Compounds > 2-4-3--5--tetrahydroxystilbene

2-4-3--5--tetrahydroxystilbene and Neuroblastoma

2-4-3--5--tetrahydroxystilbene has been researched along with Neuroblastoma* in 2 studies

Other Studies

2 other study(ies) available for 2-4-3--5--tetrahydroxystilbene and Neuroblastoma

Article	Year
Inhibiting effect of oleocanthal on neuroblastoma cancer cell proliferation in culture. Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2020, Volume: 95, Issue:3 We investigated the potential anticancer effects of oleocanthal (OC) on neuroblastoma cells. Cells were divided into four groups: group 1, neuroblastoma cells were treated with OC; group 2, neurons that differentiated from neuroblastoma cells were treated with phosphate-buffered saline(PBS); group 3, bone marrow derived neuronal (BMDN) cells that were differentiated from bone marrow derived mesenchymal stem cells (BMSCs) were treated with OC; group 4, BMDN cells that were differentiated from BMSCs were treated with PBS. Groups 2 and 4 were control groups. The effects of OC on cell viability, oxidative stress, neurite inhibition and apoptosis at IC Topics: Aldehydes; Animals; Apoptosis; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclopentane Monoterpenes; Mesenchymal Stem Cells; Neural Stem Cells; Neuroblastoma; Phenols	2020
Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells. Food & function, 2020, Apr-30, Volume: 11, Issue:4 Several studies published in the last decade suggest that the beneficial role of extra-virgin olive oil (EVOO) in human health is mostly attributable to the main secoiridoid derivatives (oleuropein, oleocanthal, and oleacein). Anti-cancer properties have also been demonstrated for certain compounds present in small quantities in EVOO, including oleuropein and hydroxytyrosol, which have been extensively studied, while minor attention has been given to the most abundant secoiridoid oleacein. The aim of our research was to study the molecular mechanisms underlying the anti-proliferative and anti-metastatic capacity of oleacein in the SH-SY5Y human neuroblastoma cell line. Our results demonstrate that oleacein is able to reduce the proliferation of the SH-SY5Y cells by blocking the cell cycle in the S phase and inducing apoptotic cell death through the increase in both Bax and p53 as well as a reduction in the Bcl-2 expression and STAT3 phosphorylation. Moreover, oleacein caused reduction in the SH-SY5Y cell adhesion and migration. Overall, these findings indicate that oleacein exerts anti-cancer effects against neuroblastoma cells, suggesting a promising role as a candidate against this type of cancer. Topics: Aldehydes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentane Monoterpenes; Fibroblasts; Humans; Iridoid Glucosides; Iridoids; Neuroblastoma; Olive Oil; Phenols; STAT3 Transcription Factor	2020

Article

Year

Inhibiting effect of oleocanthal on neuroblastoma cancer cell proliferation in culture.

Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2020, Volume: 95, Issue:3

We investigated the potential anticancer effects of oleocanthal (OC) on neuroblastoma cells. Cells were divided into four groups: group 1, neuroblastoma cells were treated with OC; group 2, neurons that differentiated from neuroblastoma cells were treated with phosphate-buffered saline(PBS); group 3, bone marrow derived neuronal (BMDN) cells that were differentiated from bone marrow derived mesenchymal stem cells (BMSCs) were treated with OC; group 4, BMDN cells that were differentiated from BMSCs were treated with PBS. Groups 2 and 4 were control groups. The effects of OC on cell viability, oxidative stress, neurite inhibition and apoptosis at IC

Topics: Aldehydes; Animals; Apoptosis; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclopentane Monoterpenes; Mesenchymal Stem Cells; Neural Stem Cells; Neuroblastoma; Phenols

2020

Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells.

Food & function, 2020, Apr-30, Volume: 11, Issue:4

Several studies published in the last decade suggest that the beneficial role of extra-virgin olive oil (EVOO) in human health is mostly attributable to the main secoiridoid derivatives (oleuropein, oleocanthal, and oleacein). Anti-cancer properties have also been demonstrated for certain compounds present in small quantities in EVOO, including oleuropein and hydroxytyrosol, which have been extensively studied, while minor attention has been given to the most abundant secoiridoid oleacein. The aim of our research was to study the molecular mechanisms underlying the anti-proliferative and anti-metastatic capacity of oleacein in the SH-SY5Y human neuroblastoma cell line. Our results demonstrate that oleacein is able to reduce the proliferation of the SH-SY5Y cells by blocking the cell cycle in the S phase and inducing apoptotic cell death through the increase in both Bax and p53 as well as a reduction in the Bcl-2 expression and STAT3 phosphorylation. Moreover, oleacein caused reduction in the SH-SY5Y cell adhesion and migration. Overall, these findings indicate that oleacein exerts anti-cancer effects against neuroblastoma cells, suggesting a promising role as a candidate against this type of cancer.

Topics: Aldehydes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclopentane Monoterpenes; Fibroblasts; Humans; Iridoid Glucosides; Iridoids; Neuroblastoma; Olive Oil; Phenols; STAT3 Transcription Factor

2020