Page last updated: 2024-10-27

2,5-dihydroxybenzoic acid and Reperfusion Injury

2,5-dihydroxybenzoic acid has been researched along with Reperfusion Injury in 14 studies

2,5-dihydroxybenzoic acid: RN given refers to parent cpd; a oxidative product of saligenin
2,5-dihydroxybenzoic acid : A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
"Preexisting hyperglycemia is associated with enhanced reperfusion injury in the postischemic rat brain."1.30Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion. ( Huang, NC; Quast, MJ; Wei, J, 1997)
"Preischemic hyperglycemia is known to aggravate brain damage resulting from transient ischemia."1.30Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia. ( Floyd, RA; He, QP; Li, PA; Liu, GJ; Siesjö, BK, 1999)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (78.57)18.2507
2000's0 (0.00)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Song, E1
Ramos, SV1
Huang, X1
Liu, Y1
Botta, A1
Sung, HK1
Turnbull, PC1
Wheeler, MB1
Berger, T1
Wilson, DJ1
Perry, CGR1
Mak, TW1
Sweeney, G1
Arab, HA1
Walker, NI1
Cheung, K1
Hickman, PE1
Potter, JM1
Kadkhodaee, M1
Roberts, MS1
Yang, ZJ1
Xie, Y1
Bosco, GM1
Chen, C1
Camporesi, EM1
Delbarre, B2
Delbarre, G2
Calinon, F2
Ophir, A1
Berenshtein, E1
Kitrossky, N3
Berman, ER1
Photiou, S1
Rothman, Z1
Chevion, M3
Hu, D1
Feng, YP1
Lancelot, E1
Callebert, J1
Revaud, ML1
Boulu, RG1
Plotkine, M1
Obata, T1
Wei, J1
Huang, NC1
Quast, MJ1
Li, PA1
Liu, GJ1
He, QP1
Floyd, RA2
Siesjö, BK1
Zager, RA1
Gmur, DJ1
Schimpf, BA1
Bredl, CR1
Foerder, CA1
Udassin, R2
Ariel, I1
Haskel, Y2
Arieli, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Enriched Oxygen Mixtures and Exercise on Oxidative Stress and Stem Cells Proliferation in Athletes.[NCT04366427]Phase 242 participants (Actual)Interventional2020-09-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

14 other studies available for 2,5-dihydroxybenzoic acid and Reperfusion Injury

ArticleYear
Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 02-13, Volume: 115, Issue:7

    Topics: Animals; Gentisates; Hydroxybenzoates; Iron; Lipocalin-2; Male; Mice; Mice, Knockout; Mitochondria;

2018
Free radical scavengers improve liver function but not morphological changes induced by reperfusion injury.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2015, Volume: 28, Issue:2

    Topics: Acetylcysteine; Animals; Aspartate Aminotransferases; Chromans; Disease Models, Animal; Female; Free

2015
Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release.
    European journal of applied physiology, 2010, Volume: 108, Issue:3

    Topics: Animals; Blood Pressure; Brain; Brain Injuries; Gentisates; Glutamates; Hydroxybenzoates; Hydroxyl R

2010
Action of trimetazidine on retina of gerbils after ischemia reperfusion insult: determination of .OH, amino acids, and electroretinogram.
    Annals of the New York Academy of Sciences, 1994, Nov-17, Volume: 738

    Topics: Amino Acids; Animals; Aspartic Acid; Electroretinography; Female; gamma-Aminobutyric Acid; Gentisate

1994
Hydroxyl radical generation in the cat retina during reperfusion following ischemia.
    Experimental eye research, 1993, Volume: 57, Issue:3

    Topics: Animals; Cats; Eye Proteins; Free Radicals; Gentisates; Hydroxybenzoates; Reactive Oxygen Species; R

1993
[HPLC--detection of hydroxyl radicals in striatum extracellular fluid in rats subjected to reperfusion after cerebral ischemia and the action of vitamin E].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:5

    Topics: Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Corpus Striatum; Extracellular Space;

1993
Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: possible implication in tissue damage.
    Neuroscience letters, 1995, Sep-08, Volume: 197, Issue:2

    Topics: Analysis of Variance; Animals; Cerebral Infarction; Corpus Striatum; Disease Models, Animal; Gentisa

1995
Use of microdialysis for in-vivo monitoring of hydroxyl free-radical generation in the rat.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:7

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Electric Stimulation; Gentisates; Hydrogen Per

1997
Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion.
    Free radical biology & medicine, 1997, Volume: 23, Issue:7

    Topics: Animals; Arterial Occlusive Diseases; Cerebral Arteries; Cerebral Infarction; Enzyme Inhibitors; Gen

1997
Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia.
    Free radical biology & medicine, 1999, Volume: 27, Issue:9-10

    Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Gentisates; Hydroxybenzoates; Hydroxyl Radical; Hype

1999
Evidence against increased hydroxyl radical production during oxygen deprivation-reoxygenation proximal tubular injury.
    Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:11

    Topics: Acute Kidney Injury; Animals; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl Radi

1992
Glutamate accumulation and increased hydroxyl free radical formation in the abdominal aorta and heart of gerbil after ischemia/reperfusion insult.
    Free radical biology & medicine, 1992, Volume: 13, Issue:1

    Topics: Animals; Aorta, Abdominal; Female; Free Radicals; Gentisates; Gerbillinae; Glutamates; Glutamic Acid

1992
Salicylate as an in vivo free radical trap: studies on ischemic insult to the rat intestine.
    Free radical biology & medicine, 1991, Volume: 10, Issue:1

    Topics: Animals; Disease Models, Animal; Free Radicals; Gentisates; Hydroxides; Hydroxybenzoates; Hydroxyl R

1991
Direct evidence for the involvement of free radicals in ischemic insult to the intestine.
    Free radical research communications, 1991, Volume: 12-13 Pt 2

    Topics: Animals; Disease Models, Animal; Free Radicals; Gentisates; Hydroxybenzoates; Intestines; Male; Rats

1991