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2,4-dichlorophenoxyacetic acid and Abnormalities, Drug-Induced

2,4-dichlorophenoxyacetic acid has been researched along with Abnormalities, Drug-Induced in 54 studies

2,4-Dichlorophenoxyacetic Acid: An herbicide with irritant effects on the eye and the gastrointestinal system.
2,4-D : A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"The overall relative risk (RR) for spina bifida associated with paternal exposure to AO was 2."2.46Paternal exposure to Agent Orange and spina bifida: a meta-analysis. ( Ngo, AD; Roberts, CL; Taylor, R, 2010)
"Agent Orange was composed of two herbicides: 2,4-D and 2,4,5-T, the latter contaminated by small amounts of a highly toxic dioxin (TCDD)."2.37Does Agent Orange cause birth defects? ( Friedman, JM, 1984)
" Adverse effects were analyzed by means of the isotoxicity curves for lethality, malformations, stage-dependent susceptibility, and ultrastructural features."1.37Stage-dependent toxicity of 2,4-dichlorophenoxyacetic on the embryonic development of a South American toad, Rhinella arenarum. ( Aronzon, CM; Herkovits, J; Pérez-Coll, CS; Sandoval, MT, 2011)
" Significantly decreased fetal body weights and increased fetal variations were seen in rats only at maternally toxic dose levels in excess of 90 mg/kg/day acid equivalent."1.31Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms. ( Bus, JS; Charles, JM; Hanley, TR; van Ravenzwaay, B; Wilson, RD, 2001)
"The women had had a high number of miscarriages and premature births."1.31Impact of chemical warfare with agent orange on women's reproductive lives in Vietnam: a pilot study. ( Johansson, A; Le, TN, 2001)
" The incidence of dead fetuses/resorptions and malformed fetuses (especially cleft palate) was increased in the highest dosage group."1.28Effects of gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice. ( Blakley, PM; Firneisz, GD; Kim, JS, 1989)

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-199036 (66.67)18.7374
1990's3 (5.56)18.2507
2000's9 (16.67)29.6817
2010's5 (9.26)24.3611
2020's1 (1.85)2.80

Authors

AuthorsStudies
Martins, RX1
Vieira, L1
Souza, JACR1
Silva, MGF1
Muniz, MS1
Souza, T1
Queiroga, FR1
Machado, MRF1
da Silva, PM1
Farias, D1
Schmidt, C1
Fraser, FC1
Ngo, AD2
Taylor, R2
Roberts, CL2
Aronzon, CM1
Sandoval, MT1
Herkovits, J1
Pérez-Coll, CS1
Gomez, JG1
Nguyen, TV1
Handler, S1
Schecter, A1
Constable, JD1
Stone, R1
Juhász, E1
Szabó, R1
Keserü, M1
Budai, P1
Várnagy, L1
Fox, JL1
Friedman, JM1
Casey, PH1
Collie, WR1
Erickson, JD3
Mulinare, J3
McClain, PW1
Fitch, TG2
James, LM2
McClearn, AB1
Adams, MJ1
Dan, BB1
LaVecchio, FA1
Pashayan, HM1
Singer, W1
Gunby, P1
Duffard, R1
Traini, L1
de Duffard, AM1
Hall, P1
Selinger, B2
Field, B1
Kerr, C1
Stevens, KM1
Novikov, IuV1
Minin, GD1
Saĭfutdinov, MM1
Wolfe, WH1
Michalek, JE1
Miner, JC1
Rahe, AJ1
Moore, CA1
Needham, LL1
Patterson, DG1
Charles, JM1
Hanley, TR1
Wilson, RD1
van Ravenzwaay, B1
Bus, JS1
Le, TN1
Johansson, A1
Ishikiriyama, S1
Steele, EJ1
Bellett, AJ1
McCullagh, PJ1
Blakley, PM1
Kim, JS1
Firneisz, GD1
Hall, W4
Hatch, MC2
Stein, ZA2
Bidnenko, LI1
Konstantinova, TK2
Shevelo, FS1
Kaye, CI1
Rao, S1
Simpson, SJ1
Rosenthal, FS1
Cohen, MM1
Pearn, JH1
Sterling, TD1
Arundel, A1
MacPhee, D1
Antonenko, TA1
Ermolov, VI1
Somers, J1
Moran, ET1
Reinhart, BS1
Gyrd-Hansen, N1
Dalgaard-Mikkelsen Sv+DALGAARDAAMIKKELSEN, Sv1
Aleksashina, ZA1
Buslovich, SIu1
Kolosovskaia, VM1
Båge, G1
Cekanova, E1
Larsson, KS1
Clegg, DJ1
Lutz-Ostertag, Y1
Lutz, H1
Khera, KS1
McKinley, WP1
Schwetz, BA1
Sparschu, GL1
Gehring, PJ1

Reviews

7 reviews available for 2,4-dichlorophenoxyacetic acid and Abnormalities, Drug-Induced

ArticleYear
Paternal exposure to Agent Orange and spina bifida: a meta-analysis.
    European journal of epidemiology, 2010, Volume: 25, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2010
Association between Agent Orange and birth defects: systematic review and meta-analysis.
    International journal of epidemiology, 2006, Volume: 35, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Does Agent Orange cause birth defects?
    Teratology, 1984, Volume: 29, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
[Dioxins in the environment].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Adul

1995
Reappraisal of the findings on Agent Orange by the Australian Royal Commission.
    Toxicology letters, 1990, Volume: 51, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1990
Herbicides and congenital malformations: a review for the paediatrician.
    Australian paediatric journal, 1985, Volume: 21, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acci

1985
Embryotoxicity of chemical contaminants of foods.
    Food and cosmetics toxicology, 1971, Volume: 9, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1971

Other Studies

47 other studies available for 2,4-dichlorophenoxyacetic acid and Abnormalities, Drug-Induced

ArticleYear
Exposure to 2,4-D herbicide induces hepatotoxicity in zebrafish larvae.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2021, Volume: 248

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Biomarkers; Chemical and Drug

2021
The Fog of Agent Orange.
    Scientific American, 2016, Volume: 314, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2016
Does paternal exposure to Agent Orange cause birth defects?
    American journal of medical genetics. Part A, 2009, Volume: 149A, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2009
Stage-dependent toxicity of 2,4-dichlorophenoxyacetic on the embryonic development of a South American toad, Rhinella arenarum.
    Environmental toxicology, 2011, Volume: 26, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Bufonidae; Embryo, Nonmammalia

2011
Letter to the editor and response. Re: Production of illicit drugs, the environment, and human health, J of Toxicology and Environmental Medicine 2009;72 (15-16).
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2010
Herbicide exposure and veterans with covered service in Korea. Final rule.
    Federal register, 2011, Jan-25, Volume: 76, Issue:16

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Cong

2011
Story short on science.
    Minnesota medicine, 2006, Volume: 89, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Commentary: Agent Orange and birth defects in Vietnam.
    International journal of epidemiology, 2006, Volume: 35, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2006
Epidemiology. Agent Orange's bitter harvest.
    Science (New York, N.Y.), 2007, Jan-12, Volume: 315, Issue:5809

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2007
Teratogenicity testing of a 2,4-D containing herbicide formulation and three heavy metals in chicken embryos.
    Communications in agricultural and applied biological sciences, 2006, Volume: 71, Issue:2 Pt A

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Biological Assay; Cadmium Comp

2006
Agent Orange study is like a chameleon.
    Science (New York, N.Y.), 1984, Mar-16, Volume: 223, Issue:4641

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acne

1984
Vietnam veterans' risks for fathering babies with birth defects.
    MMWR. Morbidity and mortality weekly report, 1984, Aug-17, Volume: 33, Issue:32

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
Severe mental retardation and multiple congenital anomalies of uncertain cause after extreme parental exposure to 2,4-D.
    The Journal of pediatrics, 1984, Volume: 104, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Environ

1984
Vietnam veterans' risks for fathering babies with birth defects.
    JAMA, 1984, Aug-17, Volume: 252, Issue:7

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
Vietnam and birth defects.
    JAMA, 1984, Aug-17, Volume: 252, Issue:7

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1984
Agent Orange and birth defects.
    The New England journal of medicine, 1983, Mar-24, Volume: 308, Issue:12

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1983
More questions, not answers, emerge from Agent Orange studies.
    JAMA, 1983, May-27, Volume: 249, Issue:20

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1983
Agent Orange and birth defects.
    The New England journal of medicine, 1983, Aug-25, Volume: 309, Issue:8

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1983
Embryotoxic and teratogenic effects of phenoxy herbicides.
    Acta physiologica latino americana, 1981, Volume: 31, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1981
Antipodean 2,4,5-T.
    Nature, 1981, Mar-05, Volume: 290, Issue:5801

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1981
Agent Orange toxicity: a quantitative perspective.
    Human toxicology, 1981, Volume: 1, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1981
Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand.
    Epidemiology (Cambridge, Mass.), 1995, Volume: 6, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abor

1995
Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 60, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Ataxia; Body Weight; Dose-Resp

2001
Impact of chemical warfare with agent orange on women's reproductive lives in Vietnam: a pilot study.
    Reproductive health matters, 2001, Volume: 9, Issue:18

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abor

2001
Vietnamese sisters with Grebe syndrome on a TV program in Japan.
    Clinical genetics, 2001, Volume: 60, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

2001
Effects of gestational exposure to Tordon 202c on fetal growth and development in CD-1 mice.
    Journal of toxicology and environmental health, 1989, Volume: 28, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Dr

1989
The logic of a controversy: the case of Agent Orange in Australia.
    Social science & medicine (1982), 1989, Volume: 29, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1989
Agent Orange and risks to reproduction: the limits of epidemiology.
    Teratogenesis, carcinogenesis, and mutagenesis, 1986, Volume: 6, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1986
Agent orange and risks to reproduction: the limits of epidemiology.
    Teratogenesis, carcinogenesis, and mutagenesis, 1987, Volume: 7, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1987
Agent Orange and risks to reproduction: the limits of epidemiology.
    Teratogenesis, carcinogenesis, and mutagenesis, 1987, Volume: 7, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1987
Occupational exposures to chlorophenoxy herbicides.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1986, Volume: 41

    Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Ac

1986
The Agent Orange controversy.
    The Medical journal of Australia, 1987, Apr-20, Volume: 146, Issue:8

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1987
The Agent Orange controversy after the Evatt Royal Commission.
    The Medical journal of Australia, 1986, Sep-01, Volume: 145, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1986
[Various aspects of the hygiene and toxicology of the herbicide sangor].
    Gigiena i sanitariia, 1986, Issue:3

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Food Cont

1986
[The degree of toxicity of the combined effects of chlorophenoxy derivative herbicides on reproductive function of warm-blooded animals, and the problems of their hygienic regulation].
    Gigiena i sanitariia, 1986, Issue:10

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1986
Evaluation of chromosomal damage in males exposed to agent orange and their families.
    Journal of craniofacial genetics and developmental biology. Supplement, 1985, Volume: 1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Abor

1985
Design and execution of a very large birth-defects case-control study.
    Progress in clinical and biological research, 1985, Volume: 163B

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1985
Vietnam veterans risk for fathering children with birth defects.
    JAMA, 1985, Aug-02, Volume: 254, Issue:5

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1985
The Agent Orange controversy in Australia: a contribution to the debate.
    Community health studies, 1985, Volume: 9, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Agen

1985
[Mechanism of the embryotropic action of 2,4-dichlorophenoxyacetic acid].
    Gigiena i sanitariia, 1985, Issue:10

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Animals, Newborn; Dose-Respons

1985
Effect of external application of pesticides to the fertile egg on hatching success and early chick performance. 2. Commercial-herbicide mixtures of 2,4-D with picloram or 2,4,5-T using the pheasant.
    Bulletin of environmental contamination and toxicology, 1974, Volume: 11, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1974
The effect of phenoxy-herbicides on the hatchability of eggs and the viability of the chicks.
    Acta pharmacologica et toxicologica, 1974, Volume: 35, Issue:4

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1974
[Embryotoxic action of the diethylamine salt of 2,4-D].
    Gigiena i sanitariia, 1973, Volume: 38, Issue:2

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Animals; Diethylamines; Dose-Response R

1973
Teratogenic and embryotoxic of the herbicides di- and trichlorophenoxyacetic acids (2,4-D and 2,4,5-T).
    Acta pharmacologica et toxicologica, 1973, Volume: 32, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Anim

1973
[Baleful action of the weed-killer 2,4D on the embryonic development and fecundity of feather game].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1970, Dec-21, Volume: 271, Issue:25

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acetates; Animals; Birds; Disorders of

1970
Pre- and postnatal studies on 2,4,5-trichlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and their derivatives in rats.
    Toxicology and applied pharmacology, 1972, Volume: 22, Issue:1

    Topics: 2,4-Dichlorophenoxyacetic Acid; 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acet

1972
The effect of 2,4-dichlorophenoxyacetic acid (2,4-D) and esters of 2,4-D on rat embryonal, foetal and neonatal growth and development.
    Food and cosmetics toxicology, 1971, Volume: 9, Issue:6

    Topics: 2,4-Dichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Acetates; Animals; Animals, Newborn; Bi

1971