Compounds > 2-4-2--4--tetrachlorobiphenyl

2-4-2--4--tetrachlorobiphenyl and Neoplasms--Experimental

2-4-2--4--tetrachlorobiphenyl has been researched along with Neoplasms--Experimental* in 1 studies

Other Studies

1 other study(ies) available for 2-4-2--4--tetrachlorobiphenyl and Neoplasms--Experimental

Article	Year
The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays. Carcinogenesis, 1985, Volume: 6, Issue:3 Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3,4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic gamma-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was approximately 10-fold greater than that of the 2,2',5,5'-isomer. Topics: Adenoma; Animals; Carcinogens; Female; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Polychlorinated Biphenyls; Rats; Skin Neoplasms	1985

Article

Year

The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays.

Carcinogenesis, 1985, Volume: 6, Issue:3

Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3,4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic gamma-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was approximately 10-fold greater than that of the 2,2',5,5'-isomer.

Topics: Adenoma; Animals; Carcinogens; Female; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Polychlorinated Biphenyls; Rats; Skin Neoplasms

1985