2-acetylaminofluorene has been researched along with Bladder Cancer in 75 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of bladder and liver neoplasms developed in mice continuously fed 2-acetylaminofluorene (2-AAF) in a multidisciplined study conducted at the National Center for Toxicological Research (NCTR) is represented using a probit model." | 7.66 | Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously. ( Farmer, JH; Greenman, DL; Kodell, RL; Shaw, GW, 1980) |
| " Two diets used widely in toxicological and/or nutritional studies, and considered to be nutritionally adequate, were compared with respect to their influence on growth, body weight, lifespan, spontaneous neoplasia, and neoplastic responses to 2-acetylaminofluorene (2-AAF)." | 3.68 | Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet. ( Bucci, TJ; Fullerton, FR; Greenman, DL, 1992) |
| "The incidence of bladder and liver neoplasms developed in mice continuously fed 2-acetylaminofluorene (2-AAF) in a multidisciplined study conducted at the National Center for Toxicological Research (NCTR) is represented using a probit model." | 3.66 | Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously. ( Farmer, JH; Greenman, DL; Kodell, RL; Shaw, GW, 1980) |
| " Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents." | 2.39 | Role of cell proliferation in regenerative and neoplastic disease. ( Cohen, SM, 1995) |
| " The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation." | 2.38 | Cell proliferation in carcinogenesis. ( Cohen, SM; Ellwein, LB, 1990) |
| " The slopes of the dose-response curves for bladder neoplasms from 17 months through 33 months were consistently very steep, while those for liver neoplasms increased from a shallow slope at 18 months to a steep slope at 33 months." | 1.32 | Thresholds of carcinogenicity in the ED01 study. ( Waddell, WJ, 2003) |
| " Chronic dosing experiments in animal models are of interest for human risk assessment because human exposure is typically intermittent, involving repeated exposures." | 1.30 | Aromatic amine DNA adduct formation in chronically-exposed mice: considerations for human comparison. ( Beland, FA; Poirier, MC, 1997) |
| " Hence, the levels of statistical significance obtained for dose-response trends and comparisons of treated and control groups were similar using 48 animals per dose groups with B6C3 mice, or combinations of 24 animals per dose from 2 genotypes, or 12 animals per dose from the 4 hybrid genotypes." | 1.28 | Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment. ( Blackwell, BN; Gaylor, DW; Moore, GE; Wolff, GL, 1991) |
| "The two-stage clonal expansion model for a single, less-than-lifetime period of dosing is formulated and applied to the liver and bladder tumor data from the ED01 study." | 1.28 | Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data. ( Felton, RP; Kodell, RL, 1991) |
| " Each group consisted of 96 mice, except the groups of females dosed at 0 and 150 ppm, which consisted of 120 and 72 mice, respectively." | 1.28 | Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet. ( Bucci, TJ; Fullerton, FR; Greenman, DL; McCarty, CC, 1991) |
| " By using a biologically based model of two-event carcinogenesis accounting explicitly for both genotoxic and nongenotoxic proliferative effects at the cellular level, we provide a unifying explanation for the apparently disparate dose-response results observed in the urinary bladder and liver." | 1.28 | Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study. ( Cohen, SM; Ellwein, LB, 1990) |
| "However, although no bladder neoplasms occurred in rats given either BHT or FAA alone, groups fed BHT and FAA together developed bladder neoplasms in proportion to the dose of BHT." | 1.27 | Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene. ( Maeura, Y; Weisburger, JH; Williams, GM, 1984) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " There were substantial differences in the diagnoses of both tumor types by the pathologists, but the implications for detection of a dose-response relationship are important only for liver carcinomas." | 1.27 | Analysis of agreement among findings of pathologists in ED01 experiment. ( Amato, DA; Lagakos, SW, 1988) |
| " A number of mathematical dose-response models have been proposed for extrapolation purposes; we have shown how similar they can appear to one another in the range of observable response rates, yet how different they become at lower, unobservable response rates, the region of primary interest." | 1.27 | Statistical aspects of the estimation of human risks. ( Brown, CC, 1985) |
| "One element of the ED01 Study contained a group of animals that were dosed with 2-acetylaminofluorene for 9, 12, 15, 18, or 24 mo and then sacrificed at 18 or 24 mo." | 1.27 | Influence of total dose and dose rate in carcinogenicity studies. ( Gaylor, DW; Littlefield, NA, 1985) |
| "The sequential morphogenesis of bladder tumors induced in mice with 2-acetylaminofluorene were studied in order to understand better the morphogenesis of bladder tumors in humans." | 1.26 | Sequential morphogenesis of urinary bladder tumors in BALB/c mice given 2-acetylaminofluorene. ( Frith, CH; Shinohara, Y; Wiley, LD, 1982) |
| " The study design consisted of sacrifice intervals, life span, and discontinued dosing groups." | 1.26 | Effects of dose and time in a long-term, low-dose carcinogenic study. ( Farmer, JH; Gaylor, DW; Littlefield, NA; Sheldon, WG, 1980) |
| "Mild hyperplasia was retained in a portion of each population and the prevalence of this hyperplasia was dependent on both the period of exposure and the dose of 2-AAF." | 1.26 | Effects of continuous and discontinued exposure to 2-AAF on urinary bladder hyperplasia and neoplasia. ( Farmer, JH; Greenman, DL; Littlefield, NA; Sheldon, WG, 1980) |
| " Although a pronounced dose-response for time-to-tumor was expressed for both bladder and liver neoplasms, the time required for death from either neoplasm following its appearance was not dose-related." | 1.26 | Estimation of distributions of time to appearance of tumor and time to death from tumor after appearance in mice fed 2-acetylaminofluorene. ( Farmer, JH; Frith, CH; Greenman, DL; Kodell, RL, 1980) |
| " The linear dose-response relationship of tissue binding correlated well with the previously reported linear dose response curve for liver tumors but did not correlated with the reported non-linear dose response curve for bladder tumors." | 1.26 | Tissue binding of 2-acetylaminofluorene in BAlB/c and C57Bl/6 mice during chronic oral administration. ( Jackson, CD; Shellenberger, TE; Weis, C, 1980) |
| "Bladder cancer was also present in rats administered the sequence of FANFT, 2-FAA, and 3,3'-DCB." | 1.26 | Summation effect of N-butyl-n-(4-hydroxybutyl)nitrosamine, N-(4-(5-nitro-2-furyl)-2-thiazoly)formamide, N-2-fluoroenylacetamide, and 3,3'-dichlorobenzidine on urinary bladder carcinogenesis in rats. ( Hananouchi, M; Hirose, M; Miyata, Y; Mizutani, M; Tatematsu, M, 1977) |
| " Feeding the chemical at levels of 8 to 86 ppm results in a dose-response related urinary bladder hyperplasia and, after 9 to 12 months, in bladder neoplasia at the higher dose levels." | 1.26 | Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals. ( Farmer, J; Frith, C; Haley, TJ; Jaques, WE; Schieferstein, G; Sprowls, RW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (62.67) | 18.7374 |
| 1990's | 19 (25.33) | 18.2507 |
| 2000's | 8 (10.67) | 29.6817 |
| 2010's | 1 (1.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sone, M | 1 |
| Toyoda, T | 1 |
| Cho, YM | 1 |
| Akagi, JI | 1 |
| Matsushita, K | 1 |
| Mizuta, Y | 1 |
| Morikawa, T | 1 |
| Nishikawa, A | 1 |
| Ogawa, K | 1 |
| FOULDS, L | 1 |
| Oyasu, R | 4 |
| Sumie, H | 1 |
| Burg, HE | 1 |
| BIELSCHOWSKY, F | 1 |
| Waddell, WJ | 1 |
| Crump, KS | 1 |
| Clewell, HJ | 1 |
| Andersen, ME | 1 |
| Conolly, RB | 1 |
| Gaylor, DW | 5 |
| DUNNING, WF | 2 |
| CURTIS, MR | 2 |
| JABARA, AG | 1 |
| MELICOW, MM | 1 |
| USON, AC | 1 |
| PRICE, TD | 1 |
| MILLER, EC | 1 |
| MILLER, JA | 1 |
| ENOMOTO, M | 1 |
| Hoogervorst, EM | 3 |
| van Oostrom, CT | 2 |
| Beems, RB | 2 |
| van Benthem, J | 1 |
| Gielis, S | 1 |
| Vermeulen, JP | 1 |
| Wester, PW | 1 |
| Vos, JG | 1 |
| de Vries, A | 3 |
| van Steeg, H | 3 |
| MAUN, ME | 1 |
| Zhang, Z | 1 |
| Sun, J | 1 |
| Sun, L | 1 |
| Bruins, W | 2 |
| Zwart, E | 1 |
| van den Aardweg, GJ | 1 |
| van den Berg, J | 1 |
| Jacks, T | 1 |
| Jonker, MJ | 1 |
| Bruning, O | 1 |
| Pennings, JL | 1 |
| Schaap, MM | 1 |
| Breit, TM | 1 |
| Williams, GM | 3 |
| Maeura, Y | 3 |
| Weisburger, JH | 3 |
| Schut, HA | 1 |
| Daniel, FB | 1 |
| Schenck, KM | 1 |
| Loeb, TR | 1 |
| Stoner, GD | 1 |
| Ito, N | 4 |
| Fukushima, S | 3 |
| Shirai, T | 2 |
| Nakanishi, K | 2 |
| Hagiwara, A | 2 |
| Tamano, S | 2 |
| Shinohara, Y | 2 |
| Frith, CH | 5 |
| Greenman, DL | 8 |
| Althoff, J | 1 |
| Chesterman, FC | 1 |
| Wiley, LD | 1 |
| Carlborg, FW | 1 |
| Farmer, JH | 6 |
| Shaw, GW | 2 |
| Littlefield, NA | 5 |
| Sheldon, WG | 2 |
| Kodell, RL | 4 |
| Kakizoe, T | 1 |
| Komatsu, H | 1 |
| Niijima, T | 1 |
| Kawachi, T | 1 |
| Sugimura, T | 1 |
| Rowland, RG | 1 |
| Jackson, CD | 1 |
| Weis, C | 1 |
| Shellenberger, TE | 1 |
| Poirier, MC | 6 |
| Beland, FA | 7 |
| Cohen, SM | 5 |
| Ellwein, LB | 4 |
| Devidas, M | 1 |
| George, EO | 1 |
| Zelterman, D | 2 |
| Tanaka, H | 1 |
| Imaida, K | 2 |
| Chen, JJ | 1 |
| Zhang, H | 1 |
| Lin, SS | 1 |
| Hung, CF | 1 |
| Tyan, YS | 1 |
| Yang, CC | 1 |
| Hsia, TC | 1 |
| Yang, MD | 1 |
| Chung, JG | 1 |
| Sivak, A | 1 |
| Anichkov, NM | 1 |
| Jull, JW | 1 |
| Pozharisskiĭ, KM | 1 |
| Tomatis, L | 1 |
| Tatematsu, M | 1 |
| Miyata, Y | 1 |
| Mizutani, M | 1 |
| Hananouchi, M | 1 |
| Hirose, M | 2 |
| Haley, TJ | 1 |
| Farmer, J | 1 |
| Jaques, WE | 1 |
| Frith, C | 1 |
| Sprowls, RW | 1 |
| Schieferstein, G | 1 |
| Matsumoto, M | 2 |
| Hopp, ML | 2 |
| Flanagan, MJ | 1 |
| Ekbal, S | 1 |
| Coogan, PS | 1 |
| Kalin, G | 1 |
| Hass, GM | 1 |
| Cueto, C | 1 |
| Davis, AK | 1 |
| Medlock, K | 1 |
| Manning, DJ | 1 |
| Fullerton, FR | 2 |
| Bucci, TJ | 2 |
| Wolff, GL | 1 |
| Blackwell, BN | 1 |
| Moore, GE | 1 |
| Tanaka, T | 1 |
| Maruyama, H | 1 |
| Zang, E | 1 |
| Felton, RP | 1 |
| McCarty, CC | 1 |
| Fullerton, NF | 4 |
| Kinouchi, T | 3 |
| Smith, BA | 3 |
| Marques, MM | 1 |
| Melchior, WB | 1 |
| Chiang, CL | 1 |
| Conforti, PM | 1 |
| Amato, DA | 1 |
| Lagakos, SW | 1 |
| Wang, CY | 1 |
| Zukowski, K | 1 |
| Lee, MS | 1 |
| Boothe, A | 1 |
| Kodell, R | 1 |
| Tsuda, H | 1 |
| Ogiso, T | 1 |
| Brown, CC | 1 |
9 reviews available for 2-acetylaminofluorene and Bladder Cancer
| Article | Year |
|---|---|
DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; DNA Adducts; Female; Incidence | 1994 |
Use of cell proliferation data in modeling urinary bladder carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; FANFT; Female; Humans; Male; Models | 1993 |
Role of cell proliferation in regenerative and neoplastic disease.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Humans; Regeneration; Risk Assessment; S | 1995 |
Cocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Viral; Cocarcinogenesis; Diet; Gas | 1979 |
[Experimental replication of bladder tumors. Morphologic features of early stages of their development].
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; Animals; Butylhydroxybutylnitrosamine; Cell Membrane; Cell T | 1979 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyr | 1975 |
Cell proliferation and bladder tumor promotion.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Cell Division; FANFT; Male; Models, Biologica | 1991 |
Cell proliferation in carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Humans; Liver; Liver Neoplasms; Mice; Mi | 1990 |
Metabolic activation of aromatic amine carcinogens in vitro and in vivo.
Topics: 2-Acetylaminofluorene; Acetylation; Amines; Animals; Biotransformation; Carcinogens; Cytochrome P-45 | 1989 |
66 other studies available for 2-acetylaminofluorene and Bladder Cancer
| Article | Year |
|---|---|
Immunohistochemistry of γ-H2AX as a method of early detection of urinary bladder carcinogenicity in mice.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Early Detection of Cancer; Histones; Immunohistoc | 2019 |
The structure and progression of vesical tumours induced in mice by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Abdominal Cavity; Animals; Disease Progression; Mice; Neoplasms; Tissues; Uri | 1950 |
Neoplasms of urinary bladders of hamsters treated with 2-acetylaminofluorene and indole.
Topics: 2-Acetylaminofluorene; Animals; Animals, Newborn; Carcinogens; Carcinoma, Transitional Cell; Criceti | 1970 |
The carcinogenic action of 2-acetylaminofluorene and related compounds.
Topics: 2-Acetylaminofluorene; Carcinogens; Fluorenes; Humans; Neoplasms; Urinary Bladder Neoplasms | 1946 |
Thresholds of carcinogenicity in the ED01 study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Dose-Response Relationship, Drug | 2003 |
Evidence of a "clear and consistent threshold" for bladder and liver cancer in the large ED01 carcinogenicity study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Data Interpretation, Statistical | 2003 |
Thresholds of carcinogenicity in the ED01 study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Data Interpretation, Statistical | 2003 |
The role of dietary tryptophane in the incidence of 2-acetylaminofluorene-induced bladder cancer in rats.
Topics: 2-Acetylaminofluorene; Animals; Diet; Fluoresceins; Incidence; Rats; Tryptophan; Urinary Bladder Neo | 1955 |
A COMPARISON OF THE PATHOLOGICAL EFFECTS OF 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOBIPHENYL, AND 2-ACETYLAMINOBIPHENYL IN THE DOG.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Biphenyl Compounds; Carcinogens; Carcinoma, | 1963 |
BLADDER TUMOR INDUCTION IN RATS FED 2-ACETAMIDOFLUORENE (2-AAF) AND A PYRIDOXINE-DEFICIENT DIET.
Topics: 2-Acetylaminofluorene; Carcinogens; Diet; Fluorenes; Liver; Liver Cirrhosis; Liver Cirrhosis, Experi | 1964 |
THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cricetinae; Croton Oil; Fluorenes; Guinea Pigs; Injecti | 1964 |
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Division; Crosses, Geneti | 2004 |
The effect of added dietary tryptophane on the occurrence of 2-acetylaminofluorene-induced liver and bladder cancer in rats.
Topics: 2-Acetylaminofluorene; Animals; Diet; Liver; Neoplasms; Rats; Tryptophan; Urinary Bladder Neoplasms | 1950 |
Statistical analysis of current status data with informative observation times.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Carcinogens; Computer Simulation; Female; Lun | 2005 |
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; DNA Damage; Female; Genes, p53; Lymphoma; Male; Mice; M | 2005 |
Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Gene Expression Regulation, Neoplastic; Gene | 2007 |
Simultaneous inhibition of liver carcinogenicity and enhancement of bladder carcinogenicity of N-2-fluorenylacetamide by butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Carcinoma; Carcinoma, Hepatocellular; Coca | 1983 |
Metabolism and DNA adduct formation of 2-acetylaminofluorene by bladder explants from human, dog, monkey, hamster and rat.
Topics: 2-Acetylaminofluorene; Acetylation; Animals; Biotransformation; Cricetinae; DNA; Dogs; Humans; Hydro | 1984 |
Dose-dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Dose-Response Relationship, Drug; Drug Ant | 1984 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Correlation of urothelial morphologic characteristics with the development of bladder carcinomas in BALB/c female mice administered 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cystitis; Female; Hyperplasia; Lymphocytes; Metaplasia; Mice; Mice, | 1982 |
Tumours of the urinary bladder, renal pelvis, ureter and urethra.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cricetinae; Diethylstilbestrol; Humans; Kidney Neoplasm | 1982 |
Sequential morphogenesis of urinary bladder tumors in BALB/c mice given 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Transitional Cell; Epithelium; Female; Mice; Mice, Inbred | 1982 |
2-acetylaminofluorene and the Weibull model.
Topics: 2-Acetylaminofluorene; Animals; Asbestos; Dose-Response Relationship, Drug; Humans; Mice; Models, Th | 1981 |
Biologic and morphologic characteristics of urinary bladder neoplasms induced in BALB/c female mice with 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Female; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasms, E | 1980 |
The ED01 study: summary and conclusions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Dose-Response Relationship, Drug; Life Expectancy; Live | 1980 |
Effects of dose and time in a long-term, low-dose carcinogenic study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Dose-Response Relationship, Drug; Female; Liver Neoplas | 1980 |
Effects of continuous and discontinued exposure to 2-AAF on urinary bladder hyperplasia and neoplasia.
Topics: 2-Acetylaminofluorene; Animals; Drug Administration Schedule; Female; Hyperplasia; Mice; Mice, Inbre | 1980 |
Dose and time responses models for the incidence of bladder and liver neoplasms in mice fed 2-acetylaminofluorene continuously.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Mice; Mic | 1980 |
Analysis of life-shortening effects in female BALB/C mice fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Diet; Female; Life Expectancy; Liver Neoplasms; Mice; Mice, Inbred B | 1980 |
Estimation of distributions of time to appearance of tumor and time to death from tumor after appearance in mice fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Female; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasms, Exper | 1980 |
Increased agglutinability of bladder cells by concanavalin A after administration of carcinogens.
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; Benzidines; Carcinogens; Cell Aggregation; Concanavalin A; C | 1980 |
Permeability of heterotopic and homotopic rat urinary bladders to water, sodium and a carcinogenic aromatic amine.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Female; Permeability; Rats; Sodium; T | 1980 |
Tissue binding of 2-acetylaminofluorene in BAlB/c and C57Bl/6 mice during chronic oral administration.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Female; Liver; Liver Neoplasms; Mice; Mice, In | 1980 |
Generalized logistic models for low-dose response data.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Logistic Models; Mice; Ris | 1993 |
Correlation between medium-term multi-organ carcinogenesis bioassay data and long-term observation results in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Butylated Hydroxyanisole; Carcinogenicity Tests; Carcin | 1993 |
Global tests for analysis of multiple tumour data from animal carcinogenicity experiments.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens; Carci | 1996 |
Aromatic amine DNA adduct formation in chronically-exposed mice: considerations for human comparison.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; DNA Adducts; DNA Repair; Human | 1997 |
Binary regression for risks in excess of subject-specific thresholds.
Topics: 2-Acetylaminofluorene; Animals; Biometry; Carcinogens; Drug Tolerance; Female; Humans; Liver Neoplas | 1999 |
Ellagic [correction of ellagica] acid inhibits arylamine N-acetyltransferase activity and DNA adduct formation in human bladder tumor cell lines (T24 and TSGH 8301).
Topics: 2-Acetylaminofluorene; 4-Aminobenzoic Acid; Antineoplastic Agents, Phytogenic; Arylamine N-Acetyltra | 2001 |
The effect of time on the incidence of carcinomas obtained by the implantation of paraffin wax pellets into mouse bladder.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma; Female; Mice; Naphthols; Neoplasms, Experimental; Paraffi | 1979 |
Validity and limitations of long-term experimentation in cancer research.
Topics: 2-Acetylaminofluorene; Amines; Animals; Bis(Chloromethyl) Ether; Carcinogens, Environmental; Dichlor | 1977 |
Summation effect of N-butyl-n-(4-hydroxybutyl)nitrosamine, N-(4-(5-nitro-2-furyl)-2-thiazoly)formamide, N-2-fluoroenylacetamide, and 3,3'-dichlorobenzidine on urinary bladder carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; 3,3'-Dichlorobenzidine; Animals; Benzidines; Biliary Tract Diseases; Butylhyd | 1977 |
Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, | 1976 |
Effect of pair-feeding of carcinogen on the incidence of bladder tumors in hamsters. Role of indole, age, and sex.
Topics: 2-Acetylaminofluorene; Administration, Oral; Age Factors; Animals; Carcinoma; Cricetinae; Diet; Fema | 1976 |
Tryptophan urinary bladder absorption and bladder cancer.
Topics: 2-Acetylaminofluorene; Absorption; Animals; Carbon Isotopes; Disease Models, Animal; Humans; Neoplas | 1975 |
Chronic dose-response studies in mice fed 2-AAF.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Female; Fluoren | 1975 |
Heterotopic urinary bladder with a communicating reservoir.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Disease Models, Animal; Drug Evaluation, Preclinical; E | 1976 |
Effects of diet type on incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in BALB/c mice fed AIN-76A diet versus NIH-07 diet.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Eating; Female; Foo | 1992 |
Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma; Female; Genotype; Liver Neoplasms, Experimental; Male; Mi | 1991 |
Modulation by butylated hydroxytoluene of liver and bladder carcinogenesis induced by chronic low-level exposure to 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Butylated Hydroxytoluene; Dose-Response Relationship, D | 1991 |
Two-stage and Weibull models for carcinogenesis applied to the ED01 discontinued dosing data.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Female; Liver Neoplasms; Mice; Models | 1991 |
Increased incidence of spontaneous and 2-acetylaminofluorene-induced liver and bladder tumors in B6C3F1 mice fed AIN-76A diet versus NIH-07 diet.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Eating; Energy Intake; Female; Growth; Liver Neop | 1991 |
Comparison between DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adenoma; Animals; Autoradiography; Carcinoma; Chromatography, High Pressure L | 1991 |
DNA adduct formation in relation to tumorigenesis in mice continuously administered 4-aminobiphenyl.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; Deoxyguanosine; DNA; DNA Damag | 1990 |
DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Deoxyguanosine; DNA; DNA Damage; Dose-Response | 1990 |
Proliferative and genotoxic cellular effects in 2-acetylaminofluorene bladder and liver carcinogenesis: biological modeling of the ED01 study.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Data Interpretation, Statistical; DNA; Dose-Response Re | 1990 |
A survival model and estimation of time to tumor.
Topics: 2-Acetylaminofluorene; Animals; Female; Humans; Mice; Models, Biological; Neoplasms; Stochastic Proc | 1989 |
DNA adduct formation during continuous feeding of 2-acetylaminofluorene at multiple concentrations.
Topics: 2-Acetylaminofluorene; Animals; DNA; Dose-Response Relationship, Drug; Female; Liver Neoplasms, Expe | 1988 |
Analysis of agreement among findings of pathologists in ED01 experiment.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms, Experimen | 1988 |
Production of urothelial tumors in the heterotopic bladder of rats by instillation of N-glucuronosyl or N-acetyl derivatives of N-hydroxy-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Epithelium; Fluorenes; Glucuronates; Hydroxyacetylaminofluorene; Mal | 1987 |
Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice.
Topics: 2-Acetylaminofluorene; Aging; Animals; Body Weight; Environment; Female; Liver Neoplasms; Liver Neop | 1987 |
Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Interactio | 1987 |
Statistical aspects of the estimation of human risks.
Topics: 2-Acetylaminofluorene; Carcinogens; Environmental Pollution; Humans; Liver Neoplasms; Models, Biolog | 1985 |
Influence of total dose and dose rate in carcinogenicity studies.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Liver Neo | 1985 |