2,5-hexanedione has been researched along with Nervous System Disorders in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (64.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, S; Lehning, EJ; LoPachin, RM; Mansukhani, S; Reid, ML; Ross, JF | 1 |
| Song, F; Xie, K; Yu, L; Yu, S; Zhang, C; Zhao, X | 1 |
| Mendell, JR; Sahenk, Z | 1 |
| Iwasaki, K; Tsuruta, H | 1 |
| Abou-Donia, MB | 1 |
| Anthony, DC; Boekelheide, K; Graham, DG; Maschmann, NA; Richards, RG; Shaw, BR; Wolfram, JW | 1 |
| Couri, D; Milks, M | 1 |
| DeCaprio, AP; Olajos, EJ; Weber, P | 1 |
| Pellegrino, RG; Politis, MJ; Spencer, PS | 1 |
| Griffin, JW; Price, DL | 1 |
| Takeuchi, Y | 1 |
| Duncan, ID; Jacobs, JM; King, RH; Muddle, JR; Sarsilmaz, M; Thomas, PK | 1 |
| Hisanaga, N; Iwata, M; Ono, Y; Saito, I; Shibata, E; Takeuchi, Y | 1 |
| Csanády, GA; Dietz, W; Filser, JG; Kessler, W; Kreuzer, PE; Richter, M; Störmer, A | 1 |
| Batoréu, MC; dos Santos, AP; Mateus, ML | 1 |
| Bastone, A; Frontali, N; Mallozzi, C; Monaco, E; Sbraccia, M; Settimi, L; Siracusa, G | 1 |
| De Rojas, TC; Goldstein, BD | 1 |
| Autilio-Gambetti, L; Gambetti, P; Sayre, LM | 1 |
| Anthony, DC; Graham, DG; St Clair, MB; Wikstrand, CJ | 1 |
| LoPachin, RM; Medrano, CJ | 1 |
| Aldridge, WN | 1 |
| Bertoli, E; Fiorini, RM; Governa, M; Rocco, M; Valentino, M; Zolese, G | 1 |
| Braendgaard, H; Sidenius, P | 1 |
| Cunningham, VJ; Planas, AM | 1 |
| Anthony, DC; Boekelheide, K; Gottfried, MR; Graham, DG; Szakál-Quin, G | 1 |
4 review(s) available for 2,5-hexanedione and Nervous System Disorders
| Article | Year |
|---|---|
Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione.
Topics: Animals; Biotransformation; Drug Synergism; Hexanes; Hexanones; Humans; Ketones; Lethal Dose 50; Methyl n-Butyl Ketone; Nervous System Diseases; Occupational Diseases; Rats; Solvents | 1982 |
n-hexane polyneuropathy in Japan: a review of n-hexane poisoning and its preventive measures.
Topics: Animals; Hexanes; Hexanones; Humans; Japan; Nervous System Diseases; Occupational Exposure; Poisoning | 1993 |
Pathogenesis of experimental giant neurofilamentous axonopathies: a unified hypothesis based on chemical modification of neurofilaments.
Topics: Animals; Axonal Transport; Axons; Chickens; Cytoskeleton; Disease Models, Animal; Glyceraldehyde-3-Phosphate Dehydrogenases; Hexanones; Humans; In Vitro Techniques; Intermediate Filament Proteins; Intermediate Filaments; Mice; Nervous System Diseases; Neurofilament Proteins; Nitriles; Phosphorylation; Pyrroles; Rats | 1985 |
The biological basis and measurement of thresholds.
Topics: Acrylamides; Animals; Carcinogens; Chemical Phenomena; Chemistry; Environmental Pollutants; Hexanones; Humans; Mutagens; Nervous System Diseases; Organophosphorus Compounds; Poisons | 1986 |
1 trial(s) available for 2,5-hexanedione and Nervous System Disorders
| Article | Year |
|---|---|
Comparative estimation of the neurotoxic risks of N-hexane and N-heptane in rats and humans based on the formation of the metabolites 2,5-hexanedione and 2,5-heptanedione.
Topics: Administration, Inhalation; Adult; Animals; Body Burden; Cross-Linking Reagents; Half-Life; Heptanes; Hexanes; Hexanones; Humans; Ketones; Male; Nervous System Diseases; Pyrroles; Rats; Rats, Wistar; Risk Assessment | 1996 |
20 other study(ies) available for 2,5-hexanedione and Nervous System Disorders
| Article | Year |
|---|---|
Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione.
Topics: Acrylamide; Animals; Axons; Hexanones; Hindlimb; Male; Nervous System Diseases; Neurologic Examination; Rats; Rats, Sprague-Dawley | 2002 |
Time-dependent alteration of cytoskeletal proteins in cerebral cortex of rat during 2,5-hexanedione-induced neuropathy.
Topics: Animals; Cerebral Cortex; Cytoskeletal Proteins; Hexanones; Male; Nervous System Diseases; Neurotoxins; Rats; Rats, Wistar; Time Factors | 2007 |
Studies on the morphologic alterations of axonal membraneous organelles in neurofilamentous neuropathies.
Topics: Animals; Axonal Transport; Axons; Cell Membrane; Endoplasmic Reticulum; Hexanones; Male; Microscopy, Electron; Nervous System Diseases; Nitriles; Organoids; Rats; Rats, Inbred Strains; Tibial Nerve | 1983 |
Molecular mechanism of hexane neuropathy: significant differences in pharmacokinetics between 2.3-, 2.4-, and 2.5-hexanedione.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Hexanes; Hexanones; Ketones; Kinetics; Male; Nervous System Diseases; Rats; Rats, Inbred Strains; Tissue Distribution | 1984 |
Interaction between neurotoxicities induced by organophosphorus and long-chain hexacarbon compounds.
Topics: Animals; Chickens; Drug Synergism; Female; Glycols; Hexanes; Hexanones; Insecticides; Ketones; Methyl n-Butyl Ketone; Nervous System Diseases; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester | 1983 |
Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking.
Topics: Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Hexanes; Hexanones; Lysine; Nervous System Diseases; Pyrroles | 1982 |
Covalent binding of a neurotoxic n-hexane metabolite: conversion of primary amines to substituted pyrrole adducts by 2,5-hexanedione.
Topics: Amines; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chickens; Chromogenic Compounds; Female; Hexanes; Hexanones; Ketones; Nervous System Diseases; Proteins; Pyrroles | 1982 |
Ultrastructural studies of the dying-back process. V. Axonal neurofilaments accumulate at sites of 2,5-hexanedione application: evidence for nerve fibre dysfunction in experimental hexacarbon neuropathy.
Topics: Animals; Axons; Cytoskeleton; Glycols; Hexanones; Ketones; Male; Myelin Sheath; Nervous System Diseases; Organoids; Rats; Schwann Cells; Sciatic Nerve | 1980 |
Demyelination in experimental beta, beta'-iminodipropionitrile and hexacarbon neuropathies. Evidence for an axonal influence.
Topics: Animals; Axons; Demyelinating Diseases; Hexanones; Nervous System Diseases; Nitriles; Rats | 1981 |
Axonal neurofilamentous accumulations: a comparison between human and canine giant axonal neuropathy and 2,5-HD neuropathy.
Topics: Animals; Axons; Child; Child, Preschool; Dogs; Hexanones; Humans; Immunohistochemistry; Intermediate Filaments; Male; Microscopy, Electron; Nervous System Diseases; Rats; Species Specificity; Sural Nerve | 1993 |
Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene.
Topics: Adhesives; Adolescent; Animals; Drug Interactions; Environmental Monitoring; Female; Hexanes; Hexanones; Humans; Nervous System Diseases; Occupational Diseases; Occupational Exposure; Rats; Toluene | 1993 |
Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure.
Topics: Administration, Oral; Animals; Biomarkers; Dose-Response Relationship, Drug; Drug Interactions; Hexanones; Injections, Intraperitoneal; Male; Nervous System Diseases; Neurotoxins; Pyrroles; Rats; Rats, Wistar; Zinc Acetate | 2001 |
Effects of 2,5-hexanedione on the ovary and fertility. An experimental study in mice.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Electromyography; Female; Fertility; Hexanones; Male; Mice; Microscopy; Nervous System Diseases; Ovary; Time Factors | 1992 |
Lack of evidence for the size principle of selective vulnerability of axons in toxic neuropathies. I. The effects of subcutaneous injections of 2,5-hexanedione on behavior and muscle spindle function.
Topics: Animals; Axons; Behavior, Animal; Cats; Dose-Response Relationship, Drug; Female; Hexanones; Ketones; Male; Muscle Spindles; Nervous System Diseases; Neurons, Afferent | 1990 |
Neurofilament protein crosslinking in gamma-diketone neuropathy: in vitro and in vivo studies using the seaworm myxicola infundibulum.
Topics: Alkylation; Animals; Axons; Cross-Linking Reagents; Cytoskeleton; Hexanones; Immunohistochemistry; Intermediate Filaments; Ketones; Nerve Tissue Proteins; Nervous System Diseases; Polychaeta | 1989 |
Effects of acrylamide and 2,5-hexanedione on brain mitochondrial respiration.
Topics: Acrylamide; Acrylamides; Animals; Brain; Hexanones; In Vitro Techniques; Ketones; Male; Mitochondria; Nervous System Diseases; Oxygen Consumption; Random Allocation; Rats; Rats, Inbred Strains | 1989 |
Modification of erythrocyte membrane fluidity in rats exposed to 2,5-hexanedione.
Topics: Animals; Erythrocyte Membrane; Hexanones; Ketones; Membrane Fluidity; Nervous System Diseases; Rats; Rats, Inbred Strains | 1987 |
Anterograde components of axonal transport in motor and sensory nerves in experimental 2,5-hexanedione neuropathy.
Topics: Animals; Axons; Biological Transport; Fucose; Hexanones; In Vitro Techniques; Leucine; Male; Methionine; Movement; Nervous System; Nervous System Diseases; Rats; Rats, Inbred Strains; Sensation; Time Factors | 1986 |
Uncoupling of cerebral glucose supply and utilization after hexane-2,5-dione intoxication in the rat.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Glucose; Hexanones; Ketones; Male; Nervous System Diseases; Rats | 1987 |
Covalent crosslinking of neurofilaments in the pathogenesis of n-hexane neuropathy.
Topics: Acrylamide; Acrylamides; Animals; Axons; Carbon Disulfide; Chemical Phenomena; Chemistry; Hexanones; Intermediate Filament Proteins; Intermediate Filaments; Ketones; Nervous System Diseases; Neurofilament Proteins; Nitriles; Rats | 1985 |