2,4-thiazolidinedione has been researched along with Chemical and Drug Induced Liver Injury in 7 studies
thiazolidine-2,4-dione: structure in first source
1,3-thiazolidine-2,4-dione : A thiazolidenedione carrying oxo substituents at positions 2 and 4.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone was designed to combine tocopherol, anti-peroxidant, and thiazolidinedione." | 2.41 | [The development of thiazolidinedione drugs as anti-diabetic agents]. ( Kuzuya, T, 2000) |
| "Insulin resistance is the major defect in type 2 diabetes." | 2.41 | [Glitazones (thiazolidinedione)]. ( Ducobu, J; Sternon, J, 2000) |
| "The first thiazolidinedione derivative drug for diabetes, troglitazone, was found to cause fatal hepatotoxicity, although it was judged as safe during the clinical trial." | 2.41 | [Evaluation of thiazolidinedione derivative drugs for safety]. ( Iwata, M; Kobayashi, M, 2001) |
| "particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications." | 2.41 | Hepatotoxicity with thiazolidinediones: is it a class effect? ( Scheen, AJ, 2001) |
| "Sepsis was induced in rats by dissecting the cecum and placing the discontinued organ back into the abdomen CLP." | 1.42 | [Rosiglitazone protects against endotoxin-induced acute liver injury in rats]. ( Bu, Y; Yu, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (85.71) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bu, Y | 1 |
| Yu, J | 1 |
| Kuzuya, T | 1 |
| Kawano, M | 1 |
| Kanazawa, Y | 1 |
| Ducobu, J | 1 |
| Sternon, J | 1 |
| Kobayashi, M | 1 |
| Iwata, M | 1 |
| Scheen, AJ | 1 |
| Tolman, KG | 1 |
6 reviews available for 2,4-thiazolidinedione and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
[The development of thiazolidinedione drugs as anti-diabetic agents].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellit | 2000 |
[Diabetes mellitus].
Topics: Blood Coagulation; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Drug Therapy, | 2000 |
[Glitazones (thiazolidinedione)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Type 2; Gluconeogenesis; Humans; | 2000 |
[Evaluation of thiazolidinedione derivative drugs for safety].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Edema; Heart Fa | 2001 |
Hepatotoxicity with thiazolidinediones: is it a class effect?
Topics: Aged; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellitus, | 2001 |
Thiazolidinedione hepatotoxicity: a class effect?
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Ag | 2000 |
1 other study available for 2,4-thiazolidinedione and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
[Rosiglitazone protects against endotoxin-induced acute liver injury in rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2015 |