2,4-dinitrophenol has been researched along with Disease Models, Animal in 26 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of novel mitochondrial uncoupler prodrug of 2,4-dinitrophenol (DNP), MP201, to prevent neuronal damage and preserve visual function in an experimental autoimmune encephalomyelitis (EAE) model of optic neuritis was evaluated." | 7.85 | Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis. ( Dine, K; Geisler, JG; Khan, RS; Shindler, KS, 2017) |
| "The ability of novel mitochondrial uncoupler prodrug of 2,4-dinitrophenol (DNP), MP201, to prevent neuronal damage and preserve visual function in an experimental autoimmune encephalomyelitis (EAE) model of optic neuritis was evaluated." | 3.85 | Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis. ( Dine, K; Geisler, JG; Khan, RS; Shindler, KS, 2017) |
| " These results suggest that acute mitochondrial dysfunction can be targeted to impart neuroprotection from reactive oxygen species, but chronic administration may have an added benefit in recovery." | 1.48 | Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice. ( Geisler, JG; Harwood, CL; Hubbard, WB; Sullivan, PG; Vekaria, HJ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Varma, H | 1 |
| Cheng, R | 1 |
| Voisine, C | 1 |
| Hart, AC | 1 |
| Stockwell, BR | 1 |
| Khoshgoo, N | 1 |
| Kholdebarin, R | 1 |
| Pereira-Terra, P | 1 |
| Mahood, TH | 1 |
| Falk, L | 1 |
| Day, CA | 1 |
| Iwasiow, BM | 1 |
| Zhu, F | 1 |
| Mulhall, D | 1 |
| Fraser, C | 1 |
| Correia-Pinto, J | 1 |
| Keijzer, R | 1 |
| Kishimoto, Y | 1 |
| Johnson, J | 1 |
| Fang, W | 1 |
| Halpern, J | 2 |
| Marosi, K | 2 |
| Liu, D | 1 |
| Geisler, JG | 4 |
| Mattson, MP | 2 |
| Lee, Y | 1 |
| Heo, G | 1 |
| Lee, KM | 1 |
| Kim, AH | 1 |
| Chung, KW | 1 |
| Im, E | 1 |
| Chung, HY | 1 |
| Lee, J | 1 |
| Khan, RS | 1 |
| Dine, K | 1 |
| Shindler, KS | 1 |
| Cho, I | 1 |
| Song, HO | 1 |
| Cho, JH | 1 |
| Samaiya, PK | 1 |
| Narayan, G | 1 |
| Kumar, A | 1 |
| Krishnamurthy, S | 1 |
| Hubbard, WB | 1 |
| Harwood, CL | 1 |
| Vekaria, HJ | 1 |
| Sullivan, PG | 4 |
| Haouzi, P | 1 |
| Van de Louw, A | 1 |
| Patel, SP | 1 |
| Pandya, JD | 2 |
| Rabchevsky, AG | 1 |
| Paula Lima, AC | 1 |
| Arriagada, C | 1 |
| Toro, R | 1 |
| Cárdenas, AM | 1 |
| Caviedes, R | 1 |
| Ferreira, ST | 2 |
| Caviedes, P | 1 |
| da Costa, RF | 1 |
| Martinez, AM | 1 |
| Petrenko, AY | 1 |
| Cherkashina, DV | 1 |
| Somov, AY | 1 |
| Tkacheva, EN | 1 |
| Semenchenko, OA | 1 |
| Lebedinsky, AS | 1 |
| Fuller, BJ | 1 |
| Liu, S | 1 |
| Lu, F | 1 |
| Wang, X | 1 |
| Sun, W | 1 |
| Chen, P | 1 |
| Dong, W | 1 |
| Jin, Y | 1 |
| McEwen, ML | 1 |
| Nottingham, SA | 1 |
| Maragos, WF | 3 |
| Dragicevic, NB | 1 |
| Springer, JE | 1 |
| Li, J | 1 |
| French, BA | 1 |
| Nan, L | 1 |
| Fu, P | 1 |
| French, SW | 1 |
| Korde, AS | 2 |
| Pettigrew, LC | 1 |
| Craddock, SD | 1 |
| Pauly, JR | 1 |
| Nukala, VN | 1 |
| Sebastian, AH | 1 |
| Day, KM | 1 |
| Hall, ED | 1 |
| Shah, AJ | 1 |
| Sahgal, V | 2 |
| Muschler, G | 1 |
| Subramani, V | 2 |
| Singh, H | 1 |
| Stad, RK | 1 |
| Bruijn, JA | 1 |
| van Gijlswijk-Janssen, DJ | 1 |
| van Es, LA | 1 |
| Daha, MR | 1 |
| Kaneko, M | 1 |
| Schimming, A | 1 |
| Gleich, GJ | 1 |
| Kita, H | 1 |
| Jackson, MJ | 1 |
| Brooke, MH | 1 |
| Kaiser, K | 1 |
| Edwards, RH | 1 |
| Shah, A | 1 |
| Sahgal, S | 1 |
| Kochar, H | 1 |
| Kepron, W | 1 |
| Jackson, CJ | 1 |
| Sehon, AH | 1 |
| Byrne, E | 1 |
| Hayes, DJ | 1 |
| Shoubridge, EA | 1 |
| Morgan-Hughes, JA | 1 |
| Clark, JB | 1 |
26 other studies available for 2,4-dinitrophenol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibitors of metabolism rescue cell death in Huntington's disease models.
Topics: Adenosine Triphosphate; Animals; Caspases; Cell Death; Cell Line; Disease Models, Animal; Drosophila | 2007 |
Prenatal microRNA miR-200b Therapy Improves Nitrofen-induced Pulmonary Hypoplasia Associated With Congenital Diaphragmatic Hernia.
Topics: 2,4-Dinitrophenol; Abnormalities, Multiple; Animals; Disease Models, Animal; Fetal Therapies; Hernia | 2019 |
A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease.
Topics: 2,4-Dinitrophenol; Animals; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Mice, Inbred C | 2020 |
Neuroprotective effects of 2,4-dinitrophenol in an acute model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,4-Dinitrophenol; Animals; Cell Death; Dinitrophenols | 2017 |
Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis.
Topics: 2,4-Dinitrophenol; Animals; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Mitoch | 2017 |
Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans.
Topics: 2,4-Dinitrophenol; Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease | 2017 |
2,4 Dinitrophenol Attenuates Mitochondrial Dysfunction and Improves Neurobehavioral Outcomes Postanoxia in Neonatal Rats.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Animals, Newborn; bcl-2-Associated X Protein; Ca | 2018 |
Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice.
Topics: 2,4-Dinitrophenol; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Energy Metabolism; Ma | 2018 |
Persistent reduced oxygen requirement following blood transfusion during recovery from hemorrhagic shock.
Topics: 2,4-Dinitrophenol; Analysis of Variance; Animals; Blood Pressure; Blood Transfusion; Body Temperatur | 2015 |
DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya.
Topics: 2,4-Dinitrophenol; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Humans; Neuro | 2017 |
Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury.
Topics: 2,4-Dinitrophenol; Aldehydes; Animals; Antioxidants; Cell Respiration; Cyclic N-Oxides; Disease Mode | 2009 |
Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line.
Topics: 2,4-Dinitrophenol; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Ce | 2008 |
2,4-Dinitrophenol blocks neurodegeneration and preserves sciatic nerve function after trauma.
Topics: 2,4-Dinitrophenol; Amyloid beta-Protein Precursor; Animals; Axons; Cytoskeleton; Disease Models, Ani | 2010 |
Reversible mitochondrial uncoupling in the cold phase during liver preservation/reperfusion reduces oxidative injury in the rat model.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Antioxidants; Cell Respiration; Cryopreservation | 2010 |
Metabolomic study of a rat fever model induced with 2,4-dinitrophenol and the therapeutic effects of a crude drug derived from Coptis chinensis.
Topics: 2,4-Dinitrophenol; Animals; Antipyretics; Biomarkers; Coptis; Disease Models, Animal; Drugs, Chinese | 2011 |
The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.
Topics: 2,4-Dinitrophenol; Animals; Disease Models, Animal; Female; Lipid Peroxidation; Mitochondria; Oxidat | 2004 |
Uncoupling of oxidative phosphorylation prevents the urinary alcohol level cycling caused by feeding ethanol continuously at a constant rate.
Topics: 2,4-Dinitrophenol; Animals; Disease Models, Animal; Ethanol; Liver; Liver Diseases, Alcoholic; Oxida | 2005 |
The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.
Topics: 2,4-Dinitrophenol; Animals; Calcium Signaling; Cerebral Infarction; Cytochromes c; Cytoprotection; D | 2005 |
Post-Injury Administration of Mitochondrial Uncouplers Increases Tissue Sparing and Improves Behavioral Outcome following Traumatic Brain Injury in Rodents.
Topics: 2,4-Dinitrophenol; Animals; Brain; Brain Injuries; Calcium Signaling; Carbonyl Cyanide p-Trifluorome | 2007 |
Morphogenesis of the mitochondrial alterations in muscle diseases.
Topics: 2,4-Dinitrophenol; Animals; Crotoxin; Dinitrophenols; Disease Models, Animal; Humans; Intracellular | 1982 |
An acute model for IgA-mediated glomerular inflammation in rats induced by monoclonal polymeric rat IgA antibodies.
Topics: 2,4-Dinitrophenol; Acute Disease; Animals; Antibodies, Monoclonal; Antigens, Surface; Complement Hem | 1993 |
Ligation of IgE receptors causes an anaphylactic response and neutrophil infiltration but does not induce eosinophilic inflammation in mice.
Topics: 2,4-Dinitrophenol; Anaphylaxis; Animals; Antigens; Disease Models, Animal; Eosinophils; Hypersensiti | 2000 |
Glutathione depletion during experimental damage to rat skeletal muscle and its relevance to Duchenne muscular dystrophy.
Topics: 2,4-Dinitrophenol; Animals; Calcimycin; Calcium; Creatine Kinase; Dinitrophenols; Disease Models, An | 1991 |
Mitochondrial cytochemistry in experimental myopathies.
Topics: 2,4-Dinitrophenol; Animals; Crotoxin; Dinitrophenols; Disease Models, Animal; Electron Transport Com | 1985 |
A canine model for the study of hapten-specific suppression of IgE-mediated bronchoconstriction and anaphylaxis.
Topics: 2,4-Dinitrophenol; Anaphylaxis; Animals; Bronchial Provocation Tests; Bronchial Spasm; Dinitrophenol | 1987 |
Experimentally induced defects of mitochondrial metabolism in rat skeletal muscle. Biological effects of the mitochondrial uncoupling agent 2,4-dinitrophenol.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Dinitrophenols; Disease Models, Animal; Electric | 1985 |