2,4-dinitrophenol has been researched along with Weight Reduction in 9 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects." | 6.47 | 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. ( Dargan, PI; El-Zanfaly, M; Grundlingh, J; Wood, DM, 2011) |
| " 2,4-Dinitrophenol (DNP) is an oxidative phosphorylation uncoupling agent that was widely used in the early 1930s for weight loss but was quickly banned by the FDA due to the severe toxicities associated with the compound." | 4.12 | Physiologically-based pharmacokinetic model for 2,4-dinitrophenol. ( Meyer, LF; Rajadhyaksha, PM; Shah, DK, 2022) |
| "The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown." | 3.85 | Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss. ( Cowley, MA; Michael, NJ; Simonds, SE; Spanswick, D; van den Top, M, 2017) |
| "2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects." | 2.47 | 2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death. ( Dargan, PI; El-Zanfaly, M; Grundlingh, J; Wood, DM, 2011) |
| " These data indicate that dinoseb is teratogenic at maternally toxic doses, but the exposure range of dinoseb at which malformations occur seems to be narrow." | 1.36 | Prenatal developmental toxicity of gavage or feeding doses of 2-sec-butyl-4,6-dinitrophenol in rats. ( Ema, M; Fujii, S; Hirose, A; Matsumoto, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, LF | 1 |
| Rajadhyaksha, PM | 1 |
| Shah, DK | 1 |
| Sousa, D | 1 |
| Carmo, H | 1 |
| Roque Bravo, R | 1 |
| Carvalho, F | 1 |
| Bastos, ML | 1 |
| Guedes de Pinho, P | 1 |
| Dias da Silva, D | 1 |
| Michael, NJ | 1 |
| Simonds, SE | 1 |
| van den Top, M | 1 |
| Cowley, MA | 1 |
| Spanswick, D | 1 |
| Tewari, A | 1 |
| Ali, T | 1 |
| Ali, A | 1 |
| O'Donnell, J | 1 |
| O'Donnell, A | 1 |
| Butt, MS | 1 |
| Matsumoto, M | 1 |
| Fujii, S | 1 |
| Hirose, A | 1 |
| Ema, M | 1 |
| Grundlingh, J | 1 |
| Dargan, PI | 1 |
| El-Zanfaly, M | 1 |
| Wood, DM | 1 |
| McFee, RB | 2 |
| Caraccio, TR | 1 |
| McGuigan, MA | 1 |
| Reynolds, SA | 1 |
| Bellanger, P | 1 |
| Suozzi, JC | 1 |
| Rancont, CM | 1 |
| Miranda, EJ | 1 |
| McIntyre, IM | 1 |
| Parker, DR | 1 |
| Gary, RD | 1 |
| Logan, BK | 1 |
2 reviews available for 2,4-dinitrophenol and Weight Reduction
| Article | Year |
|---|---|
Diet aid or aid to die: an update on 2,4-dinitrophenol (2,4-DNP) use as a weight-loss product.
Topics: 2,4-Dinitrophenol; Anti-Obesity Agents; Diet; Dietary Exposure; Feeding Behavior; Weight Loss | 2020 |
2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death.
Topics: 2,4-Dinitrophenol; Anti-Obesity Agents; Drug Overdose; Female; Hemofiltration; Humans; Illicit Drugs | 2011 |
7 other studies available for 2,4-dinitrophenol and Weight Reduction
| Article | Year |
|---|---|
Physiologically-based pharmacokinetic model for 2,4-dinitrophenol.
Topics: 2,4-Dinitrophenol; Animals; Anti-Obesity Agents; Mice; Mice, Inbred C57BL; Obesity; Weight Loss | 2022 |
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss.
Topics: 2,4-Dinitrophenol; Adipose Tissue, Brown; Animals; Body Weight; Eating; Energy Metabolism; Male; Mel | 2017 |
Weight loss and 2,4-dinitrophenol poisoning.
Topics: 2,4-Dinitrophenol; Adult; Anti-Obesity Agents; Fatal Outcome; Female; Humans; Multiple Organ Failure | 2009 |
Prenatal developmental toxicity of gavage or feeding doses of 2-sec-butyl-4,6-dinitrophenol in rats.
Topics: 2,4-Dinitrophenol; Animals; Enteral Nutrition; Female; Fetal Weight; Fetus; Male; Musculoskeletal Ab | 2010 |
Dying to be thin: a dinitrophenol related fatality.
Topics: 2,4-Dinitrophenol; Adult; Bradycardia; Dietary Supplements; Heart Arrest; Humans; Male; Uncoupling A | 2004 |
DNP 2,4-dinitrophenol: a deadly way to lose weight.
Topics: 2,4-Dinitrophenol; Dietary Supplements; Education, Continuing; Emergency Medical Services; Humans; U | 2005 |
Two deaths attributed to the use of 2,4-dinitrophenol.
Topics: 2,4-Dinitrophenol; Adolescent; Adult; California; Fatal Outcome; Female; Humans; Male; Washington; W | 2006 |