2,4-dinitrophenol has been researched along with Myocardial Ischemia in 8 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to investigate the roles of loss of oxidative phosphorylation and activation of the mitochondrial ATP-sensitive K+ channel and permeability transition pore in VF development during myocardial ischemia by using mitochondrial uncoupling agents (carbonyl cyanide m-chlorophenylhydrazone and 2,4-dinitrophenol) and channel blockers (5-hydroxydecanoate and cyclosporine A) at concentrations that have been demonstrated to block the intended targets selectively." | 3.77 | Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts. ( Alderson, JM; Clements-Jewery, H; Hatcher, AS, 2011) |
| " omeiensis and puerarin on the fever induced by 2,4-dinitrophenol in rats were very fast and significant, maintaining for about 8 hours, while the effect of P." | 3.69 | [Comparative study on pharmacological effects of various species of Pueraria]. ( Chen, H; Cheng, B; Jiang, J; Su, X; Zhou, Y, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hatcher, AS | 1 |
| Alderson, JM | 1 |
| Clements-Jewery, H | 1 |
| Rainbow, RD | 1 |
| Lodwick, D | 1 |
| Hudman, D | 1 |
| Davies, NW | 1 |
| Norman, RI | 1 |
| Standen, NB | 1 |
| Hausenloy, D | 1 |
| Wynne, A | 1 |
| Duchen, M | 1 |
| Yellon, D | 1 |
| Mylotte, LA | 1 |
| Duffy, AM | 1 |
| Murphy, M | 1 |
| O'Brien, T | 1 |
| Samali, A | 1 |
| Barry, F | 1 |
| Szegezdi, E | 1 |
| Zhou, Y | 1 |
| Su, X | 1 |
| Cheng, B | 1 |
| Jiang, J | 1 |
| Chen, H | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Kuzio, B | 1 |
| Deslauriers, R | 1 |
| Tsutsumi, Y | 1 |
| Oshita, S | 1 |
| Kitahata, H | 1 |
| Kuroda, Y | 1 |
| Kawano, T | 1 |
| Nakaya, Y | 1 |
| Mejía-Alvarez, R | 1 |
| Marban, E | 1 |
8 other studies available for 2,4-dinitrophenol and Myocardial Ischemia
| Article | Year |
|---|---|
Mitochondrial uncoupling agents trigger ventricular fibrillation in isolated rat hearts.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cyclo | 2011 |
SUR2A C-terminal fragments reduce KATP currents and ischaemic tolerance of rat cardiac myocytes.
Topics: 2,4-Dinitrophenol; Action Potentials; Animals; Antimetabolites; ATP-Binding Cassette Transporters; C | 2004 |
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.
Topics: 2,4-Dinitrophenol; Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Anima | 2004 |
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Cell Differentiation; Cell Hypoxia; Cell Surviva | 2008 |
[Comparative study on pharmacological effects of various species of Pueraria].
Topics: 2,4-Dinitrophenol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinitrophenols; Drugs, Chinese | 1995 |
The effects of low-flow ischemia on K+ fluxes in isolated rat hearts assessed by 87Rb NMR.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Coronary Circulation; Energy Metabolism; Hemodyn | 1999 |
Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes.
Topics: 2,4-Dinitrophenol; Anesthetics, Intravenous; Animals; ATP-Binding Cassette Transporters; Cell Separa | 2000 |
Mechanism of the increase in intracellular sodium during metabolic inhibition: direct evidence against mediation by voltage-dependent sodium channels.
Topics: 2,4-Dinitrophenol; Animals; Antimetabolites; Calcium; Dinitrophenols; Electric Conductivity; Guinea | 1992 |