2-acetylaminofluorene has been researched along with Abnormalities, Autosome in 17 studies
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 ppm dosage in drinking water in a defined model of a two-stage experimental rat hepatocarcinogenesis." | 1.33 | Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Saralaya, MG, 2006) |
| " Therefore, ciprofloxacin is considered to be safe for therapeutic use." | 1.31 | Ciprofloxacin: in vivo genotoxicity studies. ( Ahr, HJ; Brendler-Schwaab, SY; Herbold, BA, 2001) |
| "The frequencies of chromosomal aberrations (CA) and sister-chromatid exchanges (SCE) in Chinese hamster cells were significantly increased by the direct-acting mutagen N-nitroso-2-acetylaminofluorene (N-NO-AAF) at the concentration of 0." | 1.28 | Chromosomal aberrations and sister-chromatid exchanges induced by N-nitroso-2-acetylaminofluorene and their modifications by arsenite and selenite in Chinese hamster ovary cells. ( Lin, JK; Tseng, SF, 1992) |
| "Nineteen rearanged chromosomes were in hepatoma 8994, whereas only 8-10 markers could be found in the 80 +/- 3 chromosome complement of hepatoma 7316A." | 1.26 | Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines. ( Kovi, E; Kovi, J; Morris, HP; Rao, MS, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takashima, R | 1 |
| Takasawa, H | 1 |
| Kawasako, K | 1 |
| Ohyama, W | 1 |
| Okada, E | 1 |
| Narumi, K | 1 |
| Fujiishi, Y | 1 |
| Wako, Y | 1 |
| Yasunaga, K | 1 |
| Hattori, A | 1 |
| Kawabata, M | 1 |
| Nakadate, K | 1 |
| Nakagawa, M | 1 |
| Hamada, S | 1 |
| Chakraborty, T | 1 |
| Chatterjee, A | 1 |
| Saralaya, MG | 1 |
| Dhachinamoorthi, D | 1 |
| Chatterjee, M | 2 |
| Rodrigues, AS | 1 |
| Silva, ID | 1 |
| Caria, MH | 1 |
| Laires, A | 1 |
| Chaveca, T | 1 |
| Glatt, HR | 1 |
| Rueff, J | 1 |
| Armstrong, MJ | 1 |
| Galloway, SM | 1 |
| Saha, BK | 1 |
| Bishayee, A | 1 |
| Kanjilal, NB | 1 |
| Herbold, BA | 1 |
| Brendler-Schwaab, SY | 1 |
| Ahr, HJ | 1 |
| Hitachi, PM | 1 |
| Yamada, K | 1 |
| Takayama, S | 1 |
| Kovi, J | 1 |
| Kovi, E | 1 |
| Morris, HP | 1 |
| Rao, MS | 1 |
| Pero, RW | 1 |
| Mitelman, F | 1 |
| Popescu, NC | 1 |
| Turnbull, D | 1 |
| DiPaolo, JA | 1 |
| Takehisa, S | 2 |
| Wolff, S | 2 |
| Lin, JK | 1 |
| Tseng, SF | 1 |
| Casciano, DA | 1 |
| Talaska, G | 1 |
| Clive, D | 1 |
| Schaaper, RM | 1 |
| Koffel-Schwartz, N | 1 |
| Fuchs, RP | 1 |
| Tanaka, T | 1 |
| Kuniyasu, T | 1 |
| Shima, H | 1 |
| Sugie, S | 1 |
| Mori, H | 1 |
| Takahashi, M | 1 |
| Hirono, I | 1 |
| Braithwaite, I | 1 |
| Ashby, J | 1 |
17 other studies available for 2-acetylaminofluorene and Abnormalities, Autosome
| Article | Year |
|---|---|
Evaluation of a repeated dose liver micronucleus assay in rats treated with two genotoxic hepatocarcinogens, dimethylnitrosamine and 2-acetylaminofluorene: the possibility of integrating micronucleus tests with multiple tissues into a repeated dose genera
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Bone Marrow; Carcinogens; Chromosome Aberratio | 2015 |
Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chromosome Aberra | 2006 |
Genotoxicity assessment of aromatic amines and amides in genetically engineered V79 cells.
Topics: 2-Acetylaminofluorene; Animals; Anthracenes; Biotransformation; Cell Line; Chromosome Aberrations; C | 1994 |
Micronuclei induced in peripheral blood of E mu-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Benzene; Chromosome Aberrations; Diethylnitros | 1993 |
1Alpha,25-dihydroxyvitamin D3 inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Carcinogenicity Tests; Carcinogens; Chromosome Aberrat | 2001 |
Ciprofloxacin: in vivo genotoxicity studies.
Topics: 2-Acetylaminofluorene; Animals; Area Under Curve; Bone Marrow Cells; Chromosome Aberrations; Ciprofl | 2001 |
Cytologic changes induced in rat livers cells by short-term exposure to chemical substances.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Butanes; Carcinogens; Chromosome Aberrations; DDT; Dieth | 1975 |
Chromosome banding patterns and breakpoints of three transplantable hepatomas induced in rats by aromatic amines.
Topics: 2-Acetylaminofluorene; Amines; Aminobiphenyl Compounds; Aniline Compounds; Animals; Carcinoma, Hepat | 1978 |
Another approach to in vivo estimation of genetic damage in humans.
Topics: 2-Acetylaminofluorene; Chromosome Aberrations; DNA; DNA Repair; Humans; Lymphocytes; Mutagens | 1979 |
Sister chromatid exchange and chromosome aberration analysis with the use of several carcinogens and noncarcinogens.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acridines; Benzop | 1977 |
The induction of sister-chromatid exchanges in Chinese hamster ovary cells by prolonged exposure to 2-acetylaminofluorene and S-9 mix.
Topics: 2-Acetylaminofluorene; Cell Line; Chromosome Aberrations; Chromosomes; Crossing Over, Genetic; Fluor | 1978 |
Sister-chromatid exchanges induced in rabbit lymphocytes by 2-aminofluorene and 2-acetylaminofluorene after in vitro and in vivo metabolic activation.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cells, Cultured; Chromosome Aberrations; Chromoso | 1978 |
Chromosomal aberrations and sister-chromatid exchanges induced by N-nitroso-2-acetylaminofluorene and their modifications by arsenite and selenite in Chinese hamster ovary cells.
Topics: 2-Acetylaminofluorene; Animals; Arsenic; Arsenites; Cell Cycle; CHO Cells; Chromosome Aberrations; C | 1992 |
The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chromosome Aberrations; Colony-Forming Units Assay; Dim | 1991 |
N-acetoxy-N-acetyl-2-aminofluorene-induced mutagenesis in the lacI gene of Escherichia coli.
Topics: 2-Acetylaminofluorene; Bacterial Proteins; Base Sequence; Chromosome Aberrations; Chromosome Deletio | 1990 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
A non-invasive micronucleus assay in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Nucleus; Chromosome Aberrations; Hepatectomy; Live | 1988 |