2-4-6-trimethyl-n-(meta-3-trifluoromethylphenyl)benzenesulfonamide has been researched along with Leukemia--Monocytic--Acute* in 1 studies
1 other study(ies) available for 2-4-6-trimethyl-n-(meta-3-trifluoromethylphenyl)benzenesulfonamide and Leukemia--Monocytic--Acute
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The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis.
We investigated the effect of the novel phospholipase C activator, m-3M3FBS, on the apoptosis of leukemic cells. m-3M3FBS inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. m-3M3FBS induced the apoptosis of U937 cells, which was accompanied by chromatin condensation and DNA fragmentation. Moreover, m-3M3FBS-induced apoptosis appeared to involve the down-regulation of anti-apoptotic Bcl-2, the up-regulation of pro-apoptotic Bax, the release of cytochrome c, and caspase activation. m-3M3FBS-induced apoptosis of U937 cells was also partly inhibited by BAPTA-AM and EGTA, indicating the involvement of intracellular calcium signaling on the apoptosis in U937 cells. The results of our study suggest that m-3M3FBS can be developed as a novel anti-leukemic agent. Topics: Apoptosis; bcl-2-Associated X Protein; Cell Survival; Down-Regulation; Humans; Leukemia, Monocytic, Acute; Monocytes; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Tumor Cells, Cultured; Up-Regulation | 2005 |