2,4-methanoglutamate has been researched along with Nerve Degeneration in 3 studies
2,4-methanoglutamate: structure given in first source; selective N-methyl-D-aspartate receptor agonist; inhibits high affinity L-glutamic acid uptake into rat cortical synaptosomes; RN given for (trans)-isomer
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response showed that DL-(tetrazol-5-yl)glycine was about 100 and 500 times more potent than cis-methanoglutamate and NMDA, respectively." | 1.29 | The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. ( Lunn, WH; McDonald, JW; Salhoff, CR; Schoepp, DD, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schoepp, DD | 1 |
| Lunn, WH | 1 |
| Salhoff, CR | 1 |
| McDonald, JW | 1 |
| Allan, SM | 1 |
| Lawrence, CB | 1 |
| Rothwell, NJ | 2 |
| Black, MD | 1 |
| Carey, F | 1 |
| Crossman, AR | 1 |
| Relton, JK | 1 |
3 other studies available for 2,4-methanoglutamate and Nerve Degeneration
| Article | Year |
|---|---|
The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin.
Topics: Animals; Animals, Newborn; Brain; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glut | 1994 |
Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cerebral Cortex; Chelati | 1998 |
Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat.
Topics: Animals; Annexins; Calcium-Binding Proteins; Corpus Striatum; Dizocilpine Maleate; Dose-Response Rel | 1992 |