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2,4-dichlorophenoxyacetic acid and Sarcoma

2,4-dichlorophenoxyacetic acid has been researched along with Sarcoma in 22 studies

2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.
2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.

Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Research Excerpts

ExcerptRelevanceReference
"Epithelioid sarcomas are uncommon, aggressive tumours with a propensity for locoregional recurrence."5.32'Proximal-type' epithelioid sarcoma: is Agent Orange still at large? ( Chaudhuri, A; Harris, MD, 2003)
"Agent Orange was the most common herbicide used in the Second Indochina War in the course of military operations in the former South Vietnam."5.30Exposure to Agent Orange and occurrence of soft-tissue sarcomas or non-Hodgkin lymphomas: an ongoing study in Vietnam. ( Anh, CT; Cau, HD; Dai, LC; Kogevinas, M; Kramárová, E; Parkin, DM; Stellman, SD, 1998)
" Agent Orange, one toxin among many, has been linked to malignancy and the subcomponent phenoxyacetic acid has been associated with soft tissue sarcomas (STSs)."3.83Wartime toxin exposure: recognising the silent killer. ( Coleman, J; Didolkar, MS; Khan, K; Wozniak, SE, 2016)
"The objective of this study was to determine if there is an additional risk of developing Hodgkin lymphoma, multiple myeloma, or soft tissue sarcoma as a consequence of exposure to a combination of phenoxyherbicides, rubber gloves, DEET (N, N-diethyl-m-toluamide), and sunlight compared with each of the individual chemicals."3.73Hodgkin lymphoma, multiple myeloma, soft tissue sarcomas, insect repellents, and phenoxyherbicides. ( Dosman, JA; Fincham, S; McDuffie, HH; McLaughlin, JR; Pahwa, P; Robson, D; Spinelli, JJ, 2006)
"The possibility that exposure to Agent Orange or phenoxy herbicides may have increased the risk of soft tissue sarcomas has been of genuine concern to Vietnam veterans and their families."3.67Soft tissue sarcomas and military service in Vietnam: a case comparison group analysis of hospital patients. ( Breslin, PP; Kang, HK; Lee, Y; Shepard, BM; Weatherbee, L, 1986)
"In these studies soft tissue sarcoma cases have been identified from either deaths with malignant neoplasms of the connective tissue (ICD-8 171) as the underlying cause of death, from incident cancer cases with the same topography code, or from incident cases of extraskeletal sarcomas, excluding lympho and reticulosarcomas."2.37The evaluation of trends in soft tissue sarcoma according to diagnostic criteria and consumption of phenoxy herbicides. ( Jensen, OM; Lynge, E; Storm, HH, 1987)
"Epithelioid sarcomas are uncommon, aggressive tumours with a propensity for locoregional recurrence."1.32'Proximal-type' epithelioid sarcoma: is Agent Orange still at large? ( Chaudhuri, A; Harris, MD, 2003)
"Agent Orange was the most common herbicide used in the Second Indochina War in the course of military operations in the former South Vietnam."1.30Exposure to Agent Orange and occurrence of soft-tissue sarcomas or non-Hodgkin lymphomas: an ongoing study in Vietnam. ( Anh, CT; Cau, HD; Dai, LC; Kogevinas, M; Kramárová, E; Parkin, DM; Stellman, SD, 1998)
"The risk of soft tissue sarcoma following possible exposure to phenoxy acid herbicides was studied in 354,620 Swedish men, who were employed in agriculture or forestry according to a national census in 1960."1.27Soft tissue sarcoma risk in Swedish agricultural and forestry workers. ( Holm, LE; Wiklund, K, 1986)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199012 (54.55)18.7374
1990's4 (18.18)18.2507
2000's5 (22.73)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Khan, K1
Wozniak, SE1
Coleman, J1
Didolkar, MS1
Garabrant, DH1
Philbert, MA1
Chaudhuri, A1
Harris, MD1
Pahwa, P1
McDuffie, HH1
Dosman, JA1
McLaughlin, JR1
Spinelli, JJ1
Robson, D1
Fincham, S1
Spinelli, J1
Hardell, L2
Hobson, LB1
Smith, AH1
Pearce, NE1
Fisher, DO1
Giles, HJ1
Teague, CA1
Howard, JK1
Sarma, PR1
Jacobs, J1
Pierce, S1
Axelson, O1
Kramárová, E1
Kogevinas, M1
Anh, CT1
Cau, HD1
Dai, LC1
Stellman, SD1
Parkin, DM1
Sandström, A1
Vineis, P2
Faggiano, F1
Tedeschi, M1
Ciccone, G2
Kang, H1
Enzinger, FM1
Breslin, P1
Feil, M1
Lee, Y2
Shepard, B1
Enziger, F1
Lynge, E1
Storm, HH1
Jensen, OM1
Wiklund, K1
Holm, LE1
Terracini, B1
Cignetti, A1
Colombo, E1
Donna, A1
Maffi, L1
Pisa, R1
Ricci, P1
Zanini, E1
Constable, JD1
Timperi, R1
Clapp, R1
Antman, K1
Boynton, B1
Kang, HK1
Weatherbee, L1
Breslin, PP1
Shepard, BM1

Reviews

2 reviews available for 2,4-dichlorophenoxyacetic acid and Sarcoma

ArticleYear
Review of 2,4-dichlorophenoxyacetic acid (2,4-D) epidemiology and toxicology.
    Critical reviews in toxicology, 2002, Volume: 32, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Carcinogenicity Tests; Case-Control Studies; Cohort Studies

2002
The evaluation of trends in soft tissue sarcoma according to diagnostic criteria and consumption of phenoxy herbicides.
    Cancer, 1987, Oct-15, Volume: 60, Issue:8

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1987

Other Studies

20 other studies available for 2,4-dichlorophenoxyacetic acid and Sarcoma

ArticleYear
Wartime toxin exposure: recognising the silent killer.
    BMJ case reports, 2016, Dec-01, Volume: 2016

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Administration, Cutaneous; Agent

2016
'Proximal-type' epithelioid sarcoma: is Agent Orange still at large?
    Annals of the Royal College of Surgeons of England, 2003, Volume: 85, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abdominal Neoplasms; Agent Orange

2003
Hodgkin lymphoma, multiple myeloma, soft tissue sarcomas, insect repellents, and phenoxyherbicides.
    Journal of occupational and environmental medicine, 2006, Volume: 48, Issue:3

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Adult; Agricultural Workers' Di

2006
Pesticides, soft tissue sarcoma and non-Hodgkin lymphoma.
    Acta oncologica (Stockholm, Sweden), 2008, Volume: 47, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Carcinogens, Environmental; Dioxi

2008
Pesticides, soft-tissue sarcoma and non-Hodgkin lymphoma--historical aspects on the precautionary principle in cancer prevention.
    Acta oncologica (Stockholm, Sweden), 2008, Volume: 47, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Aged; Carcinogens, Environ

2008
Human effects of TCDD exposure.
    Bulletin of environmental contamination and toxicology, 1984, Volume: 33, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Acne Vulgaris; Agent Orange; Defo

1984
Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand.
    Journal of the National Cancer Institute, 1984, Volume: 73, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Agricultural Workers' Diseases; C

1984
Thoracic soft-tissue sarcoma in Vietnam veterans exposed to Agent Orange.
    The New England journal of medicine, 1982, May-06, Volume: 306, Issue:18

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Agent Orange; Defoliants,

1982
The purported link between agent orange and cancer.
    Human pathology, 1995, Volume: 26, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Agent Orange; Humans; Polychlorin

1995
Seveso: disentangling the dioxin enigma?
    Epidemiology (Cambridge, Mass.), 1993, Volume: 4, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; Accidents; Carcinogens; Dioxins; Environmental Exposure; Herbicides;

1993
Exposure to Agent Orange and occurrence of soft-tissue sarcomas or non-Hodgkin lymphomas: an ongoing study in Vietnam.
    Environmental health perspectives, 1998, Volume: 106 Suppl 2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Aged; Agent Orange; Case-C

1998
Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols.
    British journal of cancer, 1979, Volume: 39, Issue:6

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1979
Incidence rates of lymphomas and soft-tissue sarcomas and environmental measurements of phenoxy herbicides.
    Journal of the National Cancer Institute, 1991, Mar-06, Volume: 83, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Environmental Exposure; Female; H

1991
Occupational exposures to chlorophenoxy herbicides.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1986, Volume: 41

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1986
Soft tissue sarcoma and military service in Vietnam: a case-control study.
    Journal of the National Cancer Institute, 1987, Volume: 79, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Agent Orange; Diagnosis-Related G

1987
Soft tissue sarcoma risk in Swedish agricultural and forestry workers.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:2

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1986
Phenoxy herbicides and soft-tissue sarcomas in female rice weeders. A population-based case-referent study.
    Scandinavian journal of work, environment & health, 1987, Volume: 13, Issue:1

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1987
Vietnam veterans and soft tissue sarcoma.
    Journal of occupational medicine. : official publication of the Industrial Medical Association, 1987, Volume: 29, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Agent Orange; Dioxins; Humans; Po

1987
Storm in a cup of 2,4,5-T.
    The Medical journal of Australia, 1986, May-26, Volume: 144, Issue:11

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Australia; Humans; Lymphoma; Mili

1986
Soft tissue sarcomas and military service in Vietnam: a case comparison group analysis of hospital patients.
    Journal of occupational medicine. : official publication of the Industrial Medical Association, 1986, Volume: 28, Issue:12

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Agent Orange; Dioxins; Her

1986