2,4-dinitrophenol has been researched along with Body Weight in 9 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown." | 3.85 | Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss. ( Cowley, MA; Michael, NJ; Simonds, SE; Spanswick, D; van den Top, M, 2017) |
| " In this study, we evaluated the effects of chronic administration of DNP at three doses (0." | 1.46 | 2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease. ( Alonso, R; Duan, W; Geisler, JG; Hou, Z; Jiang, M; Li, G; Milne, GL; Mori, S; Peng, Q; Wu, B, 2017) |
| "In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test, Crj:CD(SD)IGS rats were dosed with dinoseb, 2-sec-butyl-4,6-dinitrophenol, by gavage at 0 (vehicle), 0." | 1.35 | Combined repeated dose and reproductive/developmental toxicity screening test of the nitrophenolic herbicide dinoseb, 2-sec-butyl-4,6-dinitrophenol, in rats. ( Ema, M; Furuhashi, T; Matsumoto, M; Poncipe, C, 2008) |
| " Males were dosed for 46 days, beginning 14 days before mating, and females were dosed for 40-47 days, from 14 days before mating to day 3 of lactation." | 1.35 | Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats. ( Ema, M; Hirata-Koizumi, M; Hirose, A; Kamata, E; Sunaga, M; Takahashi, M, 2009) |
| "The toxicities of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats was examined and the susceptibility of newborn rats was analyzed in terms of presumed unequivocally toxic and no observed adverse effect levels (NOAELs)." | 1.31 | Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats. ( Enami, T; Hasegawa, R; Ito, Y; Kamata, E; Koizumi, M; Takano, M; Yamamoto, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, B | 1 |
| Jiang, M | 1 |
| Peng, Q | 1 |
| Li, G | 1 |
| Hou, Z | 1 |
| Milne, GL | 1 |
| Mori, S | 1 |
| Alonso, R | 1 |
| Geisler, JG | 1 |
| Duan, W | 1 |
| Michael, NJ | 1 |
| Simonds, SE | 1 |
| van den Top, M | 1 |
| Cowley, MA | 1 |
| Spanswick, D | 1 |
| Takahashi, KL | 1 |
| Hojo, H | 1 |
| Aoyama, H | 1 |
| Teramoto, S | 1 |
| Staempfli, C | 1 |
| Tarradellas, J | 1 |
| Becker-van Slooten, K | 1 |
| Matsumoto, M | 1 |
| Furuhashi, T | 1 |
| Poncipe, C | 1 |
| Ema, M | 2 |
| Takahashi, M | 1 |
| Sunaga, M | 1 |
| Hirata-Koizumi, M | 1 |
| Hirose, A | 1 |
| Kamata, E | 2 |
| Okamoto, Y | 1 |
| Ishida, H | 1 |
| Tsuura, Y | 1 |
| Yasuda, K | 1 |
| Kato, S | 1 |
| Matsubara, H | 1 |
| Nishimura, M | 1 |
| Mizuno, N | 1 |
| Ikeda, H | 1 |
| Seino, Y | 1 |
| Dominguez, SE | 1 |
| Menkel, JL | 1 |
| Fairbrother, A | 1 |
| Williams, BA | 1 |
| Tanner, RW | 1 |
| Koizumi, M | 1 |
| Yamamoto, Y | 1 |
| Ito, Y | 1 |
| Takano, M | 1 |
| Enami, T | 1 |
| Hasegawa, R | 1 |
9 other studies available for 2,4-dinitrophenol and Body Weight
| Article | Year |
|---|---|
2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease.
Topics: 2,4-Dinitrophenol; Animals; Body Weight; Corpus Striatum; Disks Large Homolog 4 Protein; Dopamine an | 2017 |
Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss.
Topics: 2,4-Dinitrophenol; Adipose Tissue, Brown; Animals; Body Weight; Eating; Energy Metabolism; Male; Mel | 2017 |
Comparative studies on the spermatotoxic effects of dinoseb and its structurally related chemicals.
Topics: 2,4-Dinitrophenol; Animals; Body Weight; Cresols; Dinitrocresols; Dinitrophenols; Epididymis; Genita | 2004 |
Effects of dinoseb on energy reserves in the soil arthropod Folsomia candida.
Topics: 2,4-Dinitrophenol; Animals; Arthropods; Body Size; Body Weight; Dose-Response Relationship, Drug; En | 2007 |
Combined repeated dose and reproductive/developmental toxicity screening test of the nitrophenolic herbicide dinoseb, 2-sec-butyl-4,6-dinitrophenol, in rats.
Topics: 2,4-Dinitrophenol; Administration, Oral; Animals; Body Weight; Drug Synergism; Female; Hematopoiesis | 2008 |
Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats.
Topics: 2,4-Dinitrophenol; Abnormalities, Drug-Induced; Animals; Animals, Newborn; Body Weight; Female; Live | 2009 |
Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Body Weight; Calcium; Cell Membrane Permeability; Diabete | 1995 |
The effect of 2,4-dinitrophenol on the metabolic rate of bobwhite quail.
Topics: 2,4-Dinitrophenol; Animals; Body Weight; Dinitrophenols; Dose-Response Relationship, Drug; Drinking; | 1993 |
Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats.
Topics: 2,4-Dinitrophenol; Administration, Oral; Animals; Animals, Newborn; Body Weight; Coloring Agents; Do | 2001 |