2,4-dinitrophenol has been researched along with Obesity in 8 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sustained oral uncoupler 2,4-dinitrophenol (DNP) administration exerts prominent anti-obesity effects, but the adipose tissue off-target disadvantage leads to systemic adverse effects." | 8.31 | Non-Cardiotoxic Tetradecanoic Acid-2,4-Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti-Obesity Effect by Regulating Adipocyte Browning and Lipogenesis. ( Bao, C; Chen, S; Li, Y; Li, Z; Liang, S; Liu, B; Ren, F; Shi, W; Yan, H; Yuan, Y; Zhang, H, 2023) |
| "Sustained oral uncoupler 2,4-dinitrophenol (DNP) administration exerts prominent anti-obesity effects, but the adipose tissue off-target disadvantage leads to systemic adverse effects." | 4.31 | Non-Cardiotoxic Tetradecanoic Acid-2,4-Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti-Obesity Effect by Regulating Adipocyte Browning and Lipogenesis. ( Bao, C; Chen, S; Li, Y; Li, Z; Liang, S; Liu, B; Ren, F; Shi, W; Yan, H; Yuan, Y; Zhang, H, 2023) |
| " 2,4-Dinitrophenol (DNP) is an oxidative phosphorylation uncoupling agent that was widely used in the early 1930s for weight loss but was quickly banned by the FDA due to the severe toxicities associated with the compound." | 4.12 | Physiologically-based pharmacokinetic model for 2,4-dinitrophenol. ( Meyer, LF; Rajadhyaksha, PM; Shah, DK, 2022) |
| "The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown." | 3.85 | Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss. ( Cowley, MA; Michael, NJ; Simonds, SE; Spanswick, D; van den Top, M, 2017) |
| "In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol)." | 3.74 | Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. ( Gaster, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meyer, LF | 1 |
| Rajadhyaksha, PM | 1 |
| Shah, DK | 1 |
| Liang, S | 1 |
| Li, Z | 1 |
| Bao, C | 1 |
| Liu, B | 1 |
| Zhang, H | 2 |
| Yuan, Y | 1 |
| Yan, H | 1 |
| Chen, S | 1 |
| Shi, W | 1 |
| Ren, F | 1 |
| Li, Y | 1 |
| Michael, NJ | 1 |
| Simonds, SE | 1 |
| van den Top, M | 1 |
| Cowley, MA | 1 |
| Spanswick, D | 1 |
| Goldgof, M | 1 |
| Xiao, C | 1 |
| Chanturiya, T | 1 |
| Jou, W | 1 |
| Gavrilova, O | 1 |
| Reitman, ML | 1 |
| Zack, F | 1 |
| Blaas, V | 1 |
| Goos, C | 1 |
| Rentsch, D | 1 |
| Büttner, A | 1 |
| Ost, M | 1 |
| Keipert, S | 1 |
| Klaus, S | 1 |
| Gaster, M | 1 |
| Kurt, TL | 1 |
| Anderson, R | 1 |
| Petty, C | 1 |
| Bost, R | 1 |
| Reed, G | 1 |
| Holland, J | 1 |
1 review available for 2,4-dinitrophenol and Obesity
| Article | Year |
|---|---|
Targeted mitochondrial uncoupling beyond UCP1 - The fine line between death and metabolic health.
Topics: 2,4-Dinitrophenol; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Gene Expression Regulation | 2017 |
7 other studies available for 2,4-dinitrophenol and Obesity
| Article | Year |
|---|---|
Physiologically-based pharmacokinetic model for 2,4-dinitrophenol.
Topics: 2,4-Dinitrophenol; Animals; Anti-Obesity Agents; Mice; Mice, Inbred C57BL; Obesity; Weight Loss | 2022 |
Non-Cardiotoxic Tetradecanoic Acid-2,4-Dinitrophenol Ester Nanomicelles in Microneedles Exert Potent Anti-Obesity Effect by Regulating Adipocyte Browning and Lipogenesis.
Topics: 2,4-Dinitrophenol; Adipocytes; Animals; Dinitrophenols; Esters; Lipogenesis; Mice; Myristic Acid; Ob | 2023 |
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss.
Topics: 2,4-Dinitrophenol; Adipose Tissue, Brown; Animals; Body Weight; Eating; Energy Metabolism; Male; Mel | 2017 |
The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality.
Topics: 2,4-Dinitrophenol; Adipose Tissue, Brown; Adiposity; Animals; Body Temperature Regulation; Diet; Eat | 2014 |
Death within 44 days of 2,4-dinitrophenol intake.
Topics: 2,4-Dinitrophenol; Anti-Obesity Agents; Dizziness; Humans; Male; Middle Aged; Nausea; Obesity; Pigme | 2016 |
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes.
Topics: 2,4-Dinitrophenol; Antimycin A; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 2; Gl | 2007 |
Dinitrophenol in weight loss: the poison center and public health safety.
Topics: 2,4-Dinitrophenol; Cataract; Dinitrophenols; Humans; Jurisprudence; Obesity; Poison Control Centers; | 1986 |