2-acetylaminofluorene has been researched along with Aging in 16 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine if the absorption, distribution, metabolism, or elimination of 2-AAF was altered by the age of the animals, diet, or 2-AAF treatment, pharmacokinetic studies were conducted on young (11 weeks) and old (78 weeks) BALB/c mice that had been fed one of four diets containing 4 or 24% fat and 12 or 24% protein." | 1.27 | Dietary and age influence on the pharmacokinetic parameters of 2-acetylaminofluorene in BALB/c mice. ( Norvell, MJ; Young, JF, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Young, JF | 1 |
| Norvell, MJ | 1 |
| Robertson, IG | 1 |
| Birnbaum, LS | 1 |
| Shaddock, JG | 2 |
| Feuers, RJ | 2 |
| Chou, MW | 2 |
| Pegram, RA | 1 |
| Casciano, DA | 2 |
| Wang, YJ | 1 |
| Ho, YS | 1 |
| Lo, MJ | 1 |
| Lin, JK | 1 |
| Hammerl, R | 1 |
| Kirchner, T | 1 |
| Neumann, HG | 1 |
| Poole, TW | 1 |
| Parke, DV | 1 |
| Yerokun, T | 1 |
| Norton, TR | 1 |
| Howell, B | 1 |
| Ringer, DP | 1 |
| Hasegawa, R | 1 |
| Takahashi, S | 1 |
| Imaida, K | 1 |
| Yamaguchi, S | 1 |
| Shirai, T | 1 |
| Ito, N | 1 |
| Mullaart, E | 1 |
| Boerrigter, ME | 1 |
| Lohman, PH | 1 |
| Vijg, J | 1 |
| Pero, RW | 1 |
| Seidegård, J | 1 |
| Miller, DG | 1 |
| Törnquist, S | 1 |
| Sundin, M | 1 |
| Möller, L | 1 |
| Gustafsson, JA | 1 |
| Toftgård, R | 1 |
| Probst, GS | 1 |
| Hill, LE | 1 |
| Greenman, DL | 1 |
| Boothe, A | 1 |
| Kodell, R | 1 |
| Lindholm, L | 1 |
| Bryngelsson, T | 1 |
| Pero, R | 1 |
| Sugioka, Y | 1 |
| Fujii-Kuriyama, Y | 1 |
| Kitagawa, T | 1 |
| Muramatsu, M | 1 |
16 other studies available for 2-acetylaminofluorene and Aging
| Article | Year |
|---|---|
Dietary and age influence on the pharmacokinetic parameters of 2-acetylaminofluorene in BALB/c mice.
Topics: 2-Acetylaminofluorene; Aging; Animals; Diet; Dietary Fats; Dietary Proteins; Half-Life; Intestinal A | 1984 |
Age-related changes in mutagen activation by rat tissues.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Aging; Animals; Biotransformation; Female; Fluorene | 1982 |
Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aging; Animals; Dimethylnitro | 1993 |
Evidence that DNA repair may not be modified by age or chronic caloric restriction.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aging; Animals; Aroclors; Chl | 1993 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA D | 1995 |
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma | 1994 |
Effects of age, inducing agents and carcinogens on the distribution of cytochrome P-450 in microsomal membranes from rat liver.
Topics: 2-Acetylaminofluorene; Aging; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Male; Methylchol | 1978 |
Modulation of hepatic mRNA translation activity and specific expression of arylsulfotransferase IV during acetylaminofluorene-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Arylsulfotransferase; Cytosol; Female; Liver; Liver Neoplasms | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Age-related induction and disappearance of carcinogen-DNA-adducts in livers of rats exposed to low levels of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Aging; Animals; Chromatography, Gel; DNA; Female; Kinetics; Liver; Phosphorus | 1989 |
Development of biochemical markers sensitive to ecogenetic variation and their use in assessing risk from genotoxic exposures.
Topics: 2-Acetylaminofluorene; Aging; DNA Repair; Genetic Markers; Glutathione Transferase; Humans; Mutagens | 1986 |
Age dependent expression of cytochrome P-450b and metabolism of the potent carcinogen 2-nitrofluorene in the rat lung.
Topics: 2-Acetylaminofluorene; Aging; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Female; Fluorene | 1988 |
Influence of age, sex and strain on the in vitro induction of unscheduled DNA synthesis in rat hepatocyte primary cultures.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cells, Cultured; DNA Repair; Female; Liver; Male; Methylnitro | 1987 |
Age-dependent responses to 2-acetylaminofluorene in BALB/c female mice.
Topics: 2-Acetylaminofluorene; Aging; Animals; Body Weight; Environment; Female; Liver Neoplasms; Liver Neop | 1987 |
Hypertension, age, and smoking related to genotoxic sensitivity in human lymphocytes: a population study.
Topics: 2-Acetylaminofluorene; Aged; Aging; Blood Pressure; Cardiovascular Diseases; DNA; Humans; Hypertensi | 1986 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |