Page last updated: 2024-11-05

2,4-thiazolidinedione and Cardiovascular Stroke

2,4-thiazolidinedione has been researched along with Cardiovascular Stroke in 5 studies

thiazolidine-2,4-dione: structure in first source
1,3-thiazolidine-2,4-dione : A thiazolidenedione carrying oxo substituents at positions 2 and 4.

Research Excerpts

ExcerptRelevanceReference
"Over a 20-year period, patients on dapagliflozin were projected to experience relative reductions in the incidence of myocardial infarction (MI), stroke, CV death, and all-cause death of 13."3.80Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes. ( Alperin, P; Cohen, M; Dziuba, J; Goswami, D; Grossman, HL; Hardy, E; Iloeje, U; Perlstein, I; Racketa, J, 2014)
"The patients were those with type 2 diabetes mellitus hospitalized with a first MI and the controls were those with diabetes mellitus randomly selected from the same geographic area."1.33Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus. ( Berlin, JA; Cappola, AR; Kimmel, SE; Sauer, WH, 2006)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dziuba, J1
Alperin, P1
Racketa, J1
Iloeje, U1
Goswami, D1
Hardy, E1
Perlstein, I1
Grossman, HL1
Cohen, M1
Koro, CE1
Fu, Q1
Stender, M1
Frye, RL1
August, P1
Brooks, MM1
Hardison, RM1
Kelsey, SF1
MacGregor, JM1
Orchard, TJ1
Chaitman, BR1
Genuth, SM1
Goldberg, SH1
Hlatky, MA1
Jones, TL1
Molitch, ME1
Nesto, RW1
Sako, EY1
Sobel, BE1
Störk, S1
Ertl, G1
Nitschmann, S1
Sauer, WH1
Cappola, AR1
Berlin, JA1
Kimmel, SE1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes[NCT00006305]Phase 32,368 participants (Actual)Interventional2000-09-30Completed
Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645]Phase 4100 participants (Anticipated)Interventional2018-12-01Not yet recruiting
Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel[NCT01643031]Phase 4500 participants (Anticipated)Interventional2012-08-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With All-Cause Mortality

(NCT00006305)
Timeframe: five years

Interventionparticipants (Number)
Revascularization and Insulin Providing (IP)80
Revascularization and Insulin Sensitizing (IS)75
Medical Therapy and Insulin Providing (IP)80
Medical Therapy and Insulin Sensitizing (IS)81

Number of Participants With Death, Myocardial Infarction, or Stroke

(NCT00006305)
Timeframe: five years

Interventionparticipants (Number)
Revascularization and Insulin Providing (IP)145
Revascularization and Insulin Sensitizing (IS)121
Medical Therapy and Insulin Providing (IP)143
Medical Therapy and Insulin Sensitizing (IS)140

Trials

1 trial available for 2,4-thiazolidinedione and Cardiovascular Stroke

ArticleYear
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
    The New England journal of medicine, 2009, Jun-11, Volume: 360, Issue:24

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2009

Other Studies

4 other studies available for 2,4-thiazolidinedione and Cardiovascular Stroke

ArticleYear
Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes.
    Diabetes, obesity & metabolism, 2014, Volume: 16, Issue:7

    Topics: Amputation, Surgical; Benzhydryl Compounds; Blood Glucose; Blood Pressure; Body Weight; Cardiovascul

2014
An assessment of the effect of thiazolidinedione exposure on the risk of myocardial infarction in type 2 diabetic patients.
    Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:10

    Topics: Adult; Aged; Case-Control Studies; Cohort Studies; Databases, Factual; Diabetes Mellitus, Type 2; Fe

2008
[Revascularization in patients with type 2 diabetes and coronary artery disease: BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Study Group].
    Der Internist, 2010, Volume: 51, Issue:5

    Topics: Angioplasty, Balloon, Coronary; Combined Modality Therapy; Coronary Angiography; Coronary Artery Byp

2010
Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus.
    The American journal of cardiology, 2006, Mar-01, Volume: 97, Issue:5

    Topics: Adult; Aged; Case-Control Studies; Confounding Factors, Epidemiologic; Diabetes Mellitus, Type 2; Dr

2006