2,3-diphosphoglycerate has been researched along with Thalassemias in 13 studies
2,3-Diphosphoglycerate: A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
2,3-bisphosphoglyceric acid : A bisphosphoglyceric acid that is glyceric acid carrying two phospho substituents at positions 2 and 3.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationships among hemoglobin concentration (Hb), red cell 2,3-diphosphoglycerate (2,3-DPG), and p50 were studied in 20 chronically hypertransfused patients with thalassemia major." | 7.67 | Inappropriately low red cell 2,3-diphosphoglycerate and p50 in transfused beta-thalassemia. ( Correra, A; Graziano, JH; Piomelli, S; Seaman, C, 1984) |
| "The relationships among hemoglobin concentration (Hb), red cell 2,3-diphosphoglycerate (2,3-DPG), and p50 were studied in 20 chronically hypertransfused patients with thalassemia major." | 3.67 | Inappropriately low red cell 2,3-diphosphoglycerate and p50 in transfused beta-thalassemia. ( Correra, A; Graziano, JH; Piomelli, S; Seaman, C, 1984) |
| "Phosphorus-31 nuclear magnetic resonance (NMR) spectra were determined from intact erythrocytes of a patient with homozygous beta-thalassemia and from three patients with pyruvate kinase (PK) deficiency." | 3.66 | 31P NMR spectroscopy of erythrocytes in congenital hemolytic anemias: detection of heterogeneous erythrocyte populations and quantification of intracellular 2,3-diphosphoglycerate. ( Honig, GR; Labotka, RJ, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Datta, P | 1 |
| Chakrabarty, S | 1 |
| Chakrabarty, A | 1 |
| Chakrabarti, A | 1 |
| Alvarez-Sala, JL | 1 |
| Villegas, A | 1 |
| Alarcón, C | 1 |
| Espinós, D | 1 |
| Tassiopoulos, T | 2 |
| Rombos, J | 2 |
| Fessas, P | 2 |
| Correra, A | 1 |
| Graziano, JH | 2 |
| Seaman, C | 2 |
| Piomelli, S | 1 |
| Ricci, G | 1 |
| Castaldi, G | 1 |
| Zavagli, G | 1 |
| Lupi, G | 1 |
| Turati, A | 1 |
| Bezzi, T | 1 |
| Tsai, CH | 1 |
| de Leeuw, NK | 1 |
| Kaltsoya-Tassiopoulos, A | 1 |
| Alchanati, N | 1 |
| Pournaras, N | 1 |
| Labotka, RJ | 1 |
| Honig, GR | 1 |
| Fabry, ME | 1 |
| Suzuka, SM | 1 |
| Weinberg, RS | 1 |
| Lawrence, C | 1 |
| Factor, SM | 1 |
| Gilman, JG | 1 |
| Costantini, F | 1 |
| Nagel, RL | 1 |
| Como, PF | 1 |
| Hocking, DR | 1 |
| Swinton, GW | 1 |
| Trent, RJ | 1 |
| Holland, RA | 1 |
| Tibben, EA | 1 |
| Wilkinson, T | 1 |
| Kronenberg, H | 1 |
| Bayoumi, RA | 1 |
| Abu Zeid, YA | 1 |
| Abdul Sadig, A | 1 |
| Awad Elkarim, O | 1 |
| Grant, GP | 1 |
| Mansell, AL | 1 |
| Lachant, NA | 1 |
| Tanaka, KR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Studies of P. Vivax and P. Falciparum Malaria in Cambodia[NCT00663546] | 1,978 participants (Actual) | Observational | 2008-03-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for 2,3-diphosphoglycerate and Thalassemias
| Article | Year |
|---|---|
Spectrin interactions with globin chains in the presence of phosphate metabolites and hydrogen peroxide: implications for thalassaemia.
Topics: 2,3-Diphosphoglycerate; Adenosine Triphosphate; Animals; Globins; Humans; Hydrogen Peroxide; Protein | 2007 |
Intraerythrocytic adaptation to anaemia in thalassaemia.
Topics: 2,3-Diphosphoglycerate; Anemia, Hypochromic; Diphosphoglyceric Acids; Erythrocytes; Female; Humans; | 1983 |
The intraerythrocytic response to anaemia in syndromes of intermediate beta-thalassaemia.
Topics: 2,3-Diphosphoglycerate; Diphosphoglyceric Acids; Erythrocytes; Humans; Oxygen; Thalassemia | 1983 |
Inappropriately low red cell 2,3-diphosphoglycerate and p50 in transfused beta-thalassemia.
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Blood Preservation; Child; Child, Preschool; Diphosphogly | 1984 |
Red cell 2,3-diphosphoglycerate contents and oxygen affinity in heterozygous beta-thalassaemia.
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Diphosphoglyceric Acids; Erythrocytes; Female; Hemoglobin | 1982 |
Changes in 2,3-diphosphoglycerate during pregnancy and puerperium in normal women and in beta-thalassemia heterozygous women.
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Diphosphoglyceric Acids; Erythrocytes; Female; Heterozygo | 1982 |
[Anemia 2,3-DPG and tissue oxygenation in beta-thalassemia heterozygotes].
Topics: 2,3-Diphosphoglycerate; Adult; Anemia, Hypochromic; Biological Transport; Diphosphoglyceric Acids; F | 1982 |
31P NMR spectroscopy of erythrocytes in congenital hemolytic anemias: detection of heterogeneous erythrocyte populations and quantification of intracellular 2,3-diphosphoglycerate.
Topics: 2,3-Diphosphoglycerate; Adult; Anemia, Hemolytic, Congenital; Diphosphoglyceric Acids; Erythrocytes; | 1980 |
Second generation knockout sickle mice: the effect of HbF.
Topics: 2,3-Diphosphoglycerate; Age Factors; Anemia, Sickle Cell; Animals; Chromatography, High Pressure Liq | 2001 |
Hb Geelong [beta 139(H17)Asn----Asp].
Topics: 2,3-Diphosphoglycerate; Adult; Amino Acid Sequence; Diphosphoglyceric Acids; Female; Globins; Hemogl | 1991 |
Sickle cell disease in Sudan.
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Anemia, Sickle Cell; Bilirubin; Child; Child, Preschool; | 1988 |
Cardiorespiratory response to exercise in patients with thalassemia major.
Topics: 2,3-Diphosphoglycerate; Adolescent; Adult; Blood Transfusion; Cardiac Output; Child; Diphosphoglycer | 1987 |
Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria?
Topics: 2,3-Diphosphoglycerate; Antioxidants; Ascorbic Acid; Diphosphoglyceric Acids; Erythrocytes; Glutathi | 1987 |