2-4-2--4--tetrachlorobiphenyl has been researched along with Liver-Neoplasms--Experimental* in 2 studies
2 other study(ies) available for 2-4-2--4--tetrachlorobiphenyl and Liver-Neoplasms--Experimental
| Article | Year |
|---|---|
Inhibition of growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin in 5L rat hepatoma cells is associated with the presence of Ah receptor.
The role of the Ah receptor in mediating the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated in 5L rat hepatoma cells containing TCDD-inducible cytochrome P450IA1 activity and in variants lacking cytochrome P450IA1 and Ah receptor. TCDD inhibited growth of the wild-type 5L cells, but not of the Ah receptor deficient variants. The two strong Ah receptor ligands 3,3',4,4'-tetrachlorobiphenyl (3,3',4,4'-TCB) and benz[a]anthracene (BA) exerted toxic effects in 5L cells that resembled those of TCDD. The poor Ah receptor ligand 2,2',4,4'-tetrachlorobiphenyl was not toxic in 5L cells. The concentrations of TCDD, 3,3',4,4'-TCB or BA required for the toxic response were similar to those that elicited P450IA1 induction. The present results suggest strongly that interaction with the Ah receptor is a necessary link in the chain of events leading to toxic effects in 5L cells upon exposure to TCDD. Topics: Animals; Benz(a)Anthracenes; Cell Division; Cytochrome P-450 Enzyme System; DNA; In Vitro Techniques; Liver Neoplasms, Experimental; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; Tumor Cells, Cultured | 1990 |
The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays.
Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3,4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic gamma-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was approximately 10-fold greater than that of the 2,2',5,5'-isomer. Topics: Adenoma; Animals; Carcinogens; Female; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Polychlorinated Biphenyls; Rats; Skin Neoplasms | 1985 |