2,4-dinitrophenol has been researched along with Hypoxia in 36 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In all myocytes inhibition of cell metabolism, induced by hypoxia (PO2 < 5 mmHg) or by addition of 100 microM 2,4-dinitrophenol (DNP), resulted in action potential shortening, which was accompanied by an increase in outward current, likely to be carried by ATP-regulated potassium channels." | 3.69 | Biphasic response of action potential duration to metabolic inhibition in rabbit and human ventricular myocytes: role of transient outward current and ATP-regulated potassium current. ( Bouman, LN; van Ginneken, AC; Veldkamp, MW; Verkerk, AO, 1996) |
| " We measured active stress, myosin phosphorylation, O2 consumption, and tissue ATP content in bovine tracheal smooth muscle activated by K+ depolarization when glucose was replaced by pyruvate and when oxidative metabolism was inhibited by hypoxia or uncoupled by 2,4-dinitrophenol." | 3.68 | Effects of substrate and inhibition of oxidative metabolism on contraction and myosin phosphorylation in ASM. ( Hai, CM; Kim, E; Reyes, V; Wallach, SJ; Watson, C; Xu, J, 1993) |
| " To understand the underlying cellular mechanisms involved in this adaptive response, the effects of an uncoupler of oxidative phosphorylation, 2,4-dinitrophenol (DNP), and of an inhibitor of the electron transport chain, rotenone, were compared with the effect of hypoxia in L6 muscle cells and 3T3-L1 adipocytes." | 3.68 | Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells. ( Bashan, N; Burdett, E; Gumà , A; Klip, A; Liu, Z; Sargeant, R; Tumiati, L, 1993) |
| " Fluorescence was measured quantitatively under conditions stimulating flavoprotein fluorescence in cells subjected to no inhibitors (sham), to cyanide, to 2,4-dinitrophenol, and to hypoxia." | 3.66 | Sensitivity of flavoprotein fluorescence to oxidative state in single isolated heart cells. ( Koke, JR; Wills, M; Wylie, W, 1981) |
| "We report that anoxia rapidly and reversibly depolarizes the photoreceptors and induces Ca(2+) influx into these cells in the dark." | 1.31 | Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo. ( Agam, K; Ben-Ami, HC; Cook, B; Kirschfeld, K; Levy, S; Minke, B; von Campenhausen, M, 2000) |
| "While after 30 min anoxia the enzyme release still exceeded that of unstimulated control, after 60 min anoxia there was no further response to hormonal stimulation." | 1.28 | Influence of stepwise uncoupling and temporary anoxia on pancreatic enzyme secretion by isolated rat acini. ( Letko, G; Matthias, R; Pohle, T; Wilhelm, W, 1992) |
| "The effect of anoxia or 2,4-dinitrophenol (DNP) on the phosphorylase activity and the cyclic AMP and the cyclic GMP content was studied in smooth muscle preparations." | 1.27 | Influence of anoxia and dinitrophenol on the phosphorylase a activity and the cyclic nucleotide content of smooth muscle. ( Arnqvist, H; Groth, H; Lundholm, L; Pettersson, G; Wingren, G, 1983) |
| "The effect of anoxia or 2,4-dinitrophenol (DNP) on the phosphorylase a activity and the calcium content in subcellular fractions from rabbit colon smooth muscle was studied." | 1.27 | Activation of phosphorylase by anoxia and dinitrophenol in rabbit colon smooth muscle: relation to release of calcium from mitochondria. ( Pettersson, G, 1983) |
| "When isoproterenol was present in the bathing solution, the decreases in CF and APD produced by hypoxia were accelerated, but ATP and propranolol did not significantly modify the hypoxically induced changes." | 1.26 | Effects of hypoxia and metabolic inhibitors on the electrical and mechanical activities of isolated guinea pig papillary muscles. ( Asano, T; Kasuya, Y; Shigenobu, K, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (38.89) | 18.7374 |
| 1990's | 16 (44.44) | 18.2507 |
| 2000's | 3 (8.33) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vorobieva, VV | 1 |
| Shabanov, PD | 1 |
| Samaiya, PK | 1 |
| Narayan, G | 1 |
| Kumar, A | 1 |
| Krishnamurthy, S | 1 |
| Forgan, LG | 1 |
| Forster, ME | 1 |
| Tauskela, JS | 1 |
| Brunette, E | 1 |
| Monette, R | 1 |
| Comas, T | 1 |
| Morley, P | 1 |
| BEANI, L | 2 |
| GIOTTI, A | 2 |
| MOUREK, J | 1 |
| Arnqvist, H | 1 |
| Groth, H | 1 |
| Lundholm, L | 1 |
| Pettersson, G | 2 |
| Wingren, G | 1 |
| Lim, YH | 1 |
| Gould, MK | 1 |
| Shigenobu, K | 1 |
| Asano, T | 1 |
| Kasuya, Y | 1 |
| Akaike, N | 1 |
| Kiyohara, T | 1 |
| Sunano, S | 1 |
| Miyazaki, E | 1 |
| Koke, JR | 1 |
| Wylie, W | 1 |
| Wills, M | 1 |
| Anuras, S | 1 |
| Chien, SM | 1 |
| Christensen, J | 1 |
| Lazouras, K | 1 |
| Pountney, D | 1 |
| Simpson, RJ | 1 |
| Buerk, DG | 1 |
| Iturriaga, R | 2 |
| Lahiri, S | 1 |
| Hai, CM | 1 |
| Watson, C | 1 |
| Wallach, SJ | 1 |
| Reyes, V | 1 |
| Kim, E | 1 |
| Xu, J | 1 |
| Bashan, N | 1 |
| Burdett, E | 1 |
| Gumà , A | 1 |
| Sargeant, R | 1 |
| Tumiati, L | 1 |
| Liu, Z | 1 |
| Klip, A | 1 |
| Saransaari, P | 1 |
| Oja, SS | 1 |
| Verkerk, AO | 1 |
| Veldkamp, MW | 1 |
| van Ginneken, AC | 1 |
| Bouman, LN | 1 |
| Saiki, C | 1 |
| Mortola, JP | 1 |
| Nankervis, CA | 1 |
| Miller, CE | 1 |
| Otter, D | 1 |
| Austin, C | 1 |
| Alcayaga, J | 1 |
| Varas, R | 1 |
| Arroyo, J | 1 |
| Zapata, P | 1 |
| Agam, K | 1 |
| von Campenhausen, M | 1 |
| Levy, S | 1 |
| Ben-Ami, HC | 1 |
| Cook, B | 1 |
| Kirschfeld, K | 1 |
| Minke, B | 1 |
| Bailey, JK | 1 |
| Kindig, CA | 1 |
| Behnke, BJ | 1 |
| Musch, TI | 1 |
| Schmid-Schoenbein, GW | 1 |
| Poole, DC | 1 |
| Pohle, T | 1 |
| Matthias, R | 1 |
| Wilhelm, W | 1 |
| Letko, G | 1 |
| Noll, T | 1 |
| Koop, A | 1 |
| Piper, HM | 1 |
| Loeppky, JA | 1 |
| Scotto, P | 1 |
| Riedel, CE | 1 |
| Roach, RC | 1 |
| Chick, TW | 1 |
| Videla, LA | 1 |
| Meyer, M | 1 |
| Schuster, KD | 1 |
| Schulz, H | 1 |
| Mohr, M | 1 |
| Piiper, J | 1 |
| Hershenson, MB | 1 |
| O'Rourke, PP | 1 |
| Christakis, DA | 1 |
| Coopes, BJ | 1 |
| Crone, RK | 1 |
| Shoji, S | 1 |
| King, CE | 1 |
| Cain, SM | 1 |
| Nishimura, M | 1 |
| Fujise, N | 1 |
| Ohtani, H | 1 |
| Yagasaki, O | 1 |
| Ganote, CE | 1 |
| Nayler, WG | 1 |
1 review available for 2,4-dinitrophenol and Hypoxia
| Article | Year |
|---|---|
Contracture and the calcium paradox.
Topics: 2,4-Dinitrophenol; Aging; Animals; Caffeine; Calcium; Dimethyl Sulfoxide; Dinitrophenols; Freeze Fra | 1985 |
35 other studies available for 2,4-dinitrophenol and Hypoxia
| Article | Year |
|---|---|
Tissue-Specific Peculiarities of Vibration-Induced Hypoxia in Rabbit Liver and Kidney.
Topics: 2,4-Dinitrophenol; Animals; Electron Transport; Flavin-Adenine Dinucleotide; Hypoxia; Kidney; Liver; | 2019 |
2,4 Dinitrophenol Attenuates Mitochondrial Dysfunction and Improves Neurobehavioral Outcomes Postanoxia in Neonatal Rats.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Animals, Newborn; bcl-2-Associated X Protein; Ca | 2018 |
Oxygen-dependence of metabolic rate in the muscles of craniates.
Topics: 2,4-Dinitrophenol; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Energy Metabolism; F | 2010 |
Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling.
Topics: 2,4-Dinitrophenol; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Cal | 2003 |
[The effect of hypoxia, monoiodoacetate and 2-4 dinitrophenol on the heart isolated according the Langendorff method].
Topics: 2,4-Dinitrophenol; Acetates; Heart; Hypoxia; Nitrophenols | 1956 |
[The effect of hypoxia, monoiodoacetate and 2-4 dinitrophenol on the heart isolated according the Langendorff method].
Topics: 2,4-Dinitrophenol; Acetates; Heart; Hypoxia; Nitrophenols | 1956 |
[The effect of hypoxia, monoiodoacetate and 2-4 dinitrophenol on the heart isolated according the Langendorff method].
Topics: 2,4-Dinitrophenol; Acetates; Heart; Hypoxia; Nitrophenols | 1956 |
[The effect of hypoxia, monoiodoacetate and 2-4 dinitrophenol on the heart isolated according the Langendorff method].
Topics: 2,4-Dinitrophenol; Acetates; Heart; Hypoxia; Nitrophenols | 1956 |
The effect of 2,4-dinitrophenol on oxygen consumption and resistance to nitrogen anoxia during the development of the rat.
Topics: 2,4-Dinitrophenol; Animals; Dinitrophenols; Hypoxia; Nitrogen; Nitrophenols; Oxygen Consumption; Rat | 1963 |
Influence of anoxia and dinitrophenol on the phosphorylase a activity and the cyclic nucleotide content of smooth muscle.
Topics: 2,4-Dinitrophenol; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Cattle; Colon; Cyclic AMP; | 1983 |
Activation of phosphorylase by anoxia and dinitrophenol in rabbit colon smooth muscle: relation to release of calcium from mitochondria.
Topics: 2,4-Dinitrophenol; Animals; Calcium; Dinitrophenols; Egtazic Acid; Electron Transport Complex IV; En | 1983 |
ATP-dependence of 125I-insulin binding by rat soleus muscle.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Dinitrophenols; Edetic Acid; Hypoxia; In Vitro T | 1983 |
Effects of hypoxia and metabolic inhibitors on the electrical and mechanical activities of isolated guinea pig papillary muscles.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Dinitrophenols; Guinea Pigs; | 1981 |
The K+-sensitive hyperpolarization of rat skeletal muscle and metabolic inhibitors.
Topics: 2,4-Dinitrophenol; Animals; Antimetabolites; Dinitrophenols; Extremities; Hydrogen-Ion Concentration | 1981 |
A comparison of the effects of temperature and metabolic inhibition on the contraction of smooth muscle.
Topics: 2,4-Dinitrophenol; Action Potentials; Animals; Antimetabolites; Azides; Calcium; Dinitrophenols; Glu | 1981 |
Sensitivity of flavoprotein fluorescence to oxidative state in single isolated heart cells.
Topics: 2,4-Dinitrophenol; Animals; Cyanides; Dinitrophenols; Flavoproteins; Fluorescence; Heart; Hypoxia; I | 1981 |
Metabolic dependence of the electromyogram of the cat colon.
Topics: 2,4-Dinitrophenol; Action Potentials; Animals; Cats; Cold Temperature; Colon; Dinitrophenols; Electr | 1980 |
Inhibition of duodenal mucosal ferricyanide reductase.
Topics: 2,4-Dinitrophenol; Animals; Cell Membrane; Dinitrophenols; Duodenum; Hypoxia; Intestinal Mucosa; Mem | 1995 |
Testing the metabolic hypothesis of O2 chemoreception in the cat carotid body in vitro.
Topics: 2,4-Dinitrophenol; Animals; Carotid Body; Cats; Cyanides; Dinitrophenols; Electric Stimulation; Fema | 1994 |
Effects of substrate and inhibition of oxidative metabolism on contraction and myosin phosphorylation in ASM.
Topics: 2,4-Dinitrophenol; Analysis of Variance; Animals; Cattle; Dinitrophenols; Glucose; Hypoxia; Isometri | 1993 |
Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells.
Topics: 2,4-Dinitrophenol; Adaptation, Physiological; Adipose Tissue; Animals; Dinitrophenols; Energy Metabo | 1993 |
GABA release is enhanced in mouse hippocampal slices in cell-damaging conditions.
Topics: 2,4-Dinitrophenol; Animals; Brain Ischemia; Female; Free Radicals; gamma-Aminobutyric Acid; Hippocam | 1996 |
Biphasic response of action potential duration to metabolic inhibition in rabbit and human ventricular myocytes: role of transient outward current and ATP-regulated potassium current.
Topics: 2,4-Dinitrophenol; Action Potentials; Adenosine Triphosphate; Animals; Cell Membrane; Cells, Culture | 1996 |
Effect of 2,4-dinitrophenol on the hypometabolic response to hypoxia of conscious adult rats.
Topics: 2,4-Dinitrophenol; Animals; Cardiovascular System; Hypoxia; Injections; Male; Oxygen Consumption; Ra | 1997 |
Developmental differences in response of mesenteric artery to acute hypoxia in vitro.
Topics: 2,4-Dinitrophenol; Acute Disease; Aging; Animals; Animals, Newborn; Endothelium, Vascular; Enzyme In | 1998 |
Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: a comparison with metabolic inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 2,4-Dinitrophenol; Ammonium Chlo | 1999 |
Responses to hypoxia of petrosal ganglia in vitro.
Topics: 2,4-Dinitrophenol; Animals; Carotid Body; Carotid Sinus; Cats; Dopamine; Dose-Response Relationship, | 1999 |
Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium Channels; Calmodulin-Binding Proteins; D | 2000 |
Spinotrapezius muscle microcirculatory function: effects of surgical exteriorization.
Topics: 2,4-Dinitrophenol; Animals; Cell Hypoxia; Electric Stimulation; Energy Metabolism; Female; Hyperoxia | 2000 |
Influence of stepwise uncoupling and temporary anoxia on pancreatic enzyme secretion by isolated rat acini.
Topics: 2,4-Dinitrophenol; Amylases; Animals; Antineoplastic Agents; Cell Separation; Cholecystokinin; Dinit | 1992 |
Mitochondrial ATP-synthase activity in cardiomyocytes after aerobic-anaerobic metabolic transition.
Topics: 2,4-Dinitrophenol; Aerobiosis; Anaerobiosis; Animals; Dinitrophenols; Electrons; Energy Metabolism; | 1992 |
Effects of acid-base status on acute hypoxic pulmonary vasoconstriction and gas exchange.
Topics: 2,4-Dinitrophenol; Acid-Base Equilibrium; Animals; Blood Pressure; Carbon Dioxide; Dinitrophenols; D | 1992 |
Respective roles of free radicals and energy supply in hypoxic rat liver injury after reoxygenation.
Topics: 2,4-Dinitrophenol; Allopurinol; Animals; Dinitrophenols; Energy Metabolism; Free Radicals; Glutathio | 1991 |
Pulmonary diffusing capacities for nitric oxide and carbon monoxide determined by rebreathing in dogs.
Topics: 2,4-Dinitrophenol; Animals; Carbon Monoxide; Dinitrophenols; Dogs; Hypoxia; Kinetics; Models, Biolog | 1990 |
Oxygen extraction in lamb skeletal muscle.
Topics: 2,4-Dinitrophenol; Animals; Dinitrophenols; Hypoxia; Muscles; Oxidative Phosphorylation; Oxygen Cons | 1990 |
Regulation of glucose uptake in rat slow and fast skeletal muscles.
Topics: 2,4-Dinitrophenol; 3-O-Methylglucose; Animals; Biological Transport, Active; Cytochalasin B; Dinitro | 1988 |
Regional O2 uptake during hypoxia and recovery in hypermetabolic dogs.
Topics: 2,4-Dinitrophenol; Animals; Cardiac Output; Dinitrophenols; Dogs; Hindlimb; Hypoxia; Muscles; Oxygen | 1987 |
Effects of hypoxia, 2,4-dinitrophenol and ouabain on twitch potentiation elicited following conditioning pulses in the mouse phrenic nerve-diaphragm preparation.
Topics: 2,4-Dinitrophenol; Animals; Diaphragm; Dinitrophenols; Hypoxia; In Vitro Techniques; Male; Mice; Mus | 1987 |