2-acetylaminofluorene has been researched along with Cocarcinogenesis in 48 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous chronic administration of chlorpromazine (CPZ) before the start of the 2-acetylaminofluorene (2-AAF) action and during the cancerogenic process systematically facilitate the growth of apudome-like medullary tumors inside the thyroid gland." | 5.27 | [The C cell system and experimental thyroid apudomas in the rat: the combined action of 2-acetylaminofluorene and chlorpromazine in inducing systemic medullary type tumors. An ultrastructural study]. ( Alliet, J; Lalégerie, P; Théret, CG, 1984) |
| " In contrast, nongenotoxic chemicals, such as chemicals causing urinary calculi or sodium saccharin and related sodium and potassium salts, frequently are carcinogenic only at high doses and/or only in specific species." | 4.79 | Human relevance of animal carcinogenicity studies. ( Cohen, SM, 1995) |
| "The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study." | 1.28 | Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data. ( Felton, RP; Kodell, RL, 1991) |
| "Previous chronic administration of chlorpromazine (CPZ) before the start of the 2-acetylaminofluorene (2-AAF) action and during the cancerogenic process systematically facilitate the growth of apudome-like medullary tumors inside the thyroid gland." | 1.27 | [The C cell system and experimental thyroid apudomas in the rat: the combined action of 2-acetylaminofluorene and chlorpromazine in inducing systemic medullary type tumors. An ultrastructural study]. ( Alliet, J; Lalégerie, P; Théret, CG, 1984) |
| "025% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for two weeks combined with partial hepatectomy at the end of the first week and followed by long-term treatment with phenobarbital (PB) or 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from week 3 to week 86 resulted in dose-dependent development of liver and thyroid neoplastic and preneoplastic lesions." | 1.27 | Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion. ( Asamoto, M; Inoue, T; Ito, N; Nagao, M; Ogiso, T; Tsuda, H, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (66.67) | 18.7374 |
| 1990's | 11 (22.92) | 18.2507 |
| 2000's | 4 (8.33) | 29.6817 |
| 2010's | 1 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, TH | 1 |
| Sultana, S | 1 |
| Cheo, DL | 1 |
| Friedberg, EC | 1 |
| LAU, H | 1 |
| BAIER, P | 1 |
| Liu, LL | 1 |
| Gong, LK | 1 |
| Qi, XM | 1 |
| Cai, Y | 1 |
| Wang, H | 1 |
| Wu, XF | 1 |
| Xiao, Y | 1 |
| Ren, J | 1 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 1 |
| Capouya, ER | 1 |
| Lindahl, R | 2 |
| Ito, N | 9 |
| Tsuda, H | 6 |
| Hasegawa, R | 3 |
| Imaida, K | 1 |
| Solt, DB | 1 |
| Cayama, E | 1 |
| Enomoto, K | 1 |
| Lee, G | 1 |
| Farber, E | 2 |
| Williams, GM | 3 |
| Maeura, Y | 1 |
| Weisburger, JH | 1 |
| Harvey, G | 1 |
| Pagé, M | 1 |
| Dumas, L | 1 |
| Théret, CG | 1 |
| Alliet, J | 1 |
| Lalégerie, P | 1 |
| Purdy, RH | 1 |
| Marshall, MV | 1 |
| Yanagi, S | 1 |
| Sakamoto, M | 1 |
| Fuse, E | 1 |
| Rogers, AE | 1 |
| Wetsel, WC | 1 |
| Nakanishi, K | 2 |
| Fukushima, S | 2 |
| Hagiwara, A | 2 |
| Tamano, S | 1 |
| Kunz, W | 1 |
| Schaude, G | 1 |
| Schwarz, M | 1 |
| Tennekes, H | 1 |
| Stevens, FJ | 1 |
| Peraino, C | 1 |
| Allen, B | 1 |
| Miller, EC | 1 |
| Miller, JA | 1 |
| Rowland, RG | 1 |
| Oyasu, R | 1 |
| Cohen, SM | 2 |
| Ellwein, LB | 1 |
| Wada, S | 2 |
| Kato, T | 2 |
| Mutai, M | 1 |
| Ozaki, K | 1 |
| Yamaguchi, S | 2 |
| Kim, DJ | 1 |
| Baba-Toriyama, H | 1 |
| Asamoto, M | 3 |
| Imai, T | 1 |
| Masui, T | 1 |
| Ichinose, M | 1 |
| Nakanishi, H | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Muramatsu, M | 1 |
| Tatematsu, M | 2 |
| Roomi, MW | 1 |
| Parke, DV | 1 |
| van Steeg, H | 1 |
| Mullenders, LH | 1 |
| Vijg, J | 1 |
| Takahashi, S | 1 |
| Katyal, SL | 1 |
| Lombardi, B | 1 |
| Shinozuka, H | 1 |
| Murasaki, G | 1 |
| Miyata, Y | 1 |
| Hirose, M | 1 |
| Sivak, A | 1 |
| Ogawa, K | 1 |
| Kodell, RL | 1 |
| Felton, RP | 1 |
| Diwan, BA | 1 |
| Ward, JM | 1 |
| Rice, JM | 1 |
| Yamada, M | 1 |
| Neumann, HG | 3 |
| Hammerl, R | 1 |
| Hillesheim, W | 1 |
| Wildschütte, M | 1 |
| Hanausek-Walaszek, M | 1 |
| Del Rio, M | 1 |
| Adams, AK | 1 |
| Masuko, T | 1 |
| Hashimoto, Y | 1 |
| Nagase, S | 1 |
| Diez Ibañez, MA | 1 |
| Chessebeuf-Padieu, M | 1 |
| Padieu, P | 1 |
| Kroese, ED | 1 |
| van de Poll, ML | 1 |
| Mulder, GJ | 1 |
| Meerman, JH | 1 |
| Schechtman, LM | 1 |
| Hatch, GG | 1 |
| Anderson, TM | 1 |
| Putman, DL | 1 |
| Kouri, RE | 1 |
| Cameron, JW | 1 |
| Nims, RW | 1 |
| Spalding, JW | 1 |
| Tennant, RW | 1 |
| Lubet, RA | 1 |
| Tanaka, T | 3 |
| Kuniyasu, T | 1 |
| Shima, H | 1 |
| Sugie, S | 1 |
| Mori, H | 1 |
| Takahashi, M | 1 |
| Hirono, I | 1 |
| Ogiso, T | 1 |
| Inoue, T | 1 |
| Nagao, M | 1 |
| Ruthsatz, M | 1 |
| Maruyama, H | 2 |
| Préat, V | 1 |
| de Gerlache, J | 2 |
| Lans, M | 2 |
| Roberfroid, M | 1 |
| Kakizoe, Y | 1 |
| Deleener, A | 1 |
| Kirsch-Volders, M | 1 |
| Kuchlbauer, J | 1 |
| Romen, W | 1 |
6 reviews available for 2-acetylaminofluorene and Cocarcinogenesis
| Article | Year |
|---|---|
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Human relevance of animal carcinogenicity studies.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Cocarcinogenesis; Disease Models, Animal; FAN | 1995 |
Use of cell proliferation data in modeling urinary bladder carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; FANFT; Female; Humans; Male; Models | 1993 |
Cocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Viral; Cocarcinogenesis; Diet; Gas | 1979 |
Modification of liver tumor development in rodents.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; Disease Models, Animal; Disease Susceptibili | 1991 |
Role of genotoxic and nongenotoxic effects in multistage carcinogenicity of aromatic amines.
Topics: 2-Acetylaminofluorene; Amines; Animals; Carcinogens; Cocarcinogenesis; DNA; Drug Synergism; Genes; L | 1990 |
42 other studies available for 2-acetylaminofluorene and Cocarcinogenesis
| Article | Year |
|---|---|
Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study.
Topics: 2-Acetylaminofluorene; Aegle; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinogens; | 2011 |
Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Crosses, Genetic; Disease Models, Ani | 2003 |
[Experiments on cocarcinogenesis with a specific (2-acetylaminofluorene) and non-specific (choline deficiency) stimulus].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Choline; Choline Deficiency; Cocarcinogenesis; Fluorene | 1954 |
Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A | 2005 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Changes in gamma-glutamyltransferase activity during N-2-fluorenylacetamide-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; gamma-Glutamyltransferase; Histocytochemistr | 1983 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
Simultaneous inhibition of liver carcinogenicity and enhancement of bladder carcinogenicity of N-2-fluorenylacetamide by butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Carcinoma; Carcinoma, Hepatocellular; Coca | 1983 |
Binding of environmental carcinogens to asbestos and mineral fibres.
Topics: 2-Acetylaminofluorene; Adsorption; Animals; Asbestos; Benzo(a)pyrene; Benzopyrenes; Carcinogens, Env | 1984 |
[The C cell system and experimental thyroid apudomas in the rat: the combined action of 2-acetylaminofluorene and chlorpromazine in inducing systemic medullary type tumors. An ultrastructural study].
Topics: 2-Acetylaminofluorene; Animals; Apudoma; Chlorpromazine; Cocarcinogenesis; Golgi Apparatus; Microsco | 1984 |
Enhancement of the mutagenicity of carcinogenic arylamines by ethinyl estradiol.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Carcinogens; Cocarcin | 1984 |
Effects of margarine on hepatocarcinogenesis by N,N'-2, 7-fluorenylenebisacetamide in mice.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dietary Fats; Liver; Liver Neoplasms, Experimental | 1984 |
Mammary carcinogenesis in rats fed different amounts and types of fat.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Cocarcinogenesis; Die | 1981 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Development of a model to simulate the characteristics of rat liver tumor promotion by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Liver Neoplasms; Mathematics; Models, | 1982 |
Sequential 2-acetylaminofluorene--phenobarbital exposure induces a cytosolic aldehyde dehydrogenase during rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Cocarcinogenesis; Drug Administration Sche | 1982 |
Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.
Topics: 2-Acetylaminofluorene; Aflatoxins; Allylbenzene Derivatives; Animals; Anisoles; Biotransformation; C | 1981 |
Permeability of heterotopic and homotopic rat urinary bladders to water, sodium and a carcinogenic aromatic amine.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Female; Permeability; Rats; Sodium; T | 1980 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Benzo(a)pyrene; Cocarcinogenesis; DNA Repair; DNA-Bin | 2000 |
Induction of foci of altered hepatocytes by a single injection of azaserine to rats.
Topics: 2-Acetylaminofluorene; Animals; Azaserine; Choline; Cocarcinogenesis; gamma-Glutamyltransferase; Liv | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Female; Liver Neoplasms; Mice; Models | 1991 |
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; Glutathione | 1990 |
Structural and immunological identity of p65 tumor-associated factors from rat and mouse hepatocarcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Neoplasm; Biomarkers, Tumor; Carrier Proteins; Cocarcino | 1990 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1989 |
Gas chromatographic-mass spectrometric study of deacetylation and oxidation of 2-acetylaminofluorene by rat liver epithelial cell lines upon cocarcinogen induction.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cells, Cultured; Chromatography, Gas; Cocarcinoge | 1989 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamylt | 1988 |
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Ade | 1986 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Hepatectomy; Liv | 1988 |
Synergistic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene, studied at the level of DNA adduct formation.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; DNA Damage; DNA, Neoplasm; Drug Synergism; Female; | 1988 |
Activity of the anorectic agent 1,3-bis[2-cyano-5-(trifluoromethyl)-phenyl]triazene in in vitro and in vivo liver promoting assays.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Cell Communication; Cocarcinogene | 1988 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
Promoting effect of oxazepam in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamin | 1987 |
The influence of Schistosoma mansoni infection on carcinogenesis of mouse livers initiated by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Female; Liver Neoplasms, Experimental; Mice; Schis | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Syncarcinogenic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; DNA; Female; Liver Neoplasms, Experim | 1985 |