2-acetylaminofluorene has been researched along with Carcinoma, Hepatocellular in 108 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 7.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not." | 7.65 | Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. ( Becker, FF; Shurgin, A, 1975) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 5.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " In our model, rats subjected to 2-acetylaminofluorene/ partial-hepatectomy followed by aflatoxin injection (APA regimen) developed well-differentiated hepatocholangiocarcinomas." | 3.75 | Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival. ( Gasbarrini, A; Pani, G; Petersen, BE; Piscaglia, AC; Shupe, TD; Tesori, V, 2009) |
| "A rat cell line-nominated CC-62 derived from a combined hepatocellular and cholangiocellular carcinoma obtained by administration of 2-acetylaminofluorene to male Wistar rats, has been established." | 3.71 | Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma. ( Callaghan, R; Carda, C; Gil-Benso, R; Gregori-Romero, MA; Llombart-Bosch, A; Martinez-Lorente, A; Navarro-Fos, S; Pellin-Perez, A; Peydro-Olaya, A, 2001) |
| " Two diets used widely in toxicological and/or nutritional studies, and considered to be nutritionally adequate, were compared with respect to their influence on growth, body weight, lifespan, spontaneous neoplasia, and neoplastic responses to 2-acetylaminofluorene (2-AAF)." | 3.68 | Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet. ( Bucci, TJ; Fullerton, FR; Greenman, DL, 1992) |
| "The proliferative activity of tumor cells differing in DNA content (ploidy) and nuclearity was investigated in primary hepatocellular carcinomas of the rat by flow cytometric analysis of collagenase-isolated cells immunostained after labelling with bromodeoxyuridine (BrdU) in vivo." | 3.68 | Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma. ( Erikstein, B; Gerlyng, P; Grotmol, T; Seglen, PO; Stokke, T, 1992) |
| "Activation of ras protooncogenes in 11 2-acetylaminofluorene (AAF)-induced hepatocellular carcinomas (HCCs) or liver cell lines and 9 3'-methyl-(dimethylamino)azobenzene (3'-Me-DAB)-induced HCCs in rats was examined using the NIH3T3 cell transfection assay and oligonucleotide hybridization analysis." | 3.68 | Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas. ( Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K, 1991) |
| "A previous study demonstrated that cells of transplantable hepatocellular carcinomas were agglutinated by the plant lectin concanavalin A, while normal hepatocytes were not." | 3.65 | Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide. ( Becker, FF; Shurgin, A, 1975) |
| "This study aimed to analyze the biochemical, histological, and gene expression alterations produced in a hepatocarcinogenesis model induced by the chronic administration of diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in Wistar rats." | 1.91 | Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats. ( Campos-Valdez, M; Domínguez-Rosales, JA; Godínez-Rubí, JM; Martínez-López, E; Rodríguez-Reyes, SC; Sánchez-Meza, J; Sánchez-Orozco, LV; Zúñiga-González, GM, 2023) |
| " Because the administration of 2-acetylaminofluorene (2AAF) followed by a partial hepatectomy, selectively induces the HPC proliferation, we investigated the effects of chronic 2AAF administration on the HCC development caused by the chronic administration of the carcinogen diethylnitrosamine (DEN) for 16 weeks in the rat." | 1.62 | Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo. ( Arellanes-Robledo, J; Castro-Gil, MP; Del-Pozo-Jauner, L; Gabiño-López, NB; López-Torres, CD; Pérez-Carreón, JI; Quintanar-Jurado, V; Sánchez-Rodríguez, R; Torres-Mena, JE; Villa-Treviño, S, 2021) |
| "HMGB3 in human liver cancer tissues were evaluated using bioinformatics databases from GEO, TCGA, and Oncomine." | 1.48 | Abnormal expression of ( Dong, ZZ; Fang, M; Wang, L; Yao, DF; Yao, M; Zheng, WJ, 2018) |
| "To develop DR-HepG2, hepatocellular carcinoma cell line (HepG2) was transfected with 2-Acetylaminofluorene (AAF) and Aflatoxin B1 (AFB)." | 1.39 | Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: an in vitro study. ( Chaudhary, H; Jena, PK; Seshadri, S, 2013) |
| "Pioglitazone treatment was initiated the day after the first diethylnitrosamine injection." | 1.34 | The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver. ( Borbath, I; Horsmans, Y; Leclercq, I; Moulin, P; Sempoux, C, 2007) |
| "Acetaminophen was given in the diet either alone at 2400 or 4800 p." | 1.34 | Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene. ( Duan, JD; Iatropoulos, MJ; Jeffrey, AM; Perrone, CE; Williams, GM, 2007) |
| "Fumonisin B1 (FB1) is a naturally occurring mycotoxin produced by Fusarium verticillioides." | 1.32 | Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. ( Gelderblom, WC; Hall, Pde L; Kirsch, RE; Lemmer, ER; Marasas, WF; Shephard, EG; Van Schalkwyk, DJ; Van Wijk, RA; Vessey, CJ, 2004) |
| "Treating hepatoma cells with 2-AAF activated phosphoinositide 3-kinase (PI3K) and its downstream effectors Rac1, and NAD(P)H oxidase." | 1.31 | Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. ( Kuo, MT; Lin-Lee, YC; Liu, Z; Mills, GB; Tatebe, S; Unate, H; Wei, Y, 2002) |
| "Uridine uptake was always inhibited at lower concentrations than those required in the neutral red assay, suggesting that the uridine uptake assay is a more sensitive indicator of toxic action than the neutral red inclusion." | 1.31 | Uridine uptake inhibition as a cytotoxicity test for a human hepatoma cell line (HepG2 cells): comparison with the neutral red assay. ( Chagnon, M; Lhuguenot, J; Philippe, M; Valentin, I, 2001) |
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| "A supernatant prepared from the human hepatoma cell line Hep G2 was used to activate benzidine, 2-aminofluorene (2-AF) and 2-acetylaminofluorene (2-AAF) in the Salmonella typhimurium reversion assay." | 1.29 | Mutagenic activation of aromatic amines by a human hepatoma cell (Hep G2) supernatant tested by means of Salmonella typhimurium strains with different acetyltransferase activities. ( Crutzen, MC; Dierickx, PJ; Duverger-van Bogaert, M, 1995) |
| "In human hepatoma (Hep G2) cells and peripheral blood lymphocytes (HPBL) the cytokinesis-blocked micronuclei (MN) and fluorescent in situ hybridization (FISH) assays were applied to study aneugenic and clastogenic potentials of X-rays, directly and indirectly acting chemicals." | 1.29 | Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric pro ( Darroudi, F; Hadjidekova, V; Meijers, CM; Natarajan, AT, 1996) |
| "While the first hepatocellular carcinoma in R16 fed either a CS or LC was seen at 9-10 months, one R16 rat fed a CD diet had liver cancer at 4 months." | 1.28 | Genetics and diet: synergism in hepatocarcinogenesis in rats. ( Gill, TJ; Kazanecki, ME; Kunz, HW; Melhem, MF; Rao, KN, 1990) |
| "In primary hepatomas induced by 2-acetylaminofluorene, cytochrome P-450 content is 21% of that of controls, AHH activity is 11% of the activity of controls, and reductase is 50% of the control activity." | 1.26 | A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. ( Cameron, R; Farber, E; Jones, K; Lee, G; Sweeney, GD, 1976) |
| "2." | 1.26 | Purification and immunochemical characterization of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas. ( Feinstein, RN; Lindahl, R, 1976) |
| "Amount of cytochrome P-450 in hepatoma tissues also showed similar values as that in hyperplastic nodules." | 1.26 | Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. ( Fukumoto, Y; Noda, K; Okita, K; Takemoto, T, 1976) |
| "In vivo, hepatoma H-4-II-E is rapidly growing tumor with a mean doubling time of 49-2 hr." | 1.26 | Properties of the H-4-II-E tumor cell system. I. Growth and cell proliferation kinetics of an experimental hepatoma. ( Evans, MJ; Kovacs, CJ, 1977) |
| "The results indicate that the hepatoma-specific aldehyde dehydrogenases are not the result of the de-repression of genes normally repressed in adult rat liver or in some other adult tissue." | 1.26 | Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression. ( Lindahl, R, 1977) |
| "The incidence of hepatomas in the phorbol-treated offspring of AAF-injected mothers was 8/74 (11%), as compared with 2/80 (2." | 1.26 | Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice. ( Armuth, V; Berenblum, I, 1977) |
| "In contrast, the incidence of hepatocellular carcinomas in sham-operated rats was 38." | 1.26 | Inhibitory effect of hypothalamic lesions on liver tumor induction by N-2-fluorenylacetamide in male rats. ( Toh, YC, 1978) |
| "Hyperplastic nodules and hepatocellular carcinomas were induced in livers of rats by a low-protein diet containing 0." | 1.26 | Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development. ( Keenan, TW; Merritt, WD; Morré, DJ; Richardson, CL, 1978) |
| "Nineteen rearanged chromosomes were in hepatoma 8994, whereas only 8-10 markers could be found in the 80 +/- 3 chromosome complement of hepatoma 7316A." | 1.26 | Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines. ( Kovi, E; Kovi, J; Morris, HP; Rao, MS, 1978) |
| "Well to moderately well differentiated hepatocellular carcinomas developed in 50% and 75% of rats fed the CD + AAF diet for 4 and 6 months, respectively." | 1.26 | Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet. ( Lombardi, B; Shinozuka, H, 1979) |
| "Transplantable hepatomas varied in their fibronectin staining from fibronectin-negative hepatomas to ones with fibronectin staining within or around every tumor cell." | 1.26 | Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. ( Ruoslahti, E; Sell, S, 1982) |
| "alpha-BHC inhibited the induction of hepatocellular carcinomas and oval cells infiltration in rats treated with 2-FAA for 5 months." | 1.26 | Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats. ( Hiasa, Y; Murata, Y; Ohmori, T; Ohshima, M, 1978) |
| "In well differentiated, slowly growing hepatomas, the concentration of GSH approached the level in normal adult rat liver." | 1.26 | Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis. ( Fiala, AE; Fiala, S; Kettering, WG; Mohindru, A; Morris, HP, 1976) |
| "Since up to 60% of the hepatocellular carcinomas developing from this regimen will predictably produce AFP, it is tentatively concluded that hepatocellular carcinoma may arise not only from "premalignant" neoplastic nodules but also from oval cells or the atpyical differentiation of hepatocytes." | 1.26 | Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide. ( Sell, S, 1978) |
| "These neoplasms included cholangiomas, hepatoadenomas, cholangiocarcinomas, and hepatocellular cancers." | 1.25 | Tumor induction by carcinogenic agents in aquarium fish. ( Khudoley, VV; Pliss, GB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (51.85) | 18.7374 |
| 1990's | 15 (13.89) | 18.2507 |
| 2000's | 20 (18.52) | 29.6817 |
| 2010's | 13 (12.04) | 24.3611 |
| 2020's | 4 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kuo, MT | 1 |
| Liu, Z | 1 |
| Wei, Y | 1 |
| Lin-Lee, YC | 1 |
| Tatebe, S | 1 |
| Mills, GB | 1 |
| Unate, H | 1 |
| Sánchez-Meza, J | 1 |
| Campos-Valdez, M | 1 |
| Domínguez-Rosales, JA | 1 |
| Godínez-Rubí, JM | 1 |
| Rodríguez-Reyes, SC | 1 |
| Martínez-López, E | 1 |
| Zúñiga-González, GM | 1 |
| Sánchez-Orozco, LV | 1 |
| Nair, AB | 1 |
| Shah, J | 1 |
| Al-Dhubiab, BE | 1 |
| Patel, SS | 1 |
| Morsy, MA | 1 |
| Patel, V | 1 |
| Chavda, V | 1 |
| Jacob, S | 1 |
| Sreeharsha, N | 1 |
| Shinu, P | 1 |
| Attimarad, M | 1 |
| Venugopala, KN | 1 |
| Unsal, V | 1 |
| Kurutaş, EB | 1 |
| Castro-Gil, MP | 1 |
| Sánchez-Rodríguez, R | 1 |
| Torres-Mena, JE | 1 |
| López-Torres, CD | 1 |
| Quintanar-Jurado, V | 1 |
| Gabiño-López, NB | 1 |
| Villa-Treviño, S | 2 |
| Del-Pozo-Jauner, L | 1 |
| Arellanes-Robledo, J | 1 |
| Pérez-Carreón, JI | 1 |
| Ali, G | 1 |
| Omar, H | 1 |
| Hersi, F | 1 |
| Abo-Youssef, A | 1 |
| Ahmed, O | 1 |
| Mohamed, W | 1 |
| P Katare, D | 1 |
| Malik, S | 1 |
| J Mani, R | 1 |
| Ranjpour, M | 1 |
| Jain, SK | 1 |
| Amidi, S | 1 |
| Hashemi, Z | 1 |
| Motallebi, A | 1 |
| Nazemi, M | 1 |
| Farrokhpayam, H | 1 |
| Seydi, E | 2 |
| Pourahmad, J | 2 |
| Zheng, WJ | 2 |
| Yao, M | 6 |
| Fang, M | 1 |
| Wang, L | 3 |
| Dong, ZZ | 2 |
| Yao, DF | 9 |
| Matboli, M | 1 |
| ElGwad, AA | 1 |
| Hasanin, AH | 1 |
| El-Tawdi, A | 1 |
| Habib, EK | 1 |
| Elmansy, RA | 1 |
| Ibrahim, D | 1 |
| Shehata, H | 1 |
| Tash, F | 1 |
| Chaudhary, H | 1 |
| Jena, PK | 1 |
| Seshadri, S | 1 |
| Yan, XD | 1 |
| Zhang, HJ | 2 |
| Yan, MJ | 1 |
| Gu, X | 1 |
| Shi, Y | 1 |
| Chen, J | 1 |
| Kindrat, I | 1 |
| Tryndyak, V | 1 |
| de Conti, A | 1 |
| Shpyleva, S | 1 |
| Mudalige, TK | 1 |
| Kobets, T | 1 |
| Erstenyuk, AM | 1 |
| Beland, FA | 1 |
| Pogribny, IP | 1 |
| Rasekh, HR | 1 |
| Salimi, A | 1 |
| Mohsenifar, Z | 1 |
| Gjymishka, A | 1 |
| Pi, L | 1 |
| Oh, SH | 1 |
| Jorgensen, M | 1 |
| Liu, C | 1 |
| Protopapadakis, Y | 1 |
| Patel, A | 1 |
| Petersen, BE | 2 |
| Gu, JJ | 1 |
| Yang, J | 1 |
| Cai, Y | 1 |
| Yao, DB | 2 |
| Qiu, LW | 6 |
| Zong, L | 1 |
| Lu, YY | 1 |
| Huang, H | 1 |
| Wu, W | 6 |
| Wu, XH | 5 |
| Yu, HB | 2 |
| Shen, JJ | 2 |
| Wang, YL | 2 |
| Piscaglia, AC | 1 |
| Shupe, TD | 1 |
| Pani, G | 1 |
| Tesori, V | 1 |
| Gasbarrini, A | 1 |
| Jiang, H | 1 |
| Li, YM | 2 |
| Gu, WJ | 2 |
| Shen, YC | 1 |
| Sai, WL | 3 |
| Taha, MM | 1 |
| Abdul, AB | 1 |
| Abdullah, R | 1 |
| Ibrahim, TA | 1 |
| Abdelwahab, SI | 1 |
| Mohan, S | 1 |
| Bian, YZ | 1 |
| Zhang, CG | 1 |
| Yang, JL | 1 |
| Valentin-Severin, I | 1 |
| Le Hegarat, L | 1 |
| Lhuguenot, JC | 1 |
| Le Bon, AM | 1 |
| Chagnon, MC | 1 |
| Sánchez, A | 1 |
| Nagy, P | 1 |
| Thorgeirsson, SS | 1 |
| PIROZYNSKI, WJ | 1 |
| VON BERTALANFFY, L | 1 |
| MOSONYI, M | 1 |
| KORPASSY, B | 1 |
| RUTMAN, RJ | 3 |
| CANTAROW, A | 3 |
| PASCHKIS, KE | 3 |
| MORI, K | 1 |
| ICHII, S | 1 |
| NAGASE, K | 1 |
| HARUNO, K | 1 |
| MORRIS, HP | 4 |
| JABARA, AG | 1 |
| CHENG, YS | 1 |
| CHIANG, CM | 1 |
| YAO, T | 1 |
| González de Mejía, E | 1 |
| Ramírez-Mares, MV | 1 |
| Arce-Popoca, E | 1 |
| Wallig, M | 1 |
| Lemmer, ER | 1 |
| Vessey, CJ | 1 |
| Gelderblom, WC | 1 |
| Shephard, EG | 1 |
| Van Schalkwyk, DJ | 1 |
| Van Wijk, RA | 1 |
| Marasas, WF | 1 |
| Kirsch, RE | 1 |
| Hall, Pde L | 1 |
| Hoogervorst, EM | 1 |
| van Oostrom, CT | 1 |
| Beems, RB | 1 |
| van Benthem, J | 1 |
| Gielis, S | 1 |
| Vermeulen, JP | 1 |
| Wester, PW | 1 |
| Vos, JG | 1 |
| de Vries, A | 1 |
| van Steeg, H | 1 |
| Su, XQ | 1 |
| Zou, L | 1 |
| Meng, XY | 1 |
| Borbath, I | 1 |
| Leclercq, I | 1 |
| Moulin, P | 1 |
| Sempoux, C | 1 |
| Horsmans, Y | 1 |
| Williams, GM | 2 |
| Iatropoulos, MJ | 1 |
| Jeffrey, AM | 1 |
| Duan, JD | 1 |
| Perrone, CE | 1 |
| Miki, A | 1 |
| Yano, Y | 1 |
| Kato, H | 1 |
| Seo, Y | 1 |
| Kuriyama, M | 1 |
| Azuma, T | 1 |
| Hayashi, Y | 1 |
| Tatematsu, M | 1 |
| Ho, RH | 1 |
| Kaku, T | 1 |
| Ekem, JK | 1 |
| Farber, E | 6 |
| Emmelot, P | 1 |
| Scherer, E | 1 |
| Blackburn, GR | 1 |
| Andrews, JP | 1 |
| Custer, RP | 1 |
| Sorof, S | 1 |
| Noda, K | 2 |
| Ando, K | 1 |
| Numa, Y | 1 |
| Tsubota, W | 1 |
| Oda, M | 1 |
| Esaki, T | 1 |
| Okita, K | 2 |
| Takemoto, T | 2 |
| Sell, S | 4 |
| Ruoslahti, E | 1 |
| Maeura, Y | 1 |
| Weisburger, JH | 1 |
| Shoji, Y | 1 |
| Kaneda, K | 1 |
| Wake, K | 1 |
| Mishima, Y | 1 |
| Kurokawa, F | 1 |
| Duverger-van Bogaert, M | 1 |
| Dierickx, PJ | 1 |
| Crutzen, MC | 1 |
| Chen, JJ | 1 |
| Darroudi, F | 1 |
| Meijers, CM | 1 |
| Hadjidekova, V | 1 |
| Natarajan, AT | 1 |
| Hsu, JD | 1 |
| Hsu, CL | 1 |
| Chou, FP | 1 |
| Wen, PH | 1 |
| Wang, CJ | 1 |
| Kauffmann, HM | 2 |
| Schrenk, D | 2 |
| Sherwood, AL | 1 |
| Holmes, EH | 1 |
| Gariboldi, M | 1 |
| Pascale, R | 1 |
| Manenti, G | 1 |
| De Miglio, MR | 1 |
| Calvisi, D | 1 |
| Carru, A | 1 |
| Dragani, TA | 1 |
| Feo, F | 1 |
| Stål, P | 1 |
| Wang, GS | 1 |
| Olsson, JM | 1 |
| Eriksson, LC | 1 |
| Monte, MJ | 1 |
| Palomero, F | 1 |
| Sainz, GR | 1 |
| Domínguez, M | 1 |
| Díez, M | 1 |
| Toraño, A | 1 |
| Marin, JJ | 1 |
| Yusuf, AT | 1 |
| Vian, L | 1 |
| Sabatier, R | 1 |
| Cano, JP | 1 |
| Gil-Benso, R | 1 |
| Martinez-Lorente, A | 1 |
| Pellin-Perez, A | 1 |
| Navarro-Fos, S | 1 |
| Gregori-Romero, MA | 1 |
| Carda, C | 1 |
| Callaghan, R | 1 |
| Peydro-Olaya, A | 1 |
| Llombart-Bosch, A | 1 |
| Valentin, I | 1 |
| Philippe, M | 1 |
| Lhuguenot, J | 1 |
| Chagnon, M | 1 |
| Vorderstemann, B | 1 |
| Feinstein, RN | 2 |
| Fry, RJ | 1 |
| Cameron, EC | 1 |
| Peraino, C | 1 |
| Fiala, S | 1 |
| Mohindru, A | 1 |
| Kettering, WG | 1 |
| Fiala, AE | 1 |
| Solt, DB | 1 |
| Medline, A | 1 |
| Cameron, R | 2 |
| Kellen, J | 1 |
| Kolin, A | 1 |
| Malkin, A | 1 |
| Laishes, BA | 1 |
| Becker, FF | 4 |
| Wolman, SR | 1 |
| Asofsky, R | 1 |
| Leffert, HL | 1 |
| Watabe, L | 1 |
| Hiasa, Y | 2 |
| Ohshima, M | 1 |
| Ohmori, T | 1 |
| Murata, Y | 1 |
| Shurgin, A | 1 |
| Pliss, GB | 1 |
| Khudoley, VV | 1 |
| Silber, D | 1 |
| Checinska, E | 1 |
| Rabczynski, J | 1 |
| Kochman, M | 1 |
| Reuber, MD | 2 |
| Ingleton, PM | 1 |
| Hancock, MP | 1 |
| Tret'iakov, AV | 1 |
| Mukhlenov, AG | 1 |
| Gurkalo, VK | 1 |
| Kozuka, S | 1 |
| Sassa, R | 1 |
| Sweeney, GD | 1 |
| Jones, K | 1 |
| Lee, G | 1 |
| Matsushima, T | 1 |
| Sugimura, T | 1 |
| Lindahl, R | 2 |
| Rubenchik, BL | 1 |
| Romanenko, AM | 1 |
| Fukumoto, Y | 1 |
| Ivanov, SD | 1 |
| Dzhioev, FK | 1 |
| Lin, JC | 1 |
| Evans, MJ | 1 |
| Kovacs, CJ | 1 |
| Armuth, V | 1 |
| Berenblum, I | 1 |
| Nishizumi, M | 1 |
| Albert, RE | 1 |
| Burns, FJ | 1 |
| Bilger, L | 1 |
| Toh, YC | 1 |
| Merritt, WD | 2 |
| Richardson, CL | 1 |
| Keenan, TW | 2 |
| Morré, DJ | 2 |
| Stout, DL | 1 |
| Sato, K | 1 |
| Takaya, S | 1 |
| Imai, F | 1 |
| Hatayama, I | 1 |
| Ito, N | 1 |
| Kovi, J | 1 |
| Kovi, E | 1 |
| Rao, MS | 1 |
| Levin, W | 1 |
| Lu, AY | 1 |
| Thomas, PE | 1 |
| Ryan, D | 1 |
| Kizer, DE | 1 |
| Griffin, MJ | 1 |
| Lombardi, B | 1 |
| Shinozuka, H | 1 |
| Fullerton, FR | 1 |
| Greenman, DL | 1 |
| Bucci, TJ | 1 |
| Gerlyng, P | 1 |
| Grotmol, T | 1 |
| Erikstein, B | 1 |
| Stokke, T | 1 |
| Seglen, PO | 2 |
| Li, H | 1 |
| Lee, GH | 1 |
| Liu, J | 1 |
| Nomura, K | 1 |
| Ohtake, K | 1 |
| Kitagawa, T | 1 |
| Melhem, MF | 1 |
| Kazanecki, ME | 1 |
| Rao, KN | 1 |
| Kunz, HW | 1 |
| Gill, TJ | 1 |
| Saeter, G | 1 |
| Schwarze, PE | 1 |
| Adamson, RH | 1 |
| Rudo, K | 1 |
| Meyers, WC | 1 |
| Dauterman, W | 1 |
| Langenbach, R | 1 |
| Herren-Freund, SL | 1 |
| Pereira, MA | 1 |
| Hirota, N | 1 |
| Yokoyama, T | 1 |
2 reviews available for 2-acetylaminofluorene and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
The first relevant cell stage in rat liver carcinogenesis. A quantitative approach.
Topics: 2-Acetylaminofluorene; Animals; Basophils; Carcinoma, Hepatocellular; Dimethylnitrosamine; Dose-Resp | 1980 |
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; | 1976 |
106 other studies available for 2-acetylaminofluorene and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; ATP Binding Cassette Transporter, Subfamily B, Me | 2002 |
Chronic Administration of Diethylnitrosamine and 2-Acetylaminofluorene Induces Hepatocellular Carcinoma in Wistar Rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; L | 2023 |
Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Antimetabolites, Antineoplastic; Asialoglycoprotein Receptor; Carcin | 2019 |
Investigation of the Effects of Octreotide Agent on Oxidative Stress, 8-Hydroxy Deoxyguanosine in Experimental Hepatic Carcinogenesis Rat Model.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Hormonal; Carcin | 2020 |
Enrichment of progenitor cells by 2-acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2021 |
The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; Din | 2022 |
Novel mutations in transthyretin gene associated with hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Apolipoprotein A-I; Biomarkers, Tumor; Carcinom | 2018 |
Identification of (Z)-2,3-Diphenylacrylonitrileas Anti-Cancer Molecule in Persian Gulf Sea Cucumber Holothuria parva.
Topics: 2-Acetylaminofluorene; Acrylonitrile; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chr | 2017 |
Abnormal expression of
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Hepatocellular; | 2018 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Evaluation of hydro-alcoholic extract of Eclipta alba for its multidrug resistance reversal potential: an in vitro study.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cass | 2013 |
Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, N | 2013 |
MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, CD; Blotting, Western; Carcinogenesis; Carcinogens; Carcin | 2016 |
Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Apop | 2016 |
miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology.
Topics: 2-Acetylaminofluorene; Adenoviridae; Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Mov | 2016 |
Mitochondrial carnitine palmitoyl transferase-II inactivity aggravates lipid accumulation in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogenesis; C | 2017 |
Abnormal expression of insulin-like growth factor-II and its dynamic quantitative analysis at different stages of hepatocellular carcinoma development.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, N | 2008 |
[The effect of thalidomine-induced NF-kappa B activation on malignant transformation of hepatocytes].
Topics: 2-Acetylaminofluorene; Angiogenesis Inhibitors; Animals; Carcinoma, Hepatocellular; Immunohistochemi | 2009 |
Establishment of cancer cell lines from rat hepatocholangiocarcinoma and assessment of the role of granulocyte-colony stimulating factor and hepatocyte growth factor in their growth, motility and survival.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Move | 2009 |
Quantitative analysis of hepatic hypoxia-inducible factor-1alpha and its abnormal gene expression during the formation of hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Transformation, Neopl | 2009 |
Characteristics of hepatic nuclear-transcription factor-kappa B expression and quantitative analysis in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, N | 2009 |
Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet).
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Carc | 2010 |
Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Blotting, Western; Carcinoma, Hepatocellular; Cel | 2011 |
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet As | 2003 |
STAT-3 activity in chemically-induced hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Antineoplastic Agents, Hormonal; Blotting, Northe | 2003 |
Ribonucleic acid in cytoplasm of liver cells; its localization in hyperplasia and hepatoma produced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Carcinoma, Hepatocellular; Cytoplasm; Hepatocytes; Hyperplasia; Liver; Liver | 1952 |
Rapid production of malignant hepatomas by simultaneous administration of tannic acid and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Tannins | 1953 |
Studies in 2-acetylaminofluorene carcinogenesis. II. The in vitro uptake of alanine-1-C14 by preneoplastic liver and hepatoma mitochondrial protein.
Topics: 2-Acetylaminofluorene; Alanine; Carcinogenesis; Carcinoma, Hepatocellular; Fluorenes; In Vitro Techn | 1954 |
Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasm | 1954 |
Catalase and uricase studies on rats during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Catalase; En | 1954 |
Asparaginase activity in tissues of the rats fed with carcinogens, p-dimethylaminoazobenzene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Animals; Asparaginase; Carcinogens; Carcinoma, Hepatocellula | 1954 |
Hepatocarcinogenesis by 2-acetylaminofluorene and related compounds including comments on dietary and other influences.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Fluorenes; Gonadal Steroid H | 1955 |
Utilization of uracil by acetylaminofluorene-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Liver Neoplas | 1955 |
A COMPARISON OF THE PATHOLOGICAL EFFECTS OF 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOBIPHENYL, AND 2-ACETYLAMINOBIPHENYL IN THE DOG.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Biphenyl Compounds; Carcinogens; Carcinoma, | 1963 |
[THE EFFECTS OF DIET AND DOSAGE OF CARCINOGEN ON THE INDUCTION OF LIVER TUMORS IN RATS FED 2-ACETYLAMINOFLUORENE].
Topics: 2-Acetylaminofluorene; Carcinogens; Carcinoma, Hepatocellular; Diet; Fluorenes; Liver Neoplasms; Neo | 1965 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Ca | 2004 |
Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Carcinogens; Carcinogens, Environmental; Carcin | 2004 |
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Crosses, Geneti | 2004 |
Dynamic alteration of telomerase expression and its diagnostic significance in liver or peripheral blood for hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adult; Aged; Animals; Carcinoma, Hepatocellular; Female; Gene Expression Regu | 2006 |
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Carcinogens; | 2007 |
Inhibition by acetaminophen of neoplastic initiation elicited in rat liver by the DNA-reactive hepatocarcinogen N-acetyl-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Hepato | 2007 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Disease Models, Animal; Ep | 1984 |
Early events during liver carcinogenesis involving two carcinogen:protein complexes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cytosol; Ethionine; Female; | 1981 |
[Study on epoxide hydrolase in rat hyperplastic nodule and hepatoma during chemical hepatocarcinogenesis induced by 2-acetylaminofluorene (author's transl)].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Epoxide Hydrolases; Fluorescent Antibody | 1982 |
Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fibronectins; Glycopr | 1982 |
Simultaneous inhibition of liver carcinogenicity and enhancement of bladder carcinogenicity of N-2-fluorenylacetamide by butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Carcinoma; Carcinoma, Hepatocellular; Coca | 1983 |
Light and electron microscopic analysis of liver sinusoids during hepatocarcinogenesis with 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Mal | 1994 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Mutagenic activation of aromatic amines by a human hepatoma cell (Hep G2) supernatant tested by means of Salmonella typhimurium strains with different acetyltransferase activities.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Benzidines; Biotransformation; Carcinoma, Hepato | 1995 |
Global tests for analysis of multiple tumour data from animal carcinogenicity experiments.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens; Carci | 1996 |
Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric pro
Topics: 2-Acetylaminofluorene; Aneuploidy; Carcinoma, Hepatocellular; Cell Nucleus; Centromere; Colchicine; | 1996 |
Potential effect of sodium nitrite on the expression of nuclear proto-oncogenes during 2-acetyl aminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Carcinoma, Hepatocellular; Drug I | 1997 |
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene.
Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Carcinoma, Hepatocellular; Cisplatin; Clofibrate; Clo | 1998 |
Cloning and expression of the catalytic domain from rat hepatoma H35 cell GDP-fucose:GM1 alpha 1-->2fucosyltransferase, an enzyme which is activated during early stages of chemical carcinogenesis in rat liver.
Topics: 2-Acetylaminofluorene; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Carcinoma, Hepatoce | 1998 |
Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chromosome Mapping; Diethylnitrosamine; G | 1999 |
Effects of dietary iron overload on progression in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Ch | 1999 |
Bile acid secretion during rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Bile; Carcinoma, Hepatocellular; Cell Differ | 2000 |
In vitro detection of indirect-acting genotoxins in the comet assay using Hep G2 cells.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Biotransformation; Carcinog | 2000 |
Characterization of a new rat cell line established from 2'AAF-induced combined hepatocellular cholangiocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aneuploidy; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma | 2001 |
Uridine uptake inhibition as a cytotoxicity test for a human hepatoma cell line (HepG2 cells): comparison with the neutral red assay.
Topics: 2-Acetylaminofluorene; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Coloring Agents; Hepato | 2001 |
Basal expression of the rat, but not of the human, multidrug resistance protein 2 (MRP2) gene is mediated by CBF/NF-Y and Sp1 promoter-binding sites.
Topics: 2-Acetylaminofluorene; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette | 2001 |
New aldehyde dehydrogenase isozymes in chemically induced liver tumors in the rat.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Carcinoma, Hepatocellular; Ethionine; Isoe | 1976 |
Glutathione and gamma glutamyl transpeptidase in rat liver during chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Chloramphenicol; gamma-Glutamyltransferas | 1976 |
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Fluorenes; gamm | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Transfer of viable putative preneoplastic hepatocytes to the livers of syngeneic host rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; gamma-Glutamyltransferase; Liver Neoplasm | 1978 |
Sequential analysis of transplantable hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Aneuploidy; Animals; Blood Proteins; Carcinoma, Hepatocel | 1975 |
Expression of an oncodevelopmental gene product (alpha-fetoprotein) during fetal development and adult oncogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; alpha-Fetoproteins; Animals; Animals, Newborn; Carcinoma, Hepato | 1976 |
Effect of alpha-benzene hexachloride on 2-fluorenylacetamide carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hexachlorocyclohexane; Isomeri | 1978 |
Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Albumins; alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Fluorenes; | 1978 |
Concanavalin A agglutination of cells from primary hepatocellular carcinomas and hepatic nodules induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Agglutination; Animals; Carcinoma, Hepatocellular; Concanavalin A; Liver Neop | 1975 |
Tumor induction by carcinogenic agents in aquarium fish.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Adenoma, Bile Duct | 1975 |
Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fructose-Bisphosphate Aldolase; Isoenzyme | 1975 |
Influence of age and sex on carcinoma and cirrhosis of the liver in AXC strain rats ingesting 0.025% N-2-fluorenyldiacetamide.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinoma, Hepatocellular; Diet; Female; Fluorenes; Liv | 1975 |
Pituitary growth hormone and somatotrophs in rats bearing chemically induced hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Growth Hormone; Liver | 1976 |
[Isoenzyme composition and properties of mitochondrial monoamine oxidase in normal and neoplastic cells].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Isoenzymes; Liver | 1976 |
Acceleration of hepatocarcinogenesis of 2,7-bis(acetamido)fluorene by carbon tetrachloride and time relation of treatment.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Female; Fluorenes; | 1976 |
A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Carcinoma, H | 1976 |
Various degrees of susceptibility of different stocks of rats to N-2-fluorenyldiacetamide hepatic carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hyperplasia; Liver; Liver Cirr | 1976 |
Purification and immunochemical characterization of aldehyde dehydrogenase from 2-acetylaminofluorene-induced rat hepatomas.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Carcinoma, Hepatocellular; Immunodiffusion | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplas | 1976 |
[Binding of 2-acetylaminofluorene-9-14C with rat liver nucleic acids during malignization and in primary hepatomas].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; DNA, Neoplasm; Fluorenes; Liver; Liver Ne | 1977 |
Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Endoplasmic Reticulum | 1977 |
Properties of the H-4-II-E tumor cell system. I. Growth and cell proliferation kinetics of an experimental hepatoma.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Survival; | 1977 |
Aldehyde dehydrogenase in 2-acetamidofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Animals, Newborn; Carcinoma, Hepatocellula | 1977 |
Possible two-stage transplacental liver carcinogenesis in C57BL/6 mice.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Female; Fluorenes; Liver Neoplasms; Male; | 1977 |
Hepatic cell loss and proliferation induced by N-2-fluorenylacetamide, diethylnitrosamine, and aflatoxin B1 in relation to hepatoma induction.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosa | 1977 |
Inhibitory effect of hypothalamic lesions on liver tumor induction by N-2-fluorenylacetamide in male rats.
Topics: 2-Acetylaminofluorene; Adrenal Glands; Animals; Carcinoma, Hepatocellular; Fluorenes; Hypothalamus; | 1978 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Carcinoma, Hepatocellular; Fluorenes; G(M1) Gangli | 1978 |
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. II. Alterations in biosynthetic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cerebrosides; Fluorenes; Galactosyltransf | 1978 |
Alteration of the ability of liver microsomes to activate N-2-fluorenylacetamide to a mutagen of Salmonella typhimurium during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hydroxyacetylaminofluorene; Li | 1978 |
Different deviation patterns of carbohydrate-metabolizing enzymes in primary rat hepatomas induced by different chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbohydrate Metabolism; Carcinogens; Carcinoma, Hepatocellular; Cel | 1978 |
Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Aniline Compounds; Animals; Carcinoma, Hepat | 1978 |
Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.
Topics: 2-Acetylaminofluorene; Animals; Antigens, Neoplasm; Carcinoma, Hepatocellular; Epoxide Hydrolases; H | 1978 |
Enhancement of 2-acetylaminofluorene liver carcinogenesis in rats fed a choline-devoid diet.
Topics: 2-Acetylaminofluorene; Adenoma, Bile Duct; Animals; Bile Duct Neoplasms; Carcinoma, Hepatocellular; | 1979 |
Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Eating; Female; Foo | 1992 |
Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Division; Flow Cy | 1992 |
Low frequency of ras activation in 2-acetylaminofluorene- and 3'-methyl-4-(dimethylamino)azobenzene-induced rat hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Southern; Carcinoma, Hepatocellular; Cell Transformation, | 1991 |
Genetics and diet: synergism in hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Division; Choline; Diet; Genes; Live | 1990 |
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; | 1990 |
Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogens, Environmental; Carcinoma, Hepatocellular; C | 1989 |
Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biopsy; Biotransformation; Carcinoma, Hepatocellular; Female; Humans | 1987 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Comparative study of abnormality in glycogen storing capacity and other histochemical phenotypic changes in carcinogen-induced hepatocellular preneoplastic lesions in rats.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Iron; Liver Glycoge | 1985 |