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2,4-dinitrophenol and Muscle Contraction

2,4-dinitrophenol has been researched along with Muscle Contraction in 25 studies

2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

ExcerptRelevanceReference
" We measured active stress, myosin phosphorylation, O2 consumption, and tissue ATP content in bovine tracheal smooth muscle activated by K+ depolarization when glucose was replaced by pyruvate and when oxidative metabolism was inhibited by hypoxia or uncoupled by 2,4-dinitrophenol."3.68Effects of substrate and inhibition of oxidative metabolism on contraction and myosin phosphorylation in ASM. ( Hai, CM; Kim, E; Reyes, V; Wallach, SJ; Watson, C; Xu, J, 1993)
"Dantrolene has only a small effect on these responses which are larger in predominantly slow-twitch fibre preparations."1.26Does the sarcoplasmic reticulum achieve chemiosmotic equilibrium in relaxed muscle? ( Jeacocke, R, 1982)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199014 (56.00)18.7374
1990's6 (24.00)18.2507
2000's4 (16.00)29.6817
2010's1 (4.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schlagowski, AI1
Singh, F1
Charles, AL1
Gali Ramamoorthy, T1
Favret, F1
Piquard, F1
Geny, B1
Zoll, J1
Ho, RC1
Alcazar, O1
Fujii, N2
Hirshman, MF2
Goodyear, LJ2
Ribeiro, AS1
Salerno, VP1
Sorenson, M1
Nasu, T1
Sakai, N1
Washibe, T1
Ishida, Y1
Ashoori, F1
Tomita, T1
El-Guindy, MM1
Vizioli, MR1
Gomes, CB1
Jeacocke, R1
Sunano, S1
Miyazaki, E1
Anuras, S1
Chien, SM1
Christensen, J1
Fetterer, RH1
Pax, RA1
Bennett, JL1
Sobolev, VI2
Makhsudov, MS1
Merkhelevich, LG1
Chali, G1
Rabo, G1
Dakoshta, M1
Majumdar, R1
Cwik, VA1
Solonynko, G1
Brooke, MH3
Hai, CM1
Watson, C1
Wallach, SJ1
Reyes, V1
Kim, E1
Xu, J1
Otter, D1
Austin, C1
Hayashi, T1
Habinowski, SA1
Witters, LA1
Bailey, JK1
Kindig, CA1
Behnke, BJ1
Musch, TI1
Schmid-Schoenbein, GW1
Poole, DC1
Reinstrup, P1
Uski, T1
Messeter, K1
Jackson, MJ1
Kaiser, K1
Edwards, RH1
Moore, R1
Carlson, S1
Madara, JL1
Heller, SL1
Kaiser, KK1
Choski, R1
Kajiya, H1
Sakudo, F1
Soeda, H1
Noda, K1
Nishimura, M1
Fujise, N1
Ohtani, H1
Yagasaki, O1
Lapenko, NT1
Sarikas, SN1
Chlapowski, FJ1
Hunter, EG1
Elbrink, J1

Other Studies

25 other studies available for 2,4-dinitrophenol and Muscle Contraction

ArticleYear
Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations.
    Journal of applied physiology (Bethesda, Md. : 1985), 2014, Feb-15, Volume: 116, Issue:4

    Topics: 2,4-Dinitrophenol; Adaptation, Physiological; Animals; Cell Line; Energy Metabolism; Exercise Tolera

2014
p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 286, Issue:2

    Topics: 2,4-Dinitrophenol; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line;

2004
Probing actomyosin interactions with 2,4-dinitrophenol.
    Biochimica et biophysica acta, 2005, May-15, Volume: 1748, Issue:2

    Topics: 2,4-Dinitrophenol; Actins; Actomyosin; Adenosine Triphosphate; Animals; Dose-Response Relationship,

2005
Cooling-induced contraction in ileal longitudinal smooth muscle of guinea-pig.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:5

    Topics: 2,4-Dinitrophenol; Animals; Barium; Calcium; Calcium Channel Blockers; Cold Temperature; Dinitrophen

1984
Mechanical response to noradrenaline in calcium-free solution in the rat vas deferens.
    The Journal of physiology, 1983, Volume: 338

    Topics: 2,4-Dinitrophenol; Animals; Calcium; Calmodulin; Cyclic AMP; Dinitrophenols; Egtazic Acid; Fluorides

1983
The relation between effects of 2,4-dinitrophenol and adrenalin on muscle contraction induction and phosphorylase activation.
    Cellular and molecular biology, 1984, Volume: 30, Issue:3

    Topics: 2,4-Dinitrophenol; Animals; Dinitrophenols; Enzyme Activation; Epinephrine; Kinetics; Male; Muscle C

1984
Does the sarcoplasmic reticulum achieve chemiosmotic equilibrium in relaxed muscle?
    FEBS letters, 1982, Oct-18, Volume: 147, Issue:2

    Topics: 2,4-Dinitrophenol; Anaerobiosis; Animals; Calcium; Cattle; Cyanides; Dantrolene; Dinitrophenols; Mus

1982
A comparison of the effects of temperature and metabolic inhibition on the contraction of smooth muscle.
    The Japanese journal of physiology, 1981, Volume: 31, Issue:4

    Topics: 2,4-Dinitrophenol; Action Potentials; Animals; Antimetabolites; Azides; Calcium; Dinitrophenols; Glu

1981
Metabolic dependence of the electromyogram of the cat colon.
    The American journal of physiology, 1980, Volume: 239, Issue:3

    Topics: 2,4-Dinitrophenol; Action Potentials; Animals; Cats; Cold Temperature; Colon; Dinitrophenols; Electr

1980
Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni.
    European journal of pharmacology, 1980, May-30, Volume: 64, Issue:1

    Topics: 2,4-Dinitrophenol; Animals; Calcium; Cations; Dinitrophenols; Gallopamil; Isoquinolines; Muscle Cont

1980
[The influence of 2,4-dinitrophenol on the temperature effect of muscle contraction in experimental hyperthyroidism].
    Fiziologicheskii zhurnal imeni I.M. Sechenova, 1995, Volume: 81, Issue:3

    Topics: 2,4-Dinitrophenol; Analysis of Variance; Animals; Body Temperature Regulation; Dinitrophenols; Hyper

1995
Relationship of oxypurine release to contractile failure in dinitrophenol-treated rat skeletal muscle.
    Acta physiologica Scandinavica, 1993, Volume: 149, Issue:3

    Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Dinitrophenols; Hypoxanthine; Hypoxanthines; In

1993
Effects of substrate and inhibition of oxidative metabolism on contraction and myosin phosphorylation in ASM.
    The American journal of physiology, 1993, Volume: 264, Issue:6 Pt 1

    Topics: 2,4-Dinitrophenol; Analysis of Variance; Animals; Cattle; Dinitrophenols; Glucose; Hypoxia; Isometri

1993
Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: a comparison with metabolic inhibition.
    The Journal of physiology, 1999, Apr-01, Volume: 516 ( Pt 1)

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 2,4-Dinitrophenol; Ammonium Chlo

1999
Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.
    Diabetes, 2000, Volume: 49, Issue:4

    Topics: 2,4-Dinitrophenol; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biological Transport; C

2000
Spinotrapezius muscle microcirculatory function: effects of surgical exteriorization.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:6

    Topics: 2,4-Dinitrophenol; Animals; Cell Hypoxia; Electric Stimulation; Energy Metabolism; Female; Hyperoxia

2000
Oxygen modulates contractile responses to potassium and prostaglandin F2 alpha in human pial arteries.
    British journal of anaesthesia, 1992, Volume: 68, Issue:2

    Topics: 2,4-Dinitrophenol; Adult; Aged; Cerebral Arteries; Dinitrophenols; Dinoprost; Drug Interactions; Hum

1992
Glutathione depletion during experimental damage to rat skeletal muscle and its relevance to Duchenne muscular dystrophy.
    Clinical science (London, England : 1979), 1991, Volume: 80, Issue:6

    Topics: 2,4-Dinitrophenol; Animals; Calcimycin; Calcium; Creatine Kinase; Dinitrophenols; Disease Models, An

1991
Villus contraction aids repair of intestinal epithelium after injury.
    The American journal of physiology, 1989, Volume: 257, Issue:2 Pt 1

    Topics: 2,4-Dinitrophenol; Animals; Basement Membrane; Denervation; Dinitrophenols; Epithelium; Guinea Pigs;

1989
2,4-Dinitrophenol, muscle biopsy, and McArdle's disease.
    Neurology, 1988, Volume: 38, Issue:1

    Topics: 2,4-Dinitrophenol; Animals; Biopsy; Dinitrophenols; Dose-Response Relationship, Drug; Glycogen Stora

1988
[Effects of three different metabolic inhibitors (2,4-dinitrophenol, iodoacetic acid, 2,4-fluorodinitrobenzene) on the contractility of the geniohyoid and sartorius muscles].
    Fukuoka Shika Daigaku Gakkai zasshi, 1986, Volume: 13, Issue:1

    Topics: 2,4-Dinitrophenol; Animals; Anura; Dinitrofluorobenzene; Dinitrophenols; Iodoacetates; Iodoacetic Ac

1986
Effects of hypoxia, 2,4-dinitrophenol and ouabain on twitch potentiation elicited following conditioning pulses in the mouse phrenic nerve-diaphragm preparation.
    The Journal of toxicological sciences, 1987, Volume: 12, Issue:3

    Topics: 2,4-Dinitrophenol; Animals; Diaphragm; Dinitrophenols; Hypoxia; In Vitro Techniques; Male; Mice; Mus

1987
[Phases of muscular thermogenesis in experimental hyperthyroidism].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1986, Volume: 72, Issue:3

    Topics: 2,4-Dinitrophenol; Animals; Body Temperature Regulation; Dinitrophenols; Hyperthyroidism; Muscle Con

1986
Effect of ATP inhibitors on the translocation of luminal membrane between cytoplasm and cell surface of transitional epithelial cells during the expansion-contraction cycle of the rat urinary bladder.
    Cell and tissue research, 1986, Volume: 246, Issue:1

    Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Arsenates; Arsenic; Dinitrophenols; Epithelium;

1986
Electrophysiological observations on diaphragm muscle from normal and dystrophic hamsters.
    Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:11

    Topics: 2,4-Dinitrophenol; Action Potentials; Animals; Cricetinae; Diaphragm; Dinitrophenols; Electrophysiol

1985