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2,4-dichlorophenoxyacetic acid and Delayed Effects, Prenatal Exposure

2,4-dichlorophenoxyacetic acid has been researched along with Delayed Effects, Prenatal Exposure in 19 studies

2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.
2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.

Research Excerpts

ExcerptRelevanceReference
"The effect of herbicide--2,4-D, injected before pregnancy begins, on the main parameters of the reproductive function of the female rats has demonstrated that chronic administration in doses 1 mg/kg and 12 mg/kg per day for 2 months results in certain disturbances in the estrus cycle, manifesting as prolongation of the diestrus phase and in changes of estrus and meta-estrus++ duration, as well as in an essential increase in rates of anovulatory cycles."5.28[Nature of the estrous cycle, incidence of anovulation, chromosome gametopathies and fetal death in female rats with 2,4-dichlorophenoxyacetic acid (2,4-D) before pregnancy]. ( Nikitin, AI; Slozina, NM; Vin', VD, 1990)
"Agent Orange was composed of two herbicides: 2,4-D and 2,4,5-T, the latter contaminated by small amounts of a highly toxic dioxin (TCDD)."2.37Does Agent Orange cause birth defects? ( Friedman, JM, 1984)
"The effect of herbicide--2,4-D, injected before pregnancy begins, on the main parameters of the reproductive function of the female rats has demonstrated that chronic administration in doses 1 mg/kg and 12 mg/kg per day for 2 months results in certain disturbances in the estrus cycle, manifesting as prolongation of the diestrus phase and in changes of estrus and meta-estrus++ duration, as well as in an essential increase in rates of anovulatory cycles."1.28[Nature of the estrous cycle, incidence of anovulation, chromosome gametopathies and fetal death in female rats with 2,4-dichlorophenoxyacetic acid (2,4-D) before pregnancy]. ( Nikitin, AI; Slozina, NM; Vin', VD, 1990)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19906 (31.58)18.7374
1990's2 (10.53)18.2507
2000's7 (36.84)29.6817
2010's3 (15.79)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Balalian, AA1
Liu, X1
Herbstman, JB1
Daniel, S1
Whyatt, R1
Rauh, V1
Calafat, AM1
Wapner, R1
Factor-Litvak, P1
Silver, MK1
Shao, J1
Li, M1
Ji, C1
Chen, M1
Xia, Y1
Lozoff, B1
Meeker, JD1
Grufferman, S1
Lupo, PJ1
Vogel, RI1
Danysh, HE1
Erhardt, EB1
Ognjanovic, S1
Pochettino, AA1
Hapon, MB1
Biolatto, SM1
Madariaga, MJ2
Jahn, GA1
Konjuh, CN1
Bortolozzi, A3
Duffard, R3
de Duffard, AM1
Ngo, AD1
Taylor, R1
Roberts, CL1
Nguyen, TV1
Schecter, A1
Constable, JD1
Friedman, JM1
Casey, PH1
Collie, WR1
Sulik, M1
Matus, A1
Musiatowicz, B1
Sulkowska, M1
Kemona, A1
Kisielewski, W1
Sobaniec-Lotowska, M1
Barwijuk-MachaƂa, M1
Lee, K2
Johnson, VJ1
Blakley, BR3
Johnson, VL1
Garcia, G1
Tagliaferro, P1
Brusco, A1
Evangelista de Duffard, AM2
Saavedra, JP1
Antonelli, M1
Vin', VD1
Slozina, NM1
Nikitin, AI1
Cohen, FL1
Mohammad, FK2
St Omer, VE2
Blakley, PM1

Reviews

3 reviews available for 2,4-dichlorophenoxyacetic acid and Delayed Effects, Prenatal Exposure

ArticleYear
Association between Agent Orange and birth defects: systematic review and meta-analysis.
    International journal of epidemiology, 2006, Volume: 35, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Does Agent Orange cause birth defects?
    Teratology, 1984, Volume: 29, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
Paternal contributions to birth defects.
    The Nursing clinics of North America, 1986, Volume: 21, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abortion, Spontaneous; Adult; Age

1986

Other Studies

16 other studies available for 2,4-dichlorophenoxyacetic acid and Delayed Effects, Prenatal Exposure

ArticleYear
Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.
    Environmental research, 2021, Volume: 201

    Topics: 2,4-Dichlorophenoxyacetic Acid; Birth Weight; Child; Chlorpyrifos; Female; Herbicides; Humans; Infan

2021
Prenatal exposure to the herbicide 2,4-D is associated with deficits in auditory processing during infancy.
    Environmental research, 2019, Volume: 172

    Topics: 2,4-Dichlorophenoxyacetic Acid; Auditory Perceptual Disorders; China; Evoked Potentials, Auditory, B

2019
Parental military service, agent orange exposure, and the risk of rhabdomyosarcoma in offspring.
    The Journal of pediatrics, 2014, Volume: 165, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Adult; Agent Orange; Case-Control

2014
Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage.
    Drug and chemical toxicology, 2016, Volume: 39, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Administration, Oral; Animals; Endocrine Disruptors; Female; Gestati

2016
Asymmetrical development of the monoamine systems in 2,4-dichlorophenoxyacetic acid treated rats.
    Neurotoxicology, 2003, Volume: 24, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Animals, Newborn; Biogenic Monoamines; Brain; Female; Funct

2003
Commentary: Agent Orange and birth defects in Vietnam.
    International journal of epidemiology, 2006, Volume: 35, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Severe mental retardation and multiple congenital anomalies of uncertain cause after extreme parental exposure to 2,4-D.
    The Journal of pediatrics, 1984, Volume: 104, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Environ

1984
The effect of a herbicide--sodium salt of 2,4-dichlorophenoxyacetic acid on guerin carcinoma.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 1996, Volume: 41, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Cocarcinogenesis; DNA, Neoplasm; Female; Herbicides; Male;

1996
The effect of exposure to a commercial 2,4-D herbicide formulation during gestation on urethan-induced lung adenoma formation in CD-1 mice.
    Veterinary and human toxicology, 2000, Volume: 42, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Adenoma; Animals; Carcinogens; Female; Herbicides; Injections, Intra

2000
The effect of exposure to a commercial 2,4-D formulation during gestation on the immune response in CD-1 mice.
    Toxicology, 2001, Aug-13, Volume: 165, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Antigens, Surface; Body Weight; Female; Hemolytic Plaque Te

2001
Morphological study of 5-HT neurons and astroglial cells on brain of adult rats perinatal or chronically exposed to 2,4-dichlorophenoxyacetic acid.
    Neurotoxicology, 2001, Volume: 22, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Astrocytes; Brain; Female; Glial Fibrillary Acidic Protein;

2001
Increased sensitivity in dopamine D(2)-like brain receptors from 2,4-dichlorophenoxyacetic acid (2,4-D)-exposed and amphetamine-challenged rats.
    Annals of the New York Academy of Sciences, 2002, Volume: 965

    Topics: 2,4-Dichlorophenoxyacetic Acid; Aging; Amphetamine; Animals; Benzamides; Brain; Dopamine Antagonists

2002
[Nature of the estrous cycle, incidence of anovulation, chromosome gametopathies and fetal death in female rats with 2,4-dichlorophenoxyacetic acid (2,4-D) before pregnancy].
    Arkhiv anatomii, gistologii i embriologii, 1990, Volume: 99, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Anovulation; Chromosome Aberrations; Estrus; Female; Fetal

1990
Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA, protein, and nucleic acid levels.
    Bulletin of environmental contamination and toxicology, 1988, Volume: 40, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Brain Chemistry; Female;

1988
The effect of prenatal exposure to the n-butylester of 2,4-dichlorophenoxyacetic acid (2,4-D) on the immune response in mice.
    Teratology, 1986, Volume: 33, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Antibody Formation; B-Lymphocytes; Concanavalin A; Erythroc

1986
Ontogeny of swimming behavior and brain catecholamine turnover in rats prenatally exposed to a mixture of 2,4-dichlorophenoxyacetic and 2,4,5-trichlorophenoxyacetic acids.
    Neuropharmacology, 1987, Volume: 26, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Animals; Behavior, Animal; Brain;

1987