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2-acetylaminofluorene and Bladder Diseases

2-acetylaminofluorene has been researched along with Bladder Diseases in 1 studies

2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

Research Excerpts

ExcerptRelevanceReference
" Feeding the chemical at levels of 8 to 86 ppm results in a dose-response related urinary bladder hyperplasia and, after 9 to 12 months, in bladder neoplasia at the higher dose levels."1.26Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals. ( Farmer, J; Frith, C; Haley, TJ; Jaques, WE; Schieferstein, G; Sprowls, RW, 1976)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Haley, TJ1
Farmer, J1
Jaques, WE1
Frith, C1
Sprowls, RW1
Schieferstein, G1

Other Studies

1 other study available for 2-acetylaminofluorene and Bladder Diseases

ArticleYear
Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 152, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship,

1976