2-acetylaminofluorene has been researched along with Cholestasis in 1 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil was used as a P-gp specific inhibitor and acetylaminofluorene (AAF) as a P-gp inducer." | 1.30 | Effect of pharmacological modulation of liver P-glycoproteins on cyclosporin A biliary excretion and cholestasis: a study in isolated perfused rat liver. ( Alvaro, D; Benedetti, A; Bini, A; Delle Monache, MD; Di Cosimo, E; Fraioli, F; Francia, C; Gigliozzi, A; Jezequel, AM; Marucci, L; Papa, E, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delle Monache, MD | 1 |
| Gigliozzi, A | 1 |
| Benedetti, A | 1 |
| Marucci, L | 1 |
| Bini, A | 1 |
| Francia, C | 1 |
| Papa, E | 1 |
| Di Cosimo, E | 1 |
| Fraioli, F | 1 |
| Jezequel, AM | 1 |
| Alvaro, D | 1 |
1 other study available for 2-acetylaminofluorene and Cholestasis
| Article | Year |
|---|---|
Effect of pharmacological modulation of liver P-glycoproteins on cyclosporin A biliary excretion and cholestasis: a study in isolated perfused rat liver.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; Bile; Cholestasis; Cy | 1999 |