Page last updated: 2024-10-21

2,4-dichlorophenoxyacetic acid and Pregnancy

2,4-dichlorophenoxyacetic acid has been researched along with Pregnancy in 89 studies

2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.
2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Induction of oxidative stress by 2,4-dichlorophenoxyacetic acid (2,4-D) both as a pure compound and in commercial formulation was investigated during early pregnancy in mice."7.74Lack of effects of 2,4-dichlorophenoxyacetic acid administration on markers of oxidative stress during early pregnancy in mice. ( Cavieres, MF; Dinamarca, VM; Hidalgo, ME, 2007)
"The effect of herbicide--2,4-D, injected before pregnancy begins, on the main parameters of the reproductive function of the female rats has demonstrated that chronic administration in doses 1 mg/kg and 12 mg/kg per day for 2 months results in certain disturbances in the estrus cycle, manifesting as prolongation of the diestrus phase and in changes of estrus and meta-estrus++ duration, as well as in an essential increase in rates of anovulatory cycles."5.28[Nature of the estrous cycle, incidence of anovulation, chromosome gametopathies and fetal death in female rats with 2,4-dichlorophenoxyacetic acid (2,4-D) before pregnancy]. ( Nikitin, AI; Slozina, NM; Vin', VD, 1990)
"Induction of oxidative stress by 2,4-dichlorophenoxyacetic acid (2,4-D) both as a pure compound and in commercial formulation was investigated during early pregnancy in mice."3.74Lack of effects of 2,4-dichlorophenoxyacetic acid administration on markers of oxidative stress during early pregnancy in mice. ( Cavieres, MF; Dinamarca, VM; Hidalgo, ME, 2007)
"From the group of herbicidal phenoxy carbonic acids, 2-methyl-4-chlorophenoxyacetic acid (MCPA; 0-500 mg/kg), 2-(4-chloro-2-methyl-phenoxy) propionic acid (mecoprop/MCPP; 0-700 mg/kg) and 2-(2,4-dichlorophenoxy) propionic acid (dichlorprop/2,4-DP; 0-500 mg/kg) as well as the dextrorotatory compounds of MCPP (MCPPD; 0-500 mg/kg) and 2,4-DP (2,4-DPD; 0-500 mg/kg) were studied in NMRI mice after oral administration between days 6-15 of pregnancy."3.66[Comparative studies on the embryotoxicity of 2-methyl-4-chlorophenoxyacetic acid, mecoprop and dichlorprop in NMRI mice]. ( Matthiaschk, G; Roll, R, 1983)
"Agent Orange was composed of two herbicides: 2,4-D and 2,4,5-T, the latter contaminated by small amounts of a highly toxic dioxin (TCDD)."2.37Does Agent Orange cause birth defects? ( Friedman, JM, 1984)
"2,4-Dichlorophenoxyacetic acid (2,4-D), a worldwide-used herbicide, has been shown to produce a wide range of adverse effects in the health--from embryotoxicity and teratogenicity to neurotoxicity--of animals and humans."1.37Adverse effects of 2,4-dichlorophenoxyacetic acid on rat cerebellar granule cell cultures were attenuated by amphetamine. ( Bongiovanni, B; Brusco, A; Duffard, R; Evangelista de Duffard, AM; Ferri, A; Lopez, LM; Rassetto, M, 2011)
" The data, although apparently influenced by season, showed an inverted or U-shaped dose-response pattern for reduced litter size, with the low end of the dose range producing the greatest decrease in the number of live pups born."1.31Developmental toxicity of a commercial herbicide mixture in mice: I. Effects on embryo implantation and litter size. ( Cavieres, MF; Jaeger, J; Porter, W, 2002)
" Significantly decreased fetal body weights and increased fetal variations were seen in rats only at maternally toxic dose levels in excess of 90 mg/kg/day acid equivalent."1.31Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms. ( Bus, JS; Charles, JM; Hanley, TR; van Ravenzwaay, B; Wilson, RD, 2001)
"The risk of intrauterine growth retardation was not increased in any exposure category."1.30Paternal dioxin, preterm birth, intrauterine growth retardation, and infant death. ( Boyle, CA; Michalek, JE; Rahe, AJ, 1998)
"A physiologically based pharmacokinetic (PBPK) model that describes the kinetics of organic anions by using 2,4-dichlorophenoxyacetic (2,4-D) as a representative compound was constructed for the developing rabbit brain at near-term pregnancy (Gestation Day 30)."1.29Construction of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid dosimetry in the developing rabbit brain. ( Binienda, Z; Kim, CS; Sandberg, JA, 1996)
"The hypothesis that chemically induced overt maternal toxicity induces a characteristic syndrome of adverse developmental effects in the rat was investigated."1.28Effects of chemically induced maternal toxicity on prenatal development in the rat. ( Chernoff, N; Miller, DB; Rogers, JM; Rosen, MB; Setzer, RW, 1990)
"The effect of herbicide--2,4-D, injected before pregnancy begins, on the main parameters of the reproductive function of the female rats has demonstrated that chronic administration in doses 1 mg/kg and 12 mg/kg per day for 2 months results in certain disturbances in the estrus cycle, manifesting as prolongation of the diestrus phase and in changes of estrus and meta-estrus++ duration, as well as in an essential increase in rates of anovulatory cycles."1.28[Nature of the estrous cycle, incidence of anovulation, chromosome gametopathies and fetal death in female rats with 2,4-dichlorophenoxyacetic acid (2,4-D) before pregnancy]. ( Nikitin, AI; Slozina, NM; Vin', VD, 1990)
" The incidence of dead fetuses/resorptions and malformed fetuses (especially cleft palate) was increased in the highest dosage group."1.28Effects of gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice. ( Blakley, PM; Firneisz, GD; Kim, JS, 1989)
" Fetal weight and crown-rump length were reduced in the highest dosage group."1.28Effects of paternal subacute exposure to Tordon 202c on fetal growth and development in CD-1 mice. ( Blakley, PM; Firneisz, GD; Kim, JS, 1989)

Research

Studies (89)

TimeframeStudies, this research(%)All Research%
pre-199045 (50.56)18.7374
1990's9 (10.11)18.2507
2000's18 (20.22)29.6817
2010's12 (13.48)24.3611
2020's5 (5.62)2.80

Authors

AuthorsStudies
Wang, Y1
Wan, Y1
Cao, M1
Wang, A1
Mahai, G1
He, Z1
Xu, S1
Xia, W1
Nechalioti, PM1
Karampatzakis, T1
Mesnage, R1
Antoniou, MN1
Ibragim, M1
Tsatsakis, A1
Docea, AO1
Nepka, C1
Kouretas, D1
Larose, J1
Bienvenu, JF1
Bélanger, P1
Gaudreau, É1
Yu, Y1
Guise, DM1
Muñoz-Quezada, MT1
Lucero, BA1
Gutiérrez-Jara, JP1
Buralli, RJ1
Zúñiga-Venegas, L1
Muñoz, MP1
Ponce, KV1
Iglesias, V1
Balalian, AA1
Liu, X1
Herbstman, JB1
Daniel, S1
Whyatt, R1
Rauh, V1
Calafat, AM2
Wapner, R1
Factor-Litvak, P1
Dalsager, L1
Christensen, LE1
Kongsholm, MG1
Kyhl, HB1
Nielsen, F1
Schoeters, G1
Jensen, TK1
Andersen, HR1
Silver, MK1
Shao, J1
Li, M1
Ji, C1
Chen, M1
Xia, Y1
Lozoff, B1
Meeker, JD2
Grufferman, S1
Lupo, PJ1
Vogel, RI1
Danysh, HE1
Erhardt, EB1
Ognjanovic, S1
Lewis, RC1
Cantonwine, DE1
Anzalota Del Toro, LV1
Valentin-Blasini, L1
Davis, MD1
Baker, SE1
Alshawabkeh, AN1
Cordero, JF1
Pochettino, AA2
Hapon, MB1
Biolatto, SM1
Madariaga, MJ2
Jahn, GA2
Konjuh, CN1
Schmidt, C1
Bongiovanni, B2
Ferri, A1
Brusco, A3
Rassetto, M1
Lopez, LM1
Evangelista de Duffard, AM5
Duffard, R7
Troudi, A2
Ben Amara, I2
Samet, AM1
Zeghal, N2
Reagan, LJ1
Duffard, RO1
Soudani, N1
Mahjoubi Samet, A1
Mazhar, FM1
Moawad, KM1
El-Dakdoky, MH1
Amer, AS1
Cavieres, MF2
Jaeger, J1
Porter, W1
Boulakoud, MS1
Mosbah, R1
Abdennour, C1
Khelili, K1
Sulik, M3
Sulik, A2
Barwijuk-Machała, M3
Piłat-Marcinkiewicz, B2
Bortolozzi, A3
de Duffard, AM3
Knapp, GW1
Setzer, RW2
Fuscoe, JC1
Sameshima, K1
Kobae, H1
Fofana, D1
Yoshidome, K1
Nishi, J1
Miyata, K1
Yilmaz, HR1
Yuksel, E1
Ngo, AD1
Taylor, R1
Roberts, CL1
Nguyen, TV1
Schecter, A1
Constable, JD1
Dinamarca, VM1
Hidalgo, ME1
Stürtz, N1
Deis, RP1
Konjuh, C1
García, G2
López, L1
Tedeschi, LG1
Friedman, JM1
Holden, C1
Fagan, K1
Pollak, JK1
Roll, R1
Matthiaschk, G1
Casey, PH1
Collie, WR1
Erickson, JD1
Mulinare, J1
McClain, PW1
Fitch, TG1
James, LM1
McClearn, AB1
Adams, MJ1
Gunby, P1
Konstantinova, TK5
Shevelo, FS2
Stevens, KM1
Cook, RR1
Wolfe, WH1
Michalek, JE2
Miner, JC1
Rahe, AJ2
Moore, CA1
Needham, LL1
Patterson, DG1
Kim, CS3
Binienda, Z2
Sandberg, JA2
Duhart, HM1
Lipe, G1
Slikker, W1
Matus, A1
Musiatowicz, B1
Sulkowska, M2
Kemona, A1
Kisielewski, W1
Sobaniec-Lotowska, M1
Boyle, CA1
Baltaziak, M1
Klepacka, J1
Lee, K2
Johnson, VJ1
Blakley, BR3
Charles, JM1
Hanley, TR1
Wilson, RD1
van Ravenzwaay, B1
Bus, JS1
Alpöz, AR1
Tosun, N1
Eronat, C1
Delen, N1
Sen, BH1
Johnson, VL1
Tagliaferro, P1
Saavedra, JP1
Antonelli, M1
Aleksashina, ZA2
Buslovich, SIu2
Kolosovskaia, VM2
Efimenko, LP2
Antonenko, TA3
Nechkina, MA1
Shilov, VN1
Amstutz, HE1
Courtney, KD1
Sokolova, LA1
de Alderete, MN1
Chernoff, N1
Miller, DB1
Rosen, MB1
Rogers, JM1
Vin', VD1
Slozina, NM1
Nikitin, AI1
Mohammad, FK3
St Omer, VE3
Blakley, PM4
Kim, JS3
Firneisz, GD3
Hatch, MC2
Stein, ZA2
Cohen, FL1
Keizer, RF1
Pritchard, JB1
Bidnenko, LI1
Kaye, CI1
Rao, S1
Simpson, SJ1
Rosenthal, FS1
Cohen, MM1
Pearn, JH1
Ermolov, VI1
Humiczewska, M2
Stanosz, S2
Fedorova, LM1
Belova, RS1
Båge, G1
Cekanova, E1
Larsson, KS1
Clegg, DJ1
Khera, KS1
McKinley, WP1
Schwetz, BA1
Sparschu, GL1
Gehring, PJ1

Reviews

6 reviews available for 2,4-dichlorophenoxyacetic acid and Pregnancy

ArticleYear
Association between Agent Orange and birth defects: systematic review and meta-analysis.
    International journal of epidemiology, 2006, Volume: 35, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Agent Orange. Update.
    The American journal of forensic medicine and pathology, 1983, Volume: 4, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Agent Orange; Child, Presc

1983
Does Agent Orange cause birth defects?
    Teratology, 1984, Volume: 29, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
Paternal contributions to birth defects.
    The Nursing clinics of North America, 1986, Volume: 21, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abortion, Spontaneous; Adult; Age

1986
Herbicides and congenital malformations: a review for the paediatrician.
    Australian paediatric journal, 1985, Volume: 21, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acci

1985
Embryotoxicity of chemical contaminants of foods.
    Food and cosmetics toxicology, 1971, Volume: 9, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1971

Other Studies

83 other studies available for 2,4-dichlorophenoxyacetic acid and Pregnancy

ArticleYear
Urinary 2,4-dichlorophenoxyacetic acid in Chinese pregnant women at three trimesters: Variability, exposure characteristics, and association with oxidative stress biomarkers.
    Chemosphere, 2022, Volume: 304

    Topics: 2,4-Dichlorophenoxyacetic Acid; 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Female; Herbicides; Humans;

2022
Evaluation of perinatal exposure of glyphosate and its mixture with 2,4-D and dicamba οn liver redox status in Wistar rats.
    Environmental research, 2023, 07-01, Volume: 228

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Dicamba; Female; Glyphosate; Herbicides; Liver; Oxidation-R

2023
New sensitive LC-MS/MS method for the simultaneous determination of 13 phenolic and carboxylic acid pesticide biomarkers in human urine, including dicamba.
    Chemosphere, 2023, Volume: 344

    Topics: 2,4-Dichlorophenoxyacetic Acid; Biomarkers; Carboxylic Acids; Chromatography, Liquid; Cohort Studies

2023
Longitudinal exposure to pyrethroids (3-PBA and trans-DCCA) and 2,4-D herbicide in rural schoolchildren of Maule region, Chile.
    The Science of the total environment, 2020, Dec-20, Volume: 749

    Topics: 2,4-Dichlorophenoxyacetic Acid; Benzoates; Child; Chile; Environmental Exposure; Female; Herbicides;

2020
Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.
    Environmental research, 2021, Volume: 201

    Topics: 2,4-Dichlorophenoxyacetic Acid; Birth Weight; Child; Chlorpyrifos; Female; Herbicides; Humans; Infan

2021
Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort.
    Reproductive toxicology (Elmsford, N.Y.), 2018, Volume: 76

    Topics: 2,4-Dichlorophenoxyacetic Acid; Anal Canal; Anthropometry; Cohort Studies; Female; Genitalia; Humans

2018
Prenatal exposure to the herbicide 2,4-D is associated with deficits in auditory processing during infancy.
    Environmental research, 2019, Volume: 172

    Topics: 2,4-Dichlorophenoxyacetic Acid; Auditory Perceptual Disorders; China; Evoked Potentials, Auditory, B

2019
Parental military service, agent orange exposure, and the risk of rhabdomyosarcoma in offspring.
    The Journal of pediatrics, 2014, Volume: 165, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Agent Orange; Case-Control

2014
Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico.
    Environmental health : a global access science source, 2014, Nov-19, Volume: 13

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adolescent; Adult; Biomarkers; DE

2014
Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage.
    Drug and chemical toxicology, 2016, Volume: 39, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Administration, Oral; Animals; Endocrine Disruptors; Female; Gestati

2016
The Fog of Agent Orange.
    Scientific American, 2016, Volume: 314, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2016
Adverse effects of 2,4-dichlorophenoxyacetic acid on rat cerebellar granule cell cultures were attenuated by amphetamine.
    Neurotoxicity research, 2011, Volume: 19, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Amphetamine; Animals; Cell Survival; Cells, Cultured; Cerebellum; Cy

2011
Oxidative stress induced by 2,4-phenoxyacetic acid in liver of female rats and their progeny: biochemical and histopathological studies.
    Environmental toxicology, 2012, Volume: 27, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Alanine Transaminase; Animals; Catalase; Drinking Water; Female; Glu

2012
Representations and reproductive hazards of Agent Orange.
    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics, 2011,Spring, Volume: 39, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Agent Orange; Defoliants, Chemica

2011
Oxidative stress in ventral prostate, ovary, and breast by 2,4-dichlorophenoxyacetic acid in pre- and postnatal exposed rats.
    Environmental toxicology, 2013, Volume: 28, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Antioxidants; Female; Lipid Peroxidation; Male; Mammary Gla

2013
2,4-Dichlorophenoxyacetic acid effects on nephrotoxicity in rats during late pregnancy and early postnatal periods.
    Ecotoxicology and environmental safety, 2011, Volume: 74, Issue:8

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Ascorbic Acid; Catalase; Female; Glutathione; Glutathione P

2011
Fetotoxicity of 2,4-dichlorophenoxyacetic acid in rats and the protective role of vitamin E.
    Toxicology and industrial health, 2014, Volume: 30, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Body Weight; Bone and Bones; Female; Fetus; Male; Oxidative

2014
Developmental toxicity of a commercial herbicide mixture in mice: I. Effects on embryo implantation and litter size.
    Environmental health perspectives, 2002, Volume: 110, Issue:11

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Animals; Animals, Newborn; Birt

2002
The toxicological effects of the herbicide 2,4-DCPA on progesterone levels and mortality in Wistar female rats.
    Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen), 2001, Volume: 66, Issue:2b

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Dose-Response Relationship, Drug; Female; Fertility; Fetal

2001
Fetotoxic action of 2,4-dichlorophenoxyacetic acid (2,4-D). III. Morphological changes in rat kidneys.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 2002, Volume: 47

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Animals, Newborn; Disease Models, Animal; Female; Fetus; Im

2002
Asymmetrical development of the monoamine systems in 2,4-dichlorophenoxyacetic acid treated rats.
    Neurotoxicology, 2003, Volume: 24, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Animals, Newborn; Biogenic Monoamines; Brain; Female; Funct

2003
Quantitation of aberrant interlocus T-cell receptor rearrangements in mouse thymocytes and the effect of the herbicide 2,4-dichlorophenoxyacetic acid.
    Environmental and molecular mutagenesis, 2003, Volume: 42, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Base Sequence; Female; Gene Rearrangement, beta-Chain T-Cel

2003
Effects of pure 2,4-dichlorophenoxyacetic acid on cultured rat embryos.
    Congenital anomalies, 2004, Volume: 44, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Embryo Culture Techniques; Embryo, Mammalian; Female; Herbi

2004
Effect of 2,4-dichlorophenoxyacetic acid on the activities of some metabolic enzymes for generating pyridine nucleotide pool of cells from mouse liver.
    Toxicology and industrial health, 2005, Volume: 21, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; Alcohol Oxidoreductases; Animals; Enzyme Activation; Female; Hepatoc

2005
Commentary: Agent Orange and birth defects in Vietnam.
    International journal of epidemiology, 2006, Volume: 35, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Lack of effects of 2,4-dichlorophenoxyacetic acid administration on markers of oxidative stress during early pregnancy in mice.
    Toxicology, 2007, Jul-31, Volume: 237, Issue:1-3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Antioxidants; Catalase; Erythrocytes; Female; Gestational A

2007
Effect of 2,4-dichlorophenoxyacetic acid on rat maternal behavior.
    Toxicology, 2008, May-21, Volume: 247, Issue:2-3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Arcuate Nucleus of Hypothalamus; Dopamine; Dose-Response Re

2008
Neonatal hypomyelination by the herbicide 2,4-dichlorophenoxyacetic acid. Chemical and ultrastructural studies in rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 104, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Animals, Suckling; Blotting, Western; Body Weight; Brain; D

2008
Health effects of Agent Orange and dioxin contaminants. Council on scientific affairs.
    JAMA, 1982, Oct-15, Volume: 248, Issue:15

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Accidents, Occupational; Acne Vul

1982
VA study of twins may be canceled.
    Science (New York, N.Y.), 1984, Nov-02, Volume: 226, Issue:4674

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Agent Orange; Combat Disorders; F

1984
The effect of the phenoxyacetic acid herbicides 2,4,5-trichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetic acid as ascertained by direct experimentation.
    Residue reviews, 1984, Volume: 92

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Behavior, Animal; Chromo

1984
[Comparative studies on the embryotoxicity of 2-methyl-4-chlorophenoxyacetic acid, mecoprop and dichlorprop in NMRI mice].
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:10

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Animals; Drug Interactions; Emb

1983
Severe mental retardation and multiple congenital anomalies of uncertain cause after extreme parental exposure to 2,4-D.
    The Journal of pediatrics, 1984, Volume: 104, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Environ

1984
Vietnam veterans' risks for fathering babies with birth defects.
    JAMA, 1984, Aug-17, Volume: 252, Issue:7

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
More questions, not answers, emerge from Agent Orange studies.
    JAMA, 1983, May-27, Volume: 249, Issue:20

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1983
Agent Orange.
    The American journal of forensic medicine and pathology, 1983, Volume: 4, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abortion, Spontaneous; Agent Oran

1983
[Mutagenic activity of the combined action of the herbicides 2,4-D and 2,4,5-T].
    Gigiena i sanitariia, 1983, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Dose-Response Relationsh

1983
Agent Orange and birth defects.
    The New England journal of medicine, 1983, Aug-25, Volume: 309, Issue:8

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1983
Agent Orange toxicity: a quantitative perspective.
    Human toxicology, 1981, Volume: 1, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1981
Agent Orange and spontaneous abortions.
    JAMA, 1980, Apr-11, Volume: 243, Issue:14

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abortion, Spontaneous; Agent Oran

1980
Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand.
    Epidemiology (Cambridge, Mass.), 1995, Volume: 6, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abor

1995
Construction of a physiologically based pharmacokinetic model for 2,4-dichlorophenoxyacetic acid dosimetry in the developing rabbit brain.
    Toxicology and applied pharmacology, 1996, Volume: 136, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Amniotic Fluid; Animals; Brain; Female; Fetus; Herbicides; Maternal

1996
Distribution of 2,4-dichlorophenoxyacetic acid (2,4-D) in maternal and fetal rabbits.
    Journal of toxicology and environmental health, 1996, Dec-06, Volume: 49, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Area Under Curve; Brain; Brain Chemistry; Female; Fetus; In

1996
The effect of a herbicide--sodium salt of 2,4-dichlorophenoxyacetic acid on guerin carcinoma.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1996, Volume: 41, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Cocarcinogenesis; DNA, Neoplasm; Female; Herbicides; Male;

1996
Paternal dioxin, preterm birth, intrauterine growth retardation, and infant death.
    Epidemiology (Cambridge, Mass.), 1998, Volume: 9, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adolescent; Adult; Agent Orange;

1998
Fetotoxic effect of 2,4-dichlorophenoxyacetic acid (2,4-D) in rats.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1998, Volume: 43

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Disease Models, Animal; Female; Fetus; Herbicides; Immunohi

1998
The effect of exposure to a commercial 2,4-D herbicide formulation during gestation on urethan-induced lung adenoma formation in CD-1 mice.
    Veterinary and human toxicology, 2000, Volume: 42, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Adenoma; Animals; Carcinogens; Female; Herbicides; Injections, Intra

2000
Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 60, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Ataxia; Body Weight; Dose-Resp

2001
Effects of 2,4-dichlorophenoxy acetic acid dimethyl amine salt on dental hard tissue formation in rats.
    Environment international, 2001, Volume: 26, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Amelogenesis; Animals; Dental Enamel; Dimethylamines; Female; Herbic

2001
The effect of exposure to a commercial 2,4-D formulation during gestation on the immune response in CD-1 mice.
    Toxicology, 2001, Aug-13, Volume: 165, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Antigens, Surface; Body Weight; Female; Hemolytic Plaque Te

2001
Morphological study of 5-HT neurons and astroglial cells on brain of adult rats perinatal or chronically exposed to 2,4-dichlorophenoxyacetic acid.
    Neurotoxicology, 2001, Volume: 22, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Astrocytes; Brain; Female; Glial Fibrillary Acidic Protein;

2001
Increased sensitivity in dopamine D(2)-like brain receptors from 2,4-dichlorophenoxyacetic acid (2,4-D)-exposed and amphetamine-challenged rats.
    Annals of the New York Academy of Sciences, 2002, Volume: 965

    Topics: 2,4-Dichlorophenoxyacetic Acid; Aging; Amphetamine; Animals; Benzamides; Brain; Dopamine Antagonists

2002
[Characteristics of the embryotoxic action of herbicides, derivatives of 2,4-dichlorophenoxyacetic acid].
    Gigiena i sanitariia, 1979, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Embryo Loss; Embryo, Mammalian; Female; Fetal Death; Herbic

1979
[Data on hygienic standards for 2,4-D herbicides in environmental objects].
    Gigiena i sanitariia, 1978, Issue:11

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Embryo, Mammalian; Environmental Pollutants; Female; Gonads

1978
Experiences of a veterinary consultant to electric companies.
    Modern veterinary practice, 1978, Volume: 59, Issue:10

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Arsenic Poisoning; Cattle; Cattle Diseases; Electric Injuri

1978
Prenatal effects of herbicides: evaluation by the prenatal development index.
    Archives of environmental contamination and toxicology, 1977, Volume: 6, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Body Weight; Cleft Palat

1977
[Study of the effect of the herbicide 2,4-DM on the pregnant body, embryonic development on gonadal function in white rats].
    Gigiena i sanitariia, 1976, Volume: 0, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Dose-Response Relationship, Drug; Embryo, Mammalian; Female

1976
[Embryotropic effect of dissociation products of herbicides based on 2,4-dichlorphenoxyacetic acid].
    Gigiena i sanitariia, 1976, Issue:11

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Dichlorophen; Drug Interactions; Embryo, Mammalian; Female;

1976
Changes in brain serotonin and 5-hydroxyindolacetic acid levels induced by 2,4-dichlorophenoxyacetic butyl ester.
    Toxicology, 1990, Dec-03, Volume: 64, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Brain; Female; Herbicides; Hydroxyindoleacetic Acid; Male;

1990
Effects of chemically induced maternal toxicity on prenatal development in the rat.
    Teratology, 1990, Volume: 42, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Body Weight; Cacodylic A

1990
[Nature of the estrous cycle, incidence of anovulation, chromosome gametopathies and fetal death in female rats with 2,4-dichlorophenoxyacetic acid (2,4-D) before pregnancy].
    Arkhiv anatomii, gistologii i embriologii, 1990, Volume: 99, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anovulation; Chromosome Aberrations; Estrus; Female; Fetal

1990
Developing rat brain monoamine levels following in utero exposure to a mixture of 2,4-dichlorophenoxyacetic and 2,4,5-trichlorophenoxyacetic acids.
    Toxicology letters, 1985, Volume: 29, Issue:2-3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Biogenic Amines; Brain C

1985
Effects of gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice.
    Journal of toxicology and environmental health, 1989, Volume: 28, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Dr

1989
Effects of paternal subacute exposure to Tordon 202c on fetal growth and development in CD-1 mice.
    Teratology, 1989, Volume: 39, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Embryonic and Fetal Development; Female; Herbicides; Hydraz

1989
Effects of preconceptional and gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice.
    Teratology, 1989, Volume: 39, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Cohort Studies; Dose-Response Relationship, Drug; Embryonic

1989
Agent Orange and risks to reproduction: the limits of epidemiology.
    Teratogenesis, carcinogenesis, and mutagenesis, 1986, Volume: 6, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1986
Agent Orange and risks to reproduction: the limits of epidemiology.
    Teratogenesis, carcinogenesis, and mutagenesis, 1987, Volume: 7, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1987
Occupational exposures to chlorophenoxy herbicides.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1986, Volume: 41

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1986
Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA, protein, and nucleic acid levels.
    Bulletin of environmental contamination and toxicology, 1988, Volume: 40, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Brain Chemistry; Female;

1988
2,4-Dichlorophenoxyacetic acid intoxication increases its accumulation within the brain.
    Brain research, 1988, Feb-09, Volume: 440, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Autoradiography; Blood-Brain Barrier; Brain; Deoxyglucose;

1988
The effect of prenatal exposure to the n-butylester of 2,4-dichlorophenoxyacetic acid (2,4-D) on the immune response in mice.
    Teratology, 1986, Volume: 33, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Antibody Formation; B-Lymphocytes; Concanavalin A; Erythroc

1986
Ontogeny of swimming behavior and brain catecholamine turnover in rats prenatally exposed to a mixture of 2,4-dichlorophenoxyacetic and 2,4,5-trichlorophenoxyacetic acids.
    Neuropharmacology, 1987, Volume: 26, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Behavior, Animal; Brain;

1987
[Various aspects of the hygiene and toxicology of the herbicide sangor].
    Gigiena i sanitariia, 1986, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Food Cont

1986
[The degree of toxicity of the combined effects of chlorophenoxy derivative herbicides on reproductive function of warm-blooded animals, and the problems of their hygienic regulation].
    Gigiena i sanitariia, 1986, Issue:10

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1986
Evaluation of chromosomal damage in males exposed to agent orange and their families.
    Journal of craniofacial genetics and developmental biology. Supplement, 1985, Volume: 1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abor

1985
[Mechanism of the embryotropic action of 2,4-dichlorophenoxyacetic acid].
    Gigiena i sanitariia, 1985, Issue:10

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dose-Respons

1985
The effect of the phenoxyacetic acid derivatives on the enzymatic activity of the placenta in guinea-pigs.
    Folia histochemica et cytochemica, 1971, Volume: 9, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Acetates; Acid Phosphatase; Alkaline Phosphatase; Animals; Female; G

1971
[Incorporation of 2,4-D phenoxyacetic acid into animal organs and the pathways and dynamics of its excretion].
    Gigiena i sanitariia, 1974, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Feces; Female; Maternal-Fetal Exchange; Milk; Phenols; Preg

1974
Influence of protracted administration of phenoxyacetic acid derivatives and nitrogranulogen on alkaline and acid phosphatase and succinic dehydrogenase activities in the liver of guinea pigs.
    Folia morphologica, 1973, Volume: 32, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Acetates; Acid Phosphatase; Alkal

1973
[Embryotoxic action of the diethylamine salt of 2,4-D].
    Gigiena i sanitariia, 1973, Volume: 38, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Diethylamines; Dose-Response R

1973
Teratogenic and embryotoxic of the herbicides di- and trichlorophenoxyacetic acids (2,4-D and 2,4,5-T).
    Acta pharmacologica et toxicologica, 1973, Volume: 32, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1973
Pre- and postnatal studies on 2,4,5-trichlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and their derivatives in rats.
    Toxicology and applied pharmacology, 1972, Volume: 22, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acet

1972
The effect of 2,4-dichlorophenoxyacetic acid (2,4-D) and esters of 2,4-D on rat embryonal, foetal and neonatal growth and development.
    Food and cosmetics toxicology, 1971, Volume: 9, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acetates; Animals; Animals, Newborn; Bi

1971