28 | Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet. ( Bucci, TJ; Fullerton, FR; Greenman, DL; McCarty, CC, 1991) |
| "ZAMI 1305-treatment also induces liver DNA damage, as evaluated by alkaline sucrose gradient analysis." | 1.27 | Tumor-initiating activity of the beta-blocker ZAMI 1305 in the liver of the female Wistar rat. ( Braga, G; Dimito, E; Mazzocchi, C; Presta, M; Ragnotti, G; Zavanella, T; Ziliani, S, 1984) |
| " The results show that the experimental protocols using an initiator and a promotor are not equivalent (in term of latency period and premalignant lesions) to experimental protocols using a chronic administration of one carcinogenic compound." | 1.27 | [Comparative systemic analysis of experimental models of chemical hepatic carcinogenesis in the rat]. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1984) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| "However, although no bladder neoplasms occurred in rats given either BHT or FAA alone, groups fed BHT and FAA together developed bladder neoplasms in proportion to the dose of BHT." | 1.27 | Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene. ( Maeura, Y; Weisburger, JH; Williams, GM, 1984) |
| " In the second experiment, the effect of chronic administration of PB and NAF given after I without S or after S without I was analyzed." | 1.27 | Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1986) |
| " Drug resistance was not induced by chronic administration of the tumor promoters phenobarbital, choline-deficient diet, phorbol, nor with 2,3,7,8-tetrachlorodibenzo-p-dioxin, but was induced to a variable extent by three hepatotoxins (ethanol, methotrexate, carbon tetrachloride)." | 1.27 | Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats. ( Carr, BI, 1987) |
| "In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment." | 1.27 | Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma. ( Sakata, T, 1984) |
| " This demonstrates that chronic administration of an exogenous compound is not the only way to promote cancer development." | 1.27 | [Promoting effect of portacaval anastomosis in experimental hepatic carcinogenesis]. ( de Gerlache, J; Lans, M; Pector, JC; Préat, V; Roberfroid, M; Taper, H, 1984) |
| "025% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for two weeks combined with partial hepatectomy at the end of the first week and followed by long-term treatment with phenobarbital (PB) or 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from week 3 to week 86 resulted in dose-dependent development of liver and thyroid neoplastic and preneoplastic lesions." | 1.27 | Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion. ( Asamoto, M; Inoue, T; Ito, N; Nagao, M; Ogiso, T; Tsuda, H, 1988) |
| " There were substantial differences in the diagnoses of both tumor types by the pathologists, but the implications for detection of a dose-response relationship are important only for liver carcinomas." | 1.27 | Analysis of agreement among findings of pathologists in ED01 experiment. ( Amato, DA; Lagakos, SW, 1988) |
| " Male CD-1 mice, 50-100 days old, were dosed orally with N-nitrosodimethylamine (NDMA), trichloroethylene (TCE), 2-acetylaminofluorene (2-AAF), 4-acetylaminofluorene (4-AAF), phenobarbital (PB) or a vehicle." | 1.27 | The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse. ( Doolittle, DJ; Muller, G; Scribner, HE, 1987) |
| "One element of the ED01 Study contained a group of animals that were dosed with 2-acetylaminofluorene for 9, 12, 15, 18, or 24 mo and then sacrificed at 18 or 24 mo." | 1.27 | Influence of total dose and dose rate in carcinogenicity studies. ( Gaylor, DW; Littlefield, NA, 1985) |
| "MeCh both reduced the incidence of hepatic neoplasms induced by 3'-MeDAB and delayed their development." | 1.26 | 3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3'-methyl-4-dimethylaminoazobenzene or 2-acetylamino-fluorene: a comparative study. ( Flaks, A; Flaks, B, 1982) |
| "Using the Solt and Farber model (Nature, 263 (1976) 701), dose-response relationships between initiating agents and the induction of hyperplastic nodules in rat liver were investigated." | 1.26 | Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis. ( Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 225 (54.48) | 18.7374 |
| 1990's | 126 (30.51) | 18.2507 |
| 2000's | 40 (9.69) | 29.6817 |
| 2010's | 19 (4.60) | 24.3611 |
| 2020's | 3 (0.73) | 2.80 |
| Authors | Studies |
|---|---|
| Sánchez-Meza, J | 1 |
| Campos-Valdez, M | 1 |
| Domínguez-Rosales, JA | 1 |
| Godínez-Rubí, JM | 1 |
| Rodríguez-Reyes, SC | 1 |
| Martínez-López, E | 1 |
| Zúñiga-González, GM | 1 |
| Sánchez-Orozco, LV | 1 |
| Morsy, HM | 1 |
| Ahmed, OM | 1 |
| Zoheir, KMA | 1 |
| Abdel-Moneim, A | 1 |
| Zhao, BB | 1 |
| Ye, ZH | 1 |
| Gao, X | 1 |
| Li, HM | 1 |
| Unsal, V | 1 |
| Kurutaş, EB | 1 |
| Amidi, S | 1 |
| Hashemi, Z | 1 |
| Motallebi, A | 1 |
| Nazemi, M | 1 |
| Farrokhpayam, H | 1 |
| Seydi, E | 1 |
| Pourahmad, J | 1 |
| Zheng, WJ | 2 |
| Yao, M | 2 |
| Fang, M | 1 |
| Wang, L | 2 |
| Dong, ZZ | 1 |
| Yao, DF | 4 |
| Tahir, M | 1 |
| Rehman, MU | 1 |
| Lateef, A | 1 |
| Khan, AQ | 1 |
| Khan, R | 1 |
| Qamar, W | 1 |
| O'Hamiza, O | 1 |
| Ali, F | 1 |
| Hasan, SK | 1 |
| Sultana, S | 6 |
| Valencia Antúnez, CA | 1 |
| Taja Chayeb, L | 1 |
| Rodríguez-Segura, MÁ | 1 |
| López Álvarez, GS | 1 |
| García-Cuéllar, CM | 1 |
| Villa Treviño, S | 1 |
| Riedel, S | 1 |
| Abel, S | 1 |
| Swanevelder, S | 1 |
| Gelderblom, WC | 2 |
| Kindrat, I | 1 |
| Tryndyak, V | 1 |
| de Conti, A | 2 |
| Shpyleva, S | 1 |
| Mudalige, TK | 1 |
| Kobets, T | 1 |
| Erstenyuk, AM | 1 |
| Beland, FA | 9 |
| Pogribny, IP | 5 |
| Pisani, GB | 1 |
| Valenti, JL | 1 |
| Quintana, AB | 1 |
| Yang, CH | 1 |
| Chang, HY | 1 |
| Chen, YC | 1 |
| Lu, CC | 1 |
| Huang, SS | 1 |
| Huang, GJ | 1 |
| Lai, HC | 1 |
| Gu, JJ | 1 |
| Yang, J | 1 |
| Cai, Y | 2 |
| Yao, DB | 1 |
| Qiu, LW | 2 |
| Zong, L | 1 |
| Lu, YY | 1 |
| Huang, H | 1 |
| Wu, W | 2 |
| Wu, XH | 2 |
| Satoh, K | 3 |
| Yamakawa, D | 2 |
| Sugio, H | 1 |
| Kida, K | 1 |
| Sato, T | 2 |
| Hosoi, K | 1 |
| Hayakari, M | 2 |
| Furtado, KS | 1 |
| Pires, PW | 1 |
| Justulin, LA | 1 |
| Rodrigues, MA | 1 |
| Felisbino, SL | 1 |
| Barbisan, LF | 1 |
| Muskhelishvili, L | 3 |
| Tryndyak, VP | 3 |
| Yu, HB | 1 |
| Shen, JJ | 1 |
| Wang, YL | 1 |
| Hsu, JD | 1 |
| Kao, SH | 1 |
| Tu, CC | 1 |
| Li, YJ | 1 |
| Wang, CJ | 1 |
| Wen, Z | 1 |
| Shi, Z | 1 |
| Feng, P | 1 |
| Xue, X | 1 |
| Dong, K | 1 |
| Wang, X | 1 |
| Alwahaibi, NY | 1 |
| Budin, SB | 1 |
| Mohamed, J | 1 |
| Alhamdani, A | 1 |
| Khan, TH | 1 |
| Park, HJ | 1 |
| Oh, JH | 1 |
| Park, SM | 1 |
| Cho, JW | 1 |
| Yum, YN | 1 |
| Park, SN | 1 |
| Yoon, DY | 1 |
| Yoon, S | 1 |
| Koturbash, I | 1 |
| Melnyk, S | 1 |
| James, SJ | 1 |
| Malik, S | 2 |
| Bhatnagar, S | 2 |
| Chaudhary, N | 2 |
| Katare, DP | 2 |
| Jain, SK | 2 |
| Kasai, K | 1 |
| Uchida, K | 1 |
| Miura, T | 1 |
| Macías-Pérez, JR | 1 |
| Beltrán-Ramírez, O | 2 |
| Vásquez-Garzón, VR | 1 |
| Salcido-Neyoy, ME | 1 |
| Martínez-Soriano, PA | 1 |
| Ruiz-Sánchez, MB | 1 |
| Angeles, E | 1 |
| Villa-Treviño, S | 4 |
| Cui, R | 2 |
| He, J | 1 |
| Wang, B | 2 |
| Zhang, F | 2 |
| Chen, G | 2 |
| Yin, S | 2 |
| Shen, H | 1 |
| Klöhn, PC | 3 |
| Soriano, ME | 1 |
| Irwin, W | 1 |
| Penzo, D | 1 |
| Scorrano, L | 1 |
| Bitsch, A | 6 |
| Neumann, HG | 8 |
| Bernardi, P | 1 |
| MORRIS, HP | 1 |
| CANTAROW, A | 1 |
| PASCHKIS, KE | 1 |
| RUTMAN, RJ | 1 |
| MAISIN, J | 1 |
| LAMBERT, G | 1 |
| DECKERS-PASSAU, L | 1 |
| MALDAGUE, P | 1 |
| HACHISUGA, T | 1 |
| SINDO, H | 1 |
| IBATA, H | 1 |
| KATO, T | 2 |
| MIYAJI, T | 1 |
| SENOO, T | 1 |
| THERET, C | 2 |
| HOU, CT | 1 |
| REES, KR | 1 |
| González de Mejía, E | 1 |
| Ramírez-Mares, MV | 1 |
| Arce-Popoca, E | 3 |
| Wallig, M | 1 |
| Espandiari, P | 2 |
| Glauert, HP | 3 |
| Lehmler, HJ | 1 |
| Lee, EY | 1 |
| Srinivasan, C | 2 |
| Robertson, LW | 2 |
| Amin, I | 1 |
| Koh, BK | 1 |
| Asmah, R | 1 |
| Arora, A | 2 |
| Shukla, Y | 2 |
| Kalra, N | 1 |
| Katiyar, S | 1 |
| Siddiqui, IA | 1 |
| Ahmed, S | 3 |
| Jahangir, T | 2 |
| Sharma, S | 1 |
| Liu, LL | 1 |
| Gong, LK | 1 |
| Qi, XM | 1 |
| Wang, H | 1 |
| Wu, XF | 1 |
| Xiao, Y | 1 |
| Ren, J | 1 |
| Tan, B | 1 |
| Huang, JF | 1 |
| Wei, Q | 1 |
| Zhang, H | 2 |
| Ni, RZ | 1 |
| Chakraborty, T | 1 |
| Chatterjee, A | 1 |
| Saralaya, MG | 1 |
| Dhachinamoorthi, D | 1 |
| Chatterjee, M | 4 |
| Tessitore, L | 3 |
| Bollito, E | 1 |
| Groos, J | 1 |
| Kopp-Schneider, A | 1 |
| Sehrawat, A | 1 |
| Carrasco-Legleu, CE | 1 |
| Sánchez-Pérez, Y | 1 |
| Márquez-Rosado, L | 1 |
| Fattel-Fazenda, S | 2 |
| Hernández-García, S | 2 |
| Imai, K | 1 |
| Yamamoto, M | 2 |
| Tanaka, H | 4 |
| Hashimoto, N | 2 |
| Miyakoshi, M | 2 |
| Honmou, S | 1 |
| Yoshie, M | 2 |
| Tamakawa, S | 2 |
| Yaginuma, Y | 2 |
| Kasai, S | 2 |
| Ogawa, K | 4 |
| Williams, GM | 16 |
| Iatropoulos, MJ | 2 |
| Jeffrey, AM | 2 |
| Duan, JD | 1 |
| Mazzantini, RP | 1 |
| Moreno, FS | 2 |
| Honmo, S | 1 |
| Ozaki, A | 1 |
| Tokusashi, Y | 1 |
| Bagnyukova, TV | 1 |
| Montgomery, B | 1 |
| Churchwell, MI | 1 |
| Karpf, AR | 1 |
| James, SR | 1 |
| Miki, A | 1 |
| Yano, Y | 1 |
| Kato, H | 1 |
| Seo, Y | 1 |
| Kuriyama, M | 1 |
| Azuma, T | 1 |
| Hayashi, Y | 1 |
| Alemán-Lazarini, L | 1 |
| Salcido-Neyoy, M | 1 |
| Arellanes-Robledo, J | 1 |
| García-Román, R | 1 |
| Vázquez-Vázquez, P | 1 |
| Sierra-Santoyo, A | 1 |
| Tsuda, H | 14 |
| Lee, G | 3 |
| Farber, E | 15 |
| Laishes, BA | 4 |
| Rolfe, PB | 2 |
| Goldfarb, S | 3 |
| Pugh, TD | 3 |
| Enomoto, K | 4 |
| Takahashi, S | 3 |
| Lombardi, B | 3 |
| Shinozuka, H | 4 |
| Capouya, ER | 1 |
| Lindahl, R | 9 |
| Tatematsu, M | 10 |
| Nagamine, Y | 1 |
| Sakata, T | 2 |
| Watanabe, A | 2 |
| Takei, N | 1 |
| Shiota, T | 2 |
| Nakatsukasa, H | 2 |
| Fujiwara, M | 1 |
| Kobayashi, M | 2 |
| Nagashima, H | 2 |
| Rotstein, J | 1 |
| Macdonald, PD | 1 |
| Rabes, HM | 1 |
| Koen, H | 1 |
| Elliott, WL | 2 |
| Sawick, DP | 2 |
| Creek, KE | 1 |
| Deutscher, SL | 1 |
| Quinn, JF | 1 |
| Yeo, E | 1 |
| Webb, WR | 1 |
| Morré, DM | 1 |
| Harrington, DD | 1 |
| Heinstein, PF | 2 |
| Schwarze, PE | 6 |
| Pettersen, EO | 2 |
| Shoaib, MC | 1 |
| Seglen, PO | 10 |
| Benedetti, A | 1 |
| Malvaldi, G | 1 |
| Fulceri, R | 1 |
| Comporti, M | 1 |
| Numoto, S | 2 |
| Furukawa, K | 2 |
| Furuya, K | 3 |
| Moore, MA | 1 |
| Ogiso, T | 5 |
| Mera, Y | 2 |
| Ito, N | 24 |
| Digernes, V | 2 |
| Iversen, OH | 1 |
| Zavanella, T | 1 |
| Presta, M | 1 |
| Braga, G | 1 |
| Dimito, E | 1 |
| Mazzocchi, C | 1 |
| Ziliani, S | 1 |
| Ragnotti, G | 1 |
| Becker, FF | 13 |
| Lans, M | 7 |
| de Gerlache, J | 8 |
| Préat, V | 9 |
| Taper, H | 5 |
| Roberfroid, M | 7 |
| Stora, C | 3 |
| Aussel, C | 2 |
| Lafaurie, M | 3 |
| Krebs, B | 3 |
| Ayraud, N | 1 |
| Bock, KW | 4 |
| Lilienblum, W | 2 |
| Pfeil, H | 1 |
| Eriksson, LC | 23 |
| Austin, GE | 1 |
| Russo, RJ | 1 |
| Moyer, GH | 1 |
| Hasegawa, R | 7 |
| Imaida, K | 7 |
| Evarts, RP | 3 |
| Marsden, E | 2 |
| Hanna, P | 1 |
| Wirth, PJ | 2 |
| Thorgeirsson, SS | 6 |
| Pector, JC | 2 |
| Sato, K | 2 |
| Hatayama, I | 1 |
| Hoshino, K | 1 |
| Imai, F | 1 |
| Tsuchida, S | 1 |
| Nishimura, K | 2 |
| Richards, WL | 1 |
| Pitot, HC | 4 |
| Potter, VR | 2 |
| Ghoshal, AK | 1 |
| DeFrees, SA | 1 |
| Cassady, JM | 1 |
| Morré, DJ | 3 |
| Pickett, CB | 1 |
| Williams, JB | 1 |
| Lu, AY | 1 |
| Cameron, RG | 4 |
| Blanck, A | 14 |
| Hansson, T | 3 |
| Gustafsson, JA | 11 |
| Tamano, S | 3 |
| Ohshima, M | 1 |
| Kitahori, Y | 1 |
| Hosaka, S | 2 |
| Nagayama, H | 1 |
| Hirono, I | 2 |
| Vinores, SA | 1 |
| Churey, JJ | 1 |
| Haller, JM | 1 |
| Schnabel, SJ | 1 |
| Custer, RP | 3 |
| Sorof, S | 3 |
| Katayama, S | 1 |
| Ohmori, T | 2 |
| Maeura, Y | 4 |
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| Sinhorini, IL | 1 |
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| Thompson, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for 2-acetylaminofluorene and Experimental Hepatoma
| Article | Year |
|---|---|
Growth control of differentiated adult rat hepatocytes in primary culture.
Topics: 2-Acetylaminofluorene; Animals; Blood; Cell Differentiation; Cell Division; Cells, Cultured; Culture | 1980 |
[2-Acetylaminofluorene--a model mutagen and hepatocarcinogen. Characterization of its interactions with DNA].
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; DNA; DNA Mutational Analysis; Liver Neoplasms, Experi | 1992 |
Modification of liver tumor development in rodents.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; Disease Models, Animal; Disease Susceptibili | 1991 |
Growth-related alterations during liver carcinogenesis: effect of promoters.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Liver Neoplasms, Experimental; Ploidies; | 1990 |
Role of genotoxic and nongenotoxic effects in multistage carcinogenicity of aromatic amines.
Topics: 2-Acetylaminofluorene; Amines; Animals; Carcinogens; Cocarcinogenesis; DNA; Drug Synergism; Genes; L | 1990 |
DNA damage and repair in mouse liver.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Alkylating Agents; Animals; Benzene Derivatives; Ca | 1987 |
Metabolism of xenobiotics in hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Drug Resistance; Inactivation, Metabolic; Liver; Liver Neoplasms, Ex | 1987 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; C | 1985 |
404 other studies available for 2-acetylaminofluorene and Experimental Hepatoma
| Article | Year |
|---|---|
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; L | 2023 |
The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Diethylnitrosamine; Eugenol; Liv | 2023 |
Diwu Yanggan Modulates the Wnt/β-catenin Pathway and Inhibits Liver Carcinogenesis Signaling in 2-AAF/PH Model Rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Capsules; Cell Proliferation; Drugs, Chinese H | 2019 |
Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Hormonal; Carcin | 2020 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chr | 2017 |
Abnormal expression of
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Hepatocellular; | 2018 |
Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model.
Topics: 2-Acetylaminofluorene; Animals; Cell Proliferation; Cyclooxygenase 2; Diethylnitrosamine; Diosmin; D | 2013 |
DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Cyclin-Dependent Kinase Inhibitor p16; Diethylnitrosamine; DNA (Cyto | 2014 |
Induction of an altered lipid phenotype by two cancer promoting treatments in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, | 2015 |
MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, CD; Blotting, Western; Carcinogenesis; Carcinogens; Carcin | 2016 |
Hepatic preneoplasia induction in male Wistar rats: histological studies up to five months post treatment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms | 2016 |
Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Basidiomycota; Carcinogenesis; Cytoprotection; Diethylnitrosamine; E | 2017 |
Mitochondrial carnitine palmitoyl transferase-II inactivity aggravates lipid accumulation in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogenesis; C | 2017 |
Abnormal expression of insulin-like growth factor-II and its dynamic quantitative analysis at different stages of hepatocellular carcinoma development.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, N | 2008 |
Bile duct-bound growth of precursor cells of preneoplastic foci inducible in the initiation stage of rat chemical hepatocarcinogenesis by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts; Biomarkers, Tumor; gamma-Glutamyltransferase; Glutathion | 2008 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S- | 2009 |
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Cell Proliferation; Liver Neoplasms, Experim | 2009 |
[The effect of thalidomine-induced NF-kappa B activation on malignant transformation of hepatocytes].
Topics: 2-Acetylaminofluorene; Angiogenesis Inhibitors; Animals; Carcinoma, Hepatocellular; Immunohistochemi | 2009 |
Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Gl | 2009 |
Modulation of energy metabolic enzyme expression in N-nitrosodiethylamine-mediated hepatocarcinogenesis by Chinese herbs, Huqi San.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drugs, Chinese Herbal | 2008 |
The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Proliferation; DNA Damage; DNA Methylation; Epigenes | 2011 |
Nuclear factor-kappa B as a promising target for selenium chemoprevention in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cyclin D1; | 2010 |
Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study.
Topics: 2-Acetylaminofluorene; Aegle; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinogens; | 2011 |
Identification of biomarkers of chemically induced hepatocarcinogenesis in rasH2 mice by toxicogenomic analysis.
Topics: 1-Naphthylisothiocyanate; 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Cluster An | 2011 |
Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetylation; Animals; Carcinogens; Cell Line; DNA Methylation; Down-Regulatio | 2013 |
DEN+2-AAF-induced multistep hepatotumorigenesis in Wistar rats: supportive evidence and insights.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Lipid Pe | 2013 |
Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Glutathione Transferase; Hepatocyte | 2012 |
Elevated expression of complement C3 protein in chemically induced hepatotumorogenesis in Wistar rats: a correlative proteomics and histopathological study.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Biomarkers; Blotting, Western; Complement C3; D | 2013 |
The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Anticarcinogenic Agents; Antioxidants; Caffeic Acids; | 2013 |
Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Astragalus Plant; Astragalus propinquus; Blotting, Northern; Blottin | 2003 |
Suppressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Body Weight; Diethylnitrosami | 2003 |
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Galactosamine; Hepatocytes; In Vitro Techniq | 2003 |
Hepatocarcinogenesis by 2-acetylaminofluorene and related compounds including comments on dietary and other influences.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Fluorenes; Gonadal Steroid H | 1955 |
Utilization of uracil by acetylaminofluorene-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Liver Neoplas | 1955 |
Cancers of the liver in rat caused by p. dimethylaminoazobenzene and 2. acetylaminofluorene; prophylaxis & pathogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Liver Neoplasms, Experimental; Neoplasms; p-Dimethylami | 1957 |
[Hepatic tumor of rat induced by 2-acetylaminofluorene and its sex difference; tumors of the other organs].
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Liver Neoplasms; Liver Neoplasms, Experimental; Rats; Sex | 1957 |
[Experimental hepatic cancers. Selective modifications brought about by adrenaline and acetylcholine on the action of DAB and 2-AAF].
Topics: 2-Acetylaminofluorene; Acetylcholine; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcin | 1961 |
[Facilitation, by chlorpromazine, of hepatic cancer production by 2-acetylaminofluorene in female Wistar rats].
Topics: 2-Acetylaminofluorene; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chlorpromazine; Femal | 1962 |
Correlations of histological and biochemical changes in the livers of rats during prolonged administration of acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Fluorenes; Liver Neoplasms, Experimental; Rats | 1961 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Ca | 2004 |
Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Administration, Oral; Animals; Biphenyl Compounds; Body | 2004 |
Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Analysis of Variance; Animals; Biomarkers, Tumor; Cacao | 2004 |
Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Biomarkers, Tumor; | 2004 |
Comparison of different initiation protocols in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Diethylnitrosamine | 2005 |
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Diethylnitrosamine; g | 2004 |
Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apium; Cell Proliferation; Diethylnitrosami | 2005 |
Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A | 2005 |
Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Carc | 2005 |
Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chromosome Aberra | 2006 |
Early induction of TGF-beta1 through a fasting-re-feeding regimen promotes liver carcinogenesis by a sub-initiating dose of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; bcl-2-Associated X Protein; Carbon Tetrachloride; Carcino | 2006 |
Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Glutathione S-Transfer | 2006 |
Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Liver; Liver Neoplasms, | 2006 |
A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Caffeic Acids; Carcinogens; Cell Proliferation; Cell Transformation, | 2006 |
Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Growth Processes; Genetic Predisposition to Diseas | 2007 |
Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Carcinogens; Cell Division; Cell Transformation, Neopl | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Enzyme Activation; Genetic Predisposit | 2007 |
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA (Cytosine-5-) | 2008 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Caffeic Acids; Cytochrome P-450 Enzyme Syst | 2008 |
Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Dose-Response Relations | 2008 |
Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.
Topics: 2-Acetylaminofluorene; Amines; Animals; Carcinogens; Cell Division; Drug Evaluation, Preclinical; Dr | 1980 |
Quantitative assessment of liver colony formation and hepatocellular carcinoma incidence in rats receiving intravenous injections of isogeneic liver cells isolated during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; | 1980 |
Search for endogenous liver colony-forming units in F344 rats given a two-thirds hepatectomy during short-term feeding of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Clone Cells; Diet; DNA, Neoplasm; gamma-Glutamyltransfe | 1981 |
Enzyme histochemical phenotypes in primary hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Autoradiography; gamma-Glutamyltransferas | 1981 |
Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Kinetics; Liver; Live | 1982 |
Progression of carcinogen-induced foci of gamma-glutamyltranspeptidase-positive hepatocytes to hepatomas in rats fed a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animal Feed; Animals; Cell Transformation, Neoplastic; Choline Deficiency; Di | 1982 |
Changes in gamma-glutamyltransferase activity during N-2-fluorenylacetamide-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; gamma-Glutamyltransferase; Histocytochemistr | 1983 |
Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Cell Differentiation; DNA Replication; Liver; Live | 1983 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Cycle; gamma-Glutamyltransferase; Kinetics; Liver; Liver Neopla | 1984 |
Hepatocellular injury, hyperplasia and putative premalignancy in rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; gamma-Glutamyltransferase; Glucose-6-Phos | 1984 |
Early biochemical alterations induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Acid Anhydride Hydrolases; Animals; Fasting; gamma-Glutamyltransferase; Liver | 1984 |
Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Aggregation; Cell Nucleus; Diethylnitrosamine; Diploidy; DNA; F | 1984 |
Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocytochem | 1984 |
Effects of the hepatocarcinogenic peroxisome-proliferating hypolipidemic agents clofibrate and nafenopin on the rat liver cell membrane enzymes gamma-glutamyltranspeptidase and alkaline phosphatase and on the early stages of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Body Weight; Cell Division; Cell Membrane; Clo | 1984 |
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine | 1984 |
Flow cytometry of nuclear DNA content in liver cirrhosis and liver tumours in rats exposed to acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cell Nucleus; Diploidy; DNA; Flow Cytometry; Liver Ci | 1984 |
Tumor-initiating activity of the beta-blocker ZAMI 1305 in the liver of the female Wistar rat.
Topics: 2-Acetylaminofluorene; Adrenergic beta-Antagonists; Animals; DNA; Female; Hepatectomy; Liver; Liver | 1984 |
The direct and indirect effects of promoters may depend upon the nature of the initiated cell.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DN | 1983 |
[Comparative systemic analysis of experimental models of chemical hepatic carcinogenesis in the rat].
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasm | 1984 |
Comparison of different models of rat liver carcinogenesis: conclusions from a systemic analysis.
Topics: 2-Acetylaminofluorene; Animals; Diet; gamma-Glutamyltransferase; Histocytochemistry; Liver; Liver Ne | 1984 |
On the synthesis of alpha-fetoprotein during liver carcinogenesis by N-2-fluorenylacetamide and its relationships with the intracellular localization of the carcinogen.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Female; Liver Neoplasms, Experimental; Rats; Rat | 1981 |
Increased uridine diphosphate-glucuronyltransferase activity in preneoplastic liver nodules and Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Enzyme Activation; Epitopes; Glucuronosyltransferase; Liver; Liver N | 1982 |
Sequence complexity of nuclear RNA from 2-acetylaminofluorene-induced rat hepatomas and host cirrhotic liver.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; DNA, Neoplasm; Liver Cirrhosis, Experimental; Liver N | 1982 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins | 1984 |
[Promoting effect of portacaval anastomosis in experimental hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Diethylnitrosamine; Liver Neoplasms, Experimen | 1984 |
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relation | 1981 |
Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Chemical and Drug Induced Liver Injury; Cysts; H | 1982 |
The induction of resistant hepatocytes during initiation of liver carcinogenesis with chemicals in rats fed a choline deficient methionine low diet.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Ch | 1983 |
Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Carbon-Nitrogen Ligases; Dihydroorotate Oxidase; Liga | 1984 |
Regulation of glutathione transferase and DT-diaphorase mRNAs in persistent hepatocyte nodules during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; DNA; Glutathione Transferase; Liver | 1984 |
On mechanisms of sex differences in chemical carcinogenesis: effects of implantation of ectopic pituitary grafts on the early stages of liver carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; Hepatectomy; Hypothalamo-Hypophyseal Sys | 1984 |
Promotion of mouse liver neoplasms by the organochlorine pesticides chlordane and heptachlor in comparison to dichlorodiphenyltrichloroethane.
Topics: 2-Acetylaminofluorene; Animals; Chlordan; DDT; Diethylnitrosamine; Environmental Exposure; Heptachlo | 1984 |
Three-dimensional observations by scanning electron microscopy on the blood supply and organization of vasculature during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Micr | 1984 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1984 |
Suppressive effect of caffeine on the development of hepatic tumors induced by 2-acetylaminofluorene in ACI rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Caffeine; Drinking; Eating; Enzyme Induction; Liver Neo | 1984 |
Normal liver chromatin contains a firmly bound and larger protein related to the principal cytosolic target polypeptide of a hepatic carcinogen.
Topics: 2-Acetylaminofluorene; Animals; Chromatin; Liver; Liver Neoplasms, Experimental; Male; Micrococcal N | 1984 |
Early stages of N-2-fluorenylacetamide-induced hepatocarcinogenesis in male and female rats and effect of gonadectomy on liver neoplastic conversion and neoplastic development.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Castration; Cell Transformation, Neop | 1984 |
Target polypeptide of a carcinogen is associated with normal mitosis and carcinogen-induced hyperplasias in adult hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytoplasm; Female; Hyperplasia; Liver; Liver Neoplasms | 1984 |
An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Liver Neoplasms, Experimental; Male; Methapyrilene; | 1983 |
Chemical liver carcinogenesis: monitoring of the process by flow cytometric DNA measurements.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Clone Cells; Dimethylnitrosamine; DNA, Neoplasm; Flow | 1983 |
High susceptibility of specific inbred colonies of rats to n-2-fluorenylacetamide-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Disease Susceptibility; Liver Neoplasms, Experimental; Male; Precanc | 1983 |
Metabolic activation and genotoxicity of N-hydroxy-2-acetylaminofluorene and N-hydroxyphenacetin derivatives in Reuber (H4-II-E) hepatoma cells.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Biotransformation; Cell Line; DNA Replication; Dos | 1984 |
Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Dose-Response Relationship, Drug; Drug Ant | 1984 |
Effects of margarine on hepatocarcinogenesis by N,N'-2, 7-fluorenylenebisacetamide in mice.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dietary Fats; Liver; Liver Neoplasms, Experimental | 1984 |
Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Diethylnitrosamine; Female; Fetus; Glutathione Transferase; | 1984 |
Use of two sequential applications of initiators in the production of hepatomas in the rat: an examination of the Solt-Farber protocol.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Administration Schedule; Drug | 1984 |
Enhanced susceptibility to a chemical carcinogen in rats carrying MHC-linked genes influencing development (GRC).
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; DNA; Genetic Linkage; Lipid Metabolism; Lipoproteins; L | 1984 |
Interactions between dietary fats and antioxidants on DMBA-induced mammary carcinomas and on AAF-induced hyperplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Benz(a)Anthracenes; | 1980 |
Gangliosides of liver tumors induced by N-2 fluorenylacetamide III. Galactosyl and sialyl transferases in single carcinomas and nodules.
Topics: 2-Acetylaminofluorene; Animals; Galactosyltransferases; Gangliosides; Kinetics; Liver Neoplasms; Liv | 1980 |
Carcinogen-induced drug resistance in rat hepatocytes.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Cell Cycle; Cell Survival; Cells, Cultured | 1981 |
[Effect of 2 different carcinogens used separately and in combination on the liver carcinogenesis in rodents].
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Cricetinae; Drug Combinations; Female; Liver; | 1980 |
A preliminary characterization of drug-metabolizing systems in preneoplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Glutathione Tran | 1981 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethyln | 1981 |
3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3'-methyl-4-dimethylaminoazobenzene or 2-acetylamino-fluorene: a comparative study.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylcholanth | 1982 |
Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimenta | 1983 |
Changes in aldehyde dehydrogenase activity during diethylnitrosamine- or 2-acetylaminofluorene-initiated rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1983 |
Relative in vitro stability of ornithine decarboxylase from liver preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Carboxy-Lyases; Liver Neoplasms; Liver Neoplasms, | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Characteristics of transplantable tumors induced in the rat by N-2-fluorenylacetamide: elevations in tissue and serum sialic acid.
Topics: 2-Acetylaminofluorene; Animals; Gangliosides; Liver Neoplasms, Experimental; Male; Neoplasm Metastas | 1980 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Sulfotransferase and deacetylase in normal and tumor-bearing liver of CD rats: autoradiographical studies with N-hydroxy-2-acetylaminofluorene and N-hydroxy-4-acetylaminobiphenyl in vitro and in vivo.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Aminobiphenyl Compounds; Animals; Autoradiography; Chemical | 1982 |
Immunohistochemical study of epoxide hydrolase during experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epoxide Hydrolases; Histocytochemistry; Immunoen | 1981 |
Increased activity of a neutral protease in cytosol from rat hepatoma induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Isoelectric Point; Liver; Liver Neoplasms, Experimental; Li | 1981 |
Increase of T cells in the liver during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Antilymphocyte Serum; Fluorescent Antibody Technique; Liver; Liver N | 1981 |
Activity of various aldehyde-metabolizing enzymes in chemically-induced rat hepatomas.
Topics: 2-Acetylaminofluorene; Alcohol Oxidoreductases; Aldehyde Dehydrogenase; Aldehyde Oxidase; Aldehyde O | 1982 |
Expression of the tumor aldehyde dehydrogenase phenotype during 2-acetylaminofluorene-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Cell Transformatio | 1982 |
Acute effects of selected hepatotoxic agents on polyribosomes and protein synthesis in the livers of rats fed purified diets containing hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Acute Disease; Animals; Carbon Tetrachloride; Carcinogens; Chemical and Drug | 1982 |
Decreased activities of glycine and guanidinoacetate methyltransferases and increased levels of creatine in tumor cells.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Ehrlich Tumor; Creatine; Glycine; Glycine N-Methyltransfe | 1982 |
Ultrastructural abnormalities in carcinogen-induced hepatocellular altered foci identified by resistance to iron accumulation.
Topics: 2-Acetylaminofluorene; Animals; Biological Transport; Iron; Kinetics; Liver Neoplasms, Experimental; | 1982 |
Isolation and characterization of a new fucoganglioside accumulated in precancerous rat liver and in rat hepatoma induced by N-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Gangliosides; Glycolipids; Liver; Liver Neoplasms, Experimental; Mal | 1982 |
Alterations of bioelectric potential in primary hepatocellular carcinomas induced by N-2-fluorenylacetamide or diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Electrophysiology; Female; Liver; Liver Neoplasm | 1982 |
Primary culture of preneoplastic hepatocytes from rats treated with 2-acetylaminofluorene and clofibrate: relationship between resistance to dimethylnitrosamine and responsiveness of peroxisomes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Clofibrate; Dimethylnitrosamine; Drug Resistance; L | 1982 |
A new type of glycolipid change associated with oncogenesis: a fucoganglioside accumulation in premalignant hepatic lesion and in hepatoma induced by n-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Chromatography, Thin Layer; Gangliosides; Liver; Liver Neoplasms; Li | 1982 |
Sialic acid metabolism in rats undergoing chemically induced hepatocarcinogenesis in specific dietary states.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; beta-D-Galactoside alpha 2-6-Sialyltransferase; Butyla | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1982 |
In vitro carcinogenesis of hepatocytes obtained from acetylaminofluorene-treated rat liver and promotion of their growth by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Drug Synergism; Epithelium; Liver; Liver Neoplasms, | 1980 |
Presidential address. Recent concepts of initiation and promotion in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; DNA; Humans; Intestinal Polyps; Liv | 1981 |
Early change in mitochondrial monoamine oxidase activity of rat liver during 2-acetylaminofluorene feeding.
Topics: 2-Acetylaminofluorene; Animals; Female; In Vitro Techniques; Liver Neoplasms, Experimental; Male; Mi | 1981 |
Effect of neonatal castration on liver tumor induction by N-2-fluorenylacetamide in suckling BALB/c mice.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Animals, Suckling; Castration; Liver Neoplasms; Li | 1981 |
Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Drug Resistance; Hepatectomy; Liv | 1980 |
Progressive DNA damage in hepatic nodules during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; DNA, Neoplasm; Liver Neoplasms, Experimental; M | 1980 |
Biologic and morphologic characteristics of hepatocellular lesions in BALB/c female mice fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Female; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Ti | 1980 |
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethy | 1980 |
Modifications in adrenal activity during hepatocarcinogenesis by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Adrenal Glands; Aldosterone; Animals; Body Weight; Estradiol; Female; Liver N | 1980 |
S-Adenosylmethionine synthetase isozyme patterns from rat hepatoma induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Isoenzymes; Liver Neoplasms, Experimental; Male; M | 1980 |
Effects of varying the dietary concentration of phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Drug Synergism; | 1980 |
Quantitative in situ image analysis of apoptosis in well and poorly differentiated tumors from rat liver.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Image Processing, Computer-Assisted; Immunoenzyme Techniq | 1995 |
Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cell Nucleus; Clofenapate; Cyproterone A | 1994 |
Effect of ovariectomy and sex hormone replacement on glutathione and glutathione-related enzymes in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Diethylnitrosamine; Estradiol; Female; Glutathi | 1995 |
p53 gene mutational spectra in hepatocellular carcinomas induced by 2-acetylaminofluorene and N-nitroso-2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Cell Differentiation; DNA Primers; DNA, Neoplasm; Gen | 1995 |
Accumulation of p53 protein in chemically induced oval cells during early stages of rodent hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Gene Expression; Genes, p53; Liver; Liver Neoplasms, | 1995 |
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Caseins; Diet; Diethylnitrosamine; gamma-G | 1995 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA D | 1995 |
Analysis of calcium-dependent protein kinase C isoforms in the early stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Cell Division; Chromatography; Diethylnitrosamine | 1993 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul | 1994 |
Hypomethylation of the rat aryl sulfotransferase IV gene and amplification of a DNA sequence during multistage 2-acetylaminofluorene hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Cricetinae; DNA, Complementary; Gene Amplifica | 1994 |
N-nitroso-2-acetylaminofluorene: a direct-acting carcinogen inducing hepatocellular carcinoma in Sprague-Dawley rats.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body | 1994 |
Growth hormone administration after treatment in the resistant hepatocyte model does not affect progression of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Body Weight; Cell Division; Diethylnitrosamine; Fem | 1994 |
Increased expression of and sensitivity to transforming growth factor-alpha: a promotive role during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; DNA Probes; DNA, Neoplasm; Epidermal Growth Factor; E | 1994 |
Molecular mechanisms for the regulation of aryl sulfotransferase IV expression during 2-acetylaminofluorene-induced hepatocarcinogenesis in rat.
Topics: 2-Acetylaminofluorene; Animals; Down-Regulation; Female; Gene Expression Regulation, Enzymologic; Ho | 1994 |
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1994 |
Different effects of regenerative and direct mitogenic stimuli on the growth of initiated cells in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; | 1993 |
Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequen | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta | 1993 |
Inhibitory effect of beta-carotene on chronic 2-acetylaminofluorene induced hepatocarcinogenesis in rat: reflection in hepatic drug metabolism.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Liver; Liver Ne | 1994 |
Changes in bile acids metabolism during rat hepatocarcinogenesis: causative or unrelated?
Topics: 2-Acetylaminofluorene; Animals; Bile Acids and Salts; Cholic Acid; Cholic Acids; Deoxycholic Acid; D | 1994 |
Sequential alterations in tRNA population of 2-acetylaminofluorene-induced hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; | 1993 |
Sex differences at the initiation stage of rat liver carcinogenesis--influence of growth hormone.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme | 1993 |
The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Diethylnitrosamine; Glutathione Transferase; | 1993 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; | 1993 |
Alterations of nuclear pores in preneoplastic and neoplastic rat liver lesions induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Cell Nucleus; Disease Models, Animal; Freeze Fracturing; Li | 1994 |
Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Cytosol; Down-Regulation; Hydroxyacetylaminofl | 1994 |
Analbuminemia does not significantly influence hepatocarcinogenesis on comparing F344 rats and a congenic line carrying the analbuminemic mutation.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Diethylnitrosamine; DNA Primers; Liver Neoplasms, Exp | 1994 |
Inhibitory effect of the non-steroidal anti-inflammatory drugs, indomethacin and piroxicam on 2-acetylaminofluorene-induced hepatocarcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Indomethacin; Liver; Liver Neoplasms, Experimental; Mal | 1993 |
The structure and function of the H-ras proto-oncogene are not altered in rat liver tumors initiated by 2-acetylaminofluorene, 2-acetylaminophenanthrene and trans-4-acetylaminostilbene.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Base Sequence; Carcinogens; DNA Mutational Analysi | 1993 |
ras mutations in 2-acetylaminofluorene-induced lung and liver tumors from C3H/HeJ and (C3H x A/J)F1 mice.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Codon; DNA Mutational Analysis; Female; Genes, ras; L | 1993 |
Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Glutathione Peroxidase; Glutathione Transferase; Kidney; Li | 1993 |
Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Butylated Hydroxyanisole; Carcinogenicity Tests; Carcin | 1993 |
Early initiating and promoting effects in 2-AAF-induced rat liver carcinogenesis: an immunohistochemical study.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; DNA Damage; Dose-Response Relationship, Drug | 1995 |
Enhancement of GST-P positive liver cell foci development by a medium-term carcinogenicity bioassay using repeated administration of D-galactosamine.
Topics: 2-Acetylaminofluorene; Analysis of Variance; Animals; Biological Assay; Carcinogenicity Tests; Carci | 1995 |
CCAAT/enhancer-binding protein (C/EBP) immunoreactivity during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Western; Carcinogens; CCAAT-Enhancer-Binding Proteins; Cel | 1995 |
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocyte | 1996 |
Expression of the c-jun, jun-B, ets-2 and liver regeneration factor-1 (LRF-1) genes during promotion and progression of rat liver carcinogenesis in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Activating Transcription Factor 3; Animals; Carcinogens; Disease Models, Anim | 1996 |
Modulation of in vitro kidney cell growth by hepatic transfer RNAs.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Ethionine; Kidney; Liver; Liver Neoplasm | 1996 |
In vivo cell lineage analysis during chemical hepatocarcinogenesis using retroviral-mediated gene transfer.
Topics: 2-Acetylaminofluorene; Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Count; Cell | 1996 |
Different patterns of expression of ornithine decarboxylase mRNAs in rat liver after acute administration of hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Enzyme Induction; Gene Expression; Kinet | 1996 |
TUNEL--morituri te salutant. Quantitative in situ image analysis of apoptosis in well and poorly differentiated tumors from rat liver.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; DNA Damage; Image Processing, Computer-Assis | 1996 |
The BN rat strain carries dominant hepatocarcinogen resistance loci.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Genes, Dominant; Genetic Predisposition to | 1996 |
Development of hepatomas in hyperplastic nodules induced in the rat liver: detection with superparamagnetic iron oxide-enhanced magnetic resonance imaging.
Topics: 2-Acetylaminofluorene; Animals; Contrast Media; Dextrans; Ferrosoferric Oxide; Hyperplasia; Iron; Li | 1996 |
Carcinogen-induced alteration in liver epidermal growth factor receptor distribution during the promotion stage of hepatocarcinogenesis in rat.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Down-Regulation; Epidermal Growth Factor; ErbB Receptor | 1997 |
Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylni | 1997 |
Biochemical basis of selenomethionine-mediated inhibition during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; I | 1996 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hepatocyte | 1997 |
Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Enzyme Induction; | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Chemopreventive efficacy of selenomethionine and its role in the antioxidant defense system in 2-acetylaminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Carcinogens; Catalase; Glutathione; Glutathione Transf | 1996 |
Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Estradiol; Femal | 1998 |
Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats.
Topics: 2-Acetylaminofluorene; Animals; Antibiotics, Antineoplastic; Carcinogens; Cyclohexanes; Hyperplasia; | 1998 |
Cloning and expression of the catalytic domain from rat hepatoma H35 cell GDP-fucose:GM1 alpha 1-->2fucosyltransferase, an enzyme which is activated during early stages of chemical carcinogenesis in rat liver.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Carcinoma, Hepatoce | 1998 |
Mitochondrial permeability transition is altered in early stages of carcinogenesis of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cyclosporine; Intracellular Membranes; Liver Neoplasms, | 1998 |
Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis.
Topics: 2-Acetylaminofluorene; Actins; Animals; beta Carotene; Bile Ducts, Intrahepatic; Collagen; Diethylni | 1998 |
Stress protein expression in rat liver during tumour promotion: induction of heat-shock protein 27 in hepatocytes exposed to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Heat-Shock Proteins; Liver; Liver Neoplasms, Experiment | 1998 |
Nonlinearities in 2-acetylaminofluorene exposure responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Carcinogens; Cell Division; DNA Adducts; Dose- | 1998 |
Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice.
Topics: 2-Acetylaminofluorene; Animals; DNA Repair; Female; Genes, p53; Humans; Liver Neoplasms, Experimenta | 1999 |
c-fos gene expression in rat liver is induced by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Gene Expression; Genes, fos; Liver; Liver Neoplasms, Ex | 1999 |
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Transformation, Neoplastic; Chloroform; Diethylnitro | 1999 |
Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Glu | 1999 |
Development of resistance during the early stages of experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Resistan | 1999 |
Effects of dietary iron overload on progression in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Ch | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver | 1999 |
Further evidence of the usefulness of bile acids as molecules for shuttling cytostatic drugs toward liver tumors.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Bile Acids and Salts; Cells, Cultured; Cispla | 1999 |
New insights into carcinogenesis of the classical model arylamine 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Cell Division; Cell Transformation, Neoplast | 1999 |
The slow induction of resistant hepatocytes during initiation of hepatocarcinogenesis by the nongenotoxic carcinogen clofibrate.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Cell Division; Clofibrate; D | 1999 |
Diet restriction increases ubiquinone contents and inhibits progression of hepatocellular carcinoma in the rat.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Apoptosis; Carcinogens; Cell Division; Diethylnitrosam | 2000 |
Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Liver Neoplasms, Experimental; Mice; Mice | 1999 |
Bile acid secretion during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Bile; Carcinoma, Hepatocellular; Cell Differ | 2000 |
[Relationship between oval cells and preneoplastic lesions induced by 2-acetylaminofluorene in rat liver].
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Hepatectomy; Liver; Liver Neoplasms, Experimental; Ma | 1998 |
Anti-tumor promoting activity of Asteracantha longifolia against experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogens; Catalase; D | 2001 |
Binary regression for risks in excess of subject-specific thresholds.
Topics: 2-Acetylaminofluorene; Animals; Biometry; Carcinogens; Drug Tolerance; Female; Humans; Liver Neoplas | 1999 |
Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Caffeine; Carcinogens; Dose-Response Relationship, Drug; Drinking; I | 2001 |
[Expression of rasp21, C-myc, C-erbB-2, and AFP in 2-FAA induced experimental hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Liver; Liver Neoplasms, Experimental; Male; Prot | 2001 |
Abnormalities in liver iron accumulation during N-2-fluorenylacetamide hepatocarcinogenesis that are dependent or independent of continued carcinogen action.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Iron; Iron-Dextran Complex; Liver; Liver Neoplasms, Exp | 1984 |
Basal expression of the rat, but not of the human, multidrug resistance protein 2 (MRP2) gene is mediated by CBF/NF-Y and Sp1 promoter-binding sites.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette | 2001 |
Increased levels of cytosolic thioredoxin reductase activity and mRNA in rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Drug Resistance; Liver Neoplasms, Experimental; Male; Promo | 2001 |
[Effects of sex hormones on the expression of placenta form glutathione S-transferase (GST-P) in rat induced hepatocarcinoma].
Topics: 2-Acetylaminofluorene; Animals; Castration; Diethylnitrosamine; Estradiol; Female; Glutathione Trans | 1998 |
In vivo cell lineage analysis during chemical hepatocarcinogenesis in rats using retroviral-mediated gene transfer: evidence for dedifferentiation of mature hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Differentia | 2002 |
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu | 1978 |
Induction of foci of altered hepatocytes by a single injection of azaserine to rats.
Topics: 2-Acetylaminofluorene; Animals; Azaserine; Choline; Cocarcinogenesis; gamma-Glutamyltransferase; Liv | 1979 |
Biochemical characterization of liver hyperplastic nodules induced by 2-acetylaminofluorene [proceedings].
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Hyperplasia; Liver; Liver Neoplasms, Experimental; Mixed | 1978 |
Differences in serum alpha-fetoprotein concentrations during the carcinogenic sequences resulting from exposure to diethylnitrosamine or acetylaminofluorene.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Diethylnitrosamine; Fluorenes; Liver Neoplasms, | 1979 |
Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Choline Deficiency; | 1979 |
alpha-Fetoprotein levels and hepatic alterations during chemical carcinogenesis in C57BL/6N mice.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Chlordan; Liver; Liver Neoplasms, Experimental; | 1979 |
Rat alpha-macrofetoprotein (acute-phase alpha 2-macroglobulin) during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; alpha-Macroglobulins; Animals; Diethylnitrosamine; Liver | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions.
Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Con | 1978 |
Decreased fidelity of DNA polymerase activity during N-2-fluorenylacetamide hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cytoplasm; Deoxyribonucleases; DNA-Directed DNA Polyme | 1979 |
Persistence and growth of rat liver neoplastic nodules following cessation of carcinogen exposure.
Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Male; Precancerous Conditions; | 1979 |
Alteration of S-adenosylmethionine synthetases during chemical hepatocarcinogenesis and in resulting carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Female; Isoenzymes; Kinetics; Liver; Liver Neoplasms, Experimental; | 1979 |
Effect of hepatocarcinogens on the adenine purine nucleotide cycle during the initiation phase of carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenylosuccinate Lyase; Adenylosuccinate Synthase; AMP Deaminase; Animals; Ca | 1979 |
Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Hydroxyacetylaminofluorene; In Vitro Techniques; | 1979 |
Subcellular distribution and properties of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Disulfiram; Female; Immune Sera; Isoelectr | 1979 |
Aldehyde dehydrogenase in 2-acetylaminofluorene-induced rat hepatomas. Characterization of antigens recognized by anti-hepatoma aldehyde dehydrogenase sera.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Antigens; Immune Sera; Isoenzymes; Liver; | 1978 |
Rat liver aldehyde dehydrogenase--immunochemical identity of 2,3,7,8-tetrachlorodibenzo-p-dioxin inducible normal liver and 2-acetylaminofluorene inducible hepatoma isozymes.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Dioxins; Enzyme Induction; Fluorenes; Immu | 1978 |
Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Eating; Female; Foo | 1992 |
Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; Flow Cy | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Gluta | 1992 |
Role of diethylnitrosamine, 2-acetylaminofluorene and partial hepatectomy in the expression of glutathione-S-transferase-P and gamma-glutamyltranspeptidase in the early steps of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transfera | 1992 |
Rat liver nodules induced by 2-acetylaminofluorene lose an ability to take up indocyanine green in the process of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; DNA, Neoplasm; Flow Cytometry; Immunohistochemistry; Indocyanine Gre | 1992 |
Mechanisms of the enhanced liver carcinogenesis by choline in female rats: delay in liver growth after partial hepatectomy and stimulation of 2-AAF mitoinhibition.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline; Diethylnitrosamine; DNA, Neoplasm; Drug Inte | 1992 |
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
Topics: 2-Acetylaminofluorene; Adenoma; Aminobiphenyl Compounds; Animals; Base Sequence; Carcinoma; Diethyln | 1992 |
Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Arylsulfotransferase; Base Sequence; Cloning, M | 1992 |
Choline enhances acetylaminofluorene promotion of liver carcinogenesis in female but not in male rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Choline; Diethylnitrosamine; Drug Synergism; F | 1992 |
The cancer-initiating potential of the fumonisin B mycotoxins.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens, Environmen | 1992 |
Influence of poly(ADP ribose) polymerase depletion on promotion of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Liver Neoplasms, Experimental; Male; Poly(ADP-ribose) Polymerases; R | 1992 |
Modulation of hepatic mRNA translation activity and specific expression of arylsulfotransferase IV during acetylaminofluorene-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Arylsulfotransferase; Cytosol; Female; Liver; Liver Neoplasms | 1991 |
Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; gamma-Glutamyltransferase; Glucuronosyltransferase; Li | 1991 |
Effect of dietary fat on the initiation of hepatocarcinogenesis by diethylnitrosamine or 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Dietary Fats; Diethylnitrosamine; Female; | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; gamma-Glutamyltransferase; Glutathione Transfera | 1990 |
Is there a liver stem cell?
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Bile Ducts; Cell Differentiation; Cell Transform | 1990 |
Changes in alanine transport in plasma membrane vesicles from rat liver during the early stages of diethylnitrosamine-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Alanine; Animals; Biological Transport; Cell Membrane; Diethylnitrosamine; He | 1992 |
Adenylate cyclase activity in crude liver membranes during chemical hepatocarcinogenesis in portacaval shunted rats.
Topics: 2-Acetylaminofluorene; Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diethylnitrosamine; Glu | 1992 |
Protein binding, nuclear translocation and biliary secretion of metabolites of 3'-methyl-N,N-dimethyl-4-aminoazobenzene during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Bile; Body Weight; Carcinogens; Cell Nucleus; Chromatography, Gel; C | 1991 |
Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma; Female; Genotype; Liver Neoplasms, Experimental; Male; Mi | 1991 |
Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Glucuronates; Glucuronosyltransferase; Immunoblotting; Immunohistoch | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Modulation by butylated hydroxytoluene of liver and bladder carcinogenesis induced by chronic low-level exposure to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Butylated Hydroxytoluene; Dose-Response Relationship, D | 1991 |
Light & electron microscopy of proliferating oval cells during early chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Liver; Liver Neoplasms, Experimen | 1991 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosam | 1990 |
Diamine oxidase activity in a model of multistep hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amine Oxidase (Copper-Containing); Animals; Diethylnitrosamine; gamma-Glutamy | 1990 |
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Ne | 1991 |
Modifying effects of anticancer drugs adriamycin, actinomycin D, and cisplatin on N-2-fluorenylacetamide-induced hepatocarcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Cisplatin; Dactinomycin; Doxorubi | 1991 |
Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Eating; Energy Intake; Female; Growth; Liver Neop | 1991 |
Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Dose-Response Relationship, Drug; Glutathione Transfe | 1991 |
Sex-differentiated and growth-hormone-regulated mitoinhibition in rat liver during treatment with 2-acetylaminofluorene and partial hepatectomy in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Castration; Cell Division; Female; Growth Hormone; Hepatectomy; Live | 1991 |
Persistently increased expression of a 3-methylcholanthrene-inducible phenol uridine diphosphate-glucuronosyltransferase in rat hepatocyte nodules and hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies; Enzyme Induction; Glucuronosyltransferase; Liver Neoplas | 1990 |
Synergistic effect of radiation on N-2-fluorenylacetamide-induced hepatocarcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Liver; Liver Neoplasms, Experimental; Male; Neoplasm | 1990 |
[Expression of cellular oncogenes during hepatocarcinogenesis in rats].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplas | 1990 |
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; | 1990 |
High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Environmental Pollutants; Female; Glutathione Tr | 1990 |
DNA adduct formation in relation to tumorigenesis in mice continuously administered 4-aminobiphenyl.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; Deoxyguanosine; DNA; DNA Damag | 1990 |
Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin.
Topics: 2-Acetylaminofluorene; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; C | 1990 |
GDP-fucose:GM1 alpha 1----2fucosyltransferase is activated in parenchymal cells of rat liver during early stages of N-2-acetylaminofluorene induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Biomarkers, Tumor; Carbohydrate Sequence; Enzyme Acti | 1990 |
Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4'-fluoro-4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; DNA; Hydroxyacetylaminofluoren | 1990 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; | 1990 |
DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Deoxyguanosine; DNA; DNA Damage; Dose-Response | 1990 |
Structural and immunological identity of p65 tumor-associated factors from rat and mouse hepatocarcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Neoplasm; Biomarkers, Tumor; Carrier Proteins; Cocarcino | 1990 |
Effects of neonatal and adult castration and of testosterone substitution in male rats on growth of enzyme-altered hepatic foci in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Castration; Female; Liver; Liver Neoplasms, Experi | 1990 |
Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Enzyme Induction; Ethion | 1990 |
Loss of sexual differentiation of metabolism of steroids and xenobiotics in nodular hepatic tissue from male and female Wistar rats treated according to the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatect | 1990 |
2-Acetylaminofluorene-mediated alteration in the level of liver arylsulfotransferase IV during rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies; Arylsulfotransferase; Cytosol; Electrophoresis, Polyacry | 1990 |
Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Liver; | 1990 |
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver | 1986 |
Ovarian function during aflatoxin B1-induced hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; alpha-Fetoproteins; Animals; Body Weight; Dietary P | 1986 |
Circulating epoxide hydrolase immunodeterminants in rats bearing hyperplastic nodules induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Enzyme-Linked Immunosorbent Assay; Epitopes; Epoxide Hydrolases; Liv | 1988 |
Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diethylnitrosamine; Enzy | 1989 |
Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Diethylnitrosamine; gamm | 1989 |
Effects of growth hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Actins; Animals; Blotting, Northern; Diethylnitrosamine; Female; Gene Express | 1989 |
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Diethylnitrosamine; Drug Sy | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1989 |
Nucleolar organizer regions in hepatocarcinogenesis induced by N-2-fluorenylacetamide in rats: comparison with bromodeoxyuridine immunohistochemistry.
Topics: 2-Acetylaminofluorene; Animals; Bromodeoxyuridine; Immunohistochemistry; Liver Neoplasms, Experiment | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term assay system: quantitation of glutathione S-transferase P-positive foci development.
Topics: 2-Acetylaminofluorene; Animals; Disease Susceptibility; Glutathione Transferase; Liver; Liver Neopla | 1989 |
Decreased vacuolar acidification capacity in drug-resistant rat liver preneoplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; Drug Resistance; Hydrogen-Ion Concentration; Liver; L | 1989 |
Heterogeneity of hepatocyte antigen expression in rat liver carcinogenesis: concordance between neoplastic nodules and tumours.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens; Cell Transformation, Neoplastic; I | 1989 |
Rapid elevation of liver hydroxyproline content following a single administration of various chemical carcinogens to rats.
Topics: 2-Acetylaminofluorene; Animals; Hydroxyproline; Liver; Liver Neoplasms, Experimental; Male; Microbia | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosa | 1989 |
Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Barium; Bile Ducts; Cell Division; Choline Defic | 1985 |
Catalytic effect of serum albumin on the o-rearrangement of N-sulfooxy-2-acetylaminofluorene, a potential hepatocarcinogen in the rat, to nonmutagenic sulfuric acid esters of o-amidofluorenols.
Topics: 2-Acetylaminofluorene; Animals; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchan | 1989 |
Cell population kinetics and ploidy rate of early focal lesions during hepatocarcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Count; Diethylnitrosamine; DNA; Liver; Li | 1989 |
Hepatic nuclear envelope cytochrome P-450 in rats fed 2-acetylaminofluorene. Effect of dietary fats and butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Cell Nucleus; Cytochrome P-450 Enzyme Syst | 1989 |
Expression pattern of the genes for different members of the heat-shock protein 70 family, ornithine decarboxylase, and c-Ha-ras during the early stages of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, | 1989 |
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; | 1989 |
DNA adduct formation and removal in specific liver cell populations during chronic dietary administration of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Bile Ducts; Diet; DNA; Liver; Liver Neoplasms, | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, D | 1985 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin | 1985 |
Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamy | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym | 1986 |
Immunohistochemical differentiation of gamma-glutamyltranspeptidase in focal lesions and in zone I of rat liver after treatment with chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Female; gamma-Glutamyltransferase; Histocytochemistry; Liver; Liver | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Ne | 1986 |
Uptake of taurocholate by isolated gamma-glutamyltranspeptidase positive, putatively preneoplastic hepatocytes from 2-acetylaminofluorene treated rats.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; In Vitro Techniques; Kinetics; Liver; Liv | 1986 |
Effect of glutathione and N-acetylcysteine on hepatocellular modifications induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; DNA; Drug Interactions; gamma-Glutamyltransferase; G | 1986 |
Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing gamma-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Chlorophenols; gamma-Glutamyltransferase; Hydroxyac | 1987 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma | 1987 |
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamylt | 1987 |
Characterization of the proteolytic compartment in rat hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Autophagy; Liver; Liver Neoplasms, Experimental; Lysosomes; Male; Mi | 1987 |
Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats.
Topics: 2-Acetylaminofluorene; Adaptation, Physiological; Animals; Carcinogens; Drug Resistance; gamma-Gluta | 1987 |
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 1987 |
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; L | 1988 |
Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal.
Topics: 2-Acetylaminofluorene; Aldehydes; Animals; Carbon Tetrachloride; gamma-Glutamyltransferase; Liver Ne | 1988 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamylt | 1988 |
Inhibitory effect of ellagic acid on N-2-fluorenylacetamide-induced liver carcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrans; Body Weight; Ellagic Acid; gamma-Glutamyltransferase; L | 1988 |
The air pollutant 2-nitrofluorene as initiator and promoter in a liver model for chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Air Pollutants; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug | 1989 |
Kinetics of excretion of 2-acetylaminofluorene in normal and xenobiotic-treated rats and in rats with hepatocyte nodules.
Topics: 2-Acetylaminofluorene; Animals; Bile; Esters; Glucuronates; Glucuronic Acid; Liver; Liver Neoplasms, | 1989 |
Kinetics of interaction of 2-acetylaminofluorene with normal liver and carcinogen-induced hepatocyte nodules in vivo and in vitro.
Topics: 2-Acetylaminofluorene; Adipose Tissue; Administration, Oral; Animals; Brain; Cytosol; Injections, In | 1989 |
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Diploidy; DNA, Neoplasm; Liver Neoplasms, Experi | 1989 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
Binding of growth hormone to rat liver during experimental chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Golgi Apparatus; Growth Hormone; Liver; Liver Ne | 1986 |
Binding of epidermal growth factor and insulin and the autophosphorylation of their receptors in experimental primary hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epidermal Growth Factor; ErbB Receptors; Golgi A | 1986 |
Presence of albumin-positive cells in the liver of analbuminemic rats and their increase on treatment with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Neoplasms | 1986 |
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aniline Compounds; Animals; Body Weight; Butylated Hydroxyanis | 1986 |
Inhibitory effects of polyprenoic acid (E-5166) on N-2-fluorenylacetamide-initiated hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Drug Antagonism; Liver; Liver Neoplasms, Experimental; | 1986 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
Hepatocarcinogens induce gene mutations in rats in fibroblast-like cells from a subcutaneous granulation tissue.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Biotransformation; Carcinogens; Fibroblast | 1988 |
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Hepatectomy; Liv | 1988 |
Changes in rat liver N-hydroxy-2-acetylaminofluorene aryl sulfotransferase activity at early and late stages of hepatocarcinogenesis resulting from dietary administration of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Diet; Hyperplasia; Liver; Liver Neoplasms, Experimenta | 1988 |
DNA adduct formation during continuous feeding of 2-acetylaminofluorene at multiple concentrations.
Topics: 2-Acetylaminofluorene; Animals; DNA; Dose-Response Relationship, Drug; Female; Liver Neoplasms, Expe | 1988 |
Specific lectin bindings to oval cells and proliferated bile ductules.
Topics: 1-Naphthylisothiocyanate; 2-Acetylaminofluorene; Animals; Bile Ducts; Binding Sites; Epithelial Cell | 1988 |
Profile of drug metabolizing enzymes in the nuclear and microsomal fractions from rat liver nodules and normal liver.
Topics: 2-Acetylaminofluorene; Animals; Liver; Liver Neoplasms, Experimental; Male; Microscopy, Electron; Mi | 1988 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; | 1988 |
Reciprocal relationship between development of glutathione S-transferase positive liver foci and proliferation of surrounding hepatocytes in rats.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxyanisole; Cell Division; Diethylnitrosamine; Glutath | 1988 |
Synergistic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene, studied at the level of DNA adduct formation.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; DNA Damage; DNA, Neoplasm; Drug Synergism; Female; | 1988 |
Activity of the anorectic agent 1,3-bis[2-cyano-5-(trifluoromethyl)-phenyl]triazene in in vitro and in vivo liver promoting assays.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Cell Communication; Cocarcinogene | 1988 |
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Diploidy; DNA; DNA, Neoplasm; Flo | 1988 |
Characterization of tumor specific antigens on the plasma membrane surface of rat hepatomas induced by 3'-Me DAB and identification of the common tumor specific antigens from rat hepatomas induced by different chemical hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Antigens, Surface; Diethylnitrosamine; Liver Neo | 1988 |
Analysis of agreement among findings of pathologists in ED01 experiment.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms, Experimen | 1988 |
Shift from polyploidizing to nonpolyploidizing growth in carcinogen-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Flow Cytometry; Liver; Liver Neoplasms, Experime | 1988 |
Isolation and analysis of hepatoma nuclear proteins using monoclonal antibodies.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Chromatography, Affinity | 1988 |
An antigen specific to hyperplastic liver nodules defined with monoclonal antibody: a new marker for preneoplastic cells in rat chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Hybridomas; Immunoglobul | 1988 |
Experimental chemical hepatocarcinogenesis: early membrane changes of significance for drug resistance.
Topics: 2-Acetylaminofluorene; Animals; Diet; Doxorubicin; Drug Resistance; Lipid Peroxides; Liver; Liver Ne | 1986 |
Growth hormone modifies the growth rate of enzyme-altered hepatic foci in male rats treated according to the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Animals; Female; Growth Hormone; Hepatectomy; Liver Neoplasms, Experimental; | 1987 |
Experimental studies on hepatic cirrhosis and hepatocarcinogenesis. II. Influence of cirrhotic liver on 2-FAA hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Furaldehyde; Histocytochemistry; | 1986 |
Sulfation of N-hydroxy-2-acetylaminofluorene in normal and nodular liver from male Wistar rats.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Hydroxyacetylaminofluorene; Liver Neoplasms, Experi | 1987 |
Inhibition of neoplastic development in rat liver, kidney, oesophagus and forestomach by 4,4'-diaminodiphenylmethane administration.
Topics: 2-Acetylaminofluorene; Aniline Compounds; Animals; Esophageal Neoplasms; Kidney Neoplasms; Liver Neo | 1987 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
Significance of immune responses to mucosal carcinogens: a hypothesis and a workable model system.
Topics: 2-Acetylaminofluorene; Animal Nutritional Physiological Phenomena; Animals; Gastrointestinal Neoplas | 1986 |
The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; DNA Repair; DNA Replication; Interphase; Liver; | 1987 |
Benzaldehyde: NADP aldehyde dehydrogenase activity in hepatocyte nodules, hepatocellular carcinomas and drug-induced rat liver.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Benzaldehyde Dehydrogenase (NADP+); Cytoso | 1987 |
Dietary butylated hydroxytoluene protects cytochrome P-450 in hepatic nuclear membranes of rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Cytochrome P-450 Enzyme System; Dietary Fa | 1987 |
The chemical carcinogen-induced enzyme, GDP-fucose: GM1 alpha 1----2 fucosyltransferase in rat liver and hepatoma: modulation by and association with phospholipids.
Topics: 2-Acetylaminofluorene; Animals; Enzyme Activation; Enzyme Induction; Fucosyltransferases; Galactosid | 1987 |
A precursor-product relationship exists between oval cells and hepatocytes in rat liver.
Topics: 2-Acetylaminofluorene; Albumins; Animals; Cell Division; Hepatectomy; Liver; Liver Neoplasms, Experi | 1987 |
Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice.
Topics: 2-Acetylaminofluorene; Aging; Animals; Body Weight; Environment; Female; Liver Neoplasms; Liver Neop | 1987 |
Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Drug Resistance; Liver; Liver Neoplasms, Experimental; | 1987 |
Pituitary grafts modify sex differences in liver tumor formation in the rat following initiation with diethylnitrosamine and different promotion regimens.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Disease Models, Animal; Female; Hydroxyacetylami | 1986 |
Induction by phenobarbital in McA-RH7777 rat hepatoma cells of a polycyclic hydrocarbon inducible cytochrome P450.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Cell Line; Chlorodiphenyl (54% Chlorine); Cloning, Molecul | 1986 |
Enhanced O6-methylguanine-DNA alkyltransferase activity in rat liver nodules.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; DNA Repair; Female; Kinetics; Liver; Liver Neo | 1986 |
Modulation of cytotoxic and genotoxic effects of 2-acetylaminofluorene in rat and hamster hepatocytes by 3-methylcholanthrene pre-treatment.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cells, Cultured; Cricetinae; DNA Repair; Hydroxyl | 1986 |
Induction of heat shock gene expression without heat shock by hepatocarcinogens and during hepatic regeneration in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Heat-Shock Proteins; Liver; Liver N | 1986 |
Hepatoblastoma with squamous differentiation in a B6C3F1 mouse.
Topics: 2-Acetylaminofluorene; Animals; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; | 1986 |
Changes in cellular ploidy and autophagic responsiveness during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Autophagy; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1986 |
Elevated expression and cell cycle deregulation of a mitosis-associated target polypeptide of a carcinogen in hyperplastic and malignant rat hepatocytes.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Cell Cycle; Hyperplasia; Liver; Liver Neoplasms, Experiment | 1987 |
Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Interactio | 1987 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; | 1987 |
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liv | 1987 |
Initiation of hepatocarcinogenesis in infant male B6C3F1 mice by N-hydroxy-2-aminofluorene or N-hydroxy-2-acetylaminofluorene depends primarily on metabolism to N-sulfooxy-2-aminofluorene and formation of DNA-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Carcinogens; Deoxyguanosine; DNA; DNA Adducts; Fe | 1987 |
Long-term changes in mitochondrial outer membrane enzymes and microsomal enzymes involved in drug and heme metabolism during 2-acetylaminofluorene feeding.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Aminopyrine N-Demethylase; Animals; Cytochrome | 1987 |
Suppression by methionine and choline of onco-fetal patterns of liver tRNA methyltransferase activities in carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Choline; Liver; Liver Neoplasms, Experimental; Male; Methionine; Rat | 1987 |
Tumor induction in Praomys (Mastomys) natalensis by N,N'-2,7-fluorenylenebisacetamide.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Adenoma; Adrenal Gland Neoplasms; Animals; Carcinogens; Diges | 1985 |
The influence of Schistosoma mansoni infection on carcinogenesis of mouse livers initiated by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Female; Liver Neoplasms, Experimental; Mice; Schis | 1985 |
Changes in progesterone binding and metabolism in liver microsomes from persistent hepatocyte nodules and hepatomas in male rats.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Intracellular Me | 1986 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |
Alterations in nonhistone chromatin proteins during hepatocarcinogenesis induced by diverse acting carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Cycle; Chromatin; Chromosomal Proteins, Non-Histone; Diethylnit | 1985 |
Occurrence of a terminal deoxynucleotidyl transferase-like activity in N-2-fluorenylacetamide-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; DNA Nucleotidylexotransferase; DNA Nucleotidyltransferases; DNA-Dire | 1985 |
Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Enzyme Induction; Epoxide Hydrolases; Hydroxyacetyl | 1985 |
DNA ligase activities during hepatocarcinogenesis induced by N-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Chromatin; DNA Ligases; Hot Temperature; Liver; Liver | 1985 |
Syncarcinogenic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; DNA; Female; Liver Neoplasms, Experim | 1985 |
Influence of total dose and dose rate in carcinogenicity studies.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Liver Neo | 1985 |
Aldehyde dehydrogenase activities in hepatocyte nodules and hepatocellular carcinomas from Wistar rats.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Diethylnitrosamine; Kinetics; Liver; Liver N | 1985 |
Alkaline phosphatase in rat liver during early stages of experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Diethylnitrosamine; Histocytochemistry; Liver; | 1985 |