2,4-dinitrophenol has been researched along with Diabetes Mellitus, Type 2 in 6 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol)." | 3.74 | Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. ( Gaster, M, 2007) |
| "Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH)." | 1.42 | Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. ( Boyer, JL; Perry, RJ; Shulman, GI; Zhang, D; Zhang, XM, 2015) |
| "Type 2 diabetes mellitus has reached epidemic proportions; therefore, the search for novel antihyperglycemic drugs is intense." | 1.35 | Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha. ( Alpert, E; Ben Yakir, M; Cerasi, E; Cohen, G; Elgart, A; Gruzman, A; Hoffman, A; Katzhendler, Y; Sandovski, D; Sasson, S; Shamni, O, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gruzman, A | 1 |
| Shamni, O | 1 |
| Ben Yakir, M | 1 |
| Sandovski, D | 1 |
| Elgart, A | 1 |
| Alpert, E | 1 |
| Cohen, G | 1 |
| Hoffman, A | 1 |
| Katzhendler, Y | 1 |
| Cerasi, E | 1 |
| Sasson, S | 1 |
| Perry, RJ | 1 |
| Zhang, D | 1 |
| Zhang, XM | 1 |
| Boyer, JL | 1 |
| Shulman, GI | 1 |
| Kizhakekuttu, TJ | 1 |
| Wang, J | 1 |
| Dharmashankar, K | 1 |
| Ying, R | 1 |
| Gutterman, DD | 1 |
| Vita, JA | 1 |
| Widlansky, ME | 1 |
| Pelletier, A | 1 |
| Coderre, L | 1 |
| Gaster, M | 1 |
| Okamoto, Y | 1 |
| Ishida, H | 1 |
| Tsuura, Y | 1 |
| Yasuda, K | 1 |
| Kato, S | 1 |
| Matsubara, H | 1 |
| Nishimura, M | 1 |
| Mizuno, N | 1 |
| Ikeda, H | 1 |
| Seino, Y | 1 |
6 other studies available for 2,4-dinitrophenol and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Drug Design; Enzyme Activation; G | 2008 |
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; G | 2015 |
Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans.
Topics: 2,4-Dinitrophenol; Adult; Arterioles; Brachial Artery; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Ca | 2012 |
Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes.
Topics: 2,4-Dinitrophenol; 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Acetylcysteine; AMP-Activated Prot | 2007 |
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes.
Topics: 2,4-Dinitrophenol; Antimycin A; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 2; Gl | 2007 |
Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Body Weight; Calcium; Cell Membrane Permeability; Diabete | 1995 |