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2-acetylaminofluorene and Choline Deficiency

2-acetylaminofluorene has been researched along with Choline Deficiency in 17 studies

2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Research Excerpts

ExcerptRelevanceReference
" However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci."3.68Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine. ( Armstrong, D; Blanck, A; Cameron, RG, 1990)
" It has previously been shown that a multiple dosing regimen with AFB1, started after 3 weeks of CMD diet, enhances tumor incidence."1.28Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1. ( Laver, GW; McMullen, E; Mehta, R; Stapley, R, 1992)
"Well to moderately well differentiated hepatocellular carcinomas developed in 50% and 75% of rats fed the CD + AAF diet for 4 and 6 months, respectively."1.26Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet. ( Lombardi, B; Shinozuka, H, 1979)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199014 (82.35)18.7374
1990's3 (17.65)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LAU, H1
BAIER, P1
Takahashi, S1
Lombardi, B3
Shinozuka, H3
Sell, S5
Ghoshal, AK1
Farber, E1
Salman, J2
Osborn, K1
Leffert, HL1
Rogers, AE2
Lenhart, G1
Morrison, G1
Poirier, LA1
Grantham, PH1
Sells, MA1
Katyal, SL1
Mehta, R1
Laver, GW1
Stapley, R1
McMullen, E1
Gera, N1
Bhatia, A1
Sood, SK1
Cameron, RG1
Blanck, A1
Armstrong, D1
Hixson, DC2
Allison, JP1
Dunsford, HA1
Maset, R1
Faris, RA1
Watanabe, A1
Yamauchi, Y1
Kobayashi, M1
Nagashima, H1

Other Studies

17 other studies available for 2-acetylaminofluorene and Choline Deficiency

ArticleYear
[Experiments on cocarcinogenesis with a specific (2-acetylaminofluorene) and non-specific (choline deficiency) stimulus].
    Langenbecks Archiv fur klinische Chirurgie ... vereinigt mit Deutsche Zeitschrift fur Chirurgie, 1954, Volume: 278, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Choline; Choline Deficiency; Cocarcinogenesis; Fluorene

1954
Progression of carcinogen-induced foci of gamma-glutamyltranspeptidase-positive hepatocytes to hepatomas in rats fed a choline-deficient diet.
    International journal of cancer, 1982, Apr-15, Volume: 29, Issue:4

    Topics: 2-Acetylaminofluorene; Animal Feed; Animals; Cell Transformation, Neoplastic; Choline Deficiency; Di

1982
Comparison of oval cells induced in rat liver by feeding N-2-fluorenylacetamide in a choline-devoid diet and bile duct cells induced by feeding 4,4'-diaminodiphenylmethane.
    Cancer research, 1983, Volume: 43, Issue:4

    Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; alpha-Fetoproteins; Aniline Compounds; Animals; Asparta

1983
The induction of resistant hepatocytes during initiation of liver carcinogenesis with chemicals in rats fed a choline deficient methionine low diet.
    Carcinogenesis, 1983, Volume: 4, Issue:7

    Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Ch

1983
Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.
    The American journal of pathology, 1984, Volume: 114, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Transformation, Neoplastic; Choline Deficiency

1984
Autoradiography of "oval cells" appearing rapidly in the livers of rats fed N-2-fluorenylacetamide in a choline devoid diet.
    Carcinogenesis, 1981, Volume: 2, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Cell Division; Choline Deficiency; Diet; Hepatectom

1981
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
    Cancer research, 1980, Volume: 40, Issue:8 Pt 1

    Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethy

1980
The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.
    Cancer research, 1977, Volume: 37, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Choline Deficiency; Diet; Female; Fluorenes

1977
Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
    Cancer research, 1979, Volume: 39, Issue:7 Pt 1

    Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Choline Deficiency;

1979
Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet.
    International journal of cancer, 1979, Apr-15, Volume: 23, Issue:4

    Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular;

1979
Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1.
    Carcinogenesis, 1992, Volume: 13, Issue:7

    Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alanine Transaminase; Analysis of Variance; Animals; Aspartate

1992
Light & electron microscopy of proliferating oval cells during early chemical hepatocarcinogenesis.
    The Indian journal of medical research, 1991, Volume: 94

    Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Liver; Liver Neoplasms, Experimen

1991
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
    Cancer letters, 1990, Apr-20, Volume: 50, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosam

1990
Monoclonal antibodies recognizing oval cells induced in the liver of rats by N-2-fluorenylacetamide or ethionine in a choline-deficient diet.
    Cancer research, 1985, Volume: 45, Issue:8

    Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Antibody Specificity; An

1985
Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.
    The American journal of pathology, 1985, Volume: 118, Issue:2

    Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Barium; Bile Ducts; Cell Division; Choline Defic

1985
Selective proliferation of chemically altered rat liver epithelial cells following hepatic transplantation.
    Transplantation, 1989, Volume: 48, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Epithelium; Liver; Liver Transpla

1989
Enhancement of low-dose N-2-fluorenylacetamide-induced hyperplastic liver nodules by pre-existing cirrhosis.
    Carcinogenesis, 1987, Volume: 8, Issue:10

    Topics: 2-Acetylaminofluorene; Animals; Choline Deficiency; Diet; gamma-Glutamyltransferase; Hyperplasia; Li

1987