2-acetylaminofluorene has been researched along with Bladder Diseases in 1 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Feeding the chemical at levels of 8 to 86 ppm results in a dose-response related urinary bladder hyperplasia and, after 9 to 12 months, in bladder neoplasia at the higher dose levels." | 1.26 | Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals. ( Farmer, J; Frith, C; Haley, TJ; Jaques, WE; Schieferstein, G; Sprowls, RW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haley, TJ | 1 |
| Farmer, J | 1 |
| Jaques, WE | 1 |
| Frith, C | 1 |
| Sprowls, RW | 1 |
| Schieferstein, G | 1 |
1 other study available for 2-acetylaminofluorene and Bladder Diseases
| Article | Year |
|---|---|
Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 1976 |