2-acetylaminofluorene has been researched along with Cancer of Skin in 11 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mouse models that mimic the human skin cancer-prone disease xeroderma pigmentosum (XP) provide an useful experimental system with which to study the relationship between the DNA repair process of nucleotide excision repair (NER) and ultraviolet- (UV) induced skin carcinogenesis." | 2.41 | Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions. ( Burns, DK; Cheo, DL; Friedberg, EC; Meira, LB; Nahari, D; Reis, AM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MILLER, EC | 2 |
| MILLER, JA | 1 |
| ENOMOTO, M | 1 |
| RITCHIE, AC | 1 |
| SAFFIOTTI, U | 1 |
| Hoogervorst, EM | 1 |
| Bruins, W | 1 |
| Zwart, E | 1 |
| van Oostrom, CT | 1 |
| van den Aardweg, GJ | 1 |
| Beems, RB | 1 |
| van den Berg, J | 1 |
| Jacks, T | 1 |
| van Steeg, H | 2 |
| de Vries, A | 1 |
| Becker, FF | 1 |
| Dewanji, A | 1 |
| Krewski, D | 1 |
| Goddard, MJ | 1 |
| Mullenders, LH | 1 |
| Vijg, J | 1 |
| Meira, LB | 1 |
| Reis, AM | 1 |
| Cheo, DL | 1 |
| Nahari, D | 1 |
| Burns, DK | 1 |
| Friedberg, EC | 1 |
| Elejalde, BR | 1 |
| Sivak, A | 1 |
| Pozharisskiĭ, KM | 1 |
4 reviews available for 2-acetylaminofluorene and Cancer of Skin
| Article | Year |
|---|---|
Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Disease Models, Animal; DNA Repair; Genes, p53; Genetic | 2001 |
Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Biotransformation; Carcinogens; Carcinogens, Environment | 1978 |
Cocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Viral; Cocarcinogenesis; Diet; Gas | 1979 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyr | 1975 |
7 other studies available for 2-acetylaminofluorene and Cancer of Skin
| Article | Year |
|---|---|
THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cricetinae; Croton Oil; Fluorenes; Guinea Pigs; Injecti | 1964 |
Orally administered 2-acetylaminofluorene as an initiator and as a promoter in epidermal carcinogenesis in the mouse.
Topics: 2-Acetylaminofluorene; Animals; Benz(a)Anthracenes; Carcinogenesis; Croton Oil; Fluorenes; Mice; Neo | 1955 |
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; DNA Damage; Female; Genes, p53; Lymphoma; Male; Mice; M | 2005 |
Presidential address. Recent concepts of initiation and promotion in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; DNA; Humans; Intestinal Polyps; Liv | 1981 |
A Weibull model for the estimation of tumorigenic potency.
Topics: 2-Acetylaminofluorene; Aniline Compounds; Animals; Carcinogens; Death; Male; Mathematics; Models, St | 1993 |
Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Benzo(a)pyrene; Cocarcinogenesis; DNA Repair; DNA-Bin | 2000 |
In-vitro transformation of cells from patients with naevoid basal-cell-carcinoma syndrome.
Topics: 2-Acetylaminofluorene; Adult; Carcinoma, Basal Cell; Cell Transformation, Neoplastic; Child; Humans; | 1976 |