2-acetylaminofluorene has been researched along with Drug-Related Side Effects and Adverse Reactions in 2 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, the overall metabolism of toxic chemicals in hepatocyte cultures seem to be closest to the in vivo situation in the earlier time periods after isolation." | 1.27 | Xenobiotic metabolism and toxicity in primary monolayer cultures of hepatocytes. ( Holme, JA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Holme, JA | 1 |
2 other studies available for 2-acetylaminofluorene and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Xenobiotic metabolism and toxicity in primary monolayer cultures of hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cells, Cultured; Cricetinae; Culture Techniques; | 1985 |