2,4-dinitrophenol has been researched along with Fatty Liver, Nonalcoholic in 4 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined whether a functionally liver-targeted derivative of 2,4-dinitrophenol (DNP), DNP-methyl ether (DNPME), could safely decrease hypertriglyceridemia, NAFLD, and insulin resistance without systemic toxicities." | 3.79 | Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. ( Cline, GW; Jurczak, MJ; Kim, T; Lee, HY; Perry, RJ; Pesta, D; Popov, VB; Rahimi, Y; Shulman, GI; Spiegel, DA; Zhang, D; Zhang, XM, 2013) |
| "In a rat model of NAFLD, DNP-LC-gel treated rats reduced hepatic steatosis, liver triglyceride content, plasma triacylglycerol (TG) and total cholesterol (TC) content." | 1.46 | Sustained-release mitochondrial protonophore reverses nonalcoholic fatty liver disease in rats. ( Fu, Y; Gong, T; Song, X; Wei, G; Zhang, Q, 2017) |
| "Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH)." | 1.42 | Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. ( Boyer, JL; Perry, RJ; Shulman, GI; Zhang, D; Zhang, XM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, G | 1 |
| Song, X | 1 |
| Fu, Y | 1 |
| Gong, T | 1 |
| Zhang, Q | 1 |
| Perry, RJ | 2 |
| Kim, T | 1 |
| Zhang, XM | 2 |
| Lee, HY | 1 |
| Pesta, D | 1 |
| Popov, VB | 1 |
| Zhang, D | 2 |
| Rahimi, Y | 1 |
| Jurczak, MJ | 1 |
| Cline, GW | 1 |
| Spiegel, DA | 1 |
| Shulman, GI | 2 |
| Fromenty, B | 1 |
| Boyer, JL | 1 |
4 other studies available for 2,4-dinitrophenol and Fatty Liver, Nonalcoholic
| Article | Year |
|---|---|
Sustained-release mitochondrial protonophore reverses nonalcoholic fatty liver disease in rats.
Topics: 2,4-Dinitrophenol; Animals; Delayed-Action Preparations; Drug Liberation; Gels; Liver; Male; Non-alc | 2017 |
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.
Topics: 2,4-Dinitrophenol; Animals; Diet, High-Fat; Ethers; Fatty Liver; Hypertriglyceridemia; Insulin Resis | 2013 |
Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.
Topics: 2,4-Dinitrophenol; Animals; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Phosphorylation; Rats | 2014 |
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; G | 2015 |