2-acetylaminofluorene has been researched along with Chemical and Drug Induced Liver Injury in 36 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "03% 2-acetylaminofluorene (AAF) resulted, 12 to 15 months later, in a massive production of hepatic cysts." | 7.66 | Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene. ( Pitot, HC; Potter, VR; Richards, WL, 1982) |
| "After 20 weeks cysts were observed in the majority of rats." | 5.28 | Experimental liver cysts induced by 2-acetylaminofluorene. ( Itoshima, T; Mizutani, S; Tsuji, T, 1991) |
| "03% 2-acetylaminofluorene (AAF) resulted, 12 to 15 months later, in a massive production of hepatic cysts." | 3.66 | Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene. ( Pitot, HC; Potter, VR; Richards, WL, 1982) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " The ability of butylated hydroxyanisole (BHA) to attenuate the toxic effect of 2-AAF was also examined." | 1.31 | Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract. ( Agboola, AO; Emerole, GO; Farombi, EO; Nwankwo, JO; Tahnteng, JG, 2000) |
| "After 20 weeks cysts were observed in the majority of rats." | 1.28 | Experimental liver cysts induced by 2-acetylaminofluorene. ( Itoshima, T; Mizutani, S; Tsuji, T, 1991) |
| " Feeding the chemical at levels of 8 to 86 ppm results in a dose-response related urinary bladder hyperplasia and, after 9 to 12 months, in bladder neoplasia at the higher dose levels." | 1.26 | Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals. ( Farmer, J; Frith, C; Haley, TJ; Jaques, WE; Schieferstein, G; Sprowls, RW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (41.67) | 18.7374 |
| 1990's | 5 (13.89) | 18.2507 |
| 2000's | 9 (25.00) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Szücs, A | 1 |
| Paku, S | 2 |
| Sebestyén, E | 1 |
| Nagy, P | 2 |
| Dezső, K | 2 |
| Papp, V | 1 |
| Rókusz, A | 1 |
| Bugyik, E | 1 |
| Szabó, V | 1 |
| Pávai, Z | 1 |
| Adesanoye, OA | 1 |
| Adekunle, AE | 1 |
| Adewale, OB | 1 |
| Mbagwu, AE | 1 |
| Delima, AA | 1 |
| Adefegha, SA | 1 |
| Molehin, OR | 1 |
| Farombi, EO | 2 |
| Hasan, SK | 1 |
| Khan, R | 1 |
| Ali, N | 1 |
| Khan, AQ | 1 |
| Rehman, MU | 1 |
| Tahir, M | 1 |
| Lateef, A | 1 |
| Nafees, S | 1 |
| Mehdi, SJ | 1 |
| Rashid, S | 1 |
| Shahid, A | 1 |
| Sultana, S | 2 |
| Kumar, M | 1 |
| Kaur, P | 1 |
| Chandel, M | 1 |
| Singh, AP | 1 |
| Jain, A | 1 |
| Kaur, S | 1 |
| Hsu, JD | 1 |
| Kao, SH | 1 |
| Tu, CC | 1 |
| Li, YJ | 1 |
| Wang, CJ | 1 |
| KENT, G | 1 |
| MINICK, OT | 1 |
| VOLINI, FI | 1 |
| ORFEI, E | 1 |
| DELAHUERGA, J | 1 |
| HARTMANN, HA | 1 |
| Sigala, F | 1 |
| Kostopanagiotou, G | 1 |
| Andreadou, I | 1 |
| Kavatzas, N | 1 |
| Felekouras, E | 1 |
| Sigalas, P | 1 |
| Bastounis, E | 1 |
| Papalambros, E | 1 |
| Okumoto, K | 1 |
| Saito, T | 1 |
| Haga, H | 1 |
| Hattori, E | 1 |
| Ishii, R | 1 |
| Karasawa, T | 1 |
| Suzuki, A | 1 |
| Misawa, K | 1 |
| Sanjo, M | 1 |
| Ito, JI | 1 |
| Sugahara, K | 1 |
| Saito, K | 1 |
| Togashi, H | 1 |
| Kawata, S | 1 |
| Dudas, J | 1 |
| Elmaouhoub, A | 1 |
| Mansuroglu, T | 1 |
| Batusic, D | 1 |
| Tron, K | 1 |
| Saile, B | 1 |
| Papoutsi, M | 1 |
| Pieler, T | 1 |
| Wilting, J | 1 |
| Ramadori, G | 1 |
| Oh, SH | 1 |
| Witek, RP | 1 |
| Bae, SH | 1 |
| Zheng, D | 1 |
| Jung, Y | 1 |
| Piscaglia, AC | 1 |
| Petersen, BE | 1 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 1 |
| Rahman, S | 1 |
| Kojima, S | 1 |
| Hama, Y | 1 |
| Sasaki, T | 1 |
| Kubodera, A | 1 |
| Richards, WL | 1 |
| Pitot, HC | 1 |
| Potter, VR | 1 |
| Shirai, T | 1 |
| King, CM | 1 |
| Sidransky, H | 1 |
| Verney, E | 1 |
| Meerman, JH | 1 |
| Mulder, GJ | 1 |
| Wada, S | 2 |
| Kato, T | 1 |
| Mutai, M | 1 |
| Ozaki, K | 1 |
| Yamaguchi, S | 2 |
| Kim, DJ | 1 |
| Baba-Toriyama, H | 1 |
| Asamoto, M | 1 |
| Ito, N | 3 |
| Tsuda, H | 1 |
| Imai, T | 1 |
| Masui, T | 1 |
| Ichinose, M | 1 |
| Nakanishi, H | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Muramatsu, M | 1 |
| Tatematsu, M | 2 |
| Tahnteng, JG | 1 |
| Agboola, AO | 1 |
| Nwankwo, JO | 1 |
| Emerole, GO | 1 |
| Yin, L | 1 |
| Lynch, D | 1 |
| Ilic, Z | 1 |
| Sell, S | 1 |
| Murasaki, G | 1 |
| Nakanishi, K | 1 |
| Miyata, Y | 1 |
| Shinohara, Y | 1 |
| Flaks, B | 1 |
| Nicoll, JW | 1 |
| Haley, TJ | 1 |
| Farmer, J | 1 |
| Jaques, WE | 1 |
| Frith, C | 1 |
| Sprowls, RW | 1 |
| Schieferstein, G | 1 |
| Thorgeirsson, SS | 1 |
| Felton, JS | 1 |
| Nebert, DW | 1 |
| Ogawa, K | 1 |
| Hasegawa, R | 1 |
| Perrone, MC | 1 |
| Serra, D | 1 |
| D'Agostini, F | 1 |
| Cesarone, CF | 1 |
| Mizutani, S | 1 |
| Itoshima, T | 1 |
| Tsuji, T | 1 |
| Moslen, MT | 1 |
| Ahluwalia, MB | 1 |
| Farber, E | 1 |
| Carubelli, R | 1 |
| Palakodety, RB | 2 |
| Griffin, MJ | 2 |
| Vaz, AD | 1 |
| Stout, DL | 1 |
| Becker, FF | 1 |
36 other studies available for 2-acetylaminofluorene and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Postnatal, ontogenic liver growth accomplished by biliary/oval cell proliferation and differentiation.
Topics: 2-Acetylaminofluorene; Animals; Biliary Tract; Cell Differentiation; Cell Proliferation; Chemical an | 2020 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different | 2014 |
Chemoprotective effect of Vernonia amygdalina Del. (Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity in rats.
Topics: 2-Acetylaminofluorene; 5'-Nucleotidase; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxi | 2016 |
18-β Glycyrrhetinic acid alleviates 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats: Role in hyperproliferation, inflammation and oxidative stress.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Cell Pr | 2015 |
Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage in male Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Lawsonia Plant | 2017 |
Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Gl | 2009 |
IRON STORAGE IN N-2-FLUORENYLACETAMIDE-INDUCED HEPATIC INJURY. ELECTRON MICROSCOPIC OBSERVATIONS FOLLOWING THE INJECTION OF IRON-DEXTRAN.
Topics: 2-Acetylaminofluorene; Acid Phosphatase; Chemical and Drug Induced Liver Injury; Dextrans; Electrons | 1963 |
RAT LIVER AFTER N-HYDROXY-2-ACETYLAMINOFLUORENE. ULTRASTRUCTURE.
Topics: 2-Acetylaminofluorene; Carcinogens; Chemical and Drug Induced Liver Injury; Electrons; Endoplasmic R | 1965 |
Histological and lipid peroxidation changes after administration of 2-acetylaminofluorene in a rat liver injury model following selective periportal and pericentral damage.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachlor | 2004 |
Characteristics of rat bone marrow cells differentiated into a liver cell lineage and dynamics of the transplanted cells in the injured liver.
Topics: 2-Acetylaminofluorene; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Carbon Tetrachloride | 2006 |
Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".
Topics: 2-Acetylaminofluorene; Acute-Phase Reaction; alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers; Ca | 2006 |
Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Animals, Genetically Modified; Antimitotic Agent | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Protective effects of Picorrhiza kurroa extract against 2-acetylaminofluorene-induced hepatotoxicity in Wistar rats.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; DNA; Female; Lipid Peroxidat | 2007 |
Elevated uptake of 67Ga and increased heparan sulfate content in liver-damaged rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cations; Chemical and Drug Induced L | 1983 |
Hepatic cyst formation in male rats partially hepatectomized as weanlings during short-term feeding of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Chemical and Drug Induced Liver Injury; Cysts; H | 1982 |
Sulfotransferase and deacetylase in normal and tumor-bearing liver of CD rats: autoradiographical studies with N-hydroxy-2-acetylaminofluorene and N-hydroxy-4-acetylaminobiphenyl in vitro and in vivo.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Aminobiphenyl Compounds; Animals; Autoradiography; Chemical | 1982 |
Acute effects of selected hepatotoxic agents on polyribosomes and protein synthesis in the livers of rats fed purified diets containing hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Acute Disease; Animals; Carbon Tetrachloride; Carcinogens; Chemical and Drug | 1982 |
Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat by inhibition of N-O-sulfation by pentachlorophenol.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug | 1981 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Biflavonoids; Carcinogens; Chemical and Dru | 2000 |
Proliferation and differentiation of ductular progenitor cells and littoral cells during the regeneration of the rat liver to CCl4/2-AAF injury.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Bile Ducts; Biomarkers; Carbon Tetrachloride Poison | 2002 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Modification of toxic liver injury in the rat II. Protective effect of cycloheximide on ethionine-induced damage and autoprotective effects of high doses of ethionine, 3'-methyl-4-dimethylaminoazobenzene, and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Ethionine; Fluorenes; In Vit | 1975 |
Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 1976 |
Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enzyme Induct | 1975 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
[Evaluation of blood chemistry parameters of rats treated with 2-acetylaminofluorene and N-acetylcysteine].
Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; Blood Proteins; Chemical and Drug Induced Liver Inju | 1991 |
Experimental liver cysts induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts; Chemical and Drug Induced Liver Injury; Cysts; Dilatatio | 1991 |
1,2-Dibromoethane initiation of hepatic nodules in Sprague-Dawley rats selected with Solt-Farber system.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carbon Tetrachloride; Chemical and Drug Induce | 1985 |
Loss of cytochrome P-450 from hepatic nuclear membranes of rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Biotransformation; Chemical and Drug Induced L | 1986 |
Microsomal cholesterol epoxide hydrolase activity in 2-acetylaminofluorene-induced rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; Hyperpla | 1987 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li | 1987 |