2-acetylaminofluorene has been researched along with Choline Deficiency in 17 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci." | 3.68 | Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine. ( Armstrong, D; Blanck, A; Cameron, RG, 1990) |
| " It has previously been shown that a multiple dosing regimen with AFB1, started after 3 weeks of CMD diet, enhances tumor incidence." | 1.28 | Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1. ( Laver, GW; McMullen, E; Mehta, R; Stapley, R, 1992) |
| "Well to moderately well differentiated hepatocellular carcinomas developed in 50% and 75% of rats fed the CD + AAF diet for 4 and 6 months, respectively." | 1.26 | Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet. ( Lombardi, B; Shinozuka, H, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (82.35) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LAU, H | 1 |
| BAIER, P | 1 |
| Takahashi, S | 1 |
| Lombardi, B | 3 |
| Shinozuka, H | 3 |
| Sell, S | 5 |
| Ghoshal, AK | 1 |
| Farber, E | 1 |
| Salman, J | 2 |
| Osborn, K | 1 |
| Leffert, HL | 1 |
| Rogers, AE | 2 |
| Lenhart, G | 1 |
| Morrison, G | 1 |
| Poirier, LA | 1 |
| Grantham, PH | 1 |
| Sells, MA | 1 |
| Katyal, SL | 1 |
| Mehta, R | 1 |
| Laver, GW | 1 |
| Stapley, R | 1 |
| McMullen, E | 1 |
| Gera, N | 1 |
| Bhatia, A | 1 |
| Sood, SK | 1 |
| Cameron, RG | 1 |
| Blanck, A | 1 |
| Armstrong, D | 1 |
| Hixson, DC | 2 |
| Allison, JP | 1 |
| Dunsford, HA | 1 |
| Maset, R | 1 |
| Faris, RA | 1 |
| Watanabe, A | 1 |
| Yamauchi, Y | 1 |
| Kobayashi, M | 1 |
| Nagashima, H | 1 |
17 other studies available for 2-acetylaminofluorene and Choline Deficiency
| Article | Year |
|---|---|
[Experiments on cocarcinogenesis with a specific (2-acetylaminofluorene) and non-specific (choline deficiency) stimulus].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Choline; Choline Deficiency; Cocarcinogenesis; Fluorene | 1954 |
Progression of carcinogen-induced foci of gamma-glutamyltranspeptidase-positive hepatocytes to hepatomas in rats fed a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animal Feed; Animals; Cell Transformation, Neoplastic; Choline Deficiency; Di | 1982 |
Comparison of oval cells induced in rat liver by feeding N-2-fluorenylacetamide in a choline-devoid diet and bile duct cells induced by feeding 4,4'-diaminodiphenylmethane.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; alpha-Fetoproteins; Aniline Compounds; Animals; Asparta | 1983 |
The induction of resistant hepatocytes during initiation of liver carcinogenesis with chemicals in rats fed a choline deficient methionine low diet.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Ch | 1983 |
Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Transformation, Neoplastic; Choline Deficiency | 1984 |
Autoradiography of "oval cells" appearing rapidly in the livers of rats fed N-2-fluorenylacetamide in a choline devoid diet.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Division; Choline Deficiency; Diet; Hepatectom | 1981 |
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethy | 1980 |
The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Choline Deficiency; Diet; Female; Fluorenes | 1977 |
Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Choline Deficiency; | 1979 |
Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet.
Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; | 1979 |
Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alanine Transaminase; Analysis of Variance; Animals; Aspartate | 1992 |
Light & electron microscopy of proliferating oval cells during early chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Liver; Liver Neoplasms, Experimen | 1991 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosam | 1990 |
Monoclonal antibodies recognizing oval cells induced in the liver of rats by N-2-fluorenylacetamide or ethionine in a choline-deficient diet.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Antibody Specificity; An | 1985 |
Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Barium; Bile Ducts; Cell Division; Choline Defic | 1985 |
Selective proliferation of chemically altered rat liver epithelial cells following hepatic transplantation.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Epithelium; Liver; Liver Transpla | 1989 |
Enhancement of low-dose N-2-fluorenylacetamide-induced hyperplastic liver nodules by pre-existing cirrhosis.
Topics: 2-Acetylaminofluorene; Animals; Choline Deficiency; Diet; gamma-Glutamyltransferase; Hyperplasia; Li | 1987 |